Materials Today Advances最新文献

Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies. 外周神经鞘肿瘤芯片：机制和治疗研究的下一代平台。

IF 8 2区材料科学

Materials Today Advances Pub Date : 2026-06-01 Epub Date: 2026-04-16 DOI: 10.1016/j.mtadv.2026.100770

William H Delaney, Sara A Faulkner, Wilbur A Lam, Nicholas M Boulis, Yongzhi Qiu, Kecheng Lei

{"title":"Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies.","authors":"William H Delaney, Sara A Faulkner, Wilbur A Lam, Nicholas M Boulis, Yongzhi Qiu, Kecheng Lei","doi":"10.1016/j.mtadv.2026.100770","DOIUrl":"10.1016/j.mtadv.2026.100770","url":null,"abstract":"Recapitulation of the complex nerve-tumor-immune microenvironment is critical for understanding Peripheral Nerve Sheath Tumors (PNSTs). Conventional in vitro models and animal systems often struggle to model crucial intercellular and inter-organ communication with full physiological relevance, creating a bottleneck in discovering effective therapeutics. Organ-on-Chip (OoC) technologies offer a paradigm-shifting solution. These microengineered platforms precisely integrate human cell biology with controllable fluidic and mechanical cues to replicate tissue- and organ-level physiology, enabling real-time, quantitative monitoring of tissue dynamics. This review posits that OoC technology is poised to revolutionize PNST research. In this review, we summarize the development of advanced Tumor-Nerve-Immune-on-Chip systems that integrate patient-derived Schwann cells, immune components, and functional microvasculature. These systems will accurately model PNSTs. Adoption of OoC will enable a predictive and individualized experimental framework, accelerating therapeutic discovery and allowing for personalized drug prediction for these challenging diseases.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"30 ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance. 增强内体逃逸，使纳米颗粒能够共同递送阿霉素和siRNA，以克服多药耐药。

IF 8 2区材料科学

Materials Today Advances Pub Date : 2026-06-01 Epub Date: 2026-06-09 DOI: 10.1016/j.mtadv.2026.100845

Jin Zhai, Allison Surian, Trystin Cote, Wuxia Zhang, Bao-Toan Dang, Yuan Wang, Qianyu Chen, Kazunori Hoshino, Jinhyung Lee, Yupeng Chen

{"title":"Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance.","authors":"Jin Zhai, Allison Surian, Trystin Cote, Wuxia Zhang, Bao-Toan Dang, Yuan Wang, Qianyu Chen, Kazunori Hoshino, Jinhyung Lee, Yupeng Chen","doi":"10.1016/j.mtadv.2026.100845","DOIUrl":"10.1016/j.mtadv.2026.100845","url":null,"abstract":"Although co-delivery of small-molecule drugs and siRNAs is a promising platform strategy for combination therapy, current delivery systems fail to achieve efficient endosomal escape, limiting cytosolic siRNA bioavailability and therapeutic efficacy. Conventional lipid nanoparticles (LNPs) can co-encapsulate chemotherapeutics and siRNA, but their poor endosomal escape results in suboptimal siRNA bioavailability. Here, we report a novel type of sphere-like nanoparticle (SNP) platform for co-delivery of siRNA and small-molecule drugs that overcomes these limitations. In this system, doxorubicin (DOX) is intercalated within a Janus base nanotube (JBNt) structure, while siRNA is encapsulated through electrostatic interactions, enabling stable co-packaging. Notably, SNPs exhibit significantly enhanced endosomal escape compared with lipid nanoparticles, leveraging JBNt's endosomal escape, attributable to its distinct proton-sponge-mediated buffer capacity, consequently promoting efficient, coordinated cytosolic delivery of both cargos. In a proof-of-concept study, SNP-mediated co-delivery of Multidrug Resistance 1 gene (MDR1/ABCB1)-targeting siRNA and DOX was associated with effective gene silencing and enhanced apoptosis in cancer cells, tumor spheroids, and murine ovarian tumor xenograft models. Collectively, these findings deliver proof-of-concept evidence for SNPs as a promising co-delivery platform for RNA and chemotherapeutics to overcome chemoresistance and improve anticancer efficacy.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"30 ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking the β-cell storage strategy for a high-payload insulin delivery system with glucose-responsive and long-acting release 模拟β细胞储存策略的高负荷胰岛素递送系统与葡萄糖反应和长效释放

