Journal of Integrative Medicine-Jim最新文献

{"title":"Predictors of the placebo response in a nutraceutical randomized controlled trial for depression","authors":"Rosemary Arnold ,&nbsp;Jenifer Murphy-Smith ,&nbsp;Chee H. Ng ,&nbsp;David Mischoulon ,&nbsp;Gerard J. Byrne ,&nbsp;Chad A. Bousman ,&nbsp;Con Stough ,&nbsp;Michael Berk ,&nbsp;Jerome Sarris","doi":"10.1016/j.joim.2024.01.007","DOIUrl":"10.1016/j.joim.2024.01.007","url":null,"abstract":"<div><h3>Objective</h3><p>The placebo response in depression studies is the change in symptoms amongst those who receive an inactive treatment. Many well-designed randomized controlled trials (RCTs) of depression have a high proportion of placebo responders, with little understanding as to why. The present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo responders.</p></div><div><h3>Methods</h3><p>This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo (<em>n</em> = 69 in placebo group). We investigated participant characteristics such as socio-demographics, clinical features, and recruitment methods, and their association with the placebo response. Monoaminergic genetic polymorphisms were also assessed. Placebo response was measured based on change in Montgomery-Asberg Depression Rating Scale score. The association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects models.</p></div><div><h3>Results</h3><p>Greater levels of education, particularly pursuing post-high school education, better self-reported general health, marriage/de facto, greater improvement in the first trial week, and more failed antidepressant therapies in the current depressive episode were associated with greater placebo response. An increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant therapy. Single nucleotide polymorphisms from the tryptophan hydroxylase 1 (<em>TPH1</em>) gene (<em>A779C</em> and <em>A218C</em>) were weakly associated with greater placebo response, although the evidence was attenuated after accounting for multiple comparisons.</p></div><div><h3>Conclusion</h3><p>This is, to our knowledge, the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo response. Several variables appeared to predict the placebo response. Such findings may encourage future trial designs which could dampen placebo response, improve assay sensitivity, and allow for treatment effects to be potentially more detectable.</p><p>Please cite this article as: Arnold R, Murphy-Smith J, Ng CH, Mischoulon D, Byrne GJ, Bousman CA, Stough C, Berk M, Sarris J. Predictors of the placebo response in a nutraceutical randomized controlled trial for depression. <em>J Integr Med</em>. 2024; 22(1): 46–53.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496424000074/pdfft?md5=c9a4760d210596822c3c4e56242bde72&pid=1-s2.0-S2095496424000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval: A randomized controlled trial","authors":"Li-ying Liu ,&nbsp;Yang Su ,&nbsp;Rong-rong Wang ,&nbsp;Yuan-yuan Lai ,&nbsp;Lei Huang ,&nbsp;Yi-ting Li ,&nbsp;Xin-yue Tao ,&nbsp;Meng-hua Su ,&nbsp;Xiao-yan Zheng ,&nbsp;Shi-chen Huang ,&nbsp;Yong-na Wu ,&nbsp;Si-yi Yu ,&nbsp;Fan-rong Liang ,&nbsp;Jie Yang","doi":"10.1016/j.joim.2024.01.005","DOIUrl":"10.1016/j.joim.2024.01.005","url":null,"abstract":"<div><h3>Background</h3><p>Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the procedure. Some research showed that transcutaneous electrical acupoint stimulation (TEAS) can relieve intraoperative pain and postoperative nausea.</p></div><div><h3>Objective</h3><p>This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte retrieval.</p></div><div><h3>Design, setting, participants and interventions</h3><p>Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS group. The two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte retrieval.</p></div><div><h3>Main outcome measures</h3><p>The primary outcome was the visual analog scale (VAS) pain score. Secondary outcomes were pressure pain threshold, McGill score, pain rating index (PRI), present pain intensity (PPI), VAS stress score, VAS anxiety score, and postoperative adverse symptoms.