Materials Today Nano最新文献_第4页

Atomic-scale effect of 2D conjugated metal-organic frameworks as electrocatalysts for CO2 reduction reaction towards highly selective products 二维共轭金属-有机框架作为高选择性CO2还原反应电催化剂的原子尺度效应

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-17 DOI: 10.1016/j.mtnano.2025.100658

Ran Wang , Chaozheng He , Weixing Chen , Qingquan Kong , Thomas Frauenheim

{"title":"Atomic-scale effect of 2D conjugated metal-organic frameworks as electrocatalysts for CO2 reduction reaction towards highly selective products","authors":"Ran Wang , Chaozheng He , Weixing Chen , Qingquan Kong , Thomas Frauenheim","doi":"10.1016/j.mtnano.2025.100658","DOIUrl":"10.1016/j.mtnano.2025.100658","url":null,"abstract":"<div><div>Electrocatalytic CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) is key to mitigating greenhouse gas emissions and the energy crisis. However, controlling the selectivity of CO<sub>2</sub>RR products at low overpotentials remains a challenge. Herein, two-dimensional (2D) conjugated metal-organic frameworks (MOFs) with the single atomic active centers were proposed by varying the combinations of different metals and organic ligands, on which their stability, electrocatalytic CO<sub>2</sub>RR activity and product selectivity were theoretically investigated. Five high performance CO<sub>2</sub>RR catalysts with specific products (HCOOH, CH<sub>2</sub>O, CH<sub>3</sub>OH and CH<sub>4</sub>) were identified through the CO<sub>2</sub>RR mechanism and HER competitive screening. Furthermore, the mechanistic differences resulting from the competitive selectivity of carbon- and oxygen-bound species can be directly determined from the scaling of adsorption energies between COOH and HCOO. In addition, the adsorption energies of COOH/HCOO and the number of electrons involved in CO<sub>2</sub>RR depend on the location of the d-band center of 2D conjugated MOFs. Thus, the selectivity of the product can be directly influenced by modulating the d-band center of the active site. Therefore, manipulating metals and ligands allows us to tune the structure-property relationship in 2D conjugated MOFs to design and optimization of highly active and product-specific CO<sub>2</sub>RR electrocatalysts.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100658"},"PeriodicalIF":8.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the high-temperature stability and phase transformation in isolated TiO2 nanotubes using in situ heating TEM 利用原位加热透射电镜研究分离TiO2纳米管的高温稳定性和相变

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-12 DOI: 10.1016/j.mtnano.2025.100654

Chenyue Qiu , Lilly Schaffer , Mengsha Li , Maggie Paulose , Jason Tam , Shuo Chen , Paththini Kuttige S. Nonis , Aniqa Lim , Jane Y. Howe , Oomman K. Varghese

{"title":"Revealing the high-temperature stability and phase transformation in isolated TiO2 nanotubes using in situ heating TEM","authors":"Chenyue Qiu , Lilly Schaffer , Mengsha Li , Maggie Paulose , Jason Tam , Shuo Chen , Paththini Kuttige S. Nonis , Aniqa Lim , Jane Y. Howe , Oomman K. Varghese","doi":"10.1016/j.mtnano.2025.100654","DOIUrl":"10.1016/j.mtnano.2025.100654","url":null,"abstract":"<div><div>High crystallinity is key to the performance of most electronic materials, especially semiconductors. When derived from amorphous phase, heat treatment is commonly used for achieving the desired structural order and crystal phase. Understanding thermally driven phase transformations is essential for assessing material viability. Titanium dioxide (TiO<sub>2</sub>) nanotube arrays, fabricated <em>via</em> anodic oxidation, are a promising low dimensional wide band-gap semiconductor potentially useful for a myriad of applications. Nonetheless, previous studies primarily focused on the array film geometry, obscuring the nanoscale processes in single nanotubes. Herein, we report the efficacy of <em>in situ</em> heating transmission electron microscopy and electron energy loss spectroscopy to dynamically elucidate the processes of crystallization and phase transformation in a single amorphous TiO<sub>2</sub> nanotube. The study reveals that crystallization initiates at 300 °C to form anatase and rutile phases, with brookite emerging at 550 °C. Remarkably, the nanotubes retain this unique three-phase structure even at 950 °C. Supported by <em>ex situ</em> X-ray diffraction and Raman spectroscopy results, this systematic and real-time exploration demonstrates that a complete transition to rutile, the most stable phase, could be prevented in isolated nanotubes, unlocking new applications.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100654"},"PeriodicalIF":8.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphite encapsulated ZIF-67 derivatives with carbon nanotubes immobilized on carbon aerogels toward superior microwave absorption 石墨包封ZIF-67衍生物，碳纳米管固定在碳气凝胶上，具有优异的微波吸收性能

