Materials Today Nano最新文献

{"title":"Atomically dispersed iron as catalase nanozyme towards biomimetic electrochemical detection of reactive oxygen species","authors":"Vadakke Purakkal Sruthi,&nbsp;Devarasu Mohanapriya,&nbsp;Rajashri R. Urkude,&nbsp;Kathavarayan Thenmozhi,&nbsp;Sellappan Senthilkumar","doi":"10.1016/j.mtnano.2026.100880","DOIUrl":"10.1016/j.mtnano.2026.100880","url":null,"abstract":"<div><div>Single atom nanozymes are known to mimic the active metal centre of the natural enzymes and are trending in today's world owing to their enormous advantageous features which include robustness, ease of synthesis and high catalytic activity. Thus, we envisaged to explore the catalase-mimicking activity of the well-known iron single atom (FeSA), and to employ it towards the electrochemical sensing of a non-radical reactive oxygen species, hydrogen peroxide (H₂O₂). The FeSA was synthesized through pyrolysis of iron-doped zeolitic imidazole framework and detailed characterization revealed its structural resemblance to the active sites of the catalase enzyme. Notably, the enzyme-mimicking characteristics was investigated using UV-Vis and fluorescence measurements, which established the catalase-mimetic behaviour of FeSA. The FeSA nanozyme was then modified over a glassy carbon electrode (GCE) to attain the desired FeSA/GCE sensor and subjected to electrocatalytic investigation. The developed sensor was capable of detecting H₂O₂ at zero applied potential and portrayed linear ranges from 5 to 75 μM and 75 μM – 1.4 mM with a very low detection limit of 1.22 μM. The Michaelis-Menten parameters, <em>K</em>_m and <em>I</em>_max of FeSA were calculated to be 223.3 μM and 333.3 μA, respectively, which evidences the enhanced enzyme-substrate affinity compared to the catalase enzyme.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100880"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrathin scintillators enabled via rapidly growing large-area 2D lanthanide oxychloride doped with Eu3+/Tb3+ for X-ray imaging","authors":"Hao Chen,&nbsp;Liang Li,&nbsp;Xuefang Lu,&nbsp;Shunze Huang,&nbsp;Man Xia,&nbsp;Jianzhong Xu,&nbsp;Xiwei Lai,&nbsp;Zewenhui Zhang,&nbsp;Xin Qian,&nbsp;Tianyu Xu,&nbsp;Feng Huang,&nbsp;Richeng Lin","doi":"10.1016/j.mtnano.2026.100927","DOIUrl":"10.1016/j.mtnano.2026.100927","url":null,"abstract":"<div><div>Ultrathin scintillators are key components of high-spatial-resolution X-ray detectors in medical imaging, high-precision nondestructive inspection, and high-energy physics. Currently, the spatial resolution of X-ray imaging detector generally is enabled by high-light-yield scintillators with minimal optical scattering. However, suppressing optical scattering losses typically require the scintillation layers thinner than a few tens of micrometers, which is difficult to obtain through conventional top-down mechanical thinning. Here, a bottom-up method that rapidly growing inch-sized, Eu³⁺/Tb³⁺ doped lanthanide oxychloride (LaOCl) films via chemical vapor deposition (CVD) is proposed to obtain large-area ultrathin scintillators. The doping Eu³⁺/Tb³⁺ ions act as luminescent activators and provide strong red and green scintillation through efficient f-f intra-configurational transitions, which are shielded from the host lattice by the outer 5s²5p⁶ electron shells, resulting in sharp emission lines and high quantum efficiency. The layered crystal structure of LaOCl further facilitates anisotropic growth, enabling precise control of film thickness from a few atomic layers up to the micrometer scale. The growing LaOCl:Eu³⁺ film with thickness of approximately 30 μm shows a photoluminescence quantum yield (PLQY) of 99.3%, and demonstrating an ultralow X-ray dose-rate detection limit of 143.41 nGy s⁻¹, owing to efficient energy transfer from the LaOCl host to the activator ions. Furthermore, the growing LaOCl:Eu³⁺/Tb³⁺ films exhibit excellent linear response and radiation hardness under X-ray exposure, retaining above 95% of their initial intensity after prolonged cyclic irradiation at 27.8 μGy s⁻¹ for 24,000 s. These results demonstrate CVD-grown LaOCl:Ln films as a promising platform for high-resolution and low-dose X-ray imaging detection.