Respiratory Medicine and Research最新文献

{"title":"Increased delays of care during the COVID-19 pandemic: experience of a lung cancer rapid diagnostic center","authors":"Pascal Wang ,&nbsp;Anthony Canellas ,&nbsp;Floriane Millet ,&nbsp;Constance Météyé ,&nbsp;Christelle Epaud ,&nbsp;Lise Rosencher ,&nbsp;Martine Antoine ,&nbsp;Harry Etienne ,&nbsp;Matthias Barral ,&nbsp;Jacques Cadranel ,&nbsp;Antoine Parrot ,&nbsp;Vincent Fallet ,&nbsp;et Armelle Lavolé","doi":"10.1016/j.resmer.2025.101237","DOIUrl":"10.1016/j.resmer.2025.101237","url":null,"abstract":"<div><h3>Context</h3><div>The COVID-19 pandemic has disrupted hospital organisation and management of chronic pathologies, such as lung cancer. Our objective was to evaluate the impact of COVID-19 on delays in lung cancer care at a French Lung Cancer Rapid Diagnostic Center (RDC).</div></div><div><h3>Methods</h3><div>All patients diagnosed with lung cancer through the RDC at Tenon hospital were included in this retrospective study. The main outcomes were delays (in days) of medical (diagnosis and treatment) care over two periods: period 1 in 2016 (P1, pre-COVID) and period 2 in 2020 (P2, during COVID). Two individualized pathways were considered based on the type of first treatment (surgery or chemo ± immunotherapy).</div></div><div><h3>Results</h3><div>A total of 227 and 293 patients were referred to the RDC during periods P1 and P2, respectively. Lung cancer was diagnosed in 118 patients (52 %) in P1 and 145 patients (49.5 %) in P2 (p=0.29). Patient characteristics were comparable between the two periods, except for TNM stage. A higher proportion of patients with localised stage was diagnosed in P2 compared to P1 (42.1 %¦vs 29.7 %; p=0.02). All delays increased significantly during P2, both pre-hospital steps (e.g. the delay in accessing the first consultation at RDC, which increased from 4 to 13 days, p &lt; 0.0001) and in-hospital steps (e.g. the delay from the first consultation at RDC to the first treatment, which rose from 37.5 to 49 days, p &lt; 0.0001). The surgery pathway was the most impacted, with a significant increase in the overall delay (67 days in P1 vs 109 days in P2, p &lt; 0.0001). The only delay that did not increase between P1 and P2 was the delay in accessing molecular biology.</div></div><div><h3>Conclusions</h3><div>Although the RDC remained open, our delays in lung cancer care increased during the COVID-19 pandemic. These increased delays particularly affected the management of localised lung cancers, which are the most curable. Given the shift toward ambulatory care outlined in the new 2021-2030 National Cancer Plan established by french health authorities, regular evaluations of care delays should be conducted, particularly in the context of health crisis.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101237"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic liposomal amphotericin B therapy in semi-invasive pulmonary aspergillosis","authors":"Benoit Aguado ,&nbsp;Julia Ballouhey ,&nbsp;Yannick Simonneau ,&nbsp;Thomas Egenod ,&nbsp;Stéphane Moreau ,&nbsp;Elsa Clapaud","doi":"10.1016/j.resmer.2025.101233","DOIUrl":"10.1016/j.resmer.2025.101233","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101233"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac MRI and the “lung phenotype” in pulmonary hypertension: Overlap with group 3 or distinct entity?","authors":"Alexandra Mihai","doi":"10.1016/j.resmer.2026.101272","DOIUrl":"10.1016/j.resmer.2026.101272","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101272"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin side-effects of elexacaftor-tezacaftor-ivacaftor: a real-world view","authors":"Sophie Constantinou ,&nbsp;Lucy Webber ,&nbsp;Alice Darby ,&nbsp;Devika Sunil ,&nbsp;Mirain Phillips ,&nbsp;Richard Goodwin ,&nbsp;Jamie Duckers","doi":"10.1016/j.resmer.2025.101218","DOIUrl":"10.1016/j.resmer.2025.101218","url":null,"abstract":"<div><h3>Background</h3><div>Since 2020, ETI (elexacaftor/tezacaftor/ivacaftor) has been used to treat patients with cystic fibrosis. Acne and rash are listed as “common” and “very common” adverse effects in the Summary of Product Characteristics for ETI, affecting between 2-5% and 10% of patients respectively. Patients have, however, shared their experience of developing acne and rashes with clinicians and on social media. This study aimed to describe the real-world impact of rash and acne amongst patients taking ETI and to evaluate the service provided by healthcare practitioners.