Materials Today Advances最新文献

Not only a matter of disorder in I-WP minimal surface-based photonic networks: Diffusive structural color in Sternotomis amabilis longhorn beetles 基于I-WP最小表面的光子网络中不仅存在无序问题：Sternotomis amabilis 长角甲虫的扩散结构色彩

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-09-04 DOI: 10.1016/j.mtadv.2024.100524

Viola Bauernfeind, Vinodkumar Saranathan, Kenza Djeghdi, Elena Longo, Silja Flenner, Imke Greving, Ullrich Steiner, Bodo D. Wilts

{"title":"Not only a matter of disorder in I-WP minimal surface-based photonic networks: Diffusive structural color in Sternotomis amabilis longhorn beetles","authors":"Viola Bauernfeind, Vinodkumar Saranathan, Kenza Djeghdi, Elena Longo, Silja Flenner, Imke Greving, Ullrich Steiner, Bodo D. Wilts","doi":"10.1016/j.mtadv.2024.100524","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100524","url":null,"abstract":"The diverse colors of longhorn beetles arise from either pigmentary absorption or interference of light with various photonic nanostructures. Variations in structure, order, and/or material composition give rise to diverse optical signals. Here, we investigated the colors of the longhorn beetle (Cerambycidae: Lamiinae). By combining optical microscopy and detailed bulk ultrastructural analysis of the colored scales that are the basis of the multicolored patterns of bluish-green and orange markings, we document polycrystalline networks based on the triply periodic minimal surface, Schoen’s I-WP, in the bluish-green scales. In contrast, amorphous quasi-ordered networks are found in the orange scales. The optical signal from the photonic networks is further altered by absorbing pigments. Ridged, micrometer-sized protrusions diffuse reflected light and suppress iridescence in all scale types. We discuss the pivotal role that order and disorder play in these photonic structures and support our understanding of the function of the scale geometry with full-wave optical simulations. Detailed knowledge about visible light interactions within intricate mediums, such as those observed in beetle scales, is highly relevant to current challenges in the design and synthesis of photonic nanostructures operating in the visible regime.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic bilayer qubits: A bipartite quantum system 磁性双层量子比特：一个双方量子系统

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-09-01 DOI: 10.1016/j.mtadv.2024.100525

Clara Sinta Saragih, Duy Van Pham, Jun-Xiao Lin, Wei-Jhong Chen, Po-Hung Wu, Chun-Chuen Yang, Chien-Chih Lai, Chih-Hung Tsai, Hua-Shu Hsu, Yuan-Ron Ma

引用次数: 0

Unraveling the role of relaxation and rejuvenation on the structure and deformation behavior of the Zr-based bulk metallic glass Vit105 揭示弛豫和年轻化对 Zr 基块状金属玻璃 Vit105 结构和变形行为的作用

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-09 DOI: 10.1016/j.mtadv.2024.100522

Lucas M. Ruschel, Sergej Jakovlev, Oliver Gross, Nico Neuber, Bastian Adam, Maximilian Frey, Benedikt Schmidt, Benedikt Bochtler, Ralf Busch

{"title":"Unraveling the role of relaxation and rejuvenation on the structure and deformation behavior of the Zr-based bulk metallic glass Vit105","authors":"Lucas M. Ruschel, Sergej Jakovlev, Oliver Gross, Nico Neuber, Bastian Adam, Maximilian Frey, Benedikt Schmidt, Benedikt Bochtler, Ralf Busch","doi":"10.1016/j.mtadv.2024.100522","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100522","url":null,"abstract":"The influence of relaxation and rejuvenation on the deformation behavior of the Zr-based bulk metallic glass Vit105 (ZrCuNiAlTi) was investigated, where a well-defined thermal history was systematically introduced by thermal treatments. Samples with a progressively lower fictive temperature exhibit a lower enthalpic state, coupled with a reduced degree of free volume, which is responsible for a continuous embrittlement observed in three-point beam bending tests. The generated database allows an assessment of the mechanical behavior of any amorphous component made of Vit105 by simple calorimetric measurements and the determination of the fictive temperature, which is of special interest for complex parts that cannot be easily evaluated in mechanical tests. Diffraction experiments with high energy synchrotron X-ray radiation reveal a correlation between the increase in rigid 3-atom cluster connections with the reduction in the fracture strain, as a measure of ductility, indicating a strong correlation with the thermal history. While the atomic connections seem to have a crucial contribution to the ductility, changes of the short- and medium-range order seem to be equally important. The current findings provide fundamental insights into the role of thermal history in metallic glass forming alloy systems and how it can be used to manipulate the structure and tailor their mechanical properties specifically to the needs of each application.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic tweezer-driven assembly and anti-cancer property of microporous magnesium gallate 微孔没食子酸镁的声镊驱动组装和抗癌特性

