Respiratory Medicine and Research最新文献

{"title":"Chest mechanics after endoscopic lung volume reduction: Comparison between responders and non-responders based on dynamic hyperinflation","authors":"Olivier Taton ,&nbsp;Silvia Perez-Bogerd ,&nbsp;Alain Van Muylem ,&nbsp;Pierre Alain Gevenois ,&nbsp;Olivier Van Hove ,&nbsp;Benjamin Bondue ,&nbsp;Emmeline Brenard ,&nbsp;Dimitri Leduc","doi":"10.1016/j.resmer.2025.101194","DOIUrl":"10.1016/j.resmer.2025.101194","url":null,"abstract":"<div><h3>Background</h3><div>Endobronchial lung volume reduction (ELVR) improves lung function, exercise capacity, and quality of life in case of severe emphysema. Nevertheless, not all patients are improved by ELVR including those with substantially decreased lung volume. We tested the hypothesis that unilateral volume loss could impact differently both responders and non-responders.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 20 patients, classified as 13 responders and 7 non-responders based on inspiratory capacity increase ≥200 ml at isotime. We compared changes in lung volume, diaphragm shape and strength, mediastinal shift, lung function, exercise capacity, and quality of life before and three months after ELVR.</div></div><div><h3>Results</h3><div>Compared to non-responders, responders showed a more improved diaphragm strength (4 vs<em>.</em> 2 cmH₂O, <em>p</em> = 0.0318) and shape in both sides (non-treated side total area: +42 (7–54) cm², <em>p</em> = 0.0079, non-treated side zone of apposition: +26 (18–52) cm², <em>p</em> = 0.0270). Responders had a larger mediastinal shift than non-responders (13 vs<em>.</em> 3 degrees, <em>p</em> = 0.0039) with significant positive correlations between mediastinal shift and improvements in lung function (FEV₁: <em>r</em> = 0.48, <em>p</em> = 0.0365), exercise capacity (6MWD: <em>r</em> = 0.78, <em>p</em> &lt; 0.0001, inspiratory capacity: <em>r</em> = 0.48, <em>p</em> = 0.0365), and quality of life (CAT: <em>r</em>=-0.58, <em>p</em> = 0.0096).</div></div><div><h3>Conclusions</h3><div>Dynamic hyperinflation responders present a larger mediastinal shift than non-responders. This shift could be a marker of improved diaphragm shape and strength in both treated and non-treated sides.</div></div><div><h3>Clinical trial registration</h3><div>NCT05799352</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101194"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving paradigms in pulmonary hypertension: Highlights of the 6th French Pulmonary Hypertension Network Meeting","authors":"Athénaïs Boucly ,&nbsp;Antoine Beauvais ,&nbsp;Thomas Lacoste-Palasset ,&nbsp;Mitja Jevnikar ,&nbsp;Marianne Riou ,&nbsp;Sabina Solinas ,&nbsp;Fabrice Antigny ,&nbsp;Fabrice Bauer ,&nbsp;Laurent Bertoletti ,&nbsp;Damien Bonnet ,&nbsp;Ari Chaouat ,&nbsp;Vincent Cottin ,&nbsp;Michele D’Alto ,&nbsp;Marion Delcroix ,&nbsp;Mélanie Gallant Dewavrin ,&nbsp;Christophe Guignabert ,&nbsp;Sébastien Hascoet ,&nbsp;David G Kiely ,&nbsp;Xavier Jaïs ,&nbsp;Etienne-Marie Jutant ,&nbsp;David Montani","doi":"10.1016/j.resmer.2025.101215","DOIUrl":"10.1016/j.resmer.2025.101215","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101215"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to test for myositis antibodies in usual interstitial pneumonia on chest CT?","authors":"Eliott Guillois ,&nbsp;Daniel Bertin ,&nbsp;Jules Milesi ,&nbsp;Paul Habert ,&nbsp;Mathieu Di Bisceglie ,&nbsp;Xavier Heim ,&nbsp;Benjamin Coiffard ,&nbsp;Romain Naud ,&nbsp;Ana Nieves ,&nbsp;Ngoc Anh Thu Nguyen ,&nbsp;Martine Reynaud-Gaubert ,&nbsp;Nathalie Bardin ,&nbsp;Julien Bermudez","doi":"10.1016/j.resmer.2025.101211","DOIUrl":"10.1016/j.resmer.2025.101211","url":null,"abstract":"<div><h3>Introduction</h3><div>Usual interstitial pneumonia (UIP) is a key pattern of interstitial lung disease (ILD), most commonly linked to idiopathic pulmonary fibrosis (IPF). Identifying underlying autoimmune conditions such as myositis is clinically relevant, yet guidelines provide limited recommendations regarding myositis antibody (MSA) screening.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with UIP who underwent systematic MSA screening at our center. Clinical and serological characteristics were compared between MSA-positive (MSA+) and MSA-negative (MSA-) groups. Logistic regression was used to identify predictive factors.