Materials Today Advances最新文献

A BBB-penetrated, microglia-targeted, and hypoxia-responsive nanogel for treating ischemic stroke 一种血脑屏障穿透、小胶质细胞靶向、缺氧反应的纳米凝胶治疗缺血性卒中

2区材料科学

Materials Today Advances Pub Date : 2026-03-01 DOI: 10.1016/j.mtadv.2026.100738

Yuze Xia, Ran Li, Yu Ni, Xi Zhang, Yuan Liu, Huayu Kang, Yanchao Liu, Chenxuan Yu, Yuxuan Deng, Zhenyou Jiang, Wenhao Ma, Yuyang Hou, Sheng Wang, Chao Gan, Yimin Huang, Huaqiu Zhang

{"title":"A BBB-penetrated, microglia-targeted, and hypoxia-responsive nanogel for treating ischemic stroke","authors":"Yuze Xia, Ran Li, Yu Ni, Xi Zhang, Yuan Liu, Huayu Kang, Yanchao Liu, Chenxuan Yu, Yuxuan Deng, Zhenyou Jiang, Wenhao Ma, Yuyang Hou, Sheng Wang, Chao Gan, Yimin Huang, Huaqiu Zhang","doi":"10.1016/j.mtadv.2026.100738","DOIUrl":"https://doi.org/10.1016/j.mtadv.2026.100738","url":null,"abstract":"Ischemic stroke is the most common type of stroke, seriously endangering the lives and health of the population. The main treatment methods include thrombolysis and thrombectomy in the acute phase and drug therapy. Recent studies have found that inflammatory responses play a significant role in the development of ischemic stroke, and microglia are the main contributors to early neuroinflammation. However, problems such as the blood-brain barrier and poor targeting prevent anti-inflammatory drugs from being effective in treatment. This study presents a nanogel modified with multiple polypeptides, designed to effectively cross the blood-brain barrier, specifically target microglia in ischemic and hypoxic regions, and regulate the release of the anti-inflammatory drug thalidomide. This approach aims to inhibit neuroinflammation and treat ischemic stroke. In vitro results demonstrate that the nanogel can reduce the expression of the microglial inflammatory marker TNF-α, while in vivo results show that it improves learning, memory, and motor function, and mitigates anxiety and depressive behaviors associated with neuroinflammation in ischemic stroke. Overall, we have developed a drug-loaded nanogel targeting TNF-α in microglia within ischemic and hypoxic areas, enhancing anti-inflammatory effects and offering a novel therapeutic strategy for ischemic stroke. • Three biologically active polypeptides were linked to the poly(acrylic acid) backbone. • Nanogels could penetrate the blood-brain barrier and target ischemic regions. • Thalidomide had anti-inflammatory effects on microglia. • Nanogel treatment improved the neurological function of mice with ischemic stroke. .•The function of nanogels in vivo was achieved by targeting microglia.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 1","pages":"100738-100738"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes. 糖尿病伤口处理的微针策略：材料、机制和治疗结果的综合综述。

IF 8 2区材料科学

Materials Today Advances Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.mtadv.2025.100684

Kaustubh Naik, Kanhaiya Singh

{"title":"Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes.","authors":"Kaustubh Naik, Kanhaiya Singh","doi":"10.1016/j.mtadv.2025.100684","DOIUrl":"10.1016/j.mtadv.2025.100684","url":null,"abstract":"<p><p>Chronic diabetic wounds are one of the most challenging clinical problems because of poor angiogenesis, prolonged inflammation, and retarded tissue repair. Conventional wound dressing does not provide localised and continuous treatment, frequently resulting in unsuccessful therapeutic outcomes. Microneedle (MN) based delivery is envisioned as an ideal approach to transdermal interface with the wound microenvironment to deliver bioactive agents. Because of its minimally invasive nature, ease of use, and ability to bypass the stratum corneum, microneedles as a delivery medium have inherent advantages of site-specific, controllable, and painless drug administration. This review summarises recent progress in the development of MN-based systems for diabetic wound healing and emphasises their potential for delivering growth factors, anti-inflammatory agents, and gene therapies. The addition of smart materials, including stimulus-responsive and bioelectronic microneedles, makes them more efficacious as a therapeutic system. We also address current barriers, regulatory challenges, and prospects for clinical translation of MN-based wound care for diabetes.</p>","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polythioctic acid-driven biomemristor for efficient sweat pH monitoring 用于高效汗液pH监测的多硫辛酸驱动生物电阻器

