Journal of Integrative Medicine-Jim最新文献

{"title":"The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey","authors":"Peng Wang ,&nbsp;Jing Hong ,&nbsp;Zhu-qian Tang ,&nbsp;Bi-zhen Gong ,&nbsp;Xiao-rong Qi ,&nbsp;Han Jiang ,&nbsp;Bo Pan ,&nbsp;Qi Chen","doi":"10.1016/j.joim.2024.03.005","DOIUrl":"10.1016/j.joim.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><p>The efficacy of medications for Parkinson’s disease (PD) tend to decline over time, which has a serious impact on patients’ health and quality of life. To some extent, traditional Chinese medicine (TCM) can resolve the distressing problem of ineffective dopaminergic medication in PD patients. The purpose of this study was to investigate the attitude, acceptance, and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.</p></div><div><h3>Methods</h3><p>A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023. A self-report questionnaire was developed to investigate PD patients’ attitudes and acceptance of TCM based on the questionnaire. Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients’ adoption of TCM therapy.</p></div><div><h3>Results</h3><p>A total of 397 patients completed the questionnaire, of which 78.09% were willing to be treated with TCM and 21.91% indicated that they were not willing to use TCM. Multifactorial logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic regime. These included education level of a bachelor’s degree (odds ratio [OR) = 8.554; 95% confidence interval [CI]: 4.112–17.794; <em>P</em> &lt; 0.001, <em>vs</em> junior high school education), living in an urban setting (OR = 8.022; 95% CI: 4.577–14.060; <em>P</em> &lt; 0.001, <em>vs</em> rural), having other underlying diseases (OR = 5.126; 95% CI: 3.078–8.537; <em>P</em> &lt; 0.001, <em>vs</em> none), having previously used TCM (OR = 3.083; 95% CI: 1.852–5.134; <em>P</em> &lt; 0.001, <em>vs</em> not used), believing that TCM therapy is safe (OR = 3.530; 95% CI: 1.446–8.616; <em>P</em> = 0.006, <em>vs</em> not thought), believing that TCM therapy is effective (OR = 3.859; 95% CI: 1.482–10.047; <em>P</em> = 0.006, <em>vs</em> not understood), and being willing to discuss ongoing TCM therapy with an attending physician (OR = 62.468; 95% CI: 30.350–128.574; <em>P</em> &lt; 0.001, <em>vs</em> not informed).</p></div><div><h3>Conclusion</h3><p>This study initially investigated the acceptance, attitude, and independent predictors of TCM use among PD patients. To expand the prevalence of TCM use among patients with PD, we recommend to broadening the public outreach for TCM via contemporary means of Internet and broadcast communication, enhancing access to TCM services in rural communities, and strengthening the communication between doctors and patients.</p><p>Please cite this article as: Wang P, Hong J, Tang ZQ, Gong BZ, Qi XR, Jiang H, Pan B, Chen Q. The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey. <em>J Integr Med</em>. 2024; 22(2): 180–187.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 180-187"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140075299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation","authors":"Meng Li ,&nbsp;Yang Zhou ,&nbsp;Hui Zhu ,&nbsp;Lie-ming Xu ,&nbsp;Jian Ping","doi":"10.1016/j.joim.2024.03.006","DOIUrl":"10.1016/j.joim.2024.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis.</p></div><div><h3>Methods</h3><p>In vivo experiments were conducted using 8-week-old <em>multidrug resistance protein 2</em> knockout (<em>Mdr2^-/-</em>) mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver function, liver histopathology, and the expression of liver fibrosis-related proteins. Real-time polymerase chain reaction, Western blot, immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA <em>H19</em> (<em>H19</em>) and signal transducer and activator of transcription 3 (STAT3) phosphorylation in the liver tissue of <em>Mdr2^-/-</em> mice. In addition, cholangiocytes and hepatic stellate cells (HSCs) were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and <em>H19</em> expression. Cholangiocytes overexpressing <em>H19</em> were constructed, and a conditioned medium containing <em>H19</em> was collected to measure its effects on STAT3 protein expression and cell activation. The intervention effect of DHQ on these processes was also investigated. HSCs overexpressing <em>H19</em> were constructed to measure the impact of <em>H19</em> on cell activation and assess the intervention effect of DHQ.</p></div><div><h3>Results</h3><p>DHQ alleviated liver injury, ductular reaction, and fibrosis in <em>Mdr2^-/-</em> mice, and inhibited <em>H19</em> expression, STAT3 expression and STAT3 phosphorylation. This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of <em>H19</em>, inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium, and decreased the expression of activation markers in HSCs. The overexpression of <em>H19</em> in a human HSC line confirmed that <em>H19</em> promoted STAT3 phosphorylation and HSC activation, and DHQ was able to successfully inhibit these effects.