</div></div><div><h3>Results</h3><div>Among 134 patients, 15 (11 %) were MSA+. Compared with MSA- patients, MSA+ cases were more likely to present with autoimmune disease (<em>p</em> = 0.03), ANA ≥ 1:320 (<em>p</em> &lt; 0.001), and positive rheumatoid factor (<em>p</em> = 0.04). A four-parameter profile combining ANA &lt; 1:320, absence of rheumatoid factor, no hypergammaglobulinemia, and no Raynaud’s phenomenon strongly predicted MSA negativity with excellent specificity (100 %), modest sensitivity (35 %), and good overall discriminative ability (AUC = 0.82).</div></div><div><h3>Discussion</h3><div>In patients with UIP, a simple four-parameter profile (ANA &lt; 1:320, absence of rheumatoid factor, absence of hypergammaglobulinemia, and absence of Raynaud’s phenomenon) strongly predicts negative MSA status. These findings support a more targeted approach to MSA screening, potentially improving diagnostic accuracy, guiding treatment decisions, and reducing unnecessary testing in UIP.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101211"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of hemi-cannula in patients with high risk of recannulation in an intermediate respiratory care unit. A descriptive analysis and study of the predictor variables of the use of posterior non-invasive mechanical ventilation","authors":"Sergio Lopez-Ruz,&nbsp;Alba Fernández-Boza,&nbsp;Maria Andrea Jaimes-Castaño,&nbsp;Carlos Carrera-Cueva,&nbsp;Belen Muñoz-Sánchez,&nbsp;Emilio Garcia-Díaz,&nbsp;Demetrio González-Vergara,&nbsp;Javier Toral-Marin,&nbsp;Maria Barca-Hernando","doi":"10.1016/j.resmer.2025.101185","DOIUrl":"10.1016/j.resmer.2025.101185","url":null,"abstract":"<div><h3>Background</h3><div>Information about the decannulation process in patients with high risk of recannulation is limited. However, devices such as the hemi-cannula, which maintain airway permeability for a controlled period, may enhance the safety of this process.</div></div><div><h3>Aims</h3><div>Describe and analyze the variables in the decannulation process of patients with high risk of recannulation, who have used a hemi-cannula and correlate these variables with the posterior need for Non-Invasive Mechanical Ventilation (NIMV).</div></div><div><h3>Methods</h3><div>Unicentric study analyzing a retrospective cohort of consecutive patients admitted to the Intermediate Respiratory Care Unit (IRCU) to continue the decannulation process from April 2022 to April 2024. Sociodemographic and clinical variables were described and analyzed. SPSS software was used to analyze the data with T student for independent data and Chi-square with Fischer correction.</div></div><div><h3>Results</h3><div>The final cohort included 19 patients, whom most of them had no previous respiratory pathology, but a 47.4 % had some cardiovascular risk factors. All of the patients had polyneuropathy at the admission to the IRCU. No 30-day mortality was observed in any patient. The recannulation rate was 10.5 %. 21 % of the patients required subsequent NIMV. Statistical significance at the analysis of the correlation between the mean number of days of Invasive Mechanical Ventilation (IMV) and the need for subsequent NIMV was found. However, there was not with the remaining variables.</div></div><div><h3>Conclusions</h3><div>The use of devices such as the hemi-cannula can enhance safety during the complex decannulation process in patients with high risk of recannulation, reducing the likelihood of reintubation or readmission to the Intensive Care Unit (ICU).</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101185"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-acting muscarinic antagonist versus leukotriene receptor antagonist as additional treatment in uncontrolled asthma patients used inhaled corticosteroids and long-acting β2 adrenergic agonist: a randomized phase 2 screening trial","authors":"Fumiya Nihashi ,&nbsp;Kazuki Furuhashi ,&nbsp;Mitsuru Niwa ,&nbsp;Hirotsugu Hasegawa ,&nbsp;Yusuke Kaida ,&nbsp;Mikio Toyoshima ,&nbsp;Naoki Koshimizu ,&nbsp;Toshihiro Shirai ,&nbsp;Masato Fujii ,&nbsp;Kazutaka Mori ,&nbsp;Masaki Ikeda ,&nbsp;Yusuke Inoue ,&nbsp;Hideki Yasui ,&nbsp;Hironao Hozumi ,&nbsp;Yuzo Suzuki ,&nbsp;Masato Karayama ,&nbsp;Noriyuki Enomoto ,&nbsp;Tomoyuki Fujisawa ,&nbsp;Naoki Inui ,&nbsp;Takafumi