Respiratory Medicine and Research最新文献

{"title":"Corrigendum to “Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa” [Respiratory Medicine and Research 86 (2024) 101133]","authors":"Daniel L Thompson , Zoe Semersky , Richard Feinn , Pamela Huang , Paul E Turner , Ben K Chan , Jonathan L Koff , Thomas S Murray","doi":"10.1016/j.resmer.2025.101209","DOIUrl":"10.1016/j.resmer.2025.101209","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101209"},"PeriodicalIF":1.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predicted value of maximal inspiratory pressure, maximal expiratory pressure, and sniff nasal inspiratory pressure for southeast asian adults","authors":"Ngoc-Minh Nguyen ,&nbsp;Hanh Thi-Bich Tran ,&nbsp;Thi-Quynh-Nhu Do ,&nbsp;Nicolas Audag ,&nbsp;Giuseppe Liistro ,&nbsp;Philippe Fait ,&nbsp;Gregory Reychler","doi":"10.1016/j.resmer.2025.101212","DOIUrl":"10.1016/j.resmer.2025.101212","url":null,"abstract":"<div><h3>Background</h3><div>Accurate assessment of respiratory muscle strength is crucial for diagnosing and managing respiratory diseases. However, existing reference values may not be generalizable across diverse populations. This study aimed to establish predicted values for maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and sniff nasal inspiratory pressure (SNIP) in Southeast Asian adults.</div></div><div><h3>Methods</h3><div>MIP, MEP, and SNIP were measured in 301 healthy Vietnamese adults. Two-way ANOVA and post-hoc tests were used to examine differences in these measures among age groups and between genders. Stepwise multiple linear regression was used to develop predictive equations for MIP, MEP, and SNIP, with potential predictors including age, gender, body mass index, and lung function. The lower limit of the normal range (LLN) was determined using the fifth percentile of the negative residuals.</div></div><div><h3>Results</h3><div>MIP, MEP, and SNIP were higher in males than in females. MIP and MEP declined with age, while SNIP remained relatively stable. Predictive equations were established: MIP = 95.2 – 32.1 x gender (male = 0, female = 1) – 0.41 x age + 1.2 x BMI (adjusted <em>R²</em>: 41 %, LLN = predicted MIP – 34), MEP = 135.1 – 46.75 x gender (male = 0, female = 1) - 0.6 x age + 1.34 x BMI (adjusted <em>R²</em>: 41.8 %, LLN = predicted MEP – 50), SNIP = 63.8 – 18.16 x gender (male = 0, female = 1) (adjusted <em>R²</em>: 14.8 %, LLN = predicted SNIP – 30).</div></div><div><h3>Conclusions</h3><div>This study provides ethnic-specific predictive equations for MIP, MEP, and SNIP, which may serve as a preliminary step toward developing reference values for the Southeast Asian region.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101212"},"PeriodicalIF":1.8,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to test for myositis antibodies in usual interstitial pneumonia on chest CT?","authors":"Eliott Guillois ,&nbsp;Daniel Bertin ,&nbsp;Jules Milesi ,&nbsp;Paul Habert ,&nbsp;Mathieu Di Bisceglie ,&nbsp;Xavier Heim ,&nbsp;Benjamin Coiffard ,&nbsp;Romain Naud ,&nbsp;Ana Nieves ,&nbsp;Ngoc Anh Thu Nguyen ,&nbsp;Martine Reynaud-Gaubert ,&nbsp;Nathalie Bardin ,&nbsp;Julien Bermudez","doi":"10.1016/j.resmer.2025.101211","DOIUrl":"10.1016/j.resmer.2025.101211","url":null,"abstract":"<div><h3>Introduction</h3><div>Usual interstitial pneumonia (UIP) is a key pattern of interstitial lung disease (ILD), most commonly linked to idiopathic pulmonary fibrosis (IPF). Identifying underlying autoimmune conditions such as myositis is clinically relevant, yet guidelines provide limited recommendations regarding myositis antibody (MSA) screening.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with UIP who underwent systematic MSA screening at our center. Clinical and serological characteristics were compared between MSA-positive (MSA+) and MSA-negative (MSA-) groups. Logistic regression was used to identify predictive factors.</div></div><div><h3>Results</h3><div>Among 134 patients, 15 (11 %) were MSA+. Compared with MSA- patients, MSA+ cases were more likely to present with autoimmune disease (<em>p</em> = 0.03), ANA ≥ 1:320 (<em>p</em> &lt; 0.001), and positive rheumatoid factor (<em>p</em> = 0.04). A four-parameter profile combining ANA &lt; 1:320, absence of rheumatoid factor, no hypergammaglobulinemia, and no Raynaud’s phenomenon strongly predicted MSA negativity with excellent specificity (100 %), modest sensitivity (35 %), and good overall discriminative ability (AUC = 0.82).