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-11 DOI: 10.1016/j.mtnano.2025.100653

Haotian Jiang , Yanxiang Wang , Chengjuan Wang , Shichao Dai , Bohan Ding , Jinghe Guo , Yue Sun , Dongming Liu , Hui Li

{"title":"Graphite encapsulated ZIF-67 derivatives with carbon nanotubes immobilized on carbon aerogels toward superior microwave absorption","authors":"Haotian Jiang , Yanxiang Wang , Chengjuan Wang , Shichao Dai , Bohan Ding , Jinghe Guo , Yue Sun , Dongming Liu , Hui Li","doi":"10.1016/j.mtnano.2025.100653","DOIUrl":"10.1016/j.mtnano.2025.100653","url":null,"abstract":"<div><div>Exploring the synergistic effects of components and structures has emerged as a pivotal strategy for advancing high-performance electromagnetic wave (EMW) absorbing materials. In this work, we present an approach that integrates magnetic-dielectric components and porous structures by incorporating unidirectionally frozen-drying aramid nanofiber aerogels with ZIF-67 and subsequently preparing Co/Co<sub>3</sub>O<sub>4</sub>@carbon nanotubes/carbon nanofibers aerogels through heat treatment and catalyst chemical vapor deposition. By combining different functional components, a multiple heterostructure with excellent absorption capacity, wide effective absorption bandwidth (EAB), and thin thickness can be achieved. The inclusion of the magnetic-dielectric component significantly enhances the impedance matching, generating multiple loss mechanisms. Additionally, the three-dimensional porous structure of the aerogel facilitates multiple reflections and scattering of the incident EMWs, thereby enhancing the microwave absorption. Specifically, the obtained samples exhibit outstanding EMW performance, with a minimum reflection loss of −73.50 dB at a thickness of merely 2.08 mm and an EAB of 5.90 GHz. Furthermore, simulations evaluating radar cross-section values, electric field strengths, and energy loss density are conducted to assess the stealth capabilities under radar detection. This study culminates in the preparation of an aerogel characterized by excellent wave-absorbing properties and effective thermal insulation, offering vast potential for practical applications.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100653"},"PeriodicalIF":8.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling stability and size of amorphous magnesium calcium phosphate particles 控制非晶磷酸钙镁颗粒的稳定性和粒径

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-10 DOI: 10.1016/j.mtnano.2025.100655

Debora Briganti , Melissa Saibene , Giancarlo Capitani , Rita Gelli , Francesca Ridi

