Respiratory Medicine and Research最新文献

{"title":"Diabetes mellitus with poor glycemic control is a risk factor for pneumonia in COPD","authors":"Rafael Golpe ,&nbsp;Juan-Marco Figueira-Gonçalves ,&nbsp;Laura Arias-Zas ,&nbsp;David Dacal-Rivas ,&nbsp;Nagore Blanco-Cid ,&nbsp;Olalla Castro-Añón","doi":"10.1016/j.resmer.2024.101135","DOIUrl":"10.1016/j.resmer.2024.101135","url":null,"abstract":"<div><h3>Background</h3><p>Pneumonias are events of great prognostic significance in COPD, so it is important to identify predictive factors.</p></div><div><h3>Objective</h3><p>To determine whether poor glycemic control is related to an increased risk of pneumonia in COPD.</p></div><div><h3>Method</h3><p>A historical cohort study conducted in a COPD clinic. The first severe exacerbation after the first visit was analyzed. Exacerbations that presented with pulmonary infiltrates were identified. A Cox proportional hazards analysis was performed including the values of glycosylated hemoglobin (Hb1Ac) in patients with diabetes mellitus (DM) and variables that could plausibly be related to the risk of pneumonia. The best Hb1Ac value to predict pneumonia was assessed using receiver-operating characteristics analysis.</p></div><div><h3>Results</h3><p>There were 1124 cases included in the study. A total of 411 patients were admitted to the hospital at least once and 87 were diagnosed with pneumonia. Variables associated with the risk of pneumonia were previous admissions due to COPD and Hb1Ac values (HR: 2.33, 95% CI: 1.06 – 5.08, <em>p</em> = 0.03). A higher body mass index (BMI) was associated with a lower risk of pneumonia. The optimal cutoff point for Hb1Ac to predict pneumonia risk was 7.8 %. The patients were classified into 3 groups: (1) no DM, (2) controlled DM (Hb1AC &lt; 7.8 %), (3) uncontrolled DM (Hb1AC ≥ 7.8 %). The risk of pneumonia for group 2 was not different from group 1, while the risk for group 3 was significantly higher than for groups 1 and 2 (HR: 4.52, 95 % CI: 1.57 – 13.02).</p></div><div><h3>Conclusions</h3><p>Poor control of DM is a predictor of the risk of pneumonia in COPD. The cutoff point of 7.8 % for this variable seems to be the most useful to identify patients at risk.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101135"},"PeriodicalIF":2.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis-like disease probably induced by apremilast: A case report","authors":"Paul Hannetel,&nbsp;Audrey Courdurie,&nbsp;Michael Levraut,&nbsp;Jacques Boutros,&nbsp;Alice Gaudart,&nbsp;Frederic Vandenbos","doi":"10.1016/j.resmer.2024.101131","DOIUrl":"10.1016/j.resmer.2024.101131","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101131"},"PeriodicalIF":2.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of preexisting interstitial lung disease on outcomes of lung cancer surgery: A monocentric retrospective study","authors":"Alice Goga ,&nbsp;Alex Fourdrain ,&nbsp;Paul Habert ,&nbsp;Anh Thu Nguyen Ngoc ,&nbsp;Julien Bermudez ,&nbsp;Alice Mogenet ,&nbsp;Eléonore Simon ,&nbsp;Etienne Gouton ,&nbsp;Pascale Tomasini ,&nbsp;Pascal Alexandre Thomas ,&nbsp;Laurent Greillier ,&nbsp;Johan Pluvy","doi":"10.1016/j.resmer.2024.101126","DOIUrl":"10.1016/j.resmer.2024.101126","url":null,"abstract":"<div><h3>Introduction</h3><p>Interstitial lung disease (ILD) is a known risk factor for lung cancer (LC). However, the surgical risk of LC in patients with ILD remains unclear. Therefore, we conducted a single-center retrospective study to assess clinical features and outcomes of LC population who underwent surgery with or without ILD.</p></div><div><h3>Methods</h3><p>Patients who underwent surgery for LC between January 2006 and June 2023 in our center were assessed using data extracted from the nationwide EPITHOR thoracic surgery database. Suspicion of ILD was based on patients’ records. Confirmation of ILD was then made on the patient's medical and radiological history. Patients were classified according to the pattern of ILD. The study aimed to describe the outcomes after lung cancer resection in patients with confirmed LC-ILD group compared to those without ILD (LC-non-ILD): post-operative complications, disease-free survival (DFS) and overall survival (OS). A subgroup analysis was also performed on patients with idiopathic pulmonary fibrosis and lung cancer (LC-IPF).</p></div><div><h3>Results</h3><p>4073 patients underwent surgery for LC at Assistance Publique des Hôpitaux de Marseille between January 2006 and June 2023. Of these, 4030 were in the LC-non-ILD group and 30 were LC-ILD patients. In the LC-ILD group, the predominant CT scan pattern was probable UIP (50 %). OS was not significantly lower in the LC-ILD group (45 months versus 84 months, <em>p</em> = 0.068). Dyspnea and tumor size were identified as potential univariate predictors of OS. No significant differences were observed on post-operative complications or their severity. The most common post-operative complications in the LC-ILD group were prolonged air leak, respiratory failure, or pneumonia. 13 patients had cancer recurrence in the LC-ILD group.