2区材料科学

Materials Today Advances Pub Date : 2026-05-21 DOI: 10.1016/j.mtadv.2026.100817

Cheng Luo, Chunyi Xu, Shulan Ni, Li Yang, Chaofan Jin, Xingjie Zan, Dongjuan He

引用次数: 0

A BBB-penetrated, microglia-targeted, and hypoxia-responsive nanogel for treating ischemic stroke 一种血脑屏障穿透、小胶质细胞靶向、缺氧反应的纳米凝胶治疗缺血性卒中

2区材料科学

Materials Today Advances Pub Date : 2026-03-01 DOI: 10.1016/j.mtadv.2026.100738

Yuze Xia, Ran Li, Yu Ni, Xi Zhang, Yuan Liu, Huayu Kang, Yanchao Liu, Chenxuan Yu, Yuxuan Deng, Zhenyou Jiang, Wenhao Ma, Yuyang Hou, Sheng Wang, Chao Gan, Yimin Huang, Huaqiu Zhang

{"title":"A BBB-penetrated, microglia-targeted, and hypoxia-responsive nanogel for treating ischemic stroke","authors":"Yuze Xia, Ran Li, Yu Ni, Xi Zhang, Yuan Liu, Huayu Kang, Yanchao Liu, Chenxuan Yu, Yuxuan Deng, Zhenyou Jiang, Wenhao Ma, Yuyang Hou, Sheng Wang, Chao Gan, Yimin Huang, Huaqiu Zhang","doi":"10.1016/j.mtadv.2026.100738","DOIUrl":"https://doi.org/10.1016/j.mtadv.2026.100738","url":null,"abstract":"Ischemic stroke is the most common type of stroke, seriously endangering the lives and health of the population. The main treatment methods include thrombolysis and thrombectomy in the acute phase and drug therapy. Recent studies have found that inflammatory responses play a significant role in the development of ischemic stroke, and microglia are the main contributors to early neuroinflammation. However, problems such as the blood-brain barrier and poor targeting prevent anti-inflammatory drugs from being effective in treatment. This study presents a nanogel modified with multiple polypeptides, designed to effectively cross the blood-brain barrier, specifically target microglia in ischemic and hypoxic regions, and regulate the release of the anti-inflammatory drug thalidomide. This approach aims to inhibit neuroinflammation and treat ischemic stroke. In vitro results demonstrate that the nanogel can reduce the expression of the microglial inflammatory marker TNF-α, while in vivo results show that it improves learning, memory, and motor function, and mitigates anxiety and depressive behaviors associated with neuroinflammation in ischemic stroke. Overall, we have developed a drug-loaded nanogel targeting TNF-α in microglia within ischemic and hypoxic areas, enhancing anti-inflammatory effects and offering a novel therapeutic strategy for ischemic stroke. • Three biologically active polypeptides were linked to the poly(acrylic acid) backbone. • Nanogels could penetrate the blood-brain barrier and target ischemic regions. • Thalidomide had anti-inflammatory effects on microglia. • Nanogel treatment improved the neurological function of mice with ischemic stroke. .•The function of nanogels in vivo was achieved by targeting microglia.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 1","pages":"100738-100738"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes. 糖尿病伤口处理的微针策略：材料、机制和治疗结果的综合综述。

IF 8 2区材料科学

Materials Today Advances Pub Date : 2026-03-01 Epub Date: 2025-12-16 DOI: 10.1016/j.mtadv.2025.100684