{"title":"Controlling stability and size of amorphous magnesium calcium phosphate particles","authors":"Debora Briganti , Melissa Saibene , Giancarlo Capitani , Rita Gelli , Francesca Ridi","doi":"10.1016/j.mtnano.2025.100655","DOIUrl":"10.1016/j.mtnano.2025.100655","url":null,"abstract":"<div><div>The development of nanoparticles with tunable size and stability is crucial for the development of safe and effective drug delivery systems. Amorphous Magnesium Calcium Phosphate (AMCP) nanoparticles offer a promising solution due to their biocompatibility, biodegradability, and ability to load bioactive substances. However, their successful application is hindered by two main limitations: the tendency of the metastable amorphous phase to crystallize into more thermodynamically stable forms and the propensity for aggregation in the absence of stabilizing agents, which compromises their nanoscale properties. This study focuses on the preparation and characterization of AMCP nanoparticles stabilized with polyacrylic acid (PAA), with the purpose of understanding whether variations in the synthetic Ca/Mg ratio and PAA molecular weight (M<sub>w</sub>) influence nanoparticles’ physico-chemical properties such as size, crystallinity, dispersibility and stability, along with their solubility in different pH environments, to explore potential applications in the pharmacological field.</div><div>The results reveal that PAA acts as a remarkable stabilizing agent for AMCPs, significantly reducing aggregation and enhancing dispersibility. Stability and size were strongly influenced by Ca/Mg ratio and PAA M<sub>w</sub>, demonstrating the crucial interplay between these factors in nanoparticles design. Incorporating PAA not only delayed the thermal crystallization process but also improved the resistance of AMCPs to dissolution in acidic environments, highlighting their potential for pH-responsive drug delivery applications. Additionally, a higher magnesium content was found to enhance the stability of the amorphous phase, while PAA effectively prevented the transformation of AMCP into hydroxyapatite under physiological conditions, further reinforcing its role in achieving the desired nanoparticle properties.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100655"},"PeriodicalIF":8.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen-generated metal-organic framework nanoparticles for ameliorated pulmonary hypertension by ROS scavenging, hydrogen anti-inflammation, and reducing DNA damage 氢生成的金属有机框架纳米颗粒通过清除活性氧、抗氢炎症和减少DNA损伤来改善肺动脉高压

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-09 DOI: 10.1016/j.mtnano.2025.100652

Hui Zhao , Fujun Yang , Wenhui Wu , Yaqin Wei , Liang Tang , Ping Yuan , Yuqing Miao , Haipeng Liu , Shuang Gao

{"title":"Hydrogen-generated metal-organic framework nanoparticles for ameliorated pulmonary hypertension by ROS scavenging, hydrogen anti-inflammation, and reducing DNA damage","authors":"Hui Zhao , Fujun Yang , Wenhui Wu , Yaqin Wei , Liang Tang , Ping Yuan , Yuqing Miao , Haipeng Liu , Shuang Gao","doi":"10.1016/j.mtnano.2025.100652","DOIUrl":"10.1016/j.mtnano.2025.100652","url":null,"abstract":"<div><div>Pulmonary hypertension (PH) is a malignant and progressive disease lacking effective treatments, characterized primarily by pulmonary vascular remodeling resulting from endothelial cells (ECs) dysfunction. The increase of reactive oxygen species (ROS) in a pathological state is the pivotal factor that triggers ECs dysfunction, primarily through the induction of DNA damage. Currently, there is a significant scarcity of drugs capable of reducing ECs DNA damage by eliminating ROS in the microenvironment. Therefore, we synthesis hydrogen-generated metal-organic framework nanoparticles (PdH/ZIF-8), which can not only release hydrogen continuously for over 24 h, but also has efficiently ROS scavenging activity. <em>In vitro</em>, PdH/ZIF-8 inhibits hypoxia-induced dysfunction of pulmonary microvascular ECs. <em>In vivo</em> models PdH/ZIF-8 accumulates in lungs rapidly and steadily, effectively alleviating pulmonary vascular remodeling, and ultimately significantly improving cardiac function. Further, PdH/ZIF-8 decreases expression of inflammatory factors. At the same time, PdH/ZIF-8 regulates the expression of poly ADP-ribose polymerase (PARP1), reduced ataxia telangiectasia mutated and Rad3 related (ATR)/cell cycle checkpoint kinase 1 (CHK1) phosphorylation. In conclusion, this work provides a novel and effective nanotechnology with the synergistic therapy of innocuous gas to the treatment of PH.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100652"},"PeriodicalIF":8.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of a direct Z-scheme Sn3O4/In2O3 heterostructure: Boosting photocatalytic degradation of contaminants 直接z型Sn3O4/In2O3异质结构的构建：促进污染物的光催化降解

