Journal of Integrative Medicine-Jim最新文献

{"title":"Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis","authors":"Miguel Faria ,&nbsp;Mónica Teixeira ,&nbsp;Maria João Pinto ,&nbsp;Paulo Sargento","doi":"10.1016/j.joim.2024.03.002","DOIUrl":"10.1016/j.joim.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Pain associated with cancer is one of the greatest causes of reduced quality of life in patients. Acupuncture is one of the treatments used to address this issue, with the great advantage of having little or no side effects, especially when compared with pharmacological pain-killers.</p></div><div><h3>Objective</h3><p>The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain.</p></div><div><h3>Search strategy</h3><p>Six electronic databases (PubMed, EBSCO, Cochrane Library, Scielo, b-On and Scopus) were searched for relevant articles about pain relief in cancer patients from their beginning until 2022 using MeSH terms such as “acupuncture,” “electroacupuncture,” “ear acupuncture,” “acupuncture analgesia,” ‘‘oncological pain,” and “cancer pain.”</p></div><div><h3>Inclusion criteria</h3><p>Studies included were randomized controlled trials (RCTs) where acupuncture was compared with no treatment, placebo acupuncture or usual care.</p></div><div><h3>Data extraction and analysis</h3><p>Three independent reviewers participated in data extraction and evaluation of risk of bias, and a meta-analysis was conducted. The primary outcome was pain intensity, measured with the visual analog scale, numeric rating scale, or brief pain inventory. Secondary outcomes also assessed were quality of life, functionality, xerostomia, pain interference, and analgesic consumption. Results were expressed as standardized mean difference (SMD) with 95% confidence interval (CI).</p></div><div><h3>Results</h3><p>Sixteen RCTs with a total of 1124 participants were included in the meta-analysis, with the majority of the studies presenting a low or unclear risk of bias. Acupuncture was more effective in reducing pain than no treatment (SMD = –0.90, 95 % CI [–1.68, –0.12]), sham acupuncture (SMD = –1.10, 95 % CI [–1.59, –0.61]) or usual care (SMD = –1.16, 95 % CI [–1.38, –0.93]).</p></div><div><h3>Conclusion</h3><p>The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with cancer. Despite some limitations due to the low quality and small sample size of some included studies, as well as the different types and stages of cancer, acupuncture might provide an effective and safe treatment to reduce cancer pain.</p><p>Please cite this article as: Faria M, Teixeira M, Pinto MJ, Sargento P. Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis. <em>J Integr Med</em>. 2024; 22(3): 235–244.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 3","pages":"Pages 235-244"},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses","authors":"Tian-tian Meng ,&nbsp;Ya-ping You ,&nbsp;Min Li ,&nbsp;Jian-bo Guo ,&nbsp;Xin-bin Song ,&nbsp;Jing-yi Ding ,&nbsp;Xiao-long Xie ,&nbsp;An-qi Li ,&nbsp;Shang-jin Li ,&nbsp;Xiang-jun Yin ,&nbsp;Peng Wang ,&nbsp;Zhe Wang ,&nbsp;Bao-liang Wang ,&nbsp;Qing-yong He","doi":"10.1016/j.joim.2024.03.003","DOIUrl":"10.1016/j.joim.2024.03.003","url":null,"abstract":"<div><h3>Background</h3><p><em>Ginkgo biloba</em> L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published.</p></div><div><h3>Objective</h3><p>This overview aims to assess the quality of related SRs and MAs.</p></div><div><h3>Search strategy</h3><p>PubMed, Embase, Cochrane Library, Web of Science, Chinese Biological Medicine, China National Knowledge Infrastructure, Wanfang, and Chinese Science and Technology Journals databases were searched from their inception to December 31, 2022.</p></div><div><h3>Inclusion criteria</h3><p>SRs and MAs of randomized controlled trials (RCTs) that explored the efficacy of GBLPs for patients with IS were included.</p></div><div><h3>Data extraction and analysis</h3><p>Two independent reviewers extracted data and assessed the methodological quality, risk of bias (ROB), reporting quality, and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2), Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively. Additionally, descriptive analysis and data synthesis were conducted.</p></div><div><h3>Results</h3><p>Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2, and 28 had a high ROB based on the ROBIS. According to the PRISMA statement, the reporting items of the included SRs/MAs are relatively complete. The results based on GRADE showed that of the 119 outcomes, 8 were rated as moderate quality, 24 as low quality, and 87 as very low quality. Based on the data synthesis, GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.</p></div><div><h3>Conclusion</h3><p>GBLPs can be considered a beneficial supplemental therapy for IS. However, because of the low quality of the existing evidence, high-quality RCTs and SRs/MAs are warranted to further evaluate the benefits of GBLPs for treating IS.