Materials Today Advances最新文献

{"title":"An integrated flexible sensor for decoupled omnidirectional strain and human motion monitoring","authors":"Jiayi Chen, Jijun Li, Yaqian Liu","doi":"10.1016/j.mtadv.2025.100641","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100641","url":null,"abstract":"Omnidirectional strain sensors are of paramount importance in the accurate detection of human movements. The mask printing technology is employed to fabricate an integrated omnidirectional flexible strain sensor for human motion monitoring. Silica particles were incorporated into the liquid metal to improve its rheological properties and enhance its patterning capability. The developed sensor exhibits excellent characteristics, including a wide strain sensing range (1–300 %), high sensitivity as evidenced by gauge factors ranging from 1.82 to 3.34 across its operational range, and excellent cyclic stability (more than 5000 cycles) with minimal signal degradation, ensuring reliable long-term monitoring. It is particularly noteworthy that the integrated flexible strain sensor can achieve real-time decoupling of both the magnitude and direction of the principal strain at the measurement point. The reliability of the sensor is verified by utilizing the specified strain magnitude and direction. This unique capability to resolve complex multi-axis deformation patterns provides higher accuracy than conventional unidirectional strain sensors and enables precise and intelligent identification of various human actions. The strain sensing platform has great application potential in fields such as health monitoring and rehabilitation medicine.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100641-100641"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-triggered in situ gelation of indocyanine green-upconversion nanocomposite hydrogel for combating refractory keratitis via synergistic antimicrobial therapy and corneal repair","authors":"Zhiwei Zha, Ying Huang, Xunjie Shang, Yate Huang, Li Zhu, Juan Li, Yongqing Shao, Chun Yang, Weiwei Zheng, Lei Qi, Kaihui Nan, Tonghe Pan","doi":"10.1016/j.mtadv.2025.100636","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100636","url":null,"abstract":"Refractory infectious keratitis presents significant therapeutic challenges due to persistent microbial infections, rising antimicrobial resistance, and the limited precorneal bioavailability of conventional eye drop treatments. While photothermal (PTT) and photodynamic therapies (PDT) offer promising energy-based alternatives, their clinical application is limited by the shallow tissue penetration of visible light and rapid clearance from the ocular surface. Here, we report an integrated near-infrared (NIR)-triggered nanocomposite hydrogel platform (GUCNI) that combines mesoporous silica-coated upconversion nanoparticles (UCNPs@mSiO 2 ), indocyanine green (ICG), and photocrosslinkable gelatin methacrylate (GelMA) to address these convergent clinical challenges. Under a single 808 nm NIR irradiation, this system enables simultaneous in situ gelation for enhanced precorneal retention and spatiotemporally controlled synergistic PTT/PDT. The mesoporous nanoconfinement strategy effectively suppresses ICG aggregation-induced quenching and photobleaching, substantially enhancing photostability and therapeutic efficacy. In refractory bacterial keratitis models, GUCNI demonstrated superior antimicrobial efficacy through combined photothermal and photodynamic mechanisms, achieving complete pathogen eradication while suppressing inflammatory spread and promoting accelerated corneal repair. Transcriptomic analysis confirmed its dual therapeutic action through modulation of host defense pathways (inflammatory chemotaxis, phagocytosis) and tissue regeneration mechanisms (cell adhesion, extracellular matrix remodeling). With its integrated antimicrobial, anti-inflammatory, and pro-repair capabilities delivered via a clinically accessible workflow, GUCNI represents a promising next-generation therapeutic strategy for refractory infectious keratitis. A near-infrared-responsive nanocomposite hydrogel (GUCNI) was engineered by integrating upconversion nanoparticles (UCNPs@mSiO 2 ), indocyanine green (ICG), and photocrosslinkable gelatin (GelMA), leveraging NIR-triggered in situ gelation to enable spatiotemporally controlled synergistic photothermal/photodynamic therapy and sustained drug retention for refractory keratitis treatment, achieving complete bacterial eradication and expedited corneal ulcer repair.