Kaustubh Naik, Kanhaiya Singh

{"title":"Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes.","authors":"Kaustubh Naik, Kanhaiya Singh","doi":"10.1016/j.mtadv.2025.100684","DOIUrl":"10.1016/j.mtadv.2025.100684","url":null,"abstract":"Chronic diabetic wounds are one of the most challenging clinical problems because of poor angiogenesis, prolonged inflammation, and retarded tissue repair. Conventional wound dressing does not provide localised and continuous treatment, frequently resulting in unsuccessful therapeutic outcomes. Microneedle (MN) based delivery is envisioned as an ideal approach to transdermal interface with the wound microenvironment to deliver bioactive agents. Because of its minimally invasive nature, ease of use, and ability to bypass the stratum corneum, microneedles as a delivery medium have inherent advantages of site-specific, controllable, and painless drug administration. This review summarises recent progress in the development of MN-based systems for diabetic wound healing and emphasises their potential for delivering growth factors, anti-inflammatory agents, and gene therapies. The addition of smart materials, including stimulus-responsive and bioelectronic microneedles, makes them more efficacious as a therapeutic system. We also address current barriers, regulatory challenges, and prospects for clinical translation of MN-based wound care for diabetes.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A GSH-responsive drug delivery system based on self-assembly of polyoxometalates modified camptothecin for chemotherapy 基于多金属氧酸酯修饰喜树碱自组装的化疗用谷胱甘肽反应性药物递送系统

2区材料科学

Materials Today Advances Pub Date : 2025-12-11 DOI: 10.1016/j.mtadv.2025.100679

Lingmei Li, Shuwan Li, Lin Gao, Sitong Chen, Dejin Zang, Qing Fan, Zhiyuan Lu, Teng Liu

{"title":"A GSH-responsive drug delivery system based on self-assembly of polyoxometalates modified camptothecin for chemotherapy","authors":"Lingmei Li, Shuwan Li, Lin Gao, Sitong Chen, Dejin Zang, Qing Fan, Zhiyuan Lu, Teng Liu","doi":"10.1016/j.mtadv.2025.100679","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100679","url":null,"abstract":"Amphiphilic self-assembly bridges nanoscale engineering with biological functionality, forming compartmentalized nanocarriers that enable stimuli-responsive drug delivery. We engineered a glutathione (GSH)-responsive amphiphilic conjugate (POMs-SS-CPT) by covalently linking hydrophilic polyoxometalates (POMs) with hydrophobic drug camptothecin (CPT) through disulfide bonds, alongside a non-responsive carbon-bonded control (POMs-CC-CPT). Both compounds spontaneously self-assembled into vesicles in aqueous solution, enhancing cellular internalization. The GSH-responsive POMs-SS-CPT vesicles leveraged amphiphilic nanostructuring to achieve tumor-specific triggered co-release of POMs and CPT. This spatially controlled release minimized off-target toxicity while exerting potent synergistic antitumor activity. Both in vitro and in vivo studies demonstrated that POMs-SS-CPT vesicles exhibited superior antitumor efficacy and markedly inhibited tumor growth. This work establishes a novel GSH-responsive vesicular platform for efficient POM-based combination chemotherapy and elucidates critical design principles for redox-responsive delivery, providing a mechanistic framework for nanomedicine delivery systems. A GSH-responsive delivery system (POMs-SS-CPT) is constructed by linking hydrophilic POMs to the hydrophobic drug camptothecin (CPT) via disulfide bonds, with a non-responsive carbon-bonded control (POMs-CC-CPT). Both systems can self-assemble into stable nanomedicine delivery platforms.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 1","pages":"100679-100679"},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic neuroprotection against ischemic stroke: A biomimetic nanoplatform simultaneously targeting calcium Dyshomeostasis and ferroptosis 对缺血性中风的协同神经保护：同时针对钙平衡失调和铁下沉的仿生纳米平台

2区材料科学

Materials Today Advances Pub Date : 2025-12-08 DOI: 10.1016/j.mtadv.2025.100673

Yi Li, Zhicheng Xiao, Jianwei Wan, Ting Chen, Cuihong Wang, Xiaoqing Liu, Yafen Dong, Sunjia He, Jian Cai, Chuan Zhang, Tingfang Wang, Min Chen