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-09 DOI: 10.1016/j.mtadv.2024.100523

Badrinathan Sridharan, Daehun Kim, Karthika Viswanathan, Ji Won Nam, Hae Gyun Lim

{"title":"Acoustic tweezer-driven assembly and anti-cancer property of microporous magnesium gallate","authors":"Badrinathan Sridharan, Daehun Kim, Karthika Viswanathan, Ji Won Nam, Hae Gyun Lim","doi":"10.1016/j.mtadv.2024.100523","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100523","url":null,"abstract":"The study focuses on fabrication and characterization of magnesium gallate (Mg-Gal), and introduces the use of single beam acoustic tweezers for aggregation and manipulation of Mg-Gal. Initially, microparticles are fabricated and thoroughly characterized, revealing their crystalline nature and thermostability stability. Through techniques like X-ray Diffraction (XRD), Fourier Transform-Infrared (FT-IR) spectroscopy, and electron microscopy, the structural and compositional features are elucidated. Subsequently, we intended to explore the effect of acoustic tweezer which are upcoming technology that possess multiple biological applications like drug delivery, cell analysis and tissue engineering. We demonstrated a successful aggregation and manipulation of these microparticles using a single beam acoustic tweezer system equipped with 7.5 MHz transducer. Within a short duration of 12 s, aggregates of around 100 μm size are formed and manipulated within the field of vision. Additionally, the anti-cancer potential of Mg-Gal microparticles was investigated in vitro, displaying significant cytotoxicity and anti-proliferative activity against MDA-MB-231 cells, with an IC value of 79.18 μg/ml. The study emphasizes the promising prospects of Mg-Gal microparticles in targeted drug delivery using ultrasound for cancer treatment and underscores the material's potential for conjugation with therapeutic drugs to address various complex diseases. Overall, this research highlights the interdisciplinary approach in advancing both material manipulation techniques and biomedical applications.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured proton-exchange membranes from self-cross-linking perfluoroalkyl-free block-co-polymers 自交联无全氟烷基嵌段共聚物的纳米结构质子交换膜

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-08-07 DOI: 10.1016/j.mtadv.2024.100521

Sebastian Auffarth, Maximilian Maier, Philipp Martschin, Theresa Stigler, Maximilian Wagner, Thomas Böhm, Andreas Hutzler, Simon Thiele, Jochen Kerres