</p></div><div><h3>Results</h3><p>The baseline characteristics of the two groups were comparable (<em>P</em> &gt; 0.05). The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval (<em>P</em> &lt; 0.05). The McGill score, PRI and PPI in the TEAS group were significantly lower than those in the control group at 60 min after oocyte retrieval (<em>P</em> &lt; 0.05). However, the two groups had equivalent beneficial effects regarding the negative emotions, such as nervousness and anxiety (<em>P</em> &gt; 0.05). The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.</p><p>Please cite this article as: Liu LY, Su Y, Wang RR, Lai YY, Huang L, Li YT, Tao XY, Su MH, Zheng XY, Huang SC, Wu YN, Yu SY, Liang FR, Yang J. Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval: A randomized controlled trial. <em>J Integr Med</em>. 2024; 22(1): 32–38.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling","authors":"Lu-lu Han ,&nbsp;Xin Zhang ,&nbsp;Hui Zhang ,&nbsp;Ting Li ,&nbsp;Yi-chen Zhao ,&nbsp;Ming-hui Tian ,&nbsp;Feng-lei Sun ,&nbsp;Bo Feng","doi":"10.1016/j.joim.2024.01.003","DOIUrl":"10.1016/j.joim.2024.01.003","url":null,"abstract":"<div><h3>Objective</h3><p>Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs; however, concerns regarding complexities and side effects persist, driving research for more effective, low-risk strategies. The promotion of white adipose tissue (WAT) browning has emerged as a promising approach. Moreover, alisol B 23-acetate (AB23A) has demonstrated efficacy in addressing metabolic disorders, suggesting its potential as a therapeutic agent in obesity management. Therefore, in this study, we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet (HFD).</p></div><div><h3>Methods</h3><p>An obesity mouse model was established by administration of an HFD. Glucose and insulin metabolism were assessed via glucose and insulin tolerance tests. Adipocyte size was determined using hematoxylin and eosin staining. The expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain reaction. Metabolic cage monitoring involved the assessment of various parameters, including food and water intake, energy metabolism, respiratory exchange rates, and physical activity. Moreover, oil red O staining was used to evaluate intracellular lipid accumulation. A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling pathways.</p></div><div><h3>Results</h3><p>AB23A administration significantly reduced the weight of obese mice, decreased the mass of inguinal WAT, epididymal WAT, and perirenal adipose tissue, improved glucose and insulin metabolism, and reduced adipocyte size. Moreover, treatment with AB23A promoted the expression of browning markers in WAT, enhanced overall energy metabolism in mice, and had no discernible effect on food intake, water consumption, or physical activity. In 3T3-L1 cells, AB23A inhibited lipid accumulation, and both AB23A and rapamycin inhibited the mammalian target of rapamycin-sterol regulatory element-binding protein-1 (mTOR-SREBP1) signaling pathway. Furthermore, 3-isobutyl-1-methylxanthine, dexamethasone and insulin, at concentrations of 0.25 mmol/L, 0.25 μmol/L and 1 μg/mL, respectively, induced activation of the mTOR-SREBP1 signaling pathway, which was further strengthened by an mTOR activator MHY1485. Notably, MHY1485 reversed the beneficial effects of AB23A in 3T3-L1 cells.</p></div><div><h3>Conclusion</h3><p>AB23A promoted WAT browning by inhibiting the mTOR-SREBP1 signaling pathway, offering a potential strategy to prevent obesity.</p><p>Please cite this article as: Han LL, Zhang X, Zhang H, Li T, Zhao YC, Tian MH, Sun FL, Feng B. Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling. <em>J Integr Med</em>. 2024; 22(1): 83–92.</","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496424000037/pdfft?md5=aa5eacc46ad058398ada8236b7b97dab&pid=1-s2.0-S2095496424000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency","authors":"Jing-shun Meng ,&nbsp;Yun He ,&nbsp;Heng-bin Yang ,&nbsp;Li-ping Zhou ,&nbsp;Si-yuan Wang ,&nbsp;Xi-lin Feng ,&nbsp;Omar Yahya Al-shargi ,&nbsp;Xiao-min Yu ,&nbsp;Li-qing Zhu ,&nbsp;Chang-quan Ling","doi":"10.1016/j.joim.2024.01.001","DOIUrl":"10.1016/j.joim.2024.01.001","url":null,"abstract":"<div><h3>Objective</h3><p><span><span>Melittin<span> and its derivative have been developed to support effective gene delivery systems. Their ability to facilitate endosomal release enhances the delivery of nanoparticle-based gene therapy. Nevertheless, its potential application in the context of viral vectors has not received much attention. Therefore, we would like to optimize the </span></span>rAAV vector<span> by Melittin analog to improve the transduction efficiency of rAAV in liver </span></span>cancer cells and explore the mechanism of Melittin analog on rAAV.