{"title":"Synergistic neuroprotection against ischemic stroke: A biomimetic nanoplatform simultaneously targeting calcium Dyshomeostasis and ferroptosis","authors":"Yi Li, Zhicheng Xiao, Jianwei Wan, Ting Chen, Cuihong Wang, Xiaoqing Liu, Yafen Dong, Sunjia He, Jian Cai, Chuan Zhang, Tingfang Wang, Min Chen","doi":"10.1016/j.mtadv.2025.100673","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100673","url":null,"abstract":"In ischemic stroke, calcium overload and ferroptosis-inducing ROS production are two critically interlinked drivers. These elements engage in a vicious, self-reinforcing cycle, which in turn propagates a destructive cascade that triggers both apoptotic and necrotic cell death pathways. We developed a ROS-responsive liposome that efficiently encapsulates the hydrophobic prodrug BAPTA-AM and is camouflaged with a macrophage-membrane coating co-loaded with Salvianolic acid B (SAB). The macrophage membrane confers blood–brain barrier penetration and ischemia-targeting specificity. Upon reaching the ischemic lesion, ROS-responsive bonds cleave, triggering controlled release of BAPTA-AM. The membrane-permeable prodrug is then hydrolyzed by intracellular esterases to active BAPTA, which rapidly chelates Ca 2+ to relieve calcium overload. Meanwhile, SAB exerts dual effects by (1) activating the Nrf2/HO-1 pathway to counter oxidative stress and (2) modulating the Bcl-2-associated X protein/B-cell lymphoma 2 balance to inhibit neuronal apoptosis. This coordinated, multi-target strategy reduces intracellular Ca 2+ , mitigates oxidative damage, and attenuates neuroinflammation, collectively addressing the complex pathophysiology of ischemic stroke.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"29 1","pages":"100673-100673"},"PeriodicalIF":0.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional drug in drug nano-assembly with antibiofilm and remineralization for preventing dental caries 具有抗生素膜和再矿化的药物纳米组装中的多功能药物用于预防龋齿

2区材料科学

Materials Today Advances Pub Date : 2025-11-28 DOI: 10.1016/j.mtadv.2025.100668

Tingfang Jia, Zhaohui Yang, Yue Xin, Da‐Yuan Wang, Linqi Shi, Jing Shen

{"title":"Multifunctional drug in drug nano-assembly with antibiofilm and remineralization for preventing dental caries","authors":"Tingfang Jia, Zhaohui Yang, Yue Xin, Da‐Yuan Wang, Linqi Shi, Jing Shen","doi":"10.1016/j.mtadv.2025.100668","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100668","url":null,"abstract":"Dental caries remains a widespread oral health concern and presents a significant clinical challenge. Despite ongoing research advancements, current treatment strategies often fall short of simultaneously addressing several critical factors—namely, effective removal of cariogenic biofilm, promotion of enamel remineralization, preservation of the oral microecological balance, and avoidance of cytotoxic residues within the repair layer. Herein, we developed a multifunctional \"drug-in-drug\" nano-assembly (TA-BBR-ACP) by integrating natural phytochemicals—tannic acid (TA) and berberine (BBR)—as anti-biofilm agents and targeting carriers, with amorphous calcium phosphate (ACP) serving as the remineralization component. The TA-BBR-ACP assembly exhibits significantly anti Streptococcus mutans biofilm activity both in vitro and in vivo. Meanwhile, it enhances ACP efficacy in promoting enamel remineralization and occluding exposed dentinal tubules, without leaving residual matter. In the dental caries rat model, TA-BBR-ACP demonstrates excellent ability to prevent dental caries and maintain oral microbiota homeostasis.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100668-100668"},"PeriodicalIF":0.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virus-mimetic nanovesicle for the Hijacking- Integration-Vesicular amplification-Exocytosis treatment of ocular tumor 模拟病毒纳米囊泡劫持-整合-囊泡扩增-胞吐治疗眼部肿瘤

