Respiratory Medicine and Research最新文献

{"title":"Multimodal evaluation in pulmonary hypertension: Contextualizing native T1 mapping","authors":"Simon Valentin , Freddy Odille , David Sorel , Bruno Ribeiro Baptista , Ari Chaouat","doi":"10.1016/j.resmer.2026.101279","DOIUrl":"10.1016/j.resmer.2026.101279","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101279"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAP-1 in the diagnosis of malignant pleural mesothelioma","authors":"Irene Sansano ,&nbsp;Ana Vázquez ,&nbsp;Oscar Persiva ,&nbsp;Marc Simó ,&nbsp;Leire Sánchez ,&nbsp;Pilar Montoya ,&nbsp;Carme Dinarès ,&nbsp;Carmen Alemán","doi":"10.1016/j.resmer.2025.101231","DOIUrl":"10.1016/j.resmer.2025.101231","url":null,"abstract":"<div><h3>Background</h3><div>The diagnosis of malignant pleural mesothelioma (MPM) can be challenging for clinicians and pathologists.</div></div><div><h3>Patients and methods</h3><div>This study included all patients diagnosed with pleural mesothelioma between October 2013 and April 2024. Clinical data, history of asbestos exposure, pleural fluid analysis, chest-X-ray, thoracic computed tomography and positron emission tomography findings, video-assisted thoracic surgery report, pleural fluid cytology and pleural biopsy results were included. Loss of BRCA1-associated protein 1 (BAP1) nuclear staining was examined in cytologies and biopsies.</div></div><div><h3>Results</h3><div>Forty-one patients were diagnosed with pleural mesothelioma, 35 epithelioid, 5 sarcomatoid and 1 biphasic. The diagnosis was established after the first sample in 30 patients, while a second one was necessary in 11 patients. BAP1 loss in pleural cytology and histology was not always consistent. Sixteen patients showed loss of BAP1 expression in cytology. Among these, 10 patients also presented BAP1 loss in pleural histology, whereas 5 patients with BAP1 loss in histology did not show BAP1 loss in cytology. Additionally, two patients initially diagnosed with idiopathic pleural effusion and 3 patients diagnosed with benign pleural effusion due to asbestos showed BAP1 loss and were later diagnosed with MPM during follow-up.</div></div><div><h3>Conclusion</h3><div>MPM remains difficult to diagnose. Performing BAP1 immunohistochemistry in patients with an undiagnosed pleural effusion or a history of asbestos exposure can aid in identifying those with mesothelioma.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101231"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment of Yu Tian et al. on “Increasing sleep apnoea burden in the elderly in Finland from 1996 to 2018: A national registry study”","authors":"Hannele Hasala,&nbsp;Tiina Mattila,&nbsp;Hanna-Riikka Kreivi,&nbsp;Heidi Avellan-Hietanen,&nbsp;Tuula Vasankari,&nbsp;Fredrik Herse,&nbsp;Riikka-Leena Leskelä,&nbsp;Sanna Toppila-Salmi,&nbsp;Marina Erhola,&nbsp;Tuija Jääskeläinen,&nbsp;Tari Haahtela","doi":"10.1016/j.resmer.2025.101226","DOIUrl":"10.1016/j.resmer.2025.101226","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101226"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic myelomonocytic leukaemia occurring in patients with pulmonary Langerhans cell histiocytosis: A common progenitor?","authors":"Pierre Thoré,&nbsp;Sérine Chaibi,&nbsp;Matthieu Duchmann,&nbsp;Raphaël Itzykson,&nbsp;Amira Benattia,&nbsp;Abdellatif Tazi","doi":"10.1016/j.resmer.2025.101221","DOIUrl":"10.1016/j.resmer.2025.101221","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101221"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world evidence on hospitalization, infection, and vascular outcomes among interstitial lung disease subtypes","authors":"Wen-Cheng Chao ,&nbsp;Shu-Yi Liao","doi":"10.1016/j.resmer.2026.101278","DOIUrl":"10.1016/j.resmer.2026.101278","url":null,"abstract":"<div><h3>Background and objective</h3><div>Interstitial lung diseases (ILDs) consist of idiopathic pulmonary fibrosis (IPF) and non-IPF ILDs. While pulmonary complications in IPF are relatively well-studied, there is a need for research on non-IPF ILDs, including connective tissue disease-associated ILDs (CTD-ILDs), and non-pulmonary outcomes of ILDs. We compare hospitalization, infection, and pulmonary/cardiac vascular event outcomes in patients with various ILDs.