</p></div><div><h3>Methods</h3><p><span>Various melittin-derived peptides were inserted into loop VIII of the capsid protein in recombinant adeno-associated virus vectors. These vectors carrying either </span><span><em>gfp</em></span> or <em>fluc</em><span><span> genes were subjected to quantitative polymerase chain reaction assays and transduction assays in human embryonic kidney 293 (HEK293T) cells to investigate the efficiency of vector production and gene delivery. In addition, the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo </span>tail vein<span> administration to C57BL/6 mice. Finally, the intricate details of the vector-mediated transduction mechanisms were explored by using pharmacological inhibitors of every stage of the rAAV2 intracellular life cycle.</span></span></p></div><div><h3>Results</h3><p>A total of 76 melittin-related peptides were identified from existing literature. Among them, CMA-3, p5RHH and aAR3 were found to significantly inhibit transduction of rAAV2 vector crude lysate. The p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to rAAV. Mechanistically, bafilomycin A1<span>, a vacuolar endosome acidification inhibitor, completely inhibited the transgene expression mediated by the p5RHH-rAAV2 vectors. Most importantly, p5RHH-rAAV8 vectors also increased hepatic transduction in vivo in C57BL/6 mice.</span></p></div><div><h3>Conclusion</h3><p>The incorporation of melittin analogs into the rAAV capsids results in a significant improvement in rAAV-mediated transgene expression. While further modifications remain an area of interest, our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.</p><p>Please cite this article as: Meng J, He Y, Yang H, Zhou L, Wang S, Feng X, Al-shargi OY, Yu X, Zhu L, Ling, C. Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency. <em>J Integr Med.</em> 2024; 22(1): 72–82.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139499619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instance Tracking in 3D Scenes from Egocentric Videos","authors":"Yunhan Zhao, Haoyu Ma, Shu Kong, Charless Fowlkes","doi":"arxiv-2312.04117","DOIUrl":"https://doi.org/arxiv-2312.04117","url":null,"abstract":"Egocentric sensors such as AR/VR devices capture human-object interactions\u0000and offer the potential to provide task-assistance by recalling 3D locations of\u0000objects of interest in the surrounding environment. This capability requires\u0000instance tracking in real-world 3D scenes from egocentric videos (IT3DEgo). We\u0000explore this problem by first introducing a new benchmark dataset, consisting\u0000of RGB and depth videos, per-frame camera pose, and instance-level annotations\u0000in both 2D camera and 3D world coordinates. We present an evaluation protocol\u0000which evaluates tracking performance in 3D coordinates with two settings for\u0000enrolling instances to track: (1) single-view online enrollment where an\u0000instance is specified on-the-fly based on the human wearer's interactions. and\u0000(2) multi-view pre-enrollment where images of an instance to be tracked are\u0000stored in memory ahead of time. To address IT3DEgo, we first re-purpose methods\u0000from relevant areas, e.g., single object tracking (SOT) -- running SOT methods\u0000to track instances in 2D frames and lifting them to 3D using camera pose and\u0000depth. We also present a simple method that leverages pretrained segmentation\u0000and detection models to generate proposals from RGB frames and match proposals\u0000with enrolled instance images. Perhaps surprisingly, our extensive experiments\u0000show that our method (with no finetuning) significantly outperforms SOT-based\u0000approaches. We conclude by arguing that the problem of egocentric instance\u0000tracking is made easier by leveraging camera pose and using a 3D allocentric\u0000(world) coordinate representation.","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138552534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare","authors":"Monika Rybicka ,&nbsp;Jing Zhao ,&nbsp;Karolina Piotrowicz ,&nbsp;Sara Ptasnik ,&nbsp;Kamila Mitka ,&nbsp;Magdalena Kocot-Kępska ,&nbsp;Ka-Kit Hui","doi":"10.1016/j.joim.2023.10.001","DOIUrl":"10.1016/j.joim.2023.10.001","url":null,"abstract":"<div><p>Poland has a unique history of traditional Chinese medicine (TCM) dating back to the 17th century when Polish missionary Michael (Michał) Boym was a pioneer in the field. In the 20th century, his successor, Professor Zbigniew Garnuszewski, reintroduced acupuncture to medical practice in Poland. However, other methods of TCM and its holistic approach to patient care have not found their place in modern medicine in Poland. At present, the legal status of TCM in Poland remains unregulated, with TCM included in the broad spectrum of complementary and alternative medicine (CAM) practices. Few reports are available on the use of TCM methods among the Polish population. Integrative medicine combines conventional medicine with evidence-based CAM interventions and considers all aspects of a patient’s health, including physical, emotional, mental, social, and environmental factors. An integrative healthcare model that incorporates TCM modalities and lifestyle recommendations as well as a whole person approach may provide a more sustainable solution for the constantly underfinanced Polish healthcare system, which faces challenges of multimorbidity in an aging society and limited access to care. The coronavirus disease 2019 pandemic, war in Ukraine, and ongoing climate crisis have underscored the need to strengthen the resilience of the Polish healthcare system and search for new solutions. A model of care that blends the best of biomedicine and TCM healing approaches may be a better option for both patients and the healthcare system in Poland.</p><p>Please cite this article as: Rybicka M, Zhao J, Piotrowicz K, Ptasnik S, Mitka K, Kocot-Kępska M, Hui KK. Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare. <em>J Integr Med</em>. 2023; 21(6): 509–517.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S209549642300078X/pdfft?md5=086c053321e44bbff6189eac9f60a87a&pid=1-s2.0-S209549642300078X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xiaotan Sanjie recipe, a compound Chinese herbal medicine, inhibits gastric cancer metastasis by regulating GnT-V-mediated E-cadherin glycosylation","authors":"Nian Huang ,&nbsp;Hai-wei He ,&nbsp;Yu-yu He ,&nbsp;Wei Gu ,&nbsp;Ming-juan Xu ,&nbsp;Long Liu","doi":"10.1016/j.joim.2023.11.001","DOIUrl":"10.1016/j.joim.2023.11.001","url":null,"abstract":"<div><h3>Objective</h3><p>Xiaotan Sanjie recipe (XTSJ), a Chinese herbal compound medicine, exerts a significant inhibitory effect on gastric cancer (GC) metastasis. This work investigated the mechanism underlying the XTSJ-mediated inhibition of GC metastasis.</p></div><div><h3>Methods</h3><p>The effect of XTSJ on GC metastasis and the associated mechanism were investigated <em>in vitro</em><span>, using GC cell lines, and </span><em>in vivo</em>, using a GC mouse model, by focusing on the expression of Glc-N-Ac-transferase V (GnT-V; encoded by <em>MGAT5</em>).</p></div><div><h3>Results</h3><p><span>The migration and invasion ability of GC cells decreased significantly after XTSJ administration, which confirmed the efficacy of XTSJ in treating GC </span><em>in vitro</em>. XTSJ increased the accumulation of E-cadherin at junctions between GC cells, which was reversed by <em>MGAT5</em> overexpression. XTSJ administration and <em>MGAT5</em> knockdown alleviated the structural abnormality of the cell–cell junctions, while <em>MGAT5</em> overexpression had the opposite effect. <em>MGAT5</em><span><span> knockdown and XTSJ treatment also significantly increased the accumulation of proteins associated with the E-cadherin-mediated </span>adherens junction complex. Furthermore, the expression of </span><em>MGAT5</em> was significantly lower in the lungs of BGC-823-<em>MGAT5</em> + XTSJ mice than in those of BGC-823-<em>MGAT5</em> + solvent mice, indicating that the ability of gastric tumors to metastasize to the lung was decreased <em>in vivo</em> following XTSJ treatment.</p></div><div><h3>Conclusion</h3><p>XTSJ prevented GC metastasis by inhibiting the GnT-V-mediated E-cadherin glycosylation and promoting the E-cadherin accumulation at cell–cell junctions.