</div></div><div><h3>Discussion</h3><div>In patients with UIP, a simple four-parameter profile (ANA &lt; 1:320, absence of rheumatoid factor, absence of hypergammaglobulinemia, and absence of Raynaud’s phenomenon) strongly predicts negative MSA status. These findings support a more targeted approach to MSA screening, potentially improving diagnostic accuracy, guiding treatment decisions, and reducing unnecessary testing in UIP.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101211"},"PeriodicalIF":1.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute hemodynamic response to inhaled treprostinil in pulmonary hypertension associated with interstitial lung disease: a case highlighting unresolved questions","authors":"Marianne Riou ,&nbsp;Matthieu Canuet ,&nbsp;Sandrine Hirschi ,&nbsp;Ségolène Turquier ,&nbsp;David Montani","doi":"10.1016/j.resmer.2025.101210","DOIUrl":"10.1016/j.resmer.2025.101210","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101210"},"PeriodicalIF":1.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUC5B polymorphism and post COVID-19 lung abnormalities on chest CT-scan","authors":"Celestie Yaacoub ,&nbsp;Coralie Tardivon ,&nbsp;Jean Dib ,&nbsp;Spyridon Prountzos ,&nbsp;Joe Yazbeck ,&nbsp;Elvira-Markela Antonogiannaki ,&nbsp;Ibrahima Ba ,&nbsp;Christina Kontopoulou ,&nbsp;Pinelopi Kazakou ,&nbsp;Lykourgos Kolilekas ,&nbsp;Anastasia Antoniadou ,&nbsp;Bruno Crestani ,&nbsp;Spyros A. Papiris ,&nbsp;Effrosyni D. Manali ,&nbsp;Quentin Philippot ,&nbsp;Antoine Khalil ,&nbsp;Cedric Laouenan ,&nbsp;Raphael Borie ,&nbsp;Marie-Pierre Debray ,&nbsp;on behalf of the French COVID cohort study group","doi":"10.1016/j.resmer.2025.101207","DOIUrl":"10.1016/j.resmer.2025.101207","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101207"},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding participation challenges in lung cancer screening program: Findings from the DEP’KP80 trial in France","authors":"Sébastien Couraud ,&nbsp;Emmanuel Grolleau ,&nbsp;Bernard Milleron ,&nbsp;Valérie Petigny ,&nbsp;Olivier Leleu","doi":"10.1016/j.resmer.2025.101208","DOIUrl":"10.1016/j.resmer.2025.101208","url":null,"abstract":"<div><h3>Background</h3><div>Lung cancer is the leading cause of cancer-related mortality worldwide. Low-dose computed tomography (LDCT) screening can significantly reduce mortality among high-risk populations. However, participation rates in lung cancer screening programs are often suboptimal due to various barriers.</div></div><div><h3>Method</h3><div>The DEP’KP80 trial is a multicentric prospective study conducted in the French territory of Somme, assessing the feasibility of lung cancer screening using LDCT. Participants aged 55–74 with a smoking history of over 30 pack-years were recruited between 2016 and 2020. A questionnaire was administered to all participants to evaluate motivations and barriers to participation.</div></div><div><h3>Results</h3><div>The trial enrolled 1369 participants, with 30.4 % responding to the questionnaire. Of the responders, 65 % were male, and the mean age was 61.9 years. Key motivations for participation included health concerns related to smoking (68.7 %) and healthcare professional advice (16.5 %). Main barriers were perceived lack of invitation (37.5 %) and logistical issues (21.9 %). Notably, 63 % of responders reported that participation led to smoking cessation. In addition, the most common source of information about the program was healthcare professionals (85 %).</div></div><div><h3>Conclusion</h3><div>Our study highlights the crucial role of healthcare professionals in promoting lung cancer screening and identifies significant barriers to participation. Addressing these barriers through targeted interventions could enhance screening uptake and improve lung cancer outcomes.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101208"},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of systemic lupus erythematosus in patients with interstitial pneumonia with autoimmune features using two different sets of criteria","authors":"Gabriela Martinez-Zayas ,&nbsp;David Karp ,&nbsp;Traci N. Adams ,&nbsp;Elena K. Joerns","doi":"10.1016/j.resmer.2025.101206","DOIUrl":"10.1016/j.resmer.2025.101206","url":null,"abstract":"<div><h3>Objective</h3><div>Interstitial pneumonia with autoimmune features (IPAF) describes patients with interstitial lung disease and autoimmunity who do not meet classification criteria for a systemic autoimmune rheumatic disease, including systemic lupus erythematosus (SLE). We aimed to determine whether the criteria developed by the European Alliance of Association of Rheumatology and American College of Rheumatology (EULAR/ACR) would classify more patients with IPAF as SLE, than those developed by the Systemic Lupus International Collaborating Clinics (SLICC). Increasing the recognition of SLE among patients with IPAF may affect therapy.