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100636-100636"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pH-triggered antioxidative stem cell spheroid platform restores paracrine signaling to enhance osteoporotic bone regeneration","authors":"Lina Huang, Chao Lin, Hanyi Hua, Zehao Chen, Yong Xu, Kezhen Zhou, Xiaoming Liu, Yifan Li, Jiangming Yu, Xiaojian Ye, Xiaoxiao Li, Shuai Jiang","doi":"10.1016/j.mtadv.2025.100637","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100637","url":null,"abstract":"In osteoporotic bone defects, bone marrow mesenchymal stem cells (BMSCs) play a pivotal role in tissue regeneration by orchestrating the local microenvironment through both differentiation and paracrine signaling. However, persistent pathological stimuli such as oxidative stress significantly impair their functionality, while limited cell survival and homing efficiency at the defect site remain major obstacles hindering therapeutic efficacy. To overcome these issues, we designed a stem cell delivery system using microfluidic techniques, in which microspheres were modified with resveratrol. This system leveraged a sustained-release liposomal formulation of resveratrol to enhance the antioxidant resilience of BMSCs. Simultaneously, the platform created a three-dimensional porous microenvironment using pH-responsive microspheres, which supported the maintenance of paracrine activity and promoted osteogenic differentiation of transplanted cells, thereby accelerating bone regeneration. In vitro experiments demonstrated that this system significantly enhanced mineralized nodule formation, accompanied by marked upregulation of osteogenesis-related genes and proteins including RUNX2, COL-1, and SP7. Furthermore, BMSCs exhibited increased secretion of key paracrine factors such as VEGFA, thereby improving proangiogenic support to endothelial cells. In vivo study, we employed an osteoporotic rat model with femoral bone defects, micro-CT imaging and multimodal histological analyses confirmed that the proposed platform markedly facilitated new bone formation and structural tissue reconstruction. Collectively, this study proposes a synergistic strategy for osteoporotic bone repair, providing a new approach to cell therapy design.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100637-100637"},"PeriodicalIF":0.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascularized and neuralized bone regeneration using injectable double-network cross-linked scaffolds with fully biomimetic organic and biomineralized microenvironments","authors":"Runquan Zheng, Xuesong Yan, Baoxing Tian, Suode Li, Jiawei Li, Zhaozhe Yao, Yongxian Zhang, Xianhu Yue","doi":"10.1016/j.mtadv.2025.100631","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100631","url":null,"abstract":"text. At present, reliable and effective therapeutic strategies for physiological bone regeneration are lacking. In this study, a novel injectable double-network cross-linked scaffold with fully biomimetic organic and biomineralized microenvironments for vascularized and neuralized bone regeneration was designed. Our design involved a dual-network collagen organic framework scaffold (COL1/3) with a ratio based on the natural bone composition. Subsequently, the optimal concentration (4 %) of COL1/3 scaffold for osteogenesis was determined on the basis of its efficiency in subcutaneous bone regeneration. In addition, 2 % multiple native bone inorganic salts were integrated into the COL1/3 scaffold to create a biomimetic biomineralized microenvironment. Consequently, double-network cross-linked scaffolds with a fully biomimetic organic and biomineralized microenvironment were successfully fabricated. Furthermore, in vitro studies showed that the scaffold exhibited good biocompatibility and promoted the secretion of bone-specific proteins while upregulating the expression level of osteogenic genes involved in bone microtissues formation. Finally, in vivo studies on rabbit skull defect repair indicated that the current repair strategy could enhance vascularized and neuralized bone regeneration.