Suda","doi":"10.1016/j.resmer.2025.101191","DOIUrl":"10.1016/j.resmer.2025.101191","url":null,"abstract":"<div><div>Bronchial asthma is a common disease treated primarily with inhaled corticosteroids (ICS) and long-acting beta-2 agonists (LABA), yet optimal add-on therapy with long-acting muscarinic antagonists (LAMA) or leukotriene receptor antagonists (LTRA) remains unclear. This multicenter, randomized, open-label phase 2 screening trial compared the efficacy of adding tiotropium (LAMA) versus montelukast (LTRA) to ICS/LABA therapy in adult patients with poorly controlled asthma. Patients were randomly assigned to receive either tiotropium or montelukast for 12 weeks. Primary outcome was the change in forced expiratory volume in 1 second (FEV₁), secondary outcomes included changes in asthma control questionnaire (ACQ-5), asthma control test (ACT) scores, and peak expiratory flow (PEF). Ninety-four patients were analyzed. Over 12 weeks, the tiotropium group showed significant improvements in FEV₁ and PEF, while the montelukast group showed no improvement in respiratory function. Both groups, however, showed significant improvements in ACQ-5 and ACT. The primary endpoint, change in FEV₁ improved similarly in both groups (tiotropium 2.03 ± 0.74 to 2.10 ± 0.72 L vs montelukast 2.08 ± 0.69 to 2.13 ± 0.67 L; <em>p</em> = 0.736), while the tiotropium group exhibited a significantly greater improvement in PEF (tiotropium 5.41 ± 1.85 to 5.92 ± 1.93 L/s vs montelukast 5.58 ± 1.84 to 5.65 ± 1.82 L/s; <em>p</em> = 0.025). Subgroup analysis of patients with allergic rhinitis revealed the ACQ-5 score was significantly improved in the montelukast group (tiotropium 0.94 ± 0.64 to 0.68 ± 0.76 L/s vs montelukast 1.26 ± 1.15 to 0.53 ± 0.86 L/s; <em>p</em> = 0.002). Adding tiotropium to ICS/LABA therapy improves respiratory function, whereas adding montelukast enhances symptom control, particularly in patients with allergic rhinitis. These findings underscore the importance of personalized treatment approaches in asthma management by demonstrating that both tiotropium and montelukast confer distinct benefits according to patient characteristics, while also addressing a significant gap in the literature regarding optimal adjunctive therapies for adult asthma, given the scarcity of studies directly comparing these add-on strategies. Further research is needed to establish definitive guidelines for optimal add-on therapies in asthma.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101191"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"French translation and linguistic validation of four questionnaires relevant to psychological interventions targeting persistent dyspnea: The Breathlessness catastrophizing questionnaire, the breathlessness beliefs questionnaire, the COPD self-efficacy scale, and the three-domain interoceptive sensations questionnaire.","authors":"Sophie Lavault ,&nbsp;Nicolas Roche ,&nbsp;Capucine Morélot-Panzini ,&nbsp;Christian Straus ,&nbsp;Thomas Similowski","doi":"10.1016/j.resmer.2025.101202","DOIUrl":"10.1016/j.resmer.2025.101202","url":null,"abstract":"<div><h3>Background</h3><div>Psychological interventions such as medical hypnosis, cognitive-behavioral therapy (CBT), and mindfulness-based techniques are emerging as promising tools in the management of persistent dyspnea. Their integration into clinical practice, however, is limited by the scarcity of validated outcome measures in non-English languages.</div></div><div><h3>Objectives</h3><div>This study aimed to provide linguistically validated French versions of four questionnaires selected for their potential relevance in assessing the psychological and perceptual dimensions of dyspnea: the Breathlessness Catastrophizing Questionnaire (BCQ), the Breathlessness Beliefs Questionnaire (BBQ), the COPD Self-Efficacy Scale (CSES), and the Three-Domain Interoceptive Sensations Questionnaire (THISQ).</div></div><div><h3>Methods</h3><div>Questionnaire selection was based on constructs likely to be modulated by psychological interventions: catastrophic thinking, maladaptive beliefs, self-efficacy, and interoception. Translation and linguistic validation followed internationally accepted forward–backward methodology, in collaboration with a specialized agency. Reconciliation was performed through iterative review by subject-matter experts until full consensus was achieved.