2区材料科学

Materials Today Advances Pub Date : 2025-09-17 DOI: 10.1016/j.mtadv.2025.100624

Zijun Xu, Ruiming Liu, Bai Sun, Xiaosen Pan, Zelin Cao, Kaikai Gao, Yu Cui, Hongbin Zhao, Hao Sun, Qiang Lu, Yi Lyu, Fenggang Ren

{"title":"Polythioctic acid-driven biomemristor for efficient sweat pH monitoring","authors":"Zijun Xu, Ruiming Liu, Bai Sun, Xiaosen Pan, Zelin Cao, Kaikai Gao, Yu Cui, Hongbin Zhao, Hao Sun, Qiang Lu, Yi Lyu, Fenggang Ren","doi":"10.1016/j.mtadv.2025.100624","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100624","url":null,"abstract":"Memristors have attracted widespread attention in the fields of brain-like chips and neuromorphic computing due to their parallel computing capabilities and characteristics to simulate neural synapses. However, the application of memristor in healthcare monitoring and diagnosis has not yet been well developed, which may delay the progress of smart healthcare services empowered by artificial intelligence (AI). Herein, it was demonstrated a pH-responsive memristor with an Ag/Poly(diethylene glycol ester thioctic acid)-Li/FTO structure, which shows excellent resistance switching behaviors with self-rectifying characteristics. Further, it was found the device can achieve precise acid-base discrimination through synergistic mechanisms involving the cationic conduction properties of the C-S bond in Poly(diethylene glycol ester thioctic acid) and the uniqueness of the metal-oxygen coordination bond. Accurate solution pH determination can be accomplished within 3 min via analysis of the time-dependent ΔI F-R parameter, defined as the different between forward peak and reverse currents. Finally, the device was successfully applied to determine sweat pH levels, demonstrating the potential of the pH-responsive memristor in monitoring health status through sweat. Therefore, this work provides new insights for non-invasive preliminary diagnosis and early warning of metabolic diseases such as diabetes, which effectively promotes the rapid development of smart wearable medical devices.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100624-100624"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An oxygen-responsive sprayable hydrogel with microenvironment-improving and antibacterial properties for diabetic wound therapy 一种具有改善微环境和抗菌性能的氧反应性可喷雾水凝胶用于糖尿病伤口治疗

2区材料科学

Materials Today Advances Pub Date : 2025-08-01 DOI: 10.1016/j.mtadv.2025.100611

Yang Yang, Fulei Li, Jie Zhang, Yu Wang, Guozhong Lyu

引用次数: 0

Controlled photodegradable hydrogels with photolithographic microstructure arrays as 3D scaffolds for cell culture 具有光刻微结构阵列的可控光降解水凝胶作为细胞培养的三维支架

2区材料科学

Materials Today Advances Pub Date : 2025-01-28 DOI: 10.1016/j.mtadv.2025.100561

Cong Sui, Shengting Zhang, Dachuan Zhang, Minghao Wang, Jingning Cao, Runhuai Yang

引用次数: 3

Not only a matter of disorder in I-WP minimal surface-based photonic networks: Diffusive structural color in Sternotomis amabilis longhorn beetles 基于I-WP最小表面的光子网络中不仅存在无序问题：Sternotomis amabilis 长角甲虫的扩散结构色彩

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-09-04 DOI: 10.1016/j.mtadv.2024.100524

Viola Bauernfeind, Vinodkumar Saranathan, Kenza Djeghdi, Elena Longo, Silja Flenner, Imke Greving, Ullrich Steiner, Bodo D. Wilts