</p><p>Please cite this article as: Meng TT, You YP, Li M, Guo JB, Song XB, Ding JY, Xie XL, Li AQ, Li SJ, Yin XJ, Wang P, Wang Z, Wang BL, He QY. Chinese herbal medicine <em>Ginkgo biloba</em> L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses. <em>J Integr Med</em>. 2024;22(2): 163–179.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 163-179"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrononutrition in traditional European medicine—Ideal meal timing for cardiometabolic health promotion","authors":"Nora Selena Eberli,&nbsp;Ludivine Colas,&nbsp;Anne Gimalac","doi":"10.1016/j.joim.2024.02.002","DOIUrl":"10.1016/j.joim.2024.02.002","url":null,"abstract":"<div><p>Meal timing plays a crucial role for cardiometabolic health, given the circadian regulation of cardiometabolic function. However, to the best of our knowledge, no concept of meal timing exists in traditional European medicine (TEM). Therefore, in this narrative review, we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further implications. By reviewing literature published between 2002 and 2022, we found that optimal timing for energy intake may be between 06:00 and 09:00, 12:00 and 14:00, and between 15:00 and 18:00, with high energy breakfast, medium energy lunch and low energy dinner and possibly further adjustments according to one’s chronotype and genetics. Also, timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction, a concept describing digestion and metabolism in TEM.</p><p>Please cite this article as: Eberli NS, Colas L, Gimalac A. Chrononutrition in traditional European medicine—Ideal meal timing for cardiometabolic health promotion. <em>J Integr Med</em>. 2024; 22(2);115–125.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 115-125"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for obesity and related diseases: Insight for regulating neural circuit","authors":"Lin-yan Jiang ,&nbsp;Jun Tian ,&nbsp;Ya-nan Yang ,&nbsp;Shao-hui Jia ,&nbsp;Qing Shu","doi":"10.1016/j.joim.2024.03.001","DOIUrl":"10.1016/j.joim.2024.03.001","url":null,"abstract":"<div><p>Obesity is defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with numerous pathological changes including insulin resistance, fatty liver, hyperlipidemias, and other obesity-related diseases. These comorbidities comprise a significant public health threat. Existing anti-obesity drugs have been limited by side effects that include depression, suicidal thoughts, cardiovascular complications and stroke. Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions, while avoiding side effects. However, the mechanisms of acupuncture in treating obesity-related diseases, especially its effect on neural circuits, are not well understood. A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural circuits. In this article, recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system, as well as some neural circuits involved, was summarized. Based on this, acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed, leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.</p><p>Please cite this article as: Jiang LY, Tian J, Yang YN, Jia SH, Shu Q. Acupuncture for obesity and related diseases: insight for regulating neural circuit. <em>J Integr Med</em>. 2024; 22(2): 93–101.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 93-101"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496424000256/pdfft?md5=58d62d8eaa2d4d391ae8fb9d76c12368&pid=1-s2.0-S2095496424000256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials","authors":"Zhen-yu Ma ,&nbsp;Shu-ping Yang ,&nbsp;Ying Li ,&nbsp;Tian-tian Xu ,&nbsp;Ya-lin Yang ,&nbsp;Hui-yong Yang ,&nbsp;Heng-bing Li ,&nbsp;Le-jin Zhou ,&nbsp;Yong Diao ,&nbsp;Su-yun Li","doi":"10.1016/j.joim.2024.01.008","DOIUrl":"10.1016/j.joim.2024.01.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Red yeast rice (RYR), a natural lipid-lowering agent, is widely used in clinical practice. However, the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results, and the credibility of the evidence has not been quantified.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health outcomes.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Search strategy&lt;/h3&gt;&lt;p&gt;Seven literature databases were searched from inception to May 5, 2023, using medical subject headings and free-text terms (e.g., “red yeast rice,” “&lt;em&gt;Xuezhikang&lt;/em&gt;,” and “&lt;em&gt;Zhibitai&lt;/em&gt;”).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Inclusion criteria&lt;/h3&gt;&lt;p&gt;Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this study.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Data extraction and analysis&lt;/h3&gt;&lt;p&gt;Two researchers independently extracted data using a standardized data collection table; any disagreements were resolved by consulting a third researcher. Based on the participant, intervention, comparator and outcome (PICO) framework in each eligible meta-analysis, a series of unique associations between the use of RYR preparations and adverse health outcomes were determined. The associations’ effect estimates were re-evaluated using random-effect models.