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-07-03 DOI: 10.1016/j.mtnano.2025.100651

Wei Zhang , Yuxin Tian , Lina Zhang , Xiaodong Li , Xiaotong Yin , Jiaju Wang , Jialin Wu , Xiaoming Zhou , Jinwen Ma

{"title":"Construction of a direct Z-scheme Sn3O4/In2O3 heterostructure: Boosting photocatalytic degradation of contaminants","authors":"Wei Zhang , Yuxin Tian , Lina Zhang , Xiaodong Li , Xiaotong Yin , Jiaju Wang , Jialin Wu , Xiaoming Zhou , Jinwen Ma","doi":"10.1016/j.mtnano.2025.100651","DOIUrl":"10.1016/j.mtnano.2025.100651","url":null,"abstract":"<div><div>Constructing a heterostructure is regarded as one of the most promising strategies for boosting light absorption and promoting the separation of photoinduced charge carriers in the field of photocatalysis. In this study, a Z-scheme Sn<sub>3</sub>O<sub>4</sub>/In<sub>2</sub>O<sub>3</sub> heterostructure was constructed by in-situ growth of Sn<sub>3</sub>O<sub>4</sub> nanosheets directly on In<sub>2</sub>O<sub>3</sub> microtubes. The optimized SI-0.1 heterostructure demonstrated superior photocatalytic activity, with degradation efficiencies of 90.6 % for methyl orange (MO) and 99.0 % for Cr(VI), respectively. Notably, the rate constants for MO photodegradation and Cr(Ⅵ) photoreduction over SI-0.1 were 2.5 and 3.5 times higher than those of pristine Sn<sub>3</sub>O<sub>4</sub> nanosheets, and 29 and 6.3 times greater than those of In<sub>2</sub>O<sub>3</sub> microtubes. The exceptional photocatalytic efficiency is primarily attributed to boosted visible-light absorption, elevated reactive sites, and the close contact at the dual-shell interface, which promote effective charges separation and migration. The typical Z-scheme heterojunction between Sn<sub>3</sub>O<sub>4</sub> and In<sub>2</sub>O<sub>3</sub> was thoroughly discussed to elucidate its photocatalytic mechanism. This work offers significant insights for designing efficient photocatalytic heterostructures for wastewater treatment applications.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100651"},"PeriodicalIF":8.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer photonic crystals for shape memory applications 用于形状记忆的聚合物光子晶体

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-06-26 DOI: 10.1016/j.mtnano.2025.100650

Matin Ashurov , Maksym Stetsenko , Alexey Kavokin , Stella Kavokina

{"title":"Polymer photonic crystals for shape memory applications","authors":"Matin Ashurov , Maksym Stetsenko , Alexey Kavokin , Stella Kavokina","doi":"10.1016/j.mtnano.2025.100650","DOIUrl":"10.1016/j.mtnano.2025.100650","url":null,"abstract":"<div><div>Shape memory polymers (SMPs) are novel smart materials capable of changing their shape from original to temporary and backward under the effect of various external factors. SMPs can be used to form photonic crystals (PCs), demonstrating a switchable structural color. Herein, we compose a new shape memory photonic crystal (SMPCs) by polymerizing a mixture of ethoxyethoxyethyl acrylate (EOEOEA) and poly (ethylene glycol) diacrylate (PEGDA) monomers in the silica opal templates. The resulting macroporous inverse opal PCs are composed of a rubbery copolymer with a low glass transition temperature. The nanoscale shape memory (SM) effects in these PCs are employed to realize optical memories operational at room temperature. In these memories, photonic stop bands are suppressed by the capillary condensation of water that enables their ‘cold’ programming. The stopbands can be restored to the initial spectral positions by evaporation of liquids characterized by low surface tension such as ethanol, acetone, cyclohexane and <em>n</em>-hexane. The same effect may be achieved by weak contact pressing on the film. During cold programming and recovery, the PC structures switch between disordered and highly ordered states. At the same time, the samples demonstrated robustness, remaining undamaged under a significant mechanical load of up to ∼1 MPa. We successfully memorized complex patterns with use of the developed memories. We foresee applications of SMP-based PCs in switchable responsive sensors, liquid printing, erasable watermarks, signal resonators, information technology, and biomedical applications.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100650"},"PeriodicalIF":8.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From micro to subnano scale: Insights into the dielectric properties of BiOI nanoplates 从微观到亚纳米尺度：对BiOI纳米板介电性能的洞察