</p></div><div><h3>Conclusion</h3><p>DHQ effectively alleviated spontaneous cholestatic liver fibrosis in <em>Mdr2^-/-</em> mice by inhibiting <em>H19</em> upregulation in cholangiocytes and preventing the inhibition of STAT3 phosphorylation in HSC, thereby suppressing cell activation.</p><p>Please cite this article as: Li M, Zhou Y, Zhu H, Xu LM, Ping J. Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA <em>H19</em> derived from cholangiocytes and inhibiting hepatic stellate cell activation. <em>J Integr Med.</em> 2024; 22(2): 188–198.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 2","pages":"Pages 188-198"},"PeriodicalIF":4.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension: A systematic review and meta-analysis","authors":"Zheng-gang Zhu ,&nbsp;Jian-ru Wang ,&nbsp;Xiao-yan Pan","doi":"10.1016/j.joim.2023.11.006","DOIUrl":"10.1016/j.joim.2023.11.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Scraping therapy is widely used in treating stage I and II essential hypertension in China. However, there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Search strategy&lt;/h3&gt;&lt;p&gt;Seven electronic databases (PubMed, Scopus, Cochrane Library, Web of Science, EBSCO, China National Knowledge Infrastructure and Wanfang Data electronic databases) were searched from inception to December 2022. Based on the principle of combining subject words with text words, the search strategy was constructed around search terms for “scraping therapy,” “scraping,” “&lt;em&gt;Guasha&lt;/em&gt;,” “&lt;em&gt;Gua sha&lt;/em&gt;,” “hypertension,” and “high blood pressure” during the database searches.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Inclusion criteria&lt;/h3&gt;&lt;p&gt;Randomized controlled trials (RCTs) were included if they recruited patients with stage I and II essential hypertension and included a scraping therapy intervention. The intervention group received antihypertensive drugs and scraping therapy, while the control group only took antihypertensive drugs.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Data extraction and analysis&lt;/h3&gt;&lt;p&gt;Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the meta-analysis. The quality of the selected RCTs was assessed using the PEDro scale. The sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the outcome. Subgroup analysis was performed to find the source of heterogeneity. Funnel plots were used to evaluate the publication bias of included studies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Nine RCTs including 765 participants were selected. Meta-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure (mean difference [MD] = −5.09, 95% confidence interval [CI] = −6.50 to −3.67, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) and diastolic blood pressure (MD = −2.66, 95% CI = −3.17 to −2.14, &lt;em&gt;P&lt;/em&gt; &lt; 0.001). Subgroup analysis showed that scraping therapy improved sleep quality in middle-aged patients with hypertension, but the efficacy was better in elderly patients (MD = −7.91, 95% CI = −8.65 to −7.16, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) than in middle-aged patients (MD = −2.67, 95% CI = −4.12 to −1.21, &lt;em&gt;P&lt;/em&gt; = 0.0003).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;The available evidence indicates that scraping therapy has significant effects on patients with stage I and II hypertension, and it improves sleep quality for elderly patients with hypertension better than for middle-aged ones. Scraping therapy can be an adjunctive treatment for stage I and II essential hypertension. However, further high-quality studies are needed to verify its effectiveness and the best therapeutic strategies.&lt;/p&gt;&lt;p&gt;Please cite this article a","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 12-21"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000973/pdfft?md5=23b8e0f4bf71e751cc92063998c6a344&pid=1-s2.0-S2095496423000973-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138496866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocotrienol isoforms: The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials","authors":"Maria Younes,&nbsp;Ghady Loubnane,&nbsp;Christopher Sleiman,&nbsp;Sandra Rizk","doi":"10.1016/j.joim.2024.01.002","DOIUrl":"10.1016/j.joim.2024.01.002","url":null,"abstract":"<div><p><span>Tocotrienols<span> are found in a variety of natural sources, like rice bran, annatto seeds and palm oil, and have been shown to have several health-promoting properties, particularly against chronic diseases such as cancer. The incidence of cancer is rapidly increasing around the world, not only a result of continued aging and population growth, but also due to the adoption of aspects of the Western lifestyle, such as high-fat diets and low-physical activity. The literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers, including breast, lung, ovarian, prostate, liver, brain, colon, myeloma<span><span><span> and pancreatic cancers. These findings, along with the reported safety profile of tocotrienols in healthy human volunteers, encourage further research into these compounds’ potential use in cancer prevention and treatment. The current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different </span>vitamin E<span><span> analogues on important cancer hallmarks, such as cellular proliferation, </span>apoptosis<span>, angiogenesis<span> and metastasis. MEDLINE/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of </span></span></span></span>vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive benefits. Following an overview of pre-clinical studies, we describe several completed and ongoing </span></span></span>clinical trials<span> that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.</span></p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 1-11"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139499404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture and moxibustion for irritable bowel syndrome: An umbrella systematic review","authors":"Yue-ying Ma ,&nbsp;Zhou Hao ,&nbsp;Zi-yi Chen ,&nbsp;Yan-xi Shen ,&nbsp;Hui-rong Liu ,&nbsp;Huan-gan Wu ,&nbsp;Chun-hui Bao","doi":"10.1016/j.joim.2023.12.001","DOIUrl":"10.1016/j.joim.2023.12.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Irritable bowel syndrome (IBS) is a functional bowel disease characterized by abdominal pain or discomfort associated with altered bowel habits. Several clinical studies have demonstrated the effectiveness of acupuncture and moxibustion for IBS. Many systematic reviews of acupuncture and moxibustion for IBS have been published in recent years, but their results are not entirely consistent.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;To evaluate the methodological, reporting, and evidence quality of systematic reviews of acupuncture and moxibustion for IBS.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Search strategy&lt;/h3&gt;&lt;p&gt;Systematic reviews of acupuncture and moxibustion for IBS published before February 20, 2023 were searched in eight databases: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, VIP Database for Chinese Technical Periodicals, and China Biology Medicine. The keywords used for literature search were acupuncture, moxibustion, systematic review, meta-analysis, and irritable bowel syndrome.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Inclusion criteria&lt;/h3&gt;&lt;p&gt;Systematic reviews and meta-analyses of randomized controlled trials of acupuncture and moxibustion for IBS were included.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Data extraction and analysis&lt;/h3&gt;&lt;p&gt;Relevant information was independently extracted by two investigators. The A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020), and Grading of Recommendations Assessment, Development and Evaluation (GRADE) were used to evaluate the methodological quality, reporting quality and evidence quality, respectively.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;A total of 342 studies were retrieved and 15 systematic reviews were included. The results of AMSTAR 2 showed low methodological quality in 2 studies and very low methodological quality in the remaining 13 studies, with main issues being failure to register a protocol, incomplete search strategy, not providing a list of excluded studies, incomplete consideration of the risk of bias in the included studies, and a failure to assess the publication bias. The results of PRISMA 2020 showed seriously deficient reporting quality of 2 studies, somewhat deficient reporting quality of 12 studies, and relatively complete reporting quality of 1 study, with the main problems being lack of a complete search strategy, non-availability of a list of excluded studies with justification for their exclusion, not conducting heterogeneity and sensitivity analyses, not evaluating the credibility of the evidence, and not registering the protocol. The results of GRADE showed that the quality of the evidence is low or very low.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Most included systematic reviews interpreted findings to suggest that acupuncture and moxibustion have benefits for IBS. However, there is a need to improve the methodological, reporting and evidence quality of the systematic ","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 22-31"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000985/pdfft?md5=9c757eeab4d5876b083f9640ef681246&pid=1-s2.0-S2095496423000985-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the clinical practice of traditional, complementary and integrative medicine in oncology in Western countries: A multinational cross-sectional survey","authors":"Matthias Huemer ,&nbsp;Sandro Graca ,&nbsp;Sarah Bitsche ,&nbsp;Guenter Hofmann ,&nbsp;Mike Armour ,&nbsp;Martin Pichler","doi":"10.1016/j.joim.2023.12.002","DOIUrl":"10.1016/j.joim.2023.12.002","url":null,"abstract":"<div><h3>Background</h3><p>Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease trajectory. While acupuncture is increasingly recommended by leading oncological associations, limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine (TCIM) practitioners treating cancer patients.