黄芩苷及其葡萄糖醛酸衍生物黄芩苷的抗病毒作用综述。

IF 4.2 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Journal of Integrative Medicine-Jim Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI:10.1016/j.joim.2024.09.003
Xin-Yang Liu, Wei Xie, He-Yang Zhou, Hui-Qing Zhang, Yong-Sheng Jin
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引用次数: 0

摘要

以天然产物为基础的候选抗病毒药物受到了极大关注。然而,抗病毒领域缺乏足够的研究来有效对抗耐药性模式。黄芩苷及其葡萄糖醛酸衍生物黄芩素是从黄芩(Scutellaria baicalensis Georgi)中提取的两种主要成分。事实证明,它们通过直接杀死病毒颗粒、保护受感染细胞、靶向病毒表面的抗原等机制,对多种病毒有效。作为天然产品,它们都具有毒性低、疗效强的优点,甚至对耐药性病毒株有拮抗作用。黄芩素和黄芩苷作为强效药源支架具有广阔的发展前景,显示了它们的抗病毒特性。然而,迄今为止还没有关于黄芩苷和黄芩素抗病毒作用的综述。本综述总结了黄芩苷和黄芩素在体外和体内对各种类型病毒的抗病毒作用的最新研究进展,重点关注其剂量和潜在机制。目的是为合理开发和利用黄芩苷和黄芩素提供依据,并促进抗病毒药物的研究。本文引用如前:Liu XY, Xie W, Zhou HY, Zhang HQ, Jin YS.黄芩苷及其葡萄糖醛酸衍生物黄芩苷的抗病毒作用综述。J Integr Med.2024; Epub ahead of print.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin.

Natural product-based antiviral candidates have received significant attention. However, there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance. Baicalein and its glucuronide derivative baicalin are two main components extracted from Scutellaria baicalensis Georgi. They have proven to be effective against a broad range of viruses by directly killing virus particles, protecting infected cells, and targeting viral antigens on their surface, among other mechanisms. As natural products, they both possess the advantage of lower toxicity, enhanced therapeutic efficacy, and even antagonistic effects against drug-resistant viral strains. Baicalein and baicalin exhibit promising potential as potent pharmacophore scaffolds, demonstrating their antiviral properties. However, to date, no review on the antiviral effects of baicalein and baicalin has been published. This review summarizes the recent research progress on antiviral effects of baicalein and baicalin against various types of viruses both in vitro and in vivo with a focus on the dosages and underlying mechanisms. The aim is to provide a basis for the rational development and utilization of baicalein and baicalin, as well as to promote antiviral drug research. Please cite this article as: Liu XY, Xie W, Zhou HY, Zhang HQ, Jin YS. A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin. J Integr Med. 2024; 22(6): 621-636.

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来源期刊
Journal of Integrative Medicine-Jim
Journal of Integrative Medicine-Jim Medicine-Complementary and Alternative Medicine
CiteScore
9.20
自引率
4.20%
发文量
3319
期刊介绍: The predecessor of JIM is the Journal of Chinese Integrative Medicine (Zhong Xi Yi Jie He Xue Bao). With this new, English-language publication, we are committed to make JIM an international platform for publishing high-quality papers on complementary and alternative medicine (CAM) and an open forum in which the different professions and international scholarly communities can exchange views, share research and their clinical experience, discuss CAM education, and confer about issues and problems in our various disciplines and in CAM as a whole in order to promote integrative medicine. JIM is indexed/abstracted in: MEDLINE/PubMed, ScienceDirect, Emerging Sources Citation Index (ESCI), Scopus, Embase, Chemical Abstracts (CA), CAB Abstracts, EBSCO, WPRIM, JST China, Chinese Science Citation Database (CSCD), and China National Knowledge Infrastructure (CNKI). JIM Editorial Office uses ThomsonReuters ScholarOne Manuscripts as submitting and review system (submission link: http://mc03.manuscriptcentral.com/jcim-en). JIM is published bimonthly. Manuscripts submitted to JIM should be written in English. Article types include but are not limited to randomized controlled and pragmatic trials, translational and patient-centered effectiveness outcome studies, case series and reports, clinical trial protocols, preclinical and basic science studies, systematic reviews and meta-analyses, papers on methodology and CAM history or education, conference proceedings, editorials, commentaries, short communications, book reviews, and letters to the editor. Our purpose is to publish a prestigious international journal for studies in integrative medicine. To achieve this aim, we seek to publish high-quality papers on any aspects of integrative medicine, such as acupuncture and traditional Chinese medicine, Ayurveda medicine, herbal medicine, homeopathy, nutrition, chiropractic, mind-body medicine, taichi, qigong, meditation, and any other modalities of CAM; our commitment to international scope ensures that research and progress from all regions of the world are widely covered. These ensure that articles published in JIM have the maximum exposure to the international scholarly community. JIM can help its authors let their papers reach the widest possible range of readers, and let all those who share an interest in their research field be concerned with their study.
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