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Fifteen meta-analyses, comprising 186 (164 unique) randomized controlled trials, were identified. Based on A MeaSurement Tool to Assess Systematic Reviews version 2, 3 (20%) and 12 (80%) of these meta-analyses had low and critically low confidence, respectively. A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible meta-analyses. Based on the random-effect models, 10 (16.4%) associations indicated a significant protective effect of RYR preparations against adverse health outcomes, while 5 (8.2%) indicated an increased risk of adverse health outcomes related to uric acid, alanine transaminase and aspartate transaminase levels. The other 46 (75.4%) associations showed no significant difference between the use of RYR preparations and control treatments. Regarding the credibility of the evidence, 21 (34.4%), 34 (55.7%) and 6 (9.8%) associations showed moderate, low and very low credibility, respectively.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;The evidence examined in this study suggests that RYR preparations are safe; however, the credibility of the evidence was not high. Further high-quality evidence is required.&lt;/p&gt;&lt;p&gt;Please cite this article as: Ma ZY, Yang SP, Li Y, Xu TT, Yang YL, Yang HY, Li HB, Zhou LJ, Diao Y, Li SY. Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials. &lt;em&gt;J Integr Med","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 126-136"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139662922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordyceps as potential therapeutic agents for atherosclerosis","authors":"Yi Zhang ,&nbsp;Si-jing Liu","doi":"10.1016/j.joim.2024.03.004","DOIUrl":"10.1016/j.joim.2024.03.004","url":null,"abstract":"<div><p>Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies. Cordyceps is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for atherosclerosis. Numerous studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions, including anti-inflammatory and antioxidant activities, lowering cholesterol, inhibiting platelet aggregation, and modulating apoptosis or autophagy in vascular endothelial cells. Notably, the current misuse of the terms cordyceps and <em>Ophiocordyceps sinensis</em> has caused confusion among researchers, and complicated the current academic research on cordyceps. This review focuses on the chemical composition, pharmacological actions, and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of <em>Ophiocordyceps</em> spp. This review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.</p><p>Please cite this article as: Zhang Y, Liu SJ. Cordyceps as potential therapeutic agents for atherosclerosis. <em>J Integr Med</em>. 2024; 22(2): 102–114.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 102-114"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review","authors":"Bizhar Ahmed Tayeb ,&nbsp;Ikhwan Yuda Kusuma ,&nbsp;Alaa A.M. Osman ,&nbsp;Renáta Minorics","doi":"10.1016/j.joim.2024.02.001","DOIUrl":"10.1016/j.joim.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>The field of personalized medicine has gained increasing attention in cancer care, with the aim of tailoring treatment strategies to individual patients for improved outcomes. Herbal medicine, with its long-standing historical use and extensive bioactive compounds, offers a rich source of potential treatments for various diseases, including cancer.</p></div><div><h3>Objective</h3><p>To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases. Additionally, to explore the general characteristics of the studies included in the analysis, focusing on their key features and trends.</p></div><div><h3>Search strategy</h3><p>A comprehensive literature search was conducted from multiple online databases, including PubMed, Scopus, Web of Science, and CINAHL-EBSCO. The search strategy was designed to identify studies related to personalized cancer medicine and herbal interventions.</p></div><div><h3>Inclusion criteria</h3><p>Publications pertaining to cancer research conducted through in vitro, in vivo, and clinical studies, employing natural products were included in this review.</p></div><div><h3>Data extraction and analysis</h3><p>Two review authors independently applied inclusion and inclusion criteria, data extraction, and assessments of methodological quality. The quality assessment and biases of the studies were evaluated based on modified Jadad scales. A detailed quantitative summary of the included studies is presented, providing a comprehensive description of their key features and findings.