{"title":"Not only a matter of disorder in I-WP minimal surface-based photonic networks: Diffusive structural color in Sternotomis amabilis longhorn beetles","authors":"Viola Bauernfeind, Vinodkumar Saranathan, Kenza Djeghdi, Elena Longo, Silja Flenner, Imke Greving, Ullrich Steiner, Bodo D. Wilts","doi":"10.1016/j.mtadv.2024.100524","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100524","url":null,"abstract":"The diverse colors of longhorn beetles arise from either pigmentary absorption or interference of light with various photonic nanostructures. Variations in structure, order, and/or material composition give rise to diverse optical signals. Here, we investigated the colors of the longhorn beetle (Cerambycidae: Lamiinae). By combining optical microscopy and detailed bulk ultrastructural analysis of the colored scales that are the basis of the multicolored patterns of bluish-green and orange markings, we document polycrystalline networks based on the triply periodic minimal surface, Schoen’s I-WP, in the bluish-green scales. In contrast, amorphous quasi-ordered networks are found in the orange scales. The optical signal from the photonic networks is further altered by absorbing pigments. Ridged, micrometer-sized protrusions diffuse reflected light and suppress iridescence in all scale types. We discuss the pivotal role that order and disorder play in these photonic structures and support our understanding of the function of the scale geometry with full-wave optical simulations. Detailed knowledge about visible light interactions within intricate mediums, such as those observed in beetle scales, is highly relevant to current challenges in the design and synthesis of photonic nanostructures operating in the visible regime.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"47 1","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic bilayer qubits: A bipartite quantum system 磁性双层量子比特：一个双方量子系统

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-09-01 DOI: 10.1016/j.mtadv.2024.100525

Clara Sinta Saragih, Duy Van Pham, Jun-Xiao Lin, Wei-Jhong Chen, Po-Hung Wu, Chun-Chuen Yang, Chien-Chih Lai, Chih-Hung Tsai, Hua-Shu Hsu, Yuan-Ron Ma

引用次数: 0

Unraveling the role of relaxation and rejuvenation on the structure and deformation behavior of the Zr-based bulk metallic glass Vit105 揭示弛豫和年轻化对 Zr 基块状金属玻璃 Vit105 结构和变形行为的作用

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-09 DOI: 10.1016/j.mtadv.2024.100522

Lucas M. Ruschel, Sergej Jakovlev, Oliver Gross, Nico Neuber, Bastian Adam, Maximilian Frey, Benedikt Schmidt, Benedikt Bochtler, Ralf Busch

{"title":"Unraveling the role of relaxation and rejuvenation on the structure and deformation behavior of the Zr-based bulk metallic glass Vit105","authors":"Lucas M. Ruschel, Sergej Jakovlev, Oliver Gross, Nico Neuber, Bastian Adam, Maximilian Frey, Benedikt Schmidt, Benedikt Bochtler, Ralf Busch","doi":"10.1016/j.mtadv.2024.100522","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100522","url":null,"abstract":"The influence of relaxation and rejuvenation on the deformation behavior of the Zr-based bulk metallic glass Vit105 (ZrCuNiAlTi) was investigated, where a well-defined thermal history was systematically introduced by thermal treatments. Samples with a progressively lower fictive temperature exhibit a lower enthalpic state, coupled with a reduced degree of free volume, which is responsible for a continuous embrittlement observed in three-point beam bending tests. The generated database allows an assessment of the mechanical behavior of any amorphous component made of Vit105 by simple calorimetric measurements and the determination of the fictive temperature, which is of special interest for complex parts that cannot be easily evaluated in mechanical tests. Diffraction experiments with high energy synchrotron X-ray radiation reveal a correlation between the increase in rigid 3-atom cluster connections with the reduction in the fracture strain, as a measure of ductility, indicating a strong correlation with the thermal history. While the atomic connections seem to have a crucial contribution to the ductility, changes of the short- and medium-range order seem to be equally important. The current findings provide fundamental insights into the role of thermal history in metallic glass forming alloy systems and how it can be used to manipulate the structure and tailor their mechanical properties specifically to the needs of each application.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"43 1","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic tweezer-driven assembly and anti-cancer property of microporous magnesium gallate 微孔没食子酸镁的声镊驱动组装和抗癌特性

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-09 DOI: 10.1016/j.mtadv.2024.100523

