Respiratory Medicine and Research最新文献

{"title":"Functional status following pulmonary rehabilitation in people with ECOPD: A systematic review and meta-analysis","authors":"Inês Fernandes , André Santos , Guilherme Rodrigues , Ana Oliveira , Alda Marques","doi":"10.1016/j.resmer.2023.101045","DOIUrl":"10.1016/j.resmer.2023.101045","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101045"},"PeriodicalIF":2.3,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary vein stenosis: An unusual cause of hypoxemia after lung transplantation","authors":"Margot Combet , Domitille Mouren , Justina Motiejunaite , Vincent Bunel , Pierre Mordant , Yves Castier , Aurélie Snauwaert , Philippe Montravers , Antoine Khalil , Sébastien Hascoet , Philippe Brenot , Jonathan Messika","doi":"10.1016/j.resmer.2023.101041","DOIUrl":"10.1016/j.resmer.2023.101041","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101041"},"PeriodicalIF":2.3,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe pre-capillary pulmonary hypertension associated with kyphoscoliosis: Description of 4 cases","authors":"Guillaume Martin, Matthieu Canuet, Mohamed Rahli, Armelle Schuller, Irina Enache, Romain Kessler, Marianne Riou","doi":"10.1016/j.resmer.2023.101034","DOIUrl":"10.1016/j.resmer.2023.101034","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101034"},"PeriodicalIF":2.3,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10448746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of the two diagnostic criteria for idiopathic pleuroparenchymal fibroelastosis","authors":"Yoshiaki Kinoshita, Takuhide Utsunomiya, Kenji Wada, Shota Nakashima, Hisako Kushima, Hiroshi Ishii","doi":"10.1016/j.resmer.2023.101046","DOIUrl":"10.1016/j.resmer.2023.101046","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101046"},"PeriodicalIF":2.3,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery of Endothelium-dependent vascular relaxation impairment in convalescent COVID-19 patients: Insight from a pilot study","authors":"Fares Gouzi ,&nbsp;Aurélien Philippe ,&nbsp;Jean Pastre ,&nbsp;Bertrand Renaud ,&nbsp;Nicolas Gendron ,&nbsp;Marielle Subileau ,&nbsp;Thông Hua-Huy ,&nbsp;Benjamin Planquette ,&nbsp;Olivier Sanchez ,&nbsp;David M. Smadja ,&nbsp;Sven Günther","doi":"10.1016/j.resmer.2023.101044","DOIUrl":"10.1016/j.resmer.2023.101044","url":null,"abstract":"<div><h3>Background</h3><p><span>Endothelial dysfunction is a key-feature in acute COVID-19. However, follow-up data regarding endothelial dysfunction and injury after COVID-19 infection are lacking. We aimed to investigate the changes in endothelium-dependent </span>vasorelaxation at baseline and four months after hospital discharge in COVID-19 patients.</p></div><div><h3>Methods</h3><p>Twenty COVID-19 patients were compared to 24 healthy controls. Clinical and morphological data were collected after hospital admission for SARS-CoV-2 infection and reactive hyperaemia<span> index (RHI) measurement was performed with a delay between 24 and 48 h after hospital admission and four months after hospital discharge in the outpatient clinics. Blood tests including inflammatory markers and measurement of post-occlusive vasorelaxation by digital peripheral arterial tonometry were performed at both visits.</span></p></div><div><h3>Results</h3><p>At baseline, COVID-19 patients exhibited reduced RHI compared to controls (<em>p</em> &lt; 0.001), in line with an endothelial dysfunction. At four months follow-up, there was a 51% increase in the RHI (1.69 ± 0.32 to 2.51 ± 0.91; <em>p</em> &lt; 0.01) in favor of endothelium-dependent vascular relaxation recovery. RHI changes were positively correlated with baseline C-reactive protein (<em>r</em> = 0.68; <em>p</em> = 0.02). Compared to COVID-19 patients with a decrease in RHI, COVID-19 patients with an increase in RHI beyond the day-to-day variability (i.e. &gt;11%) had less severe systemic inflammation at baseline.</p></div><div><h3>Conclusion</h3><p>Convalescent COVID-19 patients showed a recovery of systemic artery endothelial dysfunction, in particular patients with lower inflammation at baseline. Further studies are needed to decipher the interplay between inflammation and endothelial dysfunction in COVID-19 patients.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101044"},"PeriodicalIF":2.3,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into the relationship between forced vital capacity and transfer of the lungs for carbon monoxide in patients with idiopathic pulmonary fibrosis","authors":"Thibaud Soumagne ,&nbsp;Sébastien Quétant ,&nbsp;Alicia Guillien ,&nbsp;Loïc Falque ,&nbsp;David Hess ,&nbsp;Bernard Aguilaniu ,&nbsp;Bruno Degano","doi":"10.1016/j.resmer.2023.101042","DOIUrl":"10.1016/j.resmer.2023.101042","url":null,"abstract":"<div><h3>Background</h3><p><span>Forced vital capacity (FVC) is routinely used to quantify the severity and identify the progression of </span>idiopathic pulmonary fibrosis<span> (IPF). Although less commonly used, lung transfer of carbon monoxide (TLCO) correlates better with the severity of IPF than does FVC.