{"title":"Intradermal Injection of Tranexamic Acid for the Treatment of Adult Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ling-Ya Chen, Yi-No Kang, Khanh Dinh Hoang, Kee-Hsin Chen, Chiehfeng Chen","doi":"10.1089/fpsam.2024.0187","DOIUrl":"10.1089/fpsam.2024.0187","url":null,"abstract":"<p><p><b>Background:</b> Melasma is a chronic skin pigmentation disorder, and intradermal injection of tranexamic acid (TXA) is an effective treatment option for melasma with limited comparative efficacy studies. <b>Objectives:</b> To compare the effectiveness of TXA injections with other treatment modalities for patients with melasma, as measured by Melasma Area and Severity Index (MASI). <b>Methods:</b> A total of 17 eligible randomized controlled trials were included in the meta-analysis. The MASI and the modified MASI served as the primary outcome measures of treatment effectiveness. Patient satisfaction was also evaluated. <b>Results:</b> Among the various administration routes for TXA, intradermal injection and microneedling demonstrated superior effectiveness, followed by oral administration and topical application. As for patient satisfaction, oral administration outperformed the injection method, whereas topical administration significantly underperformed injection. Furthermore, TXA injections were more effective than the majority of non-TXA standard treatments for melasma. <b>Conclusions:</b> This meta-analysis and systematic review suggested that intradermal TXA injection is an effective alternative for melasma treatment, with potential advantages over other administration routes.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":"305-312"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariline Santos, Sam P Most, Ivan Wayne, Sureyya Seneldir, Miguel Gonçalves Ferreira
{"title":"Dorsal Preservation Rhinoplasty: The Perspective of \"Preservers\" vs. \"Structured\" Surgeons.","authors":"Mariline Santos, Sam P Most, Ivan Wayne, Sureyya Seneldir, Miguel Gonçalves Ferreira","doi":"10.1089/fpsam.2024.0141","DOIUrl":"10.1089/fpsam.2024.0141","url":null,"abstract":"<p><p>The objective of this study was to describe the surgeons who have incorporated dorsal preservation (DP) into their practice and their techniques. An anonymous form reviewed by the Evidence-Based Rhinoplasty Research Group board was shared on its Telegram group. The study population was divided into three groups based on their answers: \"Preservers,\" \"Mainly Structural,\" and \"Structural exclusively.\" This study included the answers of 145 worldwide surgeons. DP was more common among plastic surgeons than otolaryngologists/facial plastic surgeons; DP techniques were mostly preferred by surgeons with 10-20 years of experience, while structural techniques were mostly preferred by surgeons with > 20 years of experience; 50.8% of the surgeons who prefer DP techniques use it in more than 90% of primaries; surface techniques (ST) have been more used, mainly by surgeons who prefer structural techniques (p < 0.001). ST were considered more stable (p < 0.001), more predictable (p < 0.001), and shorter learning curve (p < 0.001). Many surgeons using DP still perform structural rhinoplasty. The most cited concern was hump persistence/recurrence. DP rhinoplasty is gaining acceptance, and ST are favored for their perceived short learning curve, stability, and predictability. However, concerns about hump recurrence cause some to continue using structural methods alongside DP.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":"369-375"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Elhachimi, David Z Liao, Mingyang Gray, Joshua Rosenberg
{"title":"Nonsurgical Interventions for Gender-Affirming Facial Feminization: A Scoping Review.","authors":"Sarah Elhachimi, David Z Liao, Mingyang Gray, Joshua Rosenberg","doi":"10.1089/fpsam.2024.0091","DOIUrl":"10.1089/fpsam.2024.0091","url":null,"abstract":"<p><p><b>Importance:</b> Systematic review will improve understanding of nonsurgical facial feminization techniques, which are useful alternatives or adjuncts to surgical gender affirmation. <b>Objective:</b> To determine the effectiveness of nonsurgical facial feminization techniques in patients seeking gender-affirming feminization by reviewing the literature for patient-reported, subjective, and objective outcomes of feminization. <b>Evidence Review:</b> A comprehensive database search was conducted through July 28, 2022. A total of 264 titles and abstracts were screened by two independent reviewers in Covidence. Of all, 48 met the inclusion criteria for full-text review, and 20 articles were included in the final data extraction. <b>Findings:</b> The most described nonsurgical facial feminization techniques were neurotoxins, fillers, and hair removal. Techniques were derived from cisgender cosmetic procedures to achieve feminine qualities. The most common study type was expert opinion or literature reviews. There were only two studies that analyzed measurable nonsurgical facial feminization techniques. <b>Conclusions and Relevance:</b> There is a lack of high-quality prospective research and randomized, controlled trials specific to the transgender patient population that evaluate outcomes, patient satisfaction, or complications. Such studies are needed to inform evidence-based practices.