</div></div><div><h3>Methods</h3><div>A paper and/or electronic survey was distributed to adult patients taking ETI in two regional CF centres between November 2022 and February 2023.</div></div><div><h3>Results</h3><div>Of the 268 survey respondents, 20.9% reported new-onset acne and 13.8% reported a rash following the commencement of ETI. 11.9% had a past history of acne and reported an exacerbation/recurrence after starting ETI. ETI-associated acne occurred weeks to months after commencement of ETI, whereas most rashes occurred within the first 2 weeks of treatment. Reassuringly for 2/3 of affected patients, acne and rashes were minor side effects, although 1/3 experienced a greater impact on their quality of life.</div></div><div><h3>Conclusion</h3><div>This study is the first to specifically report the real-world prevalence of acne and rashes amongst patients taking ETI, which is higher than that reported in clinical trials. These findings could be used to improve counselling of patients commencing ETI. Ensuring access to up-to-date resources and treatments for patients experiencing skin side-effects would be mutually beneficial for both patients and healthcare professionals.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101218"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First steps for telemonitoring mechanical cough assistance in people with neuromuscular diseases: The Tele-INEX study","authors":"M Lebret ,&nbsp;D Zerillo ,&nbsp;A Kerfourn ,&nbsp;M Mahot ,&nbsp;R Abouly ,&nbsp;E Fresnel ,&nbsp;JC Borel","doi":"10.1016/j.resmer.2025.101213","DOIUrl":"10.1016/j.resmer.2025.101213","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101213"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hit-hard vs step-up therapies in COPD: the Goldilocks dilemma","authors":"Belen Muñoz-Sanchez ,&nbsp;José Luis Lopez-Campos ,&nbsp;Esther Quintana-Gallego","doi":"10.1016/j.resmer.2026.101246","DOIUrl":"10.1016/j.resmer.2026.101246","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101246"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of lung nodules detected by low-dose CT scan: Results from the French lung cancer screening study DEP KP-80","authors":"Nicolas Storme ,&nbsp;Marianne Auquier ,&nbsp;Sébastien Couraud ,&nbsp;Lola Soriot ,&nbsp;Alexia Letierce ,&nbsp;Vincent Jounieaux ,&nbsp;Olivier Leleu","doi":"10.1016/j.resmer.2026.101276","DOIUrl":"10.1016/j.resmer.2026.101276","url":null,"abstract":"<div><h3>Background</h3><div>DEP KP-80 is a real-world prospective study evaluating the effectiveness of organized lung cancer screening using low-dose chest CT (LDCT) across a French administrative department. Final results were published in 2024. The study, conducted from May 2016 to February 2020, included individuals aged 55–74 who were current or former smokers (within the past 15 years) with a smoking history of at least 30 pack-years. This ancillary analysis aimed to assess and compare the CT characteristics and demographic profiles of participants presenting with benign or malignant nodules within the first round of DEP KP-80 screening program.</div></div><div><h3>Methods</h3><div>We retrieved the characteristics of nodules and participants available from ADEMA80 across the first round of DEP-KP80 to investigate risk factors for malignancy.</div></div><div><h3>Results</h3><div>Over the first screening round, a total of 809 nodules were identified in 348 of 945 participants (36.8%). The mean age was 61.6 ± 5.4 years, with 66.1% male participants. Nodules were solid in 86.2%, ground-glass in 9.1%, and part-solid in 4.6%. They were located in the upper lobes in 45.4% of cases, in the middle lobe in 13.1%, and in the lower lobes in 41.5%. Sizes were &lt;5 mm in 41.3%, 5–10 mm in 47.5%, and &gt;10 mm in 11.2%. Malignancy was confirmed in 35 nodules from 30 participants (8.6%). On multivariate analysis, multiplicity of nodules (at least five nodules) was predictive of benignity, while a diameter &gt;10 mm was predictive of malignancy. No significant differences were found regarding age, sex, or nodule density.</div></div><div><h3>Conclusion</h3><div>This real-world lung cancer screening analysis shows that malignant pulmonary nodules tend to be solitary and larger than 10 mm in diameter. The multiplicity of nodules appears to be a factor of benignity and localization in the upper lobes a factor of malignancy, but these data did not reach significance in our study.