</div></div><div><h3>Methods</h3><div>We used data from 82 healthcare organizations between 2014 and 2023 on the TriNetX Research Network. In addition to IPF, we included patients with rheumatoid arthritis (RA)-ILD, systemic sclerosis (SSc)-ILD, myositis-ILD, hypersensitivity pneumonitis (HP) and pulmonary sarcoidosis. We employed propensity score matching (PSM) and assessed outcomes, including hospitalization, infection, and pulmonary/cardiac vascular events within one year of diagnosis.</div></div><div><h3>Results</h3><div>A total of 66,771 patients met the inclusion criteria, with 15,228 diagnosed with IPF and 51,543 with non-IPF ILDs. Anti-fibrotic agents were used in 30.4% of IPF patients. IPF patients had higher risks of hospitalization, cytomegalovirus disease, aspergillosis, and pulmonary/cardiac vascular event compared to those with non-IPF ILDs. Within CTD-ILDs, RA-ILD was associated with increased risks of sepsis, bacteremia, and pneumonia, while SSc-ILD had higher risks of pulmonary vascular events. Myositis-ILD showed elevated risks of hospitalization and mortality compared to RA-ILD, whereas patients with HP and pulmonary sarcoidosis experienced more favorable outcomes.</div></div><div><h3>Conclusions</h3><div>We identified distinct risk profiles across ILD subtypes, with increased infection risks in RA-ILD and heightened pulmonary/cardiac vascular event risks in SSc-ILD and IPF. These findings emphasize the need for targeted surveillance/management strategies for different ILD subtypes.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101278"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting of data on participant ethnicity and socioeconomic status in high impact respiratory journals: a targeted literature review","authors":"Ishani Kenny ,&nbsp;Caitlin Meechan ,&nbsp;Georgia Hopley ,&nbsp;Rachel Snow ,&nbsp;Arjun Menon ,&nbsp;Diana David ,&nbsp;Natasha Manuelpillai ,&nbsp;Obada Katan ,&nbsp;Keir E J Philip","doi":"10.1016/j.resmer.2026.101250","DOIUrl":"10.1016/j.resmer.2026.101250","url":null,"abstract":"<div><h3>Background</h3><div>Demographic data, including ethnicity/race and socioeconomic status (SES), of research participants is required for interpretation and application of findings. The International Committee of Medical Journal Editors recommend inclusion of representative populations in studies, and to provide relevant demographic information, but they are not prescriptive in their recommendations. This study aimed to assess the reporting of ethnicity/race and SES in high-impact respiratory journals.</div></div><div><h3>Method</h3><div>The ten most recent research articles (to 18/10/24) from the top 10 respiratory journals (using h5-index), were selected and reviewed by two researchers independently. Data was collected on reporting of key demographic data, including age, sex/gender, ethnicity/race and SES.</div></div><div><h3>Results</h3><div>100 research articles were included. 43 contained demographic information on ethnicity/race, 10 on SES, 100 on age and 99 on sex/gender. Median reporting of ethnicity/race was 4/10 per journal (range 2–8), and only 5 studies acknowledged this as a limitation. The Lancet Respiratory Medicine, in which 8/10 articles contained ethnicity/race data and 1 of the remaining articles acknowledged the lack as a limitation, is the only journal to explicitly recommend inclusion of ethnicity/race or an explanation for lack of reporting. No journals recommended inclusion of SES data with globally poor reporting; a median of 1/10 articles per journal reported SES (range 0–2).</div></div><div><h3>Conclusion</h3><div>Reporting of ethnicity/race and SES in high impact respiratory journals is poor despite both being linked to health disparities. Explicit guidelines may improve reporting of key demographic data which would improve research interpretation and application.