{"title":"Nanostructured proton-exchange membranes from self-cross-linking perfluoroalkyl-free block-co-polymers","authors":"Sebastian Auffarth, Maximilian Maier, Philipp Martschin, Theresa Stigler, Maximilian Wagner, Thomas Böhm, Andreas Hutzler, Simon Thiele, Jochen Kerres","doi":"10.1016/j.mtadv.2024.100521","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100521","url":null,"abstract":"A sustainable hydrogen economy relies on fuel cells and electrolyzers, which heavily depend on ion-conducting perfluoroalkylated materials such as Nafion or Aquivion. Together with other perfluorinated alkyl substances, their environmental accumulation, and the rising awareness of risks to human health stress the need for alternative materials. Based on block-co-polymers from octylstyrene and pentafluorostyrene, we present nanostructured proton-exchange membranes. In contrast to problematic perfluorinated alkyl constituents, the involved aromatic fluorine atoms allow mild functionalizations to form tetrafluorostyrene sulfonic acid. Meanwhile, the nonpolar block reduces the stiffness of the material. By introducing a new preparation technique, controlled mitigation of the thiol cross-linking allows membrane self-reinforcement during drying. The reinforcing cross-links enhance the dissolution stability and reduce the water uptake after 24 h down to 33 wt% at 85 °C. Cross-section imaging visualizes the influence of varying di- and tetrablock-co-polymer backbones on the membrane nanostructure with sizes between 20 and 35 nm. The membranes feature proton conductivities comparable to commercial materials at low humidity levels, surpassing commercial Nafion XL at 87 % relative humidity with up to 79 mS cm at 105 °C. As first successful H/air fuel cell tests achieve maximum power densities of up to 0.7 W cm, the nanostructured polymer membranes are a promising candidate for future fuel cell and electrolyzer applications without problematic perfluorinated alkyl substances.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretable machine learning boosting the discovery of targeted organometallic compounds with optimal bandgap 可解释的机器学习有助于发现具有最佳带隙的目标有机金属化合物

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-07-29 DOI: 10.1016/j.mtadv.2024.100520

Taehyun Park, JunHo Song, Jinyoung Jeong, Seungpyo Kang, Joonchul Kim, Joonghee Won, Jungim Han, Kyoungmin Min

{"title":"Interpretable machine learning boosting the discovery of targeted organometallic compounds with optimal bandgap","authors":"Taehyun Park, JunHo Song, Jinyoung Jeong, Seungpyo Kang, Joonchul Kim, Joonghee Won, Jungim Han, Kyoungmin Min","doi":"10.1016/j.mtadv.2024.100520","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100520","url":null,"abstract":"Organometallic compounds (OMCs) have attracted tremendous attention in various fields, such as photovoltaic cell and high-k dielectric application, due to their beneficial properties. Despite their potential, the progression of OMCs into industrial applications is hindered by the limited databases available for their properties and the absence of efficient surrogate models. To address this, in this study, optimally selected feature-based surrogate models for predicting the electronic properties of OMCs are constructed via various multiscale features and extensive database. To this end, high-throughput calculation was performed to obtain electronic properties of more than 18k materials generally known as organometallics, augmenting around 12k organic materials obtained from the public open data set, OMDB-GAP1. For generating features closely related to OMCs, descriptors encapsulating the information ranging local to global, also other widely-used composition-, structure-based features (more than 3.5k in total) were employed. Among these descriptors, we identified 48 critical features that elucidates the physicochemical underpinnings of OMCs’ properties, suggesting their impact on the properties of OMCs. The light gradient boosting machine model achieved high-accuracy predictions across the entire database with just 1 % of the total descriptors, sufficiently compared to the entire sets (decreased of around 0.01 by R score and 0.01 eV by MAE). Furthermore, the efficacy of active learning process was demonstrated to find OMCs with optimal properties rapidly. As a result, expected improvement outperforms other methods by identifying 69 % of the target materials only searching 46 % of the total search space. Our constructed platform with a high-throughput calculated database can pave the way for the rapid screening of OMCs for the targeted industrial application, and suggest a comprehensive grasp of the intrinsic properties of OMCs and related compounds.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of interface defects in gate-recessed GaN HEMTs by neutral beam etching 通过中性束蚀刻减少栅极后处理 GaN HEMT 的界面缺陷

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-07-27 DOI: 10.1016/j.mtadv.2024.100519

Chia Hao Yu, Wei Hsiang Chiang, Yi-Ho Chen, Seiji Samukawa, Dong Sing Wuu, Chin-Han Chung, Ching-Lien Hsiao, Ray Hua Horng