</div></div><div><h3>Results</h3><div>French versions of all four questionnaires were successfully produced. Specific challenges arose regarding the translation of key constructs (e.g., “catastrophizing,” “belief,” “self-efficacy”), leading to the proposal of dual titling strategies to balance semantic precision and user acceptability.</div></div><div><h3>Conclusion</h3><div>These French-language instruments address a practical need for culturally and linguistically appropriate tools in the assessment of psychological dimensions of dyspnea. While developed with medical hypnosis in mind, they may prove equally valuable in research and clinical practice involving other psychological interventions. Psychometric validation in French-speaking populations is warranted.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101202"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neutrophil extracellular traps in bronchoalveolar lavage fluid and severity of drug-induced lung injury","authors":"Genki Inui ,&nbsp;Miki Takata ,&nbsp;Yoshihiro Funaki ,&nbsp;Aditya Sri Listyoko ,&nbsp;Miyu Nishigami ,&nbsp;Hiroyuki Tanaka ,&nbsp;Hiroki Ishikawa ,&nbsp;Hiroki Kohno ,&nbsp;Tomoya Harada ,&nbsp;Ryota Okazaki ,&nbsp;Masato Morita ,&nbsp;Akira Yamasaki","doi":"10.1016/j.resmer.2025.101195","DOIUrl":"10.1016/j.resmer.2025.101195","url":null,"abstract":"<div><h3>Background</h3><div>Neutrophil extracellular traps (NETs) play a pivotal role in early immune responses and are implicated in various respiratory diseases, such as acute respiratory distress syndrome (ARDS). A correlation between NETs in bronchoalveolar lavage fluid (BALF) and the severity of ARDS has been reported. NETs are also associated with drug-induced organ disorders. However, the relationship between drug-induced lung injury (DLI) and NETs remains unclear. This study aimed to establish and substantiate this relationship.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study. We extracted DLI cases in which BAL was performed at Tottori university hospital. Based on the need for glucocorticoid treatment, patients were classified into the “moderate severity or above” group (PaO₂ &lt; 80 mmHg) and “mild” group (PaO₂ ≧ 80 mmHg). We examined myeloperoxidase, neutrophil elastase, and double-strand-DNA levels in BALFs, and examined their association with clinical findings and severity, with non-parametric Mann-Whitney U test.</div></div><div><h3>Results</h3><div>We studied 46 patients with DLI. The “moderate severity or above” group had 32 patients, while the “mild” group had 14 patients, and NETs in BALF were significantly higher in the former group. Three cases showed a diffuse alveolar damage (DAD) pattern on high-resolution computed tomography (HRCT), with significantly higher NET levels that those with non-DAD patterns.</div></div><div><h3>Conclusion</h3><div>In DLI, NETs in BALF were found to be related with disease severity and the presence of DAD patterns in HRCT images. Measuring NETs in BALF offer potential utility in guiding future treatment selection and aiding the differential diagnosis of clinical phenotypes.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101195"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial – \"Lung ultrasound and community-acquired pneumonia: from complementary tool to clinical game-changer\"","authors":"Luigi Vetrugno ,&nbsp;Damiano D’Ardes ,&nbsp;Cristian Deana ,&nbsp;Daniele Guerino Biasucci ,&nbsp;Andrea Boccatonda","doi":"10.1016/j.resmer.2025.101203","DOIUrl":"10.1016/j.resmer.2025.101203","url":null,"abstract":"<div><div>Community-acquired pneumonia (CAP) remains a major global health concern, traditionally diagnosed through chest X-ray (CXR). However, lung ultrasound (LUS) is increasingly emerging as a transformative tool in both diagnosis and management. Evidence from recent meta-analyses reveals that LUS outperforms CXR in sensitivity and rivals it in specificity, with pooled diagnostic accuracies exceeding 90 %. Unlike CXR, LUS is radiation-free, cost-effective, and ideal for bedside use, making it particularly valuable in emergency departments, intensive care units, pediatric and geriatric populations, and resource-limited settings. In children, LUS spares radiation exposure, while in elderly patients, contrast-enhanced ultrasound improves diagnostic specificity. Beyond