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101276"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas embolism during pleural lavage for empyema : potential risk factors from two clinical cases","authors":"Martin Boussuges ,&nbsp;Mathilde Cadic ,&nbsp;Aurélie Kienlen ,&nbsp;Pierre-Jean Marianne Dit Cassou ,&nbsp;Thomas Masseguin ,&nbsp;Cyril D’Andrea","doi":"10.1016/j.resmer.2025.101225","DOIUrl":"10.1016/j.resmer.2025.101225","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101225"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a pediatric dyspnea clinic management on patients with unexplained exertional dyspnea: cross-sectional assessment at three months","authors":"Florence Coquelin ,&nbsp;Aurélie Bourmaud ,&nbsp;Deborah Fuchs-Climent ,&nbsp;Artémis Toumazi ,&nbsp;Pierre Coste ,&nbsp;Nellie Buridans-Travier ,&nbsp;Chérine Benzouid ,&nbsp;Véronique Houdouin ,&nbsp;Christophe Delclaux ,&nbsp;Claudine Peiffer ,&nbsp;Jade Pautrat","doi":"10.1016/j.resmer.2025.101242","DOIUrl":"10.1016/j.resmer.2025.101242","url":null,"abstract":"<div><h3>Background</h3><div>While unexplained exertional dyspnea (ED) is a frequent complaint in children, there is little consensus on its management. Our pediatric dyspnea clinic provides multidisciplinary assessment and management of ED that includes a psychological interview and a breathing retraining. The aim of this study was to determine the evolution of ED 3±1 months after the visit at the dyspnea clinic (day 0) and to identify factors associated with improvement of ED.</div></div><div><h3>Methods</h3><div>This cross-sectional monocentric cohort study included children referred to our dyspnea clinic between March 2018 and January 2021 for unexplained ED. Thereafter, we reassessed patients by a telephone interview. The evolution of ED between day 0 and 3±1 months after dyspnea clinic was assessed with a score ranging from -8 (most important worsening of dyspnea) to +8 (most important improvement of dyspnea). Factors associated with an improvement in ED were identified through a multivariate analysis.</div></div><div><h3>Results</h3><div>We included 74 patients (median age 13.1 years, 44 girls) and reassessed 68 of them. The median of ED evolution score (ESc) between day 0 and 3±1 months after dyspnea clinic was 4.0 [0.0; 8.0]. Improvement in ED (ESc &gt;0) was observed in 46 children (68%) among whom 70% (32) had a near maximal ESc (≥6/8)</div><div>Lower compliance (&lt; 4 days per week) with breathing exercises performed at home was associated with fewer improvement in ED (OR = 0.20 [0.04; 0.87], p = 0.03).</div></div><div><h3>Conclusion</h3><div>Three months after the visit to our dyspnea clinic, most patients had improved their ED with a near maximal improvement in almost half of all patients. Compliance with breathing exercises is essential for a better outcome.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101242"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation into English and republication of: Pneumocystis jirovecii prophylaxis in non-HIV infected individuals: risk assessment and modalities1","authors":"Radhika Sood ,&nbsp;Marco Marando ,&nbsp;Pieter-Jan Gijs ,&nbsp;Zisis Balmpouzis ,&nbsp;Pre Anne Bergeron ,&nbsp;Angela Koutsokera ,&nbsp;Gregory Berra","doi":"10.1016/j.resmer.2025.101240","DOIUrl":"10.1016/j.resmer.2025.101240","url":null,"abstract":"<div><div>Infections caused by <em>Pneumocystis jirovecii</em> (PJ), an opportunistic fungus, can have major consequences in terms of morbidity and mortality. These infections occur mainly in immunocompromised patients and are known for their pulmonary tropism (<em>Pneumocystis</em> pneumonia, PCP). Epidemiologically, more PJ infections are now encountered in the non-HIV (human immunodeficiency virus) population than in HIV-infected individuals. While prevention modalities have been studied in HIV-infected populations, evidence is scarce in non-HIV patients. The decision to prescribe prophylaxis for PJ requires assessment of the clinical context, as well as existing risk factors that may predispose an individual to develop PCP. Few indicators exist that are sufficiently sensitive and specific to predict the occurrence of PCP. While certain underlying conditions have clear recommendations for prophylaxis such as solid organ transplant recipients, evidence is scarce. The decision to use prophylaxis must be made while taking into consideration the overall context of the patient.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101240"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}