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":"361-368"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaclyn A Klimczak, Manoj Abraham, Shirley Hu, Daniel E Rousso, Stephen Perkins, Mark Hamilton
{"title":"Tranexamic Acid in Rhytidectomy: A Split-Face Multi-Institutional Study.","authors":"Jaclyn A Klimczak, Manoj Abraham, Shirley Hu, Daniel E Rousso, Stephen Perkins, Mark Hamilton","doi":"10.1089/fpsam.2024.0008","DOIUrl":"10.1089/fpsam.2024.0008","url":null,"abstract":"<p><p><b>Background:</b> Tranexamic acid (TXA) has the ability to reduce intraoperative bleeding and facilitate hemostasis in addition to its anti-inflammatory properties that can potentially aid in recovery among patients who underwent rhytidectomy. <b>Objective:</b> To compare postoperative ecchymosis in patients who underwent rhytidectomy with TXA added to the tumescent anesthetic. <b>Methods:</b> A multi-institutional, single-blind study was performed on patients who underwent rhytidectomy. The sidedness of the face was randomized to receive either local anesthetic with TXA or without, prior to incision for rhytidectomy. The primary outcome was postoperative ecchymosis that was graded by the surgeons at the 1 week postoperative time frame in standard photograph review. <b>Results:</b> A total of 70 patients, mean age 62.1, were enrolled in the study. The surface area of postoperative ecchymosis at 1 week was shown to be significantly less on the side of the face that received local anesthetic infiltration prior to incision with TXA than the side that had local anesthetic without TXA (<i>p</i> < 0.001). These results were consistent with subjective measurements of postoperative ecchymosis graded at 1 week with two blinded investigators to the sidedness of the face that received TXA (<i>p</i> < 0.001). <b>Conclusions:</b> TXA may potentially facilitate a reduction in postoperative ecchymosis in patients undergoing rhytidectomy.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":"298-304"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Forrest W Fearington, Gloria Rodriguez, Nicholas R Randall, Jacob K Dey
{"title":"Surgical Treatments for Facial Aberrant Reinnervation Syndrome: A Systematic Review.","authors":"Forrest W Fearington, Gloria Rodriguez, Nicholas R Randall, Jacob K Dey","doi":"10.1089/fpsam.2024.0147","DOIUrl":"10.1089/fpsam.2024.0147","url":null,"abstract":"<p><p><b>Background:</b> Facial aberrant reinnervation syndrome is characterized by aberrant facial muscle reinnervation after facial nerve injury producing facial synkinesis, hypertonicity, and muscle spasm. <b>Objective:</b> To systematically review the surgical treatments for facial aberrant reinnervation syndrome and assess their effectiveness as measured by patient-reported outcomes, physician-graded outcomes, or computer-automated grading systems. <b>Methods:</b> We conducted a systematic review using PubMed, Embase, and Cochrane CENTRAL in accordance with PRISMA guidelines. Texts reporting outcomes of any surgical treatment for facial aberrant reinnervation syndrome from 2003 to 2023 were included. <b>Results:</b> After screening, 25 studies with 731 patients were included. Surgical procedures included selective neurectomy (SN), selective myectomy (SM), cross-facial nerve graft, masseter nerve transfer, and gracilis muscle transfer. All surgical techniques and combinations showed significant improvement in at least one clinical outcome measure from baseline (<i>p</i> < 0.05), although one study found no significant improvement. Thirty different outcome measures were used, the most common being the FaCE and eFACE scales (seven studies each). <b>Conclusions:</b> All surgical procedures in this review yield improved clinical outcome measures for facial aberrant reinnervation syndrome, with SN and SM being the dominant surgical treatments. Standardized outcome assessment and more nuanced patient evaluation are necessary to determine the most effective surgical treatments.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":"330-343"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tamara Fleihan, Russell W H Kridel, Edward S Kwak, Anand Patel, Jeffrey Watson