</div></div><div><h3>Methods</h3><div>This observational, retrospective, single-center cohort study included consecutive patients initially classified as having IPAF between December 2005-August 2019. We reviewed patients’ charts to assess whether more patients met SLE criteria by SLICC or EULAR/ACR methodology. Fisher’s exact test assessed the significance of the difference in the proportion of patients classified by the two criteria.</div></div><div><h3>Results</h3><div>We included 201 patients initially classified as IPAF. Twelve were identified as SLE by SLICC criteria and 23 by EULAR/ACR criteria. All but three patients with lymphopenia who met SLE criteria by SLICC also met it by EULAR/ACR. The difference in the proportion of IPAF patients meeting SLE criteria by the two methods was statistically significant (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Patients with IPAF were classified as SLE more frequently using EULAR/ACR criteria than by SLICC criteria. The EULAR/ACR criteria may be superior for SLE classification in patients with ILD. Patients with IPAF and SLE features should undergo full work-up to evaluate for SLE classification as it may affect therapy.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101206"},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on lung cancer diagnosis, treatment, mortality, and survival in Belgium: A population-based study","authors":"Hanne Peirelinck ,&nbsp;Hanna M. Peacock ,&nbsp;Geert Silversmit ,&nbsp;Thierry Berghmans ,&nbsp;Paul De Leyn ,&nbsp;Ingel Demedts ,&nbsp;Xavier Geets ,&nbsp;Yolande Lievens ,&nbsp;Harlinde De Schutter","doi":"10.1016/j.resmer.2025.101205","DOIUrl":"10.1016/j.resmer.2025.101205","url":null,"abstract":"<div><h3>Background</h3><div>We evaluated the impact of COVID-19 on the care pathway and outcomes for patients diagnosed with lung cancer in 2020 in Belgium.</div></div><div><h3>Methods</h3><div>Lung cancer patients diagnosed in 2017–2020 were extracted from the nationwide Belgian Cancer Registry database. Characteristics and treatment of patients in 2020 were compared with 2017–2019 at semester level (January-June: S1; July-December: S2). 90-day post-operative mortality and relative survival (RS) at 1 and 3 years for 2020 were compared with the 2017–2019 trend.</div></div><div><h3>Results</h3><div>The study included 29,721 patients diagnosed with lung cancer in 2017–2020. Patients diagnosed in 2020 had a poorer WHO Performance status and more often distant metastases compared to the corresponding semester in 2017–2019. In 2020 S2, there was slightly less surgery performed in patients with early-stage (I-II) lung cancer in favour of radiotherapy (RT) (surgery:4.7 percent-points, RT +6.0 percent-points, <em>p</em> = 0.001). RT courses had a shorter median duration (S1:4 days; S2:4 days) and lower median number of fractions (S1:5; S2:5). The unadjusted 90-day post-operative mortality increased, but this increase was no longer significant when adjusting for case-mix (unadjusted: Odds ratio (OR) =1.85 [1.05–3.24]; adjusted: (OR 1.78 [0.99–3.21]). There was no significant change in RS at 1 and 3 years, with or without case-mix adjustment (unadjusted: 1-year excess hazard ratio (EHR)=1.06 [1.00–1.12], 3-year EHR=1.05 [1.00–1.11]; adjusted: 1-year EHR=1.02 [0.96–1.08], 3-year EHR=1.02 [0.96–1.07]).</div></div><div><h3>Conclusion</h3><div>Lung cancer patients in Belgium experienced only minor changes in their care pathway during the COVID-19 pandemic. The changes in stage distribution and the increase in 90-day postoperative mortality warrant monitoring of long-term outcomes.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101205"},"PeriodicalIF":1.