</p></div><div><h3>Results</h3><p>A total of 121 studies were included in this review for analysis. Some of them were considered as comprehensive experimental investigations both in vitro and in vivo. The majority (<em>n</em> = 85) of the studies included in this review were conducted in vitro, with 44 of them specifically investigating the effects of herbal medicine on animal models. Additionally, 7 articles with a combined sample size of 31,271 patients, examined the impact of herbal medicine in clinical settings.</p></div><div><h3>Conclusion</h3><p>Personalized medication can optimize the use of herbal medicine in cancer treatment by considering individual patient factors such as genetics, medical history, and other treatments. Additionally, active phytochemicals found in herbs have shown potential for inhibiting cancer cell growth and inducing apoptosis, making them a promising area of research in preclinical and clinical investigations.</p><p>Please cite this article as: Tayeb BA, Kusuma IY, Osman AAM, Minorics R. Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review. <em>J Integr Med</em>. 2024; 22(2): 137–162.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 137-162"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140016664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey","authors":"Peng Wang ,&nbsp;Jing Hong ,&nbsp;Zhu-qian Tang ,&nbsp;Bi-zhen Gong ,&nbsp;Xiao-rong Qi ,&nbsp;Han Jiang ,&nbsp;Bo Pan ,&nbsp;Qi Chen","doi":"10.1016/j.joim.2024.03.005","DOIUrl":"10.1016/j.joim.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>The efficacy of medications for Parkinson’s disease (PD) tend to decline over time, which has a serious impact on patients’ health and quality of life. To some extent, traditional Chinese medicine (TCM) can resolve the distressing problem of ineffective dopaminergic medication in PD patients. The purpose of this study was to investigate the attitude, acceptance, and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.</p></div><div><h3>Methods</h3><p>A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023. A self-report questionnaire was developed to investigate PD patients’ attitudes and acceptance of TCM based on the questionnaire. Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients’ adoption of TCM therapy.</p></div><div><h3>Results</h3><p>A total of 397 patients completed the questionnaire, of which 78.09% were willing to be treated with TCM and 21.91% indicated that they were not willing to use TCM. Multifactorial logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic regime. These included education level of a bachelor’s degree (odds ratio [OR) = 8.554; 95% confidence interval [CI]: 4.112–17.794; <em>P</em> &lt; 0.001, <em>vs</em> junior high school education), living in an urban setting (OR = 8.022; 95% CI: 4.577–14.060; <em>P</em> &lt; 0.001, <em>vs</em> rural), having other underlying diseases (OR = 5.126; 95% CI: 3.078–8.537; <em>P</em> &lt; 0.001, <em>vs</em> none), having previously used TCM (OR = 3.083; 95% CI: 1.852–5.134; <em>P</em> &lt; 0.001, <em>vs</em> not used), believing that TCM therapy is safe (OR = 3.530; 95% CI: 1.446–8.616; <em>P</em> = 0.006, <em>vs</em> not thought), believing that TCM therapy is effective (OR = 3.859; 95% CI: 1.482–10.047; <em>P</em> = 0.006, <em>vs</em> not understood), and being willing to discuss ongoing TCM therapy with an attending physician (OR = 62.468; 95% CI: 30.350–128.574; <em>P</em> &lt; 0.001, <em>vs</em> not informed).</p></div><div><h3>Conclusion</h3><p>This study initially investigated the acceptance, attitude, and independent predictors of TCM use among PD patients. To expand the prevalence of TCM use among patients with PD, we recommend to broadening the public outreach for TCM via contemporary means of Internet and broadcast communication, enhancing access to TCM services in rural communities, and strengthening the communication between doctors and patients.</p><p>Please cite this article as: Wang P, Hong J, Tang ZQ, Gong BZ, Qi XR, Jiang H, Pan B, Chen Q. The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey. <em>J Integr Med</em>. 2024; 22(2): 180–187.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 180-187"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation","authors":"Meng Li ,&nbsp;Yang Zhou ,&nbsp;Hui Zhu ,&nbsp;Lie-ming Xu ,&nbsp;Jian Ping","doi":"10.1016/j.joim.2024.03.006","DOIUrl":"10.1016/j.joim.2024.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis.</p></div><div><h3>Methods</h3><p>In vivo experiments were conducted using 8-week-old <em>multidrug resistance protein 2</em> knockout (<em>Mdr2^-/-</em>) mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver function, liver histopathology, and the expression of liver fibrosis-related proteins. Real-time polymerase chain reaction, Western blot, immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA <em>H19</em> (<em>H19</em>) and signal transducer and activator of transcription 3 (STAT3) phosphorylation in the liver tissue of <em>Mdr2^-/-</em> mice. In addition, cholangiocytes and hepatic stellate cells (HSCs) were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and <em>H19</em> expression. Cholangiocytes overexpressing <em>H19</em> were constructed, and a conditioned medium containing <em>H19</em> was collected to measure its effects on STAT3 protein expression and cell activation. The intervention effect of DHQ on these processes was also investigated. HSCs overexpressing <em>H19</em> were constructed to measure the impact of <em>H19</em> on cell activation and assess the intervention effect of DHQ.