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100927"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced charge transfer in noble-metal-loaded gallium oxide for selective electrochemical sensing of heroin and morphine in biological matrix","authors":"Neha Anil,&nbsp;Preeti Parmar,&nbsp;Siddharth Sameer,&nbsp;Ruturaj Solanki,&nbsp;Partha Halder,&nbsp;Rupak Banerjee,&nbsp;Arvind Kumar Saxena,&nbsp;Juan Carlos Colmenares Q,&nbsp;Bappi Paul","doi":"10.1016/j.mtnano.2026.100923","DOIUrl":"10.1016/j.mtnano.2026.100923","url":null,"abstract":"<div><div>The electrochemical detection of opioids such as heroin and morphine remains a critical challenge in forensic and biomedical analysis. In this work, metal-decorated gallium oxide (Ga₂O₃) nanomaterials were synthesized via a solvent-mediated approach, in which water was found to be a superior solvent over ethylenediamine, yielding well-defined nanorods within the nanometer range. Electrochemical impedance spectroscopy revealed that the smaller, water-synthesized nanoparticles exhibited lower charge-transfer resistance (0.59 kΩ), indicating more efficient charge transfer. This nanometer-range morphology was therefore identified as optimal for the electrochemical sensing of heroin and morphine. Calcination of the synthesized materials promoted the formation of the thermodynamically stable β-Ga₂O₃ phase, thereby enhancing the electrochemical activity of the resultant nanostructures. Copper (Cu), palladium (Pd), silver (Ag), and gold (Au) were systematically loaded onto the surface of the Ga₂O₃ host framework, forming metal-Ga₂O₃ heterojunctions; Au and Ag produced discrete nanoparticle-decorated rod morphologies, while Pd and Cu formed evenly dispersed, spherical particle morphologies on the Ga₂O₃ surface. Comprehensive characterization by XRD, TEM, SEM, TGA, and XPS confirmed phase purity, morphology, thermal stability, and elemental composition of all materials. Among the synthesized composites, the silver-loaded gallium oxide modified glassy carbon electrode demonstrated the best electrochemical performance and enabled sensitive differential pulse voltametric detection of heroin (LOD = 0.175 μM) and morphine (LOD = 0.42 μM) at physiological pH 7. Interference studies with common cutting agents such as caffeine, alprazolam, and paracetamol confirmed strong selectivity with negligible cross-reactivity in complex matrices. Real-sample analysis of urine further validated the sensor's practical utility, demonstrating effective and reliable opioid detection under biologically relevant conditions.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100923"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lightweight iron oxide decorated carbon nanotube/cellulose composite for broadband and tunable electromagnetic wave absorption","authors":"Yu Hu,&nbsp;Quanxin Liu,&nbsp;Xiyu Qiu,&nbsp;Jianzhong Guo,&nbsp;Xiaofan Ma,&nbsp;Yiming Chen,&nbsp;Lin Chen","doi":"10.1016/j.mtnano.2026.100928","DOIUrl":"10.1016/j.mtnano.2026.100928","url":null,"abstract":"<div><div>Constructing lightweight, outstanding electromagnetic wave absorbers through simple methods represents one of the key strategies to tackle electromagnetic pollution. Here, Fe₂O₃-modified carbon nanotube/cellulose composite (FCCA) was prepared by freeze-drying with cellulose nanofiber (CNF) as the matrix and the Fe₂O₃ nanoparticles and carbon nanotube (CNT) as functional fillers. The results indicate that the FCCA composite effectively attenuates electromagnetic waves by extending their propagation path to enhance multi-reflection and scattering, while the introduced CNT impart excellent conductivity, leading to substantial conduction loss. Also, the weakly magnetic Fe₂O₃ nanoparticles optimizes impedance matching, offers permeability, and enriches the electromagnetic wave dissipation mechanisms. Meanwhile, the abundant heterogeneous interfaces in the FCCA composite generate significant interface polarization, enhancing the polarization relaxation loss of electromagnetic waves. With an Fe₂O₃ nanoparticle loading of 20% (Fe₂O₃:CNT = 20%), the FCCA-20 composite demonstrated a competitive density of 48.1 mg cm⁻³. When the thickness was 2 mm, it delivered excellent absorption performance, characterized by a RL_min of −63.5 dB alongside a favorable bandwidth of 5.02 GHz. Furthermore, simulation of the RCS confirmed a maximum reduction of 24.22 dB m², which indicates effective electromagnetic wave attenuation by the FCCA composite.