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-06-13 DOI: 10.1016/j.mtnano.2025.100649

Adrian Radoń , Agnieszka Ciuraszkiewicz , Dariusz Łukowiec , Bartłomiej Toroń , Tomasz Baran , Jerzy Kubacki , Patryk Włodarczyk

{"title":"From micro to subnano scale: Insights into the dielectric properties of BiOI nanoplates","authors":"Adrian Radoń , Agnieszka Ciuraszkiewicz , Dariusz Łukowiec , Bartłomiej Toroń , Tomasz Baran , Jerzy Kubacki , Patryk Włodarczyk","doi":"10.1016/j.mtnano.2025.100649","DOIUrl":"10.1016/j.mtnano.2025.100649","url":null,"abstract":"<div><div>The electrical properties of ultrathin, agglomerated BiOI nanoplates synthesized via a simple hydrolysis method in the presence of NaOH were investigated over the temperature range of 173–273 K using broadband dielectric spectroscopy. The resulting nanoplates, with an average thickness of 34.8 ± 9.02 nm and size of 543.4 ± 103.4 nm, exhibit disordered surfaces characteristic of bismuth oxyhalides, where Bi<sup>(3–x)+</sup> arise from Bi–O bond breaking. Optical measurements confirm a direct allowed band gap of 1.962 ± 0.046 eV and an Urbach energy of 0.0737 ± 0.068 eV. Two dominant electrical relaxation processes were identified and described using the Dissado–Hill model. The high-frequency process, with an activation energy of 0.13 ± 0.01 eV, is attributed to the transition between hole hopping and I<sup>−</sup> ion migration between positively charged [Bi<sub>2</sub>O<sub>2</sub>]<sup>2+</sup> layers. The low-frequency process (below 100 Hz), with an activation energy of 0.44 ± 0.02 eV, emerges at elevated temperatures and is associated with iodide ion migration along nanoplate surfaces and edges, followed by their accumulation at the electrode interface. These findings demonstrate that the dielectric behavior of layered BiOI nanoplates is governed by temperature- and frequency-dependent iodide ion dynamics between the [Bi<sub>2</sub>O<sub>2</sub>]<sup>2+</sup> layers.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100649"},"PeriodicalIF":8.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A redox-responsive nanoparticle with RGD-targeted effect for photo-chemo therapy of triple-negative breast cancer 一种具有rgd靶向作用的氧化还原反应纳米颗粒用于三阴性乳腺癌光化学治疗

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-06-10 DOI: 10.1016/j.mtnano.2025.100647

Luting Yu, Yiwen Lou, Yaning Li, Shenglong Jiang, Zhiwei Li, Lili Ren, Guoguang Chen