Badrinathan Sridharan, Daehun Kim, Karthika Viswanathan, Ji Won Nam, Hae Gyun Lim

{"title":"Acoustic tweezer-driven assembly and anti-cancer property of microporous magnesium gallate","authors":"Badrinathan Sridharan, Daehun Kim, Karthika Viswanathan, Ji Won Nam, Hae Gyun Lim","doi":"10.1016/j.mtadv.2024.100523","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100523","url":null,"abstract":"The study focuses on fabrication and characterization of magnesium gallate (Mg-Gal), and introduces the use of single beam acoustic tweezers for aggregation and manipulation of Mg-Gal. Initially, microparticles are fabricated and thoroughly characterized, revealing their crystalline nature and thermostability stability. Through techniques like X-ray Diffraction (XRD), Fourier Transform-Infrared (FT-IR) spectroscopy, and electron microscopy, the structural and compositional features are elucidated. Subsequently, we intended to explore the effect of acoustic tweezer which are upcoming technology that possess multiple biological applications like drug delivery, cell analysis and tissue engineering. We demonstrated a successful aggregation and manipulation of these microparticles using a single beam acoustic tweezer system equipped with 7.5 MHz transducer. Within a short duration of 12 s, aggregates of around 100 μm size are formed and manipulated within the field of vision. Additionally, the anti-cancer potential of Mg-Gal microparticles was investigated in vitro, displaying significant cytotoxicity and anti-proliferative activity against MDA-MB-231 cells, with an IC value of 79.18 μg/ml. The study emphasizes the promising prospects of Mg-Gal microparticles in targeted drug delivery using ultrasound for cancer treatment and underscores the material's potential for conjugation with therapeutic drugs to address various complex diseases. Overall, this research highlights the interdisciplinary approach in advancing both material manipulation techniques and biomedical applications.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 1","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured proton-exchange membranes from self-cross-linking perfluoroalkyl-free block-co-polymers 自交联无全氟烷基嵌段共聚物的纳米结构质子交换膜

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-07 DOI: 10.1016/j.mtadv.2024.100521

Sebastian Auffarth, Maximilian Maier, Philipp Martschin, Theresa Stigler, Maximilian Wagner, Thomas Böhm, Andreas Hutzler, Simon Thiele, Jochen Kerres

{"title":"Nanostructured proton-exchange membranes from self-cross-linking perfluoroalkyl-free block-co-polymers","authors":"Sebastian Auffarth, Maximilian Maier, Philipp Martschin, Theresa Stigler, Maximilian Wagner, Thomas Böhm, Andreas Hutzler, Simon Thiele, Jochen Kerres","doi":"10.1016/j.mtadv.2024.100521","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100521","url":null,"abstract":"A sustainable hydrogen economy relies on fuel cells and electrolyzers, which heavily depend on ion-conducting perfluoroalkylated materials such as Nafion or Aquivion. Together with other perfluorinated alkyl substances, their environmental accumulation, and the rising awareness of risks to human health stress the need for alternative materials. Based on block-co-polymers from octylstyrene and pentafluorostyrene, we present nanostructured proton-exchange membranes. In contrast to problematic perfluorinated alkyl constituents, the involved aromatic fluorine atoms allow mild functionalizations to form tetrafluorostyrene sulfonic acid. Meanwhile, the nonpolar block reduces the stiffness of the material. By introducing a new preparation technique, controlled mitigation of the thiol cross-linking allows membrane self-reinforcement during drying. The reinforcing cross-links enhance the dissolution stability and reduce the water uptake after 24 h down to 33 wt% at 85 °C. Cross-section imaging visualizes the influence of varying di- and tetrablock-co-polymer backbones on the membrane nanostructure with sizes between 20 and 35 nm. The membranes feature proton conductivities comparable to commercial materials at low humidity levels, surpassing commercial Nafion XL at 87 % relative humidity with up to 79 mS cm at 105 °C. As first successful H/air fuel cell tests achieve maximum power densities of up to 0.7 W cm, the nanostructured polymer membranes are a promising candidate for future fuel cell and electrolyzer applications without problematic perfluorinated alkyl substances.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"20 1","pages":""},"PeriodicalIF":10.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0