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100928"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148770377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polarization-controlled memristive switching in semiconductor–ferroelectric heterostructures for neuromorphic computing","authors":"Santu Kumar Ghosh,&nbsp;Tamal Dey,&nbsp;Subhajit Jana,&nbsp;Subham Saha,&nbsp;Chirantan Ganguly,&nbsp;Amal Kumar Das,&nbsp;Samit K. Ray","doi":"10.1016/j.mtnano.2026.100890","DOIUrl":"10.1016/j.mtnano.2026.100890","url":null,"abstract":"<div><div>Artificial synapses are essential hardware components for realizing energy-efficient, brain-inspired neuromorphic computing systems capable of overcoming the von Neumann memory bottleneck through computation-in-memory architectures. Here, we report a polarization-controlled memristive device based on semiconductor-ferroelectric heterojunction, in which MoS₂ nanosheets are incorporated into the PVDF matrix to engineer the interfacial electronic structure and modulate carrier transport. The remnant polarization of the PVDF layer generates an internal electrostatic field that dynamically controls interfacial charge trapping and detrapping, enabling polarization-assisted resistive switching in MoS₂/PVDF heterostructures. The device successfully emulates essential biological synaptic behaviors, including long-term potentiation, long-term depression, and paired-pulse facilitation, exhibiting highly stable and repeatable potentiation–depression characteristics over multiple cycles. The coupling between ferroelectric polarization and interfacial electronic transport leads to enhanced switching stability and reliable learning capability. The device exhibits a low areal programming energy of approximately 28.8 nJ mm⁻² per synaptic spike and demonstrates pulse-width-dependent conductance modulation. Leveraging these synaptic properties, handwritten pattern recognition using an artificial neural network (ANN) achieves a learning accuracy of 92.82%. Furthermore, system-level evaluation using a simulated spiking neural network (SNN), where experimentally derived conductance states are mapped as synaptic weights, yields a classification accuracy of 96% on the Modified National Institute of Standards and Technology (MNIST) dataset, confirming reliable learning capability and efficient neuromorphic computation. These results establish the heterostructures as an attractive platform for polarization-engineered memristive synapses and highlight their strong potential for energy-efficient neuromorphic hardware enabling brain-inspired computing.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100890"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of layered double hydroxides: Routes, structural control, variable parameters, and biochar hybrids – A review","authors":"Ana T.C. Aguiar,&nbsp;Clarissa P. Rodrigues,&nbsp;Kátia R. de Souza","doi":"10.1016/j.mtnano.2026.100915","DOIUrl":"10.1016/j.mtnano.2026.100915","url":null,"abstract":"<div><div>Layered Double Hydroxides (LDHs) are layered materials widely investigated for environmental remediation and energy catalysis due to their structural flexibility, high anion-exchange capacity, and compositional tunability. However, conventional synthesis pathways often lead to severe face-to-face sheet aggregation, restricted specific surface areas, and poor structural reproducibility. This review provides a critical evaluation of LDHs and their multifunctional hybrid composites, specifically focusing on the optimization of synthesis parameter synergies alongside the <em>in situ</em> crystallization of LDH layers onto porous biomass-derived biochars. It is systematically analyzed how the coupled interactions of variables (such as pH, cation ratios, and thermodynamic aging parameters) dictate phase purity, microstrain variations, and crystallization kinetics in conventional chemical methods and emerging technologies. To address the operational limitations of empirical batch precipitation, the integration of advanced methodologies, including continuous-flow microfluidics, mechanochemistry, and machine learning-guided predictive modeling, is evaluated. Furthermore, the interfacial mechanics of LDH–biochar hybrids are detailed, highlighting how carbonaceous matrices serve as heterogeneous templates. By correlating precise structural engineering with predictive synthesis parameters, this review establishes a rigorous foundation for the scalable implementation of these robust hybrids in targeted environmental remediation and electrocatalytic energy conversion.