{"title":"Reduction of interface defects in gate-recessed GaN HEMTs by neutral beam etching","authors":"Chia Hao Yu, Wei Hsiang Chiang, Yi-Ho Chen, Seiji Samukawa, Dong Sing Wuu, Chin-Han Chung, Ching-Lien Hsiao, Ray Hua Horng","doi":"10.1016/j.mtadv.2024.100519","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100519","url":null,"abstract":"This study investigates and compares the impact of different etching techniques on the fabrication of GaN high electron mobility transistors (HEMTs) between the inductively coupled plasma reactive ion etching (ICP-RIE) and the neutral beam etching (NBE) for the gate recess. By conducting direct current analysis, it was found that devices manufactured using the NBE exhibited superior electrical performance as compared with those produced using the ICP-RIE. These enhanced electrical characteristics include a transconductance of up to 100.4 mS/mm, a threshold voltage (V) of −2.3 V, an on/off current ratio of 1.1 × 10, a subthreshold swing (S.S.) of 99.63 mV/dec, and a remarkably low gate leakage current. Additionally, we noted varying degrees of hysteresis in the I–V characteristics were related to process disparities possibly leading to interface defects. Multi-frequency capacitance-voltage (C–V) measurements were used to identify the interface defects at the oxide/AlGaN interface of the gate. The results revealed that devices fabricated using the NBE exhibited a lower interface defect density as compared with those fabricated using the ICP-RIE, thereby elucidating the reduced hysteresis observed in the I–V characteristics. These findings indicated the significant advantages of the NBE process in the fabrication of GaN HEMTs.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141886666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacing two-dimensional and magnetic topological insulators: Bi bilayer on MnBi[formula omitted]Te[formula omitted]-family materials 二维拓扑绝缘体与磁性拓扑绝缘体的交界面：MnBi[式省略]Te[式省略]族材料上的双层 Bi

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-07-13 DOI: 10.1016/j.mtadv.2024.100511

I.I. Klimovskikh, S.V. Eremeev, D.A. Estyunin, S.O. Filnov, K. Shimada, V.A. Golyashov, N.Yu. Solovova, O.E. Tereshchenko, K.A. Kokh, A.S. Frolov, A.I. Sergeev, V.S. Stolyarov, V. Mikšić Trontl, L. Petaccia, G. Di Santo, M. Tallarida, J. Dai, S. Blanco-Canosa, T. Valla, A.M. Shikin, E.V. Chulkov

{"title":"Interfacing two-dimensional and magnetic topological insulators: Bi bilayer on MnBi[formula omitted]Te[formula omitted]-family materials","authors":"I.I. Klimovskikh, S.V. Eremeev, D.A. Estyunin, S.O. Filnov, K. Shimada, V.A. Golyashov, N.Yu. Solovova, O.E. Tereshchenko, K.A. Kokh, A.S. Frolov, A.I. Sergeev, V.S. Stolyarov, V. Mikšić Trontl, L. Petaccia, G. Di Santo, M. Tallarida, J. Dai, S. Blanco-Canosa, T. Valla, A.M. Shikin, E.V. Chulkov","doi":"10.1016/j.mtadv.2024.100511","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100511","url":null,"abstract":"Meeting of non-trivial topology with magnetism results in novel phases of matter, such as quantum anomalous Hall (QAH) or axion insulator phases. Even more exotic states with high and tunable Chern numbers are expected at the contact of intrinsic magnetic topological insulators (IMTIs) and 2D topological insulators (TIs). Here we synthesize a heterostructures composed of 2D TI and 3D IMTIs, specifically of bismuth bilayer on top of MnBiTe-family of compounds and study their electronic properties by means of angle-resolved photoelectron spectroscopy (ARPES) and density functional theory (DFT). The epitaxial interface is characterized by hybridized Bi and IMTI electronic states. The Bi bilayer-derived states on different members of MnBiTe-family of materials are similar, except in the region of mixing with the topological surface states of the substrate. In that region, the new, substrate dependent interface Dirac state is observed. Our calculations show rich interface phases with emergence of exchange split 1D edge states, making the Bi/IMTI heterostructures promising playground for observation of novel members in the family of quantum Hall effects.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141774171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humidity sensitive memristor based on Ni–Al layered double hydroxides 基于镍铝层状双氢氧化物的湿敏记忆晶体管