2区材料科学

Materials Today Advances Pub Date : 2025-10-31 DOI: 10.1016/j.mtadv.2025.100643

Chenyue Qiu, Jinfa Ye, Ke Lang, Xingyuan Wei, Pei-Yu Wang, Yun Han, Xiaofei Wen, Gang Liu, Chengchao Chu

{"title":"Virus-mimetic nanovesicle for the Hijacking- Integration-Vesicular amplification-Exocytosis treatment of ocular tumor","authors":"Chenyue Qiu, Jinfa Ye, Ke Lang, Xingyuan Wei, Pei-Yu Wang, Yun Han, Xiaofei Wen, Gang Liu, Chengchao Chu","doi":"10.1016/j.mtadv.2025.100643","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100643","url":null,"abstract":"We developed a kind of virus-mimetic nanovesicle (Mel-VSVG-NA), which could react with tumor cells in a membrane fusion procedure (named as First Fusion ), result by the function of Vesicular Stomatitis Virus Glycoprotein (VSVG) in acid microenvironment. Meanwhile, the melittin on Mel-VSVG-NA was transfer on the surface of targeted tumor cell, and thus execute hole-digging process on the tumor cell membrane, causing severe cell content loss and suppression of tumor growth. After the first-round treatment, a harmless ultrasound exposure was carried out, the further engineered vesicles were generated from the damaged cells. Afterwards, the produced vesicles were also confirmed to engineered with VSVG and melittin, which could further fuse with other tumor cells and induced another cell death (named as Second Fusion ). These results indicated that Mel-VSVG-NA is a reliable advance of nano-treatment in ocular tumor therapy, and we bring in this concept of Hijacking- Integration-Vesicular amplification-Exocytosis mode as HIVE therapy. • A Hijacking- Integration-Vesicular amplification-Exocytosis treatment was constructed. • The Mel-VSVG-NA could induce a fusion procedure and execute the hole-digging process, thus induce the cellular damage. • The Mel-VSVG-NA treated MUM-2B cells could in situ produce nanovesicle by an ultrasound stimulation.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100643-100643"},"PeriodicalIF":0.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated flexible sensor for decoupled omnidirectional strain and human motion monitoring 一种用于解耦全向应变和人体运动监测的集成柔性传感器

2区材料科学

Materials Today Advances Pub Date : 2025-10-15 DOI: 10.1016/j.mtadv.2025.100641

Jiayi Chen, Jijun Li, Yaqian Liu

{"title":"An integrated flexible sensor for decoupled omnidirectional strain and human motion monitoring","authors":"Jiayi Chen, Jijun Li, Yaqian Liu","doi":"10.1016/j.mtadv.2025.100641","DOIUrl":"https://doi.org/10.1016/j.mtadv.2025.100641","url":null,"abstract":"Omnidirectional strain sensors are of paramount importance in the accurate detection of human movements. The mask printing technology is employed to fabricate an integrated omnidirectional flexible strain sensor for human motion monitoring. Silica particles were incorporated into the liquid metal to improve its rheological properties and enhance its patterning capability. The developed sensor exhibits excellent characteristics, including a wide strain sensing range (1–300 %), high sensitivity as evidenced by gauge factors ranging from 1.82 to 3.34 across its operational range, and excellent cyclic stability (more than 5000 cycles) with minimal signal degradation, ensuring reliable long-term monitoring. It is particularly noteworthy that the integrated flexible strain sensor can achieve real-time decoupling of both the magnitude and direction of the principal strain at the measurement point. The reliability of the sensor is verified by utilizing the specified strain magnitude and direction. This unique capability to resolve complex multi-axis deformation patterns provides higher accuracy than conventional unidirectional strain sensors and enables precise and intelligent identification of various human actions. The strain sensing platform has great application potential in fields such as health monitoring and rehabilitation medicine.","PeriodicalId":48495,"journal":{"name":"Materials Today Advances","volume":"28 1","pages":"100641-100641"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6