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101250"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiologist-reported tension features on x-ray are not associated with physiological instability in ED patients with primary spontaneous pneumothorax","authors":"Anne-Maree Kelly,&nbsp;Marsalina Heritrenggi,&nbsp;Matthew Birdsey,&nbsp;Samuel Peat","doi":"10.1016/j.resmer.2026.101247","DOIUrl":"10.1016/j.resmer.2026.101247","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101247"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary ultrasound versus chest radiography in the diagnosis of community-acquired pneumonia in adults: an updated systematic review and meta-analysis","authors":"Víctor Juan Vera-Ponce ,&nbsp;Jhosmer Ballena-Caicedo ,&nbsp;Juan Carlos Bustamante-Rodríguez ,&nbsp;Fiorella E. Zuzunaga-Montoya ,&nbsp;Luisa Erika Milagros Vásquez-Romero ,&nbsp;Joan A. Loayza-Castro ,&nbsp;Mario J. Valladares-Garrido ,&nbsp;Carmen Inés Gutierrez De Carrillo ,&nbsp;Felix Llanos Tejada","doi":"10.1016/j.resmer.2025.101200","DOIUrl":"10.1016/j.resmer.2025.101200","url":null,"abstract":"<div><h3>Introduction</h3><div>Although chest radiography (CXR) has traditionally been used as the initial diagnostic test, pulmonary ultrasound (US) has emerged in recent years as a radiation-free, portable, and potentially more sensitive and specific alternative.</div></div><div><h3>Objective</h3><div>To evaluate the diagnostic accuracy of US compared to CXR for detecting community-acquired pneumonia (CAP) in adults through a systematic review and meta-analysis.</div></div><div><h3>Methodology</h3><div>Comprehensive searches were conducted in SCOPUS, Web of Science, PubMed, and EMBASE databases. Observational studies comparing US with CXR in diagnosing CAP were included, using computed tomography as the reference standard for all patients. Random-effect models were used for statistical analysis, calculating sensitivity, specificity, likelihood ratios (LR), and diagnostic odds ratios (DOR). Meta-regression analyses were performed, and SROC curves were constructed to compare diagnostic performance.</div></div><div><h3>Results</h3><div>Eight studies using CT as a reference standard were included. US showed superior performance with sensitivity 90.0 % (95 % CI: 81.3-96.2 %), specificity 90.8 % (95 % CI: 79.9-97.7 %), LR+ 9.45 (95 % CI: 3.73-23.94), LR- 0.12 (95 % CI: 0.06-0.24), and DOR 79.74. CXR demonstrated lower values with sensitivity 72.6 % (95 % CI: 61.7–82.4 %), specificity 82.0 % (95 % CI: 65.5–93.9 %), LR+ 3.98 (95 % CI: 1.87-8.49), LR- 0.36 (95 % CI: 0.23-0.54), and DOR 11.17. Both modalities showed significant heterogeneity, which was not explained by the sample size in meta-regression.</div></div><div><h3>Conclusions</h3><div>Pulmonary US demonstrates substantially higher diagnostic accuracy than CXR for CAP detection, with particularly strong performance in excluding pneumonia as evidenced by its low negative LR. While CXR maintains relevance where US is unavailable or for evaluating specific thoracic conditions, implementing US can optimize pneumonia diagnosis and potentially reduce unnecessary antibiotic use, particularly in emergency and critical care settings.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101200"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of adult bronchiectasis in Hong Kong from 2008–2023: A population-based cohort study","authors":"ZhiLing Yuan ,&nbsp;Philip CM Au ,&nbsp;Ching Lung Cheung ,&nbsp;James Chung Man Ho ,&nbsp;Wang Chun Kwok","doi":"10.1016/j.resmer.2025.101220","DOIUrl":"10.1016/j.resmer.2025.101220","url":null,"abstract":"<div><div>While the incidence and prevalence of bronchiectasis was reported to be increasing in different parts of the world, the epidemiological data on adult bronchiectasis in Hong Kong is lacking. We aim to investigate the incidence and prevalence of adult bronchiectasis patients in Hong Kong, and to assess the changes in trends over time.</div><div>The study population was identified through the Clinical Data Analysis and Reporting System (CDARS) of Hospital Authority, Hong Kong. Patients aged 20 or above with the diagnostic code of bronchiectasis managed in all public hospitals and clinics in Hospital Authority, Hong Kong from 2008 to 2023 were retrospectively recruited. Joinpoint regression was employed to analyze trends in prevalence and incidence, estimating the average annual percent change (AAPC).