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100631-100631"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive pure zinc anchor on promoting tendon bone healing","authors":"Hao Sun, Fan Yang, Hongyao Zeng, Feixue Yang, Hongjie Huang, Jianquan Wang","doi":"10.1016/j.mtadv.2025.100615","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100615","url":null,"abstract":"Over the past few decades, extensive research has been devoted to developing biodegradable materials for tendon suture fixation. However, achieving an optimal balance among biocompatibility, mechanical properties, and the capacity to promote tendon-bone enthesis integration remains a significant challenge, limiting clinical translation. To overcome these limitations, we developed a pure zinc (Zn) anchor. In vitro studies demonstrated its excellent biocompatibility and robust osteogenic, chondrogenic, and tenogenic potential. In vivo studies, we compared the therapeutic efficacy of pure Zn anchors with Ti6Al4V (TC4) anchors in a rabbit model of rotator cuff tear repair. The results revealed that pure Zn anchors not only accelerated tendon-bone enthesis healing but also eliminated imaging artifacts associated with conventional metallic implants, highlighting their promising clinical utility for orthopedic applications.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100615-100615"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polythioctic acid-driven biomemristor for efficient sweat pH monitoring","authors":"Zijun Xu, Ruiming Liu, Bai Sun, Xiaosen Pan, Zelin Cao, Kaikai Gao, Yu Cui, Hongbin Zhao, Hao Sun, Qiang Lu, Yi Lyu, Fenggang Ren","doi":"10.1016/j.mtadv.2025.100624","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100624","url":null,"abstract":"Memristors have attracted widespread attention in the fields of brain-like chips and neuromorphic computing due to their parallel computing capabilities and characteristics to simulate neural synapses. However, the application of memristor in healthcare monitoring and diagnosis has not yet been well developed, which may delay the progress of smart healthcare services empowered by artificial intelligence (AI). Herein, it was demonstrated a pH-responsive memristor with an Ag/Poly(diethylene glycol ester thioctic acid)-Li/FTO structure, which shows excellent resistance switching behaviors with self-rectifying characteristics. Further, it was found the device can achieve precise acid-base discrimination through synergistic mechanisms involving the cationic conduction properties of the C-S bond in Poly(diethylene glycol ester thioctic acid) and the uniqueness of the metal-oxygen coordination bond. Accurate solution pH determination can be accomplished within 3 min via analysis of the time-dependent ΔI F-R parameter, defined as the different between forward peak and reverse currents. Finally, the device was successfully applied to determine sweat pH levels, demonstrating the potential of the pH-responsive memristor in monitoring health status through sweat. Therefore, this work provides new insights for non-invasive preliminary diagnosis and early warning of metabolic diseases such as diabetes, which effectively promotes the rapid development of smart wearable medical devices.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100624-100624"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An oxygen-responsive sprayable hydrogel with microenvironment-improving and antibacterial properties for diabetic wound therapy","authors":"Yang Yang, Fulei Li, Jie Zhang, Yu Wang, Guozhong Lyu","doi":"10.1016/j.mtadv.2025.100611","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100611","url":null,"abstract":"","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"27 1","pages":"100611"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coaxial electrospun Cu-CGRP/PLLA dressing spatiotemporally orchestrates immune-reparative dynamics in infected wounds","authors":"Zeng Hao, Junfeng Sun, Shuo Zhang, Jiajin Tu, Yan Zhang, Liyun Long","doi":"10.1016/j.mtadv.2025.100609","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100609","url":null,"abstract":"The clinical challenge in healing infected wounds stems from the complex interplay between pathogen resistance mechanisms and immune microenvironment dysregulation. Dysfunctional macrophage responses serve as a pivotal driver of impaired healing, characterized by sustained inflammation, persistent infection, and inadequate tissue regeneration. To address this multifaceted issue, we engineered a multifunctional dressing-PA@Cu-CGRP, via coaxial electrospinning: the outer layer incorporates copper-doped mesoporous bioactive glass (Cu-MBG) to enable controlled and sustained Cu 