{"title":"A redox-responsive nanoparticle with RGD-targeted effect for photo-chemo therapy of triple-negative breast cancer","authors":"Luting Yu, Yiwen Lou, Yaning Li, Shenglong Jiang, Zhiwei Li, Lili Ren, Guoguang Chen","doi":"10.1016/j.mtnano.2025.100647","DOIUrl":"10.1016/j.mtnano.2025.100647","url":null,"abstract":"<div><div>Traditional chemotherapeutics for triple-negative breast cancer (TNBC) has a series of limitations, including low solubility, poor selectivity and severe side effects. To overcome these challenges, a redox-responsive polymeric nano-micelles RPSSD@IR780/DOC equipped with tumor-targeting RGD oligopeptide, and encapsulated chemotherapeutic agent docetaxel (DOC) and photosensitizer IR-780 iodide (IR780) was produced in the present study. This nanoparticle effectively improved the solubility of DOC and IR780 by 24.4-fold and 410-fold, respectively. By conjugating with the RGD oligopeptide, the selectivity and cellular uptake of DOC and IR780 in tumor cells was significantly enhanced. In tumors treated with RPSSD@IR780/DOC, high reductive microenvironment triggered breakage of disulfide bonds in the nanoparticles, thereby promoting DOC and IR780 release. IR780 generated large amounts of reactive oxygen species (ROS) and near-infrared (NIR) light-excited local heat, resulting in a synergistic anti-tumor effect. Following the treatment, the tumor suppression rate reached 92.74 %, and the survival time was extended to 50 days in mice. In addition, RPSSD@IR780/DOC had excellent biocompatibility and biosafety, significantly ameliorating systemic adverse effects associated with chemotherapeutic agents. In conclusion, RPSSD@IR780/DOC has a great potential as a novel redox-responsive and tumor-targeting nanodrug for photo-chemo therapy (PCT) in TNBC.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100647"},"PeriodicalIF":8.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation of Ni-rich Ni-Ga alloy clusters on the (221) surface of Ni5Ga3 intermetallic compounds during CO2 hydrogenation: An in-situ TEM study CO2加氢过程中Ni5Ga3金属间化合物（221）表面富Ni-Ga合金团簇形成的原位TEM研究

IF 8.2 2区材料科学

Materials Today Nano Pub Date : 2025-06-09 DOI: 10.1016/j.mtnano.2025.100648

Yasuhiro Sakamoto , Ang Li , Lizhuo Wang , Yuhan Men , Penny Xiao , Paul A. Webley , Xiaodong Han , Jun Huang

{"title":"Formation of Ni-rich Ni-Ga alloy clusters on the (221) surface of Ni5Ga3 intermetallic compounds during CO2 hydrogenation: An in-situ TEM study","authors":"Yasuhiro Sakamoto , Ang Li , Lizhuo Wang , Yuhan Men , Penny Xiao , Paul A. Webley , Xiaodong Han , Jun Huang","doi":"10.1016/j.mtnano.2025.100648","DOIUrl":"10.1016/j.mtnano.2025.100648","url":null,"abstract":"<div><div>Ni-Ga alloys are the most promising bimetallic alloy catalysts for CO<sub>2</sub> hydrogenation due to their high activity and selectivity. This study used in-situ transmission electron microscopy (TEM) to clarify the structural changes in the Ni<sub>5</sub>Ga<sub>3</sub> intermetallic compound catalysts during the CO<sub>2</sub> oxidation and CO<sub>2</sub> hydrogenation processes. The results showed that as the temperature increased from 50 °C to 300 °C under CO<sub>2</sub> conditions, crystalline Ga oxides, primarily the <em>β</em>-Ga<sub>2</sub>O<sub>3</sub> phase, formed on the Ni<sub>5</sub>Ga<sub>3</sub>(211) surface, resulting in the formation of parallel moiré fringes. At the same time, Ni-rich Ni-Ga alloy nanoclusters appeared due to the excess Ni on the surface. Under H<sub>2</sub>/CO<sub>2</sub> conditions, Ni-rich Ni-Ga alloy nanoclusters were also observed, but the formation of Ga oxide was limited. Electron energy loss spectroscopy (EELS) analysis also revealed the presence of Ga oxide but not Ni oxide phase.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"31 ","pages":"Article 100648"},"PeriodicalIF":8.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0