</p></div><div><h3>Methods</h3><p>An international online-survey assessed the demographical data, clinical practice, and sources of information used by TCIM practitioners in Austria, Germany, United States of America, Australia, and New Zealand.</p></div><div><h3>Results</h3><p>In total, 404 respondents completed the survey, of which 254 (62.9%) treated cancer patients. Most practitioners were acupuncturists and herbalists (57.1%), had (16.8 ± 9.9) years of clinical experience and see a median of 2 (1, 4) cancer patients per week. Breast cancer (61.8%) is the most common cancer type seen in TCIM clinics. Adjunctive TCIM treatments are frequently concurrent with the patient’s cancer specific treatment (39.9%), which is also reflected by the main goal of a TCIM treatment to alleviate side effects (52.4%). However, only 28.0% of the respondents are in contact with the treating oncologist. According to the respondents, pain is most effectively treated using acupuncture, while herbal medicine is best for cancer-related fatigue. TCIM practitioners mostly use certified courses (33.1%) or online databases (28.3%) but often believe that experts are more reliable to inform their practice (37.0%) than research publications (32.7%).</p></div><div><h3>Conclusion</h3><p>Acupuncturists and herbalists commonly treat cancer patients. Most practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines.</p></div><div><h3>Please cite this article as</h3><p>Huemer M, Graca S, Bitsche S, Hofmann G, Armour M, Pichler M. Mapping the clinical practice of traditional, complementary and integrative medicine in oncology in Western countries: A multinational cross-sectional survey. <em>J Integr Med</em>. 2024; 22(1): 64–71.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 64-71"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496423000997/pdfft?md5=f637883b5829283bfea8ef2a3c578818&pid=1-s2.0-S2095496423000997-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139052180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain: A prospective, multicenter randomized trial","authors":"Jun-yan He ,&nbsp;Xiao-yu Tu ,&nbsp;Zi-fei Yin ,&nbsp;Hui Mu ,&nbsp;Ming-jun Luo ,&nbsp;Xing-yu Chen ,&nbsp;Wei-bin Cai ,&nbsp;Xue Zhao ,&nbsp;Can Peng ,&nbsp;Fan-fu Fang ,&nbsp;Can Lü ,&nbsp;Bai Li","doi":"10.1016/j.joim.2024.01.004","DOIUrl":"10.1016/j.joim.2024.01.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;As one of the most common musculoskeletal ailments, chronic nonspecific low-back pain (CNLBP) causes persistent disability and substantial medical expenses. Epidemiological evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is rising. Recent guidelines indicate a reduced role for medicines in the management of CNLBP.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;The present study investigates the short-term effects of cupping and scraping therapy&lt;span&gt; using a medicated balm, compared to nonsteroidal anti-inflammatory drug (NSAID) with a capsaicin plaster, in the treatment of CNLBP.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design, setting, participants and interventions&lt;/h3&gt;&lt;p&gt;We designed a prospective multicenter randomized clinical trial&lt;span&gt; enrolling patients from January 1, 2022 to December 31, 2022. A total of 156 patients with CNLBP were randomized into two parallel groups. Diclofenac sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied externally. Patients in the test group were treated with cupping and scraping using a medical device and medicated balm.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main outcome measures&lt;/h3&gt;&lt;p&gt;&lt;span&gt;Primary outcome was pain recorded using the visual analogue scale&lt;span&gt; (VAS). Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale (JOA) and the &lt;/span&gt;&lt;/span&gt;traditional Chinese medicine (TCM) syndrome integral scale (TCMS) as assessment tools.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Between baseline and postintervention, all changes in outcome metric scales were statistically significant (&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt; 0.001). Compared to the control group, patients in the test group had a significantly greater treatment effect in all outcome variables, as indicated by lower VAS and TCMS scores and higher JOA scores, after the one-week intervention period (&lt;/span&gt;&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt; 0.001). Further, according to the findings of multivariate linear regression analysis&lt;span&gt;, the participants’ pain (VAS score) was related to their marital status, age, smoking habits and body mass index. No adverse reactions were reported for any participants in this trial.