</span></p></div><div><h3>Methods</h3><p>Aiming at studying how FVC behaves in relation to TLCO, we analysed cross-sectional data from 430 IPF patients, of which 221 had at least 2 assessments (performed 2.4 ± 1.9 years apart) available for longitudinal analyses. Thresholds for identifying “abnormal” FVC and TLCO values were the statistically-defined lower limits of normal (LLN). For patients with longitudinal data, mean annual absolute declines of FVC and TLCO were calculated.</p></div><div><h3>Results</h3><p>The correlation between FVC and TLCO (%predicted) was weak (R²=0.21). FVC was “abnormal” (i.e., &lt;LLN) in 38% of patients while 84% of patients had an “abnormal” TLCO. A large majority of the 268 patients with a “normal” FVC had nevertheless an “abnormal” TLCO (<em>n</em> = 209; 78%). On longitudinal analysis, 67/221 patients had an annual absolute decline in FVC≥5%, 34/221 had an annual absolute decline in TLCO ≥10%, and 22 had both.</p></div><div><h3>Conclusion</h3><p>In IPF, a “normal” FVC should be viewed with caution as it is most often associated with an “abnormal” TLCO, a parameter that is strongly correlated with the morphological extent of the disease. Only 1/3 of the patients with a FVC-based progression criterion also had a TLCO progression criterion. In contrast, 2/3 of patients with a TLCO progression criterion also had a FVC progression criterion.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101042"},"PeriodicalIF":2.3,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of amikacin lung delivery between AKITA® and eFlow rapid® nebulizers in healthy controls and patients with CF: A randomized cross-over trial","authors":"Anne-Sophie Aubriot ,&nbsp;Guillaume Maerckx ,&nbsp;Teresinha Leal ,&nbsp;Sophie Gohy ,&nbsp;Gregory Reychler","doi":"10.1016/j.resmer.2023.101038","DOIUrl":"10.1016/j.resmer.2023.101038","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Nebulization plays a key role in the treatment of </span>cystic fibrosis<span><span><span>. The Favorite function couple to jet nebulizers (AKITA®) emerged recently. The aim of this study was to assess the efficiency of the lung delivery by the AKITA® by comparing the </span>urinary concentration of </span>amikacin after nebulization with the AKITA® and the eFlow rapid®, in healthy subjects and patients with CF (PwCF).</span></p></div><div><h3>Method</h3><p>The two samples (healthy subjects and PwCF) were randomized (cross-over 1:1) for two nebulizations (500 mg of amikacin diluted in 4 mL of normal saline solution), with the AKITA® and with the eFlow rapid®. The primary endpoint was the amount of urinary excretion of amikacin over 24 h. The constant of elimination (Ke) was calculated based on the maximal cumulative urinary amikacin excretion plotted over time.</p></div><div><h3>Results</h3><p><span>The total amount of urinary amikacin excretion was greater when AKITA® was used in PwCF (11.7 mg (8.2–14.1) vs 6.1 mg (3.7–13.3); </span><em>p</em> = 0.02) but not different in healthy subjects (14.5 mg (11.7–18.5) vs 12.4 mg (8.0–17.1); <em>p</em> = 0.12). The duration of the nebulization was always shorter with eFlow rapid® than with AKITA® (PwCF: 6.5 ± 0.6 min vs 9.2 ± 1.8 min; <em>p</em> = 0.001 – Healthy: 4.7 ± 1.3 min vs 9.7 ± 1.6 min; <em>p</em> = 0.03). The constant of elimination was similar between the two modalities in CF subjects (0.153 (0.071–0.205) vs 0.149 (0.041–0.182); <em>p</em> = 0.26) and in healthy subjects (0.166 (0.130–0.218) vs 0.167 (0.119–0.210), <em>p</em> = 0.25).</p></div><div><h3>Conclusion</h3><p>the Favorite inhalation is better to deliver a specific amount of drug than a mesh nebulizer (eFlow rapid®) in PwCF but not in healthy subjects.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101038"},"PeriodicalIF":2.3,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervening in primary spontaneous pneumothorax – Less is more","authors":"Steven Walker,&nbsp;Eleanor Barton,&nbsp;Nick Maskell","doi":"10.1016/j.resmer.2023.101039","DOIUrl":"10.1016/j.resmer.2023.101039","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101039"},"PeriodicalIF":2.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of management in Chronic Thromboembolic Pulmonary Hypertension in a non-Surgical/ Balloon Pulmonary Angioplasty center.","authors":"M. Jevnikar, D. Montani, E. Fadel, X. Jais","doi":"10.1016/j.resmer.2023.101043","DOIUrl":"https://doi.org/10.1016/j.resmer.2023.101043","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"115 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77233336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awake prone position in patients with acute hypoxic respiratory failure: A narrative review","authors":"Zainab Al Duhailib,&nbsp;Ken Kuljit S. Parhar,&nbsp;Kevin Solverson,&nbsp;Waleed Alhazzani,&nbsp;Jason Weatherald","doi":"10.1016/j.resmer.2023.101037","DOIUrl":"10.1016/j.resmer.2023.101037","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"84 ","pages":"Article 101037"},"PeriodicalIF":2.3,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10062972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}