diagnosis, LUS enables dynamic monitoring, prognostic scoring (e.g., LUS score, CPIS-PLUS), and supports treatment decisions such as ventilator weaning and antibiotic stewardship. Recent applications during the COVID-19 pandemic have demonstrated its effectiveness in triage and outcome prediction. Despite challenges such as operator dependency and reduced penetration for deep lesions, technological advances—particularly artificial intelligence and handheld devices—are mitigating these limitations. Deep learning models now interpret LUS images with high accuracy, enhancing reproducibility and accessibility for general practitioners. In low- and middle-income countries, LUS serves as a crucial diagnostic bridge, improving access and reducing reliance on costly imaging modalities. As training programs and standardized scoring systems evolve, LUS is becoming a frontline tool rather than a supplementary option. Its integration into clinical practice promises to reshape pneumonia care through rapid, accurate, and scalable diagnostics. In light of these advancements, LUS is not just complementary to radiography—it is redefining the diagnostic landscape of pneumonia.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101203"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the mini nutritional assessment short-form and SpO₂/FiO₂ ratio at admission for in-hospital mortality in patients with interstitial lung disease","authors":"Mayuko Ishiwari,&nbsp;Yuta Kono,&nbsp;Yuki Togashi,&nbsp;Kenichi Kobayashi,&nbsp;Ryota Kikuchi,&nbsp;Mariko Kogami,&nbsp;Shinji Abe","doi":"10.1016/j.resmer.2025.101222","DOIUrl":"10.1016/j.resmer.2025.101222","url":null,"abstract":"<div><h3>Background</h3><div>Hospitalization of patients with interstitial lung disease (ILD) is a poor prognostic factor. Simple and rapid biomarkers at the time of admission of hospitalized ILD patients are needed. The aim of this study was to investigate prognostic biomarkers in hospitalized patients with ILD.</div></div><div><h3>Methods</h3><div>A total of 95 consecutive hospitalized patients aged ≥ 65 years with ILD were retrospectively enrolled from April 2022 to December 2024 at Tokyo Medical University Hospital, Tokyo, Japan. Clinical and laboratory parameters at admission were retrospectively collected, and risk factors for in-hospital mortality were evaluated.</div></div><div><h3>Results</h3><div>The median age was 77 years (IQR: 72–83), and 62 patients (65.0 %) were male. Sixty-nine patients (73.0 %) were ex-smokers. Thirty patients (31.5 %) died during hospitalization, with a median time to death of 19 days (IQR: 10–28). Univariable analysis revealed that a low SpO₂/FiO₂ (S/F) ratio (&lt;419) (<em>p</em> = 0.0003), high neutrophil-to-lymphocyte ratio (NLR) (≥6.5) (<em>p</em> = 0.0003), Glasgow Prognostic Score (GPS) 2 (<em>p</em> = 0.0383), and low Mini Nutritional Assessment Short-Form (MNA-SF) score (&lt;11) (<em>p</em> = 0.0007) were significantly associated with in-hospital mortality of hospitalized patients with ILD. In the multivariable analysis, S/F ratio (<em>p</em> = 0.0116) and low MNA-SF score (<em>p</em> = 0.0289) had a significant effect on the prognosis of hospitalized patients with ILD.</div></div><div><h3>Conclusions</h3><div>Nutritional risk assessed by the MNA-SF, together with oxygenation status measured by the S/F ratio, could serve as valuable and readily available prognostic biomarkers for hospitalized patients with ILD.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101222"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUC5B polymorphism and post COVID-19 lung abnormalities on chest CT-scan","authors":"Celestie Yaacoub ,&nbsp;Coralie Tardivon ,&nbsp;Jean Dib ,&nbsp;Spyridon Prountzos ,&nbsp;Joe Yazbeck ,&nbsp;Elvira-Markela Antonogiannaki ,&nbsp;Ibrahima Ba ,&nbsp;Christina Kontopoulou ,&nbsp;Pinelopi Kazakou ,&nbsp;Lykourgos Kolilekas ,&nbsp;Anastasia Antoniadou ,&nbsp;Bruno Crestani ,&nbsp;Spyros A. Papiris ,&nbsp;Effrosyni D. Manali ,&nbsp;Quentin Philippot ,&nbsp;Antoine Khalil ,&nbsp;Cedric Laouenan ,&nbsp;Raphael Borie ,&nbsp;Marie-Pierre Debray ,&nbsp;on behalf of the French COVID cohort study group","doi":"10.1016/j.resmer.2025.101207","DOIUrl":"10.1016/j.resmer.2025.101207","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101207"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}