&lt;/span&gt;&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;The effectiveness of TCM combined with the new physiotherapy tool is superior to that of NSAID combined with topical plasters, regarding to pain intensity, TCM symptoms&lt;span&gt; and quality of life. The TCM plus physiotherapy also showed more stable and long-lasting therapeutic effects.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Trial registration&lt;/h3&gt;&lt;p&gt;This study was registered at Chinese Clinical Trial Registry (ChiCTR2200055655).&lt;/p&gt;&lt;p&gt;Please cite this article as: He JY, Tu XY, Yin ZF, Mu H, Luo MJ, Chen XY, Cai WB, Zhao X, Peng C, Fang FF, Lü C, Li B. Short-term effects of cupping and scraping therapy for chronic nonspecific low-back ","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 39-45"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying behavioral determinants and stage of readiness for performing knee massage among individuals with knee osteoarthritis: An observational study","authors":"Donya Nemati ,&nbsp;Niki Munk ,&nbsp;Navin Kaushal","doi":"10.1016/j.joim.2024.01.006","DOIUrl":"10.1016/j.joim.2024.01.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;&lt;span&gt;Patients who experience knee osteoarthritis or chronic knee pain can alleviate their &lt;/span&gt;symptoms by performing self-knee massage. Understanding the readiness and types of determinants needed to facilitate self-knee massage is needed to design effective, theory-informed interventions. The primary objective of this study was to apply the transtheoretical model of behavior change to identify how factors, which include the type of knee condition and pain level, predict an individual’s readiness to adopt self-knee massage. The secondary objective employed the capability, opportunity and motivation-behavior (COM-B) model to identify relevant determinants that are predictive of an individual’s readiness to undertake self-knee massage.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;An observational study design was used to recruit individuals with knee osteoarthritis (&lt;em&gt;n&lt;/em&gt; = 270) and chronic knee pain (&lt;em&gt;n&lt;/em&gt;&lt;span&gt; = 130). Participants completed an online survey that assessed the transtheoretical model of behavior change stages, COM-B determinants (capability, opportunity and motivation), along with self-administered massage behavior. Multivariate analysis of covariance and structural equation modeling were used to test the primary and secondary objective, respectively.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Participants who had knee osteoarthritis scored higher on the action stage compared to those with chronic pain (&lt;em&gt;P&lt;/em&gt; = 0.003), and those who experienced greater level of pain scored higher in the contemplation (&lt;em&gt;P&lt;/em&gt; &lt; 0.001) and action phases (&lt;em&gt;P&lt;/em&gt; &lt; 0.001) of performing knee massage compared to those with milder pain. The COM-B structural equation model revealed self-administered knee massage to be predicted by capability (β = 0.31, &lt;em&gt;P&lt;/em&gt; = 0.004) and motivation (β = 0.29, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), but not opportunity (β = –0.10, &lt;em&gt;P&lt;/em&gt; = 0.39). Pain level predicted motivation (β = 0.27, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), but not capability (β = 0.09, &lt;em&gt;P&lt;/em&gt; = 0.07) or opportunity (β = 0.01, &lt;em&gt;P&lt;/em&gt; = 0.83). Tests for mediating effects found that determinants of COM-B (motivation and capability) mediate between pain level and self-administered massage behavior (β = 0.10, &lt;em&gt;P&lt;/em&gt; = 0.002).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Clinicians and researchers can expect that patients diagnosed with knee osteoarthritis or who have chronic knee pain are ready (action stage) or are considering the behavior (contemplation stage) of self-knee massage. Individuals who report having knee osteoarthritis or chronic knee pain should be coached to develop the skills to perform self-knee massage and helped to develop the motivation to carry out the therapy.&lt;/p&gt;&lt;p&gt;Please cite this article as: Nemati D, Munk N, Kaushal N. Identifying behavioral determinants and stage of readiness for performing knee massage among individuals with knee osteoarthritis: an observational study. &lt;em&gt;J Integr Med&lt;/em&gt;. 