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100915"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric layered films deliver low-reflection EMI protection and thermal–electric co-functionality","authors":"Yageng Bai,&nbsp;Han Wu,&nbsp;Yuxuan Gu,&nbsp;Zifan Bai,&nbsp;Wenchong Zhang,&nbsp;Yuansheng Ding,&nbsp;Jianxin Mu","doi":"10.1016/j.mtnano.2026.100912","DOIUrl":"10.1016/j.mtnano.2026.100912","url":null,"abstract":"<div><div>As electromagnetic (EM) pollution intensifies, EM interference (EMI) shielding materials with both high shielding effectiveness and low reflection are urgently required. In this study, an asymmetric layered composite film architecture is proposed to achieve absorption-dominant, low-reflection shielding. A heterostructured absorber, CNTs@Co@MoS₂ (CCM), is fabricated through continuous floating-catalyst chemical vapor deposition of CNT films, followed by high-temperature carbonization and <em>in situ</em> hydrothermal growth. An optimized CCM mass ratio of 1:6 maximizes the synergy between dielectric and magnetic losses while improving impedance matching, resulting in strong microwave absorption (RL_min = −53.59 dB; EAB_max = 6.96 GHz with full Ku-band coverage) and minimal radar cross-section scattering. Based on this absorber, CCMF-GMF films are assembled through electrostatic spraying/electrospinning and hot-press lamination, comprising a CNTs@Co@MoS₂/FPEEK impedance-matching/absorbing layer and a GnPs&amp;MWCNTs/FPEEK conductive reflecting layer. The resulting films exhibit high EMI shielding effectiveness across 8–18 GHz (≈69.8 dB), with significantly reduced reflection (R &lt; 0.5) and stable performance under temperature fluctuations. Moreover, the films provide integrated thermal management and enable stable photothermal–electric output when coupled with a thermoelectric module, offering a versatile platform for next-generation low-reflection EMI shielding materials.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100912"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting H2O2 dismutation via the rational design of bifunctional Ru3+–Lewis base sites on halloysite nanotubes","authors":"Jiaying Yu,&nbsp;Alessandra Zizzari,&nbsp;Monica Bianco,&nbsp;Ilenia Viola,&nbsp;Elisabetta Perrone,&nbsp;Yuxing Huang,&nbsp;Valentina Arima,&nbsp;Mauro Carraro","doi":"10.1016/j.mtnano.2026.100921","DOIUrl":"10.1016/j.mtnano.2026.100921","url":null,"abstract":"<div><div>In this study, we report the crafting of Ru-doped binary MgAl-Layered double hydroxides (Ru-LDHs) vertically standing on the surface of carboxylic acid groups-functionalized HNTs (denoted Ru-LDHs/HNTs), aiming at constructing a bifunctional catalyst with both Lewis basic sites and metal sites. The grafted MgAl-LDHs enable a full exposure of Lewis basic sites (i.e., Mg-O^2-) as well as of highly active Ru³⁺ species. Intriguingly, the strong Lewis basic sites assist the Ru³⁺ centers during H₂O₂ activation, thereby generating a strong catalytic synergy for H₂O₂ dismutation. Consequently, the Ru-LDHs/HNTs display excellent activity for the H₂O₂ dismutation with a maximum reaction rate of ∼0.2 μmol O₂ s⁻¹, much higher than the counterpart without Lewis basic sites. The catalyst retained approximately 95% of its initial O₂ yield after three consecutive reuse cycles. Notably, under the applied assay conditions, Ru-LDHs/HNTs exhibited a marked suppression of detectable hydroxyl-radical formation, demonstrating the great activity of such bifunctional catalysts as antioxidant systems. The behaviour of the functional HNTs has been finally investigated to assess their mobility when placed on a surface and in microchannels, given their potential applications as microswimmers for <em>in vitro</em> chemotactic models, and as microsensors for environmental or food safety monitoring.