</p><p><span><span>Please cite this article as: Huang N, He HW, He YY, Gu W, Xu MJ, Liu L. Xiaotan Sanjie recipe, a compound Chinese herbal medicine, inhibits gastric </span>cancer metastasis by regulating GnT-V-mediated E-cadherin glycosylation. </span><em>J Integr Med</em>. 2023; 21(6): 561–574.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Kangxian Huanji Granule as adjunctive treatment in acute exacerbation of idiopathic pulmonary fibrosis: An exploratory randomized controlled trial","authors":"Jian-sheng Li ,&nbsp;Hai-long Zhang ,&nbsp;Wen Guo ,&nbsp;Lu Wang ,&nbsp;Dong Zhang ,&nbsp;Li-min Zhao ,&nbsp;Miao Zhou","doi":"10.1016/j.joim.2023.11.003","DOIUrl":"10.1016/j.joim.2023.11.003","url":null,"abstract":"<div><h3>Background</h3><p>Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an important occurrence in the natural history of idiopathic pulmonary fibrosis (IPF), associated with high hospitalization rates, high mortality and poor prognosis. At present, there is no effective treatment for AE-IPF. Chinese herbal medicine has some advantages in treating IPF, but its utility in AE-IPF is unclear.</p></div><div><h3>Objective</h3><p>The treatment of AE-IPF with Kangxian Huanji Granule (KXHJ), a compound Chinese herbal medicine, lacks an evidence-based justification. This study explores the efficacy and safety of KXHJ in patients with AE-IPF.</p></div><div><h3>Design, setting, participants and interventions</h3><p>We designed a randomized, double-blind, placebo-controlled, exploratory clinical trial. A total of 80 participants diagnosed with AE-IPF were randomly assigned to receive KXHJ or a matching placebo; the treatment included a 10 g dose, administered twice daily for 4 weeks, in addition to conventional treatment. Participants were followed up for 12 weeks after the treatment.</p></div><div><h3>Main outcome measures</h3><p>The primary endpoints were treatment failure rate and all-cause mortality. Secondary endpoints included the length of hospitalization, overall survival, acute exacerbation rate, intubation rate, the modified British Medical Research Council (mMRC) score, and the St George’s Respiratory Questionnaire for IPF (SGRQ-I) score.</p></div><div><h3>Results</h3><p>The rate of treatment failure at 4 weeks was lower in the intervention group compared to the control group (risk ratio [RR]: 0.22; 95% confidence interval [CI]: 0.051 to 0.965, <em>P</em> = 0.023). There was no significant difference in all-cause mortality at 16 weeks (RR: 0.75; 95% CI: 0.179 to 3.138; <em>P</em> &gt; 0.999) or in the acute exacerbation rate during the 12-week follow-up period (RR: 0.69; 95% CI: 0.334 to 1.434; <em>P</em> = 0.317). The intervention group had a shorter length of hospitalization than the control group (mean difference [MD]: –3.30 days; 95% CI, –6.300 to –0.300; <em>P</em> = 0.032). Significant differences in the mean change from baseline in the mMRC (between-group difference: –0.67; 95% CI: –0.89 to –0.44; <em>P</em> &lt; 0.001) and SGRQ-I score (between-group difference: –10.36; 95% CI: –16.483 to –4.228; <em>P</em> = 0.001) were observed after 4 weeks, and also in the mMRC (between-group difference: –0.67; 95% CI: –0.91 to –0.43; <em>P</em> &lt; 0.001) and SGRQ-I (between-group difference: –10.28; 95% CI, –15.838 to –4.718; <em>P</em> &lt; 0.001) at 16 weeks. The difference in the adverse events was not significant.</p></div><div><h3>Conclusion</h3><p>KXHJ appears to be effective and safe for AE-IPF and can be considered a complementary treatment in patients with AE-IPF. As a preliminary exploratory study, our results provide a basis for further clinical research.</p></div><div><h3>Trial registration</h3><p>Chinese Clinical Tria","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000845/pdfft?md5=8b69c50f6ff985032d54df985795edab&pid=1-s2.0-S2095496423000845-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135515567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal combinations against COVID-19: A network pharmacology, molecular docking and dynamics study","authors":"Jian-bo Song ,&nbsp;Li-qin Zhao ,&nbsp;Hong-ping Wen ,&nbsp;Yuan-ping Li","doi":"10.1016/j.joim.2023.09.001","DOIUrl":"10.1016/j.joim.2023.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study is to identify molecules from traditional Chinese medicine<span> (TCM) with potential activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants.</span></p></div><div><h3>Methods</h3><p><span><span>We applied the Apriori algorithm to identify important combinations of herbs in the TCM prescriptions for the treatment of </span>coronavirus disease 2019 (COVID-19). Then, we explored the active components and core targets using network pharmacology. In addition, the </span>molecular docking approach was performed to investigate the interaction of these components with the main structural and non-structural proteins, as well as the mutants. Furthermore, their stability in the binding pockets was further evaluated with the molecular dynamics approach.</p></div><div><h3>Results</h3><p>A combination of <em>Amygdalus Communis</em> Vas., <span><em>Ephedra</em><em> Herba</em></span> and <span><em>Scutellaria baicalensis</em></span><span><span><span> Georgi was selected as the important herbal combination, and 11 main components and 20 core targets against COVID-19 were obtained. These components, including luteolin, </span>naringenin, </span>stigmasterol<span><span>, baicalein, and so on, were the potentially active compounds against COVID-19. The </span>binding affinity of these compounds with the potential targets was as high as the positive controls. Among them, baicalein could interfere with multiple targets simultaneously, and it also interfered with the interaction between spike protein and angiotensin-converting enzyme 2 receptor. Additionally, almost all the systems reached stability during dynamics simulation.</span></span></p></div><div><h3>Conclusion</h3><p>The combination of <em>A</em>. c<em>ommunis</em>, <em>Ephedra Herba</em> and <em>S</em>. <em>baicalensis</em> was the most important herbal combination for the treatment of COVID-19. Baicalein may be a potential candidate against SARS-CoV-2 and its variants.</p><p>Please cite this article as: Song JB, Zhao LQ, Wen HP, Li YP. Herbal combinations against COVID-19: A network pharmacology, molecular docking and dynamics study. <em>J Integr Med</em>. 2023;21(6):593–604.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease","authors":"Lin-hong Jiang ,&nbsp;Pei-jun Li ,&nbsp;Ying-qi Wang ,&nbsp;Mei-ling Jiang ,&nbsp;Xiao-yu Han ,&nbsp;Yi-die Bao ,&nbsp;Xin-liao Deng ,&nbsp;Wei-bing Wu ,&nbsp;Xiao-dan Liu","doi":"10.1016/j.joim.2023.11.005","DOIUrl":"10.1016/j.joim.2023.11.005","url":null,"abstract":"<div><p>Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease (COPD). However, the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized yet. Inflammation is central to the development of COPD. In this review, we elucidate the effects and underlying mechanisms of acupuncture from an anti-inflammatory perspective based on animal studies. Cigarette smoke combined with lipopolysaccharide is often used to establish animal models of COPD. Electroacupuncture can be an effective intervention to improve inflammation in COPD, and Feishu (BL13) and Zusanli (ST36) can be used as basic acupoints in COPD animal models. Different acupuncture types can regulate different types of inflammatory cytokines; meanwhile, different acupuncture types and acupoint options have similar effects on modulating the level of inflammatory cytokines. In particular, acupuncture exerts anti-inflammatory effects by inhibiting the release of inflammatory cells, inflammasomes and inflammatory cytokines. The main underlying mechanism through which acupuncture improves inflammation in COPD is the modulation of relevant signalling pathways: nuclear factor-κB (NF-κB) (e.g., myeloid differentiation primary response 88/NF-κB, toll-like receptor-4/NF-κB, silent information regulator transcript-1/NF-κB), mitogen-activated protein kinase signalling pathways (extracellular signal-regulated kinase 1/2, p38 and c-Jun NH2-terminal kinase), cholinergic anti-inflammatory pathway, and dopamine D2 receptor pathway. The current synthesis will be beneficial for further research on the effect of acupuncture on COPD inflammation.</p><p>Please cite this article as: Jiang LH, Li PJ, Wang YQ, Jiang ML, Han XY, Bao YD, Deng XL, Wu WB, Liu XD. Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease. <em>J Integr Med</em>. 2023; 21(6): 518–527.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000869/pdfft?md5=c9881d77e4efbcbcf80515e2673382b8&pid=1-s2.0-S2095496423000869-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}