</div><div>The overall prevalence of adult bronchiectasis in Hong Kong has been steadily rising from 2008 to 2023. The prevalence increased from 176.30 per 100,000 population (95 % CI 172.83 to 179.77) in 2008 to 238.09 per 100,000 population (95 % CI 234.34 to 241.85) in 2023, with AAPC 2.20 (95 % CI 1.82 to 2.22). The overall bronchiectasis incidence rate remained relatively stable from 18.48 per 100,000 population to 19.15 per 100,000 population from 2008 to 2023. In 2019, the incidence of bronchiectasis peaked at 25.38 per 100,000 population (95 % CI 21.64 to 29.11).</div><div>The prevalence of adult bronchiectasis has been increasing from year 2008 to 2023 in Hong Kong, with a largely stable incidence. The results concur with other epidemiological studies in other countries.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101220"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should segmentectomy indications be extended to NSCLC smaller than 3 cm without lymph node involvement? A retrospective single-center study","authors":"Damien Leveque ,&nbsp;Soufiane Lebal ,&nbsp;Tristan Goudou ,&nbsp;Mihaela Giol ,&nbsp;Denis Debrosse ,&nbsp;Marielle LE Roux ,&nbsp;Thérésa Khalife-Hocquemiller ,&nbsp;Anna Vayssette ,&nbsp;Juliette Camuset ,&nbsp;Alexandra Rousseau ,&nbsp;Jalal Assouad ,&nbsp;Harry Etienne","doi":"10.1016/j.resmer.2025.101179","DOIUrl":"10.1016/j.resmer.2025.101179","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical resection remains the standard treatment for stage IA non-small cell lung cancers (NSCLC). The dual objective of this study is to compare long-term outcomes of lobectomies and segmentectomies for stage IA NSCLC and to identify prognostic factors for resected stage IA NSCLC.</div></div><div><h3>Materials and Methods</h3><div>This is a retrospective monocentric study including patients diagnosed with NSCLC smaller than 3 cm, without lymph node involvement, from November 2015 to November 2021. The primary endpoint was event-free survival (EFS), defined as time from surgery to recurrence or all-cause death. Secondary endpoints included overall survival, recurrence-free survival, and short-term postoperative outcomes (length of stay, drainage duration, 30-day mortality, and postoperative complications). Prognostic factors were analyzed using multivariate Cox regression adjusted for variables identified in univariate analysis.</div></div><div><h3>Results</h3><div>A total of 457 patients underwent surgery for stage cIA NSCLC during the 11study period. Of these, 176 (38.5 %) had a segmentectomy, and 281 (61.5 %) underwent lobectomy. Among patients with cT1N0 tumors, the 5-year event-free survival did not significantly differ between the segmentectomy and lobectomy groups (adjusted HR = 0.59 (0.32; 1.08), <em>p</em> = 0.086), with 5-year event-free rates of 75.0 % and 83.0 %, respectively (<em>p</em> = 0.054). Multivariate analysis revealed an association between nodule type (solid vs. ground-glass or mixed) and event-free survival (death and/or recurrence) ([adjusted HR =2.07 (1.17–3.66), <em>p</em> = 0.01)]. Vascular and/or lymphatic invasion is associated with a decrease in event-free survival (recurrence or death) [adjusted HR = 2.25 (1.29; 3.92), <em>p</em> = 0.004]. Conversion from segmentectomy to lobectomy occurred in 6 patients (3.4 %), and they were included in the lobectomy group for analysis.</div></div><div><h3>Conclusion</h3><div>For patients with clinical stage cIA NSCLC, segmentectomy appears to offer comparable oncologic outcomes to lobectomy. Tumor characteristics, including radiological appearance and histological factors, should be carefully considered when selecting the appropriate surgical strategy. Prospective multicenter studies are needed to confirm these findings.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101179"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}