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100921"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of Co (Ni) substituents at the edges of MoS2 nanosheets to improve the efficiency of sodium-ion battery anodes","authors":"Alena A. Zaguzina,&nbsp;Victor A. Alekseev,&nbsp;Anastasiya D. Fedorenko,&nbsp;Elena V. Lisitsa,&nbsp;Svetlana V. Trubina,&nbsp;Valentina V. Zvereva,&nbsp;Vladimir V. Kriventsov,&nbsp;Yury V. Shubin,&nbsp;Tao Liu,&nbsp;Alexander V. Okotrub,&nbsp;Lyubov G. Bulusheva","doi":"10.1016/j.mtnano.2026.100899","DOIUrl":"10.1016/j.mtnano.2026.100899","url":null,"abstract":"<div><div>MoS₂ nanomaterials with varying Co or Ni substituent contents were synthesized by rapid thermolysis of mixed aerogels of ammonium tetrathiomolybdate and cobalt or nickel acetate in an inert atmosphere. Electron microscopy studies of the samples revealed microdefects in the structure of the MoS₂ platelets arising from gas evolution during decomposition of the acetate moiety. X-ray photoelectron spectroscopy data showed that Co and Ni are in the 2+ oxidation state, and their introduction into MoS₂ lowers the Fermi level. Extended X-ray absorption fine structure spectroscopy indicated that both Co and Ni are coordinated by four sulfur atoms, consistent with the substitution of Mo atoms at the edges of the MoS₂ nanosheets. Testing of samples as anodes for sodium-ion batteries (SIBs) demonstrated optimal performance for MoS₂ with 1–2% Co (Ni) substitution. The reversible specific capacity of the best samples after 55 discharge/charge cycles was ∼500 mAh·g⁻¹ at a current density of 0.1 A·g⁻¹. Analysis of cyclic voltammetry curves measured after more than 60 cycles revealed peaks of redox reactions corresponding to the reversible intercalation of Na⁺ ions between MoS₂ nanosheets. SIBs with Co-MoS₂ or Ni-MoS₂ anodes sustained a current density of 10 A·g⁻¹, while the Co-doped sample retained an exceptional capacity of 150 mAh·g⁻¹ after 1000 cycles. The superior rate performance of Co-MoS₂ is attributed to the higher electron density near the Fermi level provided by the Co substituents, as confirmed by density functional theory calculations.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100899"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional plasmonic Au-TiO2-integrated polycaprolactone-cellulose acetate nanofibrous scaffolds for synergistic photothermal osteosarcoma therapy and bone tissue regeneration","authors":"Richa Jaswal,&nbsp;Seo Yeon Lee,&nbsp;Kavitha Gopal,&nbsp;Devendra Shrestha,&nbsp;Joshua Lee,&nbsp;Dinesh Kumar,&nbsp;Hyo Sung Kwak,&nbsp;Chan Hee Park","doi":"10.1016/j.mtnano.2026.100894","DOIUrl":"10.1016/j.mtnano.2026.100894","url":null,"abstract":"<div><div>Herein, biocompatible bifunctional polycaprolactone and cellulose acetate-based (PCA) nanofibrous scaffolds incorporating core-shell Au-TiO₂ nanoparticles were fabricated for bone cancer photo-ablation and bone tissue regeneration. Gold nanoparticles (30 nm) were coated with TiO₂ (12 nm) in a core-shell form, and the core-shell Au-TiO₂ nanoparticles were integrated into PCA in 0.5, 1.0, and 2.0 mg to prepare a randomly oriented PCA@Au-TiO₂ nanofiber. PCA@Au-TiO₂ significantly improved the mechanical strength, electrical conductivity, photothermal activity, protein adsorption capacity, and osteogenic performance while maintaining excellent biocompatibility. PCA@Au-TiO₂ demonstrated superior therapeutic efficacy, with 89% of ablation of MG-63 bone cancer cells under low near-infrared (NIR) power density (0.5 W/cm²) irradiation, by maximizing cell alteration, cytoskeletal damage, and apoptosis, as validated by live/dead staining, confocal microscopy, and flow cytometry analysis. FACS analysis revealed a 74% apoptotic cell rate with PCA@Au-TiO₂ (2.0 mg) compared to PCA (0.2%), suggesting that PCA@Au-TiO₂ induced highly efficient MG-63 cell apoptosis. Also, PCA@Au-TiO₂ supported robust proliferation of MC3T3-E1 pre-osteoblasts and significantly enhanced osteogenic differentiation, as evidenced by elevated ALP activity, mineral deposition (ARS and von Kossa staining), and increased expression of osteogenic markers, including osteopontin and collagen-I. The results suggested PCA@Au-TiO₂ as a promising platform for bone cancer therapy and bone tissue regeneration.</div></div>","PeriodicalId":48517,"journal":{"name":"Materials Today Nano","volume":"35 ","pages":"Article 100894"},"PeriodicalIF":7.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148642086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}