</p></div><div><h3>Results</h3><p>DHQ alleviated liver injury, ductular reaction, and fibrosis in <em>Mdr2^-/-</em> mice, and inhibited <em>H19</em> expression, STAT3 expression and STAT3 phosphorylation. This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of <em>H19</em>, inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium, and decreased the expression of activation markers in HSCs. The overexpression of <em>H19</em> in a human HSC line confirmed that <em>H19</em> promoted STAT3 phosphorylation and HSC activation, and DHQ was able to successfully inhibit these effects.</p></div><div><h3>Conclusion</h3><p>DHQ effectively alleviated spontaneous cholestatic liver fibrosis in <em>Mdr2^-/-</em> mice by inhibiting <em>H19</em> upregulation in cholangiocytes and preventing the inhibition of STAT3 phosphorylation in HSC, thereby suppressing cell activation.</p><p>Please cite this article as: Li M, Zhou Y, Zhu H, Xu LM, Ping J. Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA <em>H19</em> derived from cholangiocytes and inhibiting hepatic stellate cell activation. <em>J Integr Med.</em> 2024; 22(2): 188–198.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 188-198"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension: A systematic review and meta-analysis","authors":"Zheng-gang Zhu ,&nbsp;Jian-ru Wang ,&nbsp;Xiao-yan Pan","doi":"10.1016/j.joim.2023.11.006","DOIUrl":"10.1016/j.joim.2023.11.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Scraping therapy is widely used in treating stage I and II essential hypertension in China. However, there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Search strategy&lt;/h3&gt;&lt;p&gt;Seven electronic databases (PubMed, Scopus, Cochrane Library, Web of Science, EBSCO, China National Knowledge Infrastructure and Wanfang Data electronic databases) were searched from inception to December 2022. Based on the principle of combining subject words with text words, the search strategy was constructed around search terms for “scraping therapy,” “scraping,” “&lt;em&gt;Guasha&lt;/em&gt;,” “&lt;em&gt;Gua sha&lt;/em&gt;,” “hypertension,” and “high blood pressure” during the database searches.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Inclusion criteria&lt;/h3&gt;&lt;p&gt;Randomized controlled trials (RCTs) were included if they recruited patients with stage I and II essential hypertension and included a scraping therapy intervention. The intervention group received antihypertensive drugs and scraping therapy, while the control group only took antihypertensive drugs.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Data extraction and analysis&lt;/h3&gt;&lt;p&gt;Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the meta-analysis. The quality of the selected RCTs was assessed using the PEDro scale. The sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the outcome. Subgroup analysis was performed to find the source of heterogeneity. Funnel plots were used to evaluate the publication bias of included studies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Nine RCTs including 765 participants were selected. Meta-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure (mean difference [MD] = −5.09, 95% confidence interval [CI] = −6.50 to −3.67, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) and diastolic blood pressure (MD = −2.66, 95% CI = −3.17 to −2.14, &lt;em&gt;P&lt;/em&gt; &lt; 0.001). Subgroup analysis showed that scraping therapy improved sleep quality in middle-aged patients with hypertension, but the efficacy was better in elderly patients (MD = −7.91, 95% CI = −8.65 to −7.16, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) than in middle-aged patients (MD = −2.67, 95% CI = −4.12 to −1.21, &lt;em&gt;P&lt;/em&gt; = 0.0003).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;The available evidence indicates that scraping therapy has significant effects on patients with stage I and II hypertension, and it improves sleep quality for elderly patients with hypertension better than for middle-aged ones. Scraping therapy can be an adjunctive treatment for stage I and II essential hypertension. However, further high-quality studies are needed to verify its effectiveness and the best therapeutic strategies.&lt;/p&gt;&lt;p&gt;Please cite this article a","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 12-21"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000973/pdfft?md5=23b8e0f4bf71e751cc92063998c6a344&pid=1-s2.0-S2095496423000973-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138496866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}