</p></div><div><h3>Conclusion</h3><p>Our study provides a comprehensive analysis of a LC-ILD population features and outcome when undergoing surgery for LC. Patients with LC-ILD appeared to have a reduced OS compared with LC-non-ILD. Further investigation<del>s</del> with larger prospective studies could be useful to confirm and develop these preliminary findings.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101126"},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000424/pdfft?md5=913718c8afc4cffa8ff0a0aea61d1b69&pid=1-s2.0-S2590041224000424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An underrecognized phenotype of pulmonary emphysema with marked pulmonary gas exchange but with mild or moderate airway obstruction","authors":"Gaelle Weisenburger ,&nbsp;Vincent Bunel ,&nbsp;Cendrine Godet ,&nbsp;Mathilde Salpin ,&nbsp;Domitille Mouren ,&nbsp;Charlotte Thibaut de Menonville ,&nbsp;Tiphaine Goletto ,&nbsp;Armelle Marceau ,&nbsp;Raphael Borie ,&nbsp;Marie-Pierre Debray ,&nbsp;Hervé Mal","doi":"10.1016/j.resmer.2024.101086","DOIUrl":"10.1016/j.resmer.2024.101086","url":null,"abstract":"<div><p>In patients with pulmonary emphysema and mild to moderate airflow limitation, one does not expect the features marked exertional dyspnea and hypoxemia as well as a profound decrease in diffusing capacity of the lung for carbon monoxide (DLCO). Here we describe this phenotype and its prognosis. From our database, we retrospectively selected cases associating emphysema, exertional breathlessness, O₂ requirement at least upon exercise, forced expiratory volume in 1 sec (FEV₁) ≥ 50% predicted, and DLCO ≤ 50% predicted, without associated combined pulmonary fibrosis and emphysema, right-to-left shunt, or severe pulmonary hypertension<del>.</del> Over a 12-year period, we identified 16 patients with emphysema and the above presentation. At the initial evaluation, the median age was 62 years (interquartile range 53.8–68.9). The median FEV₁ and DLCO% predicted and mean pulmonary artery pressure were 86 (65–95)%, 38 (31–41)%, and 20 (17–25) mm Hg, respectively. On room air, the median arterial partial pressure of oxygen and partial pressure of carbon dioxide in arterial blood were 63.5 (55.8–69) mm Hg and 34.5 (31–36) mm Hg with increased median alveolar-arterial oxygen difference (46 [39–51] mm Hg). After the initial evaluation, the respiratory condition worsened in 13 of 14 (92.8%) patients with one or more re-evaluations (median follow-up 2.6 [0.9–5.8] years). In 12, lung transplantation was considered. Four patients died after 5.8, 5.7, 7.1, and 0.8 years of follow-up, respectively. We describe an underrecognized phenotype of pulmonary emphysema featuring a particular profile characterized by marked exertional dyspnea, impaired pulmonary gas exchange with low DLCO and marked oxygen desaturation at least on exercise but with mild or moderate airway obstruction.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101086"},"PeriodicalIF":2.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa","authors":"Daniel L Thompson ,&nbsp;Zoe Semersky ,&nbsp;Richard Feinn ,&nbsp;Pamela Huang ,&nbsp;Paul E Turner ,&nbsp;Ben K Chan ,&nbsp;Jonathan L Koff ,&nbsp;Thomas S Murray","doi":"10.1016/j.resmer.2024.101133","DOIUrl":"10.1016/j.resmer.2024.101133","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101133"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of pleural infections in Finland","authors":"Antti Lehtomäki ,&nbsp;Mika Ukkonen ,&nbsp;Vesa Toikkanen ,&nbsp;Jari Laurikka ,&nbsp;Jahangir Khan","doi":"10.1016/j.resmer.2024.101132","DOIUrl":"10.1016/j.resmer.2024.101132","url":null,"abstract":"<div><h3>Background</h3><p>The incidence of pleural infections appears to be increasing in Western countries for unclear reasons. The aim of the study was to describe the incidence and treatment patterns of pleural infections in Finland over three decades.</p></div><div><h3>Methods</h3><p>Data regarding each treatment episode for pleural infections in the Finnish special medical care between January 1994 and December 2016 was obtained from a national database and compared to the demographics of Finnish residents obtained from the national census bureau. The annual incidence rates, type of treatment given, as well as the lengths of the hospitalization were analyzed.</p></div><div><h3>Results</h3><p>A total of 28,463 episodes were reported, of which 55% were inpatient episodes. Of these, 76% concerned males, and the median age of patients was 60 (interquartile range 49–70) years. The overall incidence of pleural infections was 23.4 per 100.000 patient-years, with a male-to-female -ratio of 3.3:1. The annual incidence rates increased throughout the study period with an average annual percentage change of +11.4% (95% CI ±7.4%). The highest incidence rates (&gt;200 per 100.000 patient-years) were observed in men aged 80 or more. Altogether 88% of patients were treated conservatively. The proportion of patients treated by mini-invasive surgery significantly increased during study period (0–5.9%, <em>p</em> &lt; 0.001) and was associated with shorter hospitalization (median 6 [interquartile range 4–12] days) than open surgery (median 7 [4.5–13] days) (<em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The incidence of pleural infections has increased significantly over the