2+ release, effectively synergizing antibacterial and angiogenic effects, while the core encapsulates calcitonin gene-related peptide (CGRP) to precisely orchestrate macrophage phenotypic switching from pro-inflammatory M1 to reparative M2 phenotype. In vitro studies demonstrated significantly enhanced pathogen clearance through augmented phagocytic activity and bactericidal functions of M1 macrophages during the initial healing phase, followed by the synergistic promotion of M2 polarization to amplify anti-inflammatory and pro-reparative functions, thereby resolving inflammation and initiating regenerative processes. Concurrently, PA@Cu-CGRP markedly accelerated collagen deposition, neovascularization, and re-epithelialization, facilitated by the synergistic modulation of material surface energy, nanotopography, and bioactive molecule release kinetics, thus substantially promoting comprehensive regenerative repair of infected wounds. This early antibacterial and later immunoreparative design represents a robust, translatable strategy for effective and enhanced management of infected wounds complicated by multidrug-resistant pathogens. • The PA@Cu-CGRP dressing features a coaxial structure composed of a Cu-MBG shell and a CGRP-loaded PLLA core. • PA@Cu-CGRP enables rapid Cu 2+ release to enhance bacterial clearance and initiate M1 macrophage activation. • Sustained CGRP release from PA@Cu-CGRP drives M2 polarization and mitigates excessive inflammatory responses. • PA@Cu-CGRP significantly promotes collagen deposition, angiogenesis, and epithelial regeneration in infected wounds.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"27 1","pages":"100609-100609"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled photodegradable hydrogels with photolithographic microstructure arrays as 3D scaffolds for cell culture","authors":"Cong Sui, Shengting Zhang, Dachuan Zhang, Minghao Wang, Jingning Cao, Runhuai Yang","doi":"10.1016/j.mtadv.2025.100561","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100561","url":null,"abstract":"","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"25 1","pages":"100561-100561"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive manganese-decorated titanium implants for osteoporotic bone regeneration","authors":"Lei Wang, Chaoxi Yan, Fan Wang, Qiang Wang, Degang Huang, Xin Yang, Xin Yang, Tao Ma, Pingbo Chen, Congming Li, Zhouzhou Zhang, Guoyang Wan, Xing Yang, Xing Yang","doi":"10.1016/j.mtadv.2024.100542","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100542","url":null,"abstract":"Bone defect repair in osteoporosis remains a major clinical problem due to the persistent abnormal inflammatory response and imbalance of bone homeostasis. Manganese (Mn) ions have been proven to have dual effects of promoting immunomodulation and osteogenesis, showing great potentials for bone tissue regeneration in osteoporotic bone defects. In the present study, a novel Mn 2+ -releasing coating on titanium (Ti) substrates was prepared via biomimetic mussel-inspired chemical modification. Notably, the combination of polydopamine (PDA) and Mn 2+ endowed Ti@PDA + Mn with diverse bioactivities. In addition to excellent biocompatibility and osteogenic capability, Ti@PDA + Mn exhibited the ability to regulate intracellular reactive oxygen species (ROS) and induce macrophage to polarize towards M2 phenotype by the secretion of anti-inflammatory cytokines such as IL-10 and osteogenic-related cytokines such as TGF-β, establishing an osteoimmune microenvironment that facilitates bone tissue repair, establishing an osteoimmune microenvironment that facilitates bone tissue repair. In the ovariectomized osteoporosis rat model, Ti@PDA + Mn exhibited enhanced osseointegration in femoral bone defects demonstrated by micro-CT, histopathology, and immunohistochemistry at 2 and 6 weeks after surgery. Finally, the potential signaling pathway of Mn 2+ regulating osteogenesis has been further studied. Transcriptome sequencing revealed the significant regulatory functions of Mn 2+ , which upregulated the HIF-1 signaling pathway to enhance bone regeneration. The mechanism of Mn-enhanced osteogenesis developed in this study could provide theoretical and practical insights for enhancing implant-to-bone osseointegration in osteoporotic bone defects.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"24 1","pages":"100542-100542"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}