{"title":"Transcollumelar Incision and Closure.","authors":"Tamara Fleihan, Russell W H Kridel, Edward S Kwak, Anand Patel, Jeffrey Watson","doi":"10.1089/fpsam.2025.0120","DOIUrl":"https://doi.org/10.1089/fpsam.2025.0120","url":null,"abstract":"<p><p>Achieving imperceptible scars is crucial in facial plastic surgery, particularly in rhinoplasty. The open rhinoplasty technique, which uses a transcolumellar incision with bilateral marginal incisions, provides enhanced visibility and control but can result in visible columellar scarring. In general, factors such as skin type, incision location, and closure technique are critical in reducing scar formation. The low inverted-V transcolumellar incision just superior to the labiocolumellar junction is favored for its excellent healing with precise aesthetic alignment and minimal visibility. This study presents an ideal method for columellar incision placement and closure using deep-buried absorbable sutures to reduce skin tension and to improve healing, enhancing the overall appearance of the incision.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Puccia, Eric Barbarite, Rachana Gudipudi, Kimberly McClure, Linda Lee, Phayvanh P Pecha, Krishna Patel
{"title":"Mobile Application for Perioperative Care for Patients with Cleft Lip and Palate: A Survey-Based Pilot Study.","authors":"Ryan Puccia, Eric Barbarite, Rachana Gudipudi, Kimberly McClure, Linda Lee, Phayvanh P Pecha, Krishna Patel","doi":"10.1089/fpsam.2025.0027","DOIUrl":"https://doi.org/10.1089/fpsam.2025.0027","url":null,"abstract":"","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sindhura Sridhar, Richmond L Laryea, Harry D Vildibill, Sunthosh K Sivam
{"title":"Ideal Facial Proportions in Generative Artificial Intelligence: What Does Artificial Intelligence Consider an Attractive Face?","authors":"Sindhura Sridhar, Richmond L Laryea, Harry D Vildibill, Sunthosh K Sivam","doi":"10.1089/fpsam.2025.0007","DOIUrl":"https://doi.org/10.1089/fpsam.2025.0007","url":null,"abstract":"<p><p><b>Background:</b> To investigate the facial proportions and physical characteristics deemed ideal and attractive by current popular generative artificial intelligence (AI) models. <b>Methods:</b> \"Attractive\" and \"ideal\" face images were generated using five text-to-image models. Facial proportions of the generated images were measured and compared with the neoclassical canons of facial thirds and fifths. Generated facial proportions were compared between AI models and classical facial proportions using analysis of variance and unpaired Student's <i>t</i>-test, respectively. <b>Results:</b> The generated images included 28 (70%) female faces and 29 (75%) Caucasian faces. Mean generated horizontal proportions were 33.7%, 32.0%, and 34.3%. Mean generated vertical proportions were 21.1%, 18.0%, 21.1%, 17.9%, and 21.7%. The middle horizontal segment was significantly smaller in generated \"ideal faces,\" and the lower horizontal segment was larger in generated \"attractive faces\" compared with classical proportions (<i>p</i> < 0.001 and <i>p</i> = 0.01, respectively); the left and right middle vertical segments were significantly smaller in all generated faces compared with classical proportions (<i>p</i> < 0.001). <b>Conclusion:</b> There are significant differences between the definition of attractive and ideal faces in generative AI models and classical facial proportions. These differences may reflect biases present within the models or may reflect changing cultural perceptions of facial attractiveness.</p>","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Invited Commentary on:</i> \"Ideal Facial Proportions in Generative Artificial Intelligence,\" by Sridhar et al.","authors":"Monica K Rossi Meyer","doi":"10.1089/fpsam.2025.0259","DOIUrl":"https://doi.org/10.1089/fpsam.2025.0259","url":null,"abstract":"","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roger M Roe, Soroush Farsi, Mary Catherine Brown, Jeffrey Flowers, Larry D Hartzell
{"title":"Surgical Repair of Unilateral Cleft Alveolus Using Viable Bone Allograft in Pediatrics: A Case Report.","authors":"Roger M Roe, Soroush Farsi, Mary Catherine Brown, Jeffrey Flowers, Larry D Hartzell","doi":"10.1089/fpsam.2025.0039","DOIUrl":"https://doi.org/10.1089/fpsam.2025.0039","url":null,"abstract":"","PeriodicalId":48487,"journal":{"name":"Facial Plastic Surgery & Aesthetic Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}