2024; 22(1): ","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 54-63"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of the placebo response in a nutraceutical randomized controlled trial for depression","authors":"Rosemary Arnold ,&nbsp;Jenifer Murphy-Smith ,&nbsp;Chee H. Ng ,&nbsp;David Mischoulon ,&nbsp;Gerard J. Byrne ,&nbsp;Chad A. Bousman ,&nbsp;Con Stough ,&nbsp;Michael Berk ,&nbsp;Jerome Sarris","doi":"10.1016/j.joim.2024.01.007","DOIUrl":"10.1016/j.joim.2024.01.007","url":null,"abstract":"<div><h3>Objective</h3><p>The placebo response in depression studies is the change in symptoms amongst those who receive an inactive treatment. Many well-designed randomized controlled trials (RCTs) of depression have a high proportion of placebo responders, with little understanding as to why. The present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo responders.</p></div><div><h3>Methods</h3><p>This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo (<em>n</em> = 69 in placebo group). We investigated participant characteristics such as socio-demographics, clinical features, and recruitment methods, and their association with the placebo response. Monoaminergic genetic polymorphisms were also assessed. Placebo response was measured based on change in Montgomery-Asberg Depression Rating Scale score. The association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects models.</p></div><div><h3>Results</h3><p>Greater levels of education, particularly pursuing post-high school education, better self-reported general health, marriage/de facto, greater improvement in the first trial week, and more failed antidepressant therapies in the current depressive episode were associated with greater placebo response. An increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant therapy. Single nucleotide polymorphisms from the tryptophan hydroxylase 1 (<em>TPH1</em>) gene (<em>A779C</em> and <em>A218C</em>) were weakly associated with greater placebo response, although the evidence was attenuated after accounting for multiple comparisons.</p></div><div><h3>Conclusion</h3><p>This is, to our knowledge, the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo response. Several variables appeared to predict the placebo response. Such findings may encourage future trial designs which could dampen placebo response, improve assay sensitivity, and allow for treatment effects to be potentially more detectable.</p><p>Please cite this article as: Arnold R, Murphy-Smith J, Ng CH, Mischoulon D, Byrne GJ, Bousman CA, Stough C, Berk M, Sarris J. Predictors of the placebo response in a nutraceutical randomized controlled trial for depression. <em>J Integr Med</em>. 2024; 22(1): 46–53.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 46-53"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095496424000074/pdfft?md5=c9a4760d210596822c3c4e56242bde72&pid=1-s2.0-S2095496424000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval: A randomized controlled trial","authors":"Li-ying Liu ,&nbsp;Yang Su ,&nbsp;Rong-rong Wang ,&nbsp;Yuan-yuan Lai ,&nbsp;Lei Huang ,&nbsp;Yi-ting Li ,&nbsp;Xin-yue Tao ,&nbsp;Meng-hua Su ,&nbsp;Xiao-yan Zheng ,&nbsp;Shi-chen Huang ,&nbsp;Yong-na Wu ,&nbsp;Si-yi Yu ,&nbsp;Fan-rong Liang ,&nbsp;Jie Yang","doi":"10.1016/j.joim.2024.01.005","DOIUrl":"10.1016/j.joim.2024.01.005","url":null,"abstract":"<div><h3>Background</h3><p>Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the procedure. Some research showed that transcutaneous electrical acupoint stimulation (TEAS) can relieve intraoperative pain and postoperative nausea.</p></div><div><h3>Objective</h3><p>This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte retrieval.</p></div><div><h3>Design, setting, participants and interventions</h3><p>Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS group. The two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte retrieval.</p></div><div><h3>Main outcome measures</h3><p>The primary outcome was the visual analog scale (VAS) pain score. Secondary outcomes were pressure pain threshold, McGill score, pain rating index (PRI), present pain intensity (PPI), VAS stress score, VAS anxiety score, and postoperative adverse symptoms.</p></div><div><h3>Results</h3><p>The baseline characteristics of the two groups were comparable (<em>P</em> &gt; 0.05). The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval (<em>P</em> &lt; 0.05). The McGill score, PRI and PPI in the TEAS group were significantly lower than those in the control group at 60 min after oocyte retrieval (<em>P</em> &lt; 0.05). However, the two groups had equivalent beneficial effects regarding the negative emotions, such as nervousness and anxiety (<em>P</em> &gt; 0.05). The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.</p><p>Please cite this article as: Liu LY, Su Y, Wang RR, Lai YY, Huang L, Li YT, Tao XY, Su MH, Zheng XY, Huang SC, Wu YN, Yu SY, Liang FR, Yang J. Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval: A randomized controlled trial. <em>J Integr Med</em>. 2024; 22(1): 32–38.</p></div>","PeriodicalId":48599,"journal":{"name":"Journal of Integrative Medicine-Jim","volume":"22 1","pages":"Pages 32-38"},"PeriodicalIF":4.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}