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-07-05 DOI: 10.1016/j.mtadv.2024.100515

Yanmei Sun, Bingxun Li, Ming Liu, Zekai Zhang

{"title":"Humidity sensitive memristor based on Ni–Al layered double hydroxides","authors":"Yanmei Sun, Bingxun Li, Ming Liu, Zekai Zhang","doi":"10.1016/j.mtadv.2024.100515","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100515","url":null,"abstract":"Reaping the advantages of their exceptional humidity-sensitive elements, humidity sensors exhibit a remarkable ability to adapt to alterations in ambient moisture levels. The significance of the humidity sensor in biological detection is progressively growing, owing to this characteristic. This work examines the impact of humidity on the resistive switching properties Ni–Al layered double hydroxides (LDHs) memristor. As the porous Ni–Al LDHs material contains a significant number of hydroxyl groups, the Ni–Al LDHs memristor exhibits remarkable sensitivity to changes in humidity. As the relative humidity level increases, a conspicuous decrease is observed in resistance of low resistance state, which attributed to the transition of protons facilitated by water. The humidity detection range of the Ni–Al LDHs memristor is from 30 RH% to 95 RH%, and it exhibits a sensitivity of 101.72 mV/RH. The Ni–Al LDHs memristor exhibits humidity sensitive resistive switching characteristics. In different humidity environments can produce a dynamic change between high and low resistance state switching. An artificial humidity sensing system by utilizing the unique resistance change behavior in Ni–Al LDHs memristor induced by humidity was demonstrated.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141548343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed electro-responsive system with programmable drug release 可编程药物释放的 3D 打印电响应系统

IF 1 2区材料科学

Materials Today Advances Pub Date : 2024-06-29 DOI: 10.1016/j.mtadv.2024.100509

Manal E. Alkahtani, Siyuan Sun, Christopher A.R. Chapman, Simon Gaisford, Mine Orlu, Moe Elbadawi, Abdul W. Basit

{"title":"3D printed electro-responsive system with programmable drug release","authors":"Manal E. Alkahtani, Siyuan Sun, Christopher A.R. Chapman, Simon Gaisford, Mine Orlu, Moe Elbadawi, Abdul W. Basit","doi":"10.1016/j.mtadv.2024.100509","DOIUrl":"https://doi.org/10.1016/j.mtadv.2024.100509","url":null,"abstract":"Precision medicine is the next frontier in pharmaceutical research, aiming to improve the safety and efficacy of therapeutics for patients. The ideal drug delivery system (DDS) should be programmable to provide real-time controlled delivery that is personalised to the patient's needs. However, little progress has been made in this domain. Herein, we combined two cutting-edge technologies, conductive polymers (CPs) and three-dimensional (3D) printing, to demonstrate their potential for achieving programmable controlled release. A DDS was formulated where the CP provided temporal control over drug release. 3D printing was used to ensure dimensional control over the design of the DDS. The CP used in this study is known to be fragile, and thus was blended with thermoplastic polyurethane (TPU) to achieve a conductive elastomer with sound mechanical properties. Rheological and mechanical analyses were performed, where it was revealed that formulation inks with a storage modulus in the order of 10–10 Pa were both extrudable and maintained their structural integrity. Physico-chemical analysis confirmed the presence of the CP functional groups in the 3D printed DDS. Cyclic voltammetry demonstrated that the DDS remained conductive for 100 stimulations. drug release was performed for 180 min at varying voltages, where a significant difference ( < 0.05) in cumulative release was observed between either ±1.0 V and passive release. Furthermore, the responsiveness of the DDS to pulsatile stimuli was tested, where it was found to rapidly respond to the voltage stimuli, consequently altering the release mechanism. The study is the first to 3D print electroactive medicines using CPs and paves the way for digitalising DDS that can be integrated into the Internet of Things (IoT) framework.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":null,"pages":null},"PeriodicalIF":10.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141548424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0