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary arterial stiffness as the main correlate of effective arterial elastance in pre- and post-capillary pulmonary hypertension","authors":"Denis Chemla ,&nbsp;Antoine Beurnier ,&nbsp;Christian Gerges ,&nbsp;Xavier Jaïs ,&nbsp;Athenaïs Boucly ,&nbsp;Laurent Savale ,&nbsp;Olivier Sitbon ,&nbsp;Marc Humbert ,&nbsp;David Montani ,&nbsp;Philippe Hervé","doi":"10.1016/j.resmer.2025.101204","DOIUrl":"10.1016/j.resmer.2025.101204","url":null,"abstract":"<div><h3>Background</h3><div>A simplified estimate of pulmonary effective arterial elastance (Ea_sPAP), defined as systolic pulmonary artery (PA) pressure divided by stroke volume (SV), is increasingly used to quantify total PA load and its coupling with right ventricle in pulmonary hypertension (PH), with elevated Ea_sPAP associated with worse prognosis. Although arterial elastance is thought to depend more on pulmonary vascular resistance (PVR) than on stiffness, the value of this simplified, clinically derived estimate remains unclear.</div></div><div><h3>Methods</h3><div>This retrospective invasive study included 236 adults diagnosed with idiopathic pulmonary arterial hypertension (<em>n</em> = 118) or post-capillary PH (<em>n</em> = 118), matched for age, sex, and mean PA pressure (mPAP). Total PA stiffness was defined as PA pulse pressure/SV.</div></div><div><h3>Results</h3><div>In the overall population (63 % women, median age 70 years, mPAP 38 mmHg), Ea_sPAP correlated most strongly with stiffness (Spearman <em>ρ</em>=0.95). The same was observed in both groups, with regression lines showing similar slopes and intercepts. These correlations were explained by the superimposable linear relationships between systolic and pulse pressures, together with the shared SV in the formulas. Ea_sPAP was less strongly associated with PVR (<em>ρ</em>=0.83) (<em>P</em> &lt; 0.0001), with differing slopes and intercepts between groups. Similar results were observed when downstream pressure was included in elastance calculation, and in the youngest age tertile.</div></div><div><h3>Conclusions</h3><div>In PH patients, Ea_sPAP most closely correlated with the PA pulse pressure/SV ratio, the standard clinical estimate of total PA stiffness. This overlap among clinical indices of PA load warrants recognition, suggesting right ventricular responses may be mainly driven by pulsatile load, with potential therapeutic implications.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101204"},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial – \"Lung ultrasound and community-acquired pneumonia: from complementary tool to clinical game-changer\"","authors":"Luigi Vetrugno ,&nbsp;Damiano D’Ardes ,&nbsp;Cristian Deana ,&nbsp;Daniele Guerino Biasucci ,&nbsp;Andrea Boccatonda","doi":"10.1016/j.resmer.2025.101203","DOIUrl":"10.1016/j.resmer.2025.101203","url":null,"abstract":"<div><div>Community-acquired pneumonia (CAP) remains a major global health concern, traditionally diagnosed through chest X-ray (CXR). However, lung ultrasound (LUS) is increasingly emerging as a transformative tool in both diagnosis and management. Evidence from recent meta-analyses reveals that LUS outperforms CXR in sensitivity and rivals it in specificity, with pooled diagnostic accuracies exceeding 90 %. Unlike CXR, LUS is radiation-free, cost-effective, and ideal for bedside use, making it particularly valuable in emergency departments, intensive care units, pediatric and geriatric populations, and resource-limited settings. In children, LUS spares radiation exposure, while in elderly patients, contrast-enhanced ultrasound improves diagnostic specificity. Beyond diagnosis, LUS enables dynamic monitoring, prognostic scoring (e.g., LUS score, CPIS-PLUS), and supports treatment decisions such as ventilator weaning and antibiotic stewardship. Recent applications during the COVID-19 pandemic have demonstrated its effectiveness in triage and outcome prediction. Despite challenges such as operator dependency and reduced penetration for deep lesions, technological advances—particularly artificial intelligence and handheld devices—are mitigating these limitations. Deep learning models now interpret LUS images with high accuracy, enhancing reproducibility and accessibility for general practitioners. In low- and middle-income countries, LUS serves as a crucial diagnostic bridge, improving access and reducing reliance on costly imaging modalities. As training programs and standardized scoring systems evolve, LUS is becoming a frontline tool rather than a supplementary option. Its integration into clinical practice promises to reshape pneumonia care through rapid, accurate, and scalable diagnostics. In light of these advancements, LUS is not just complementary to radiography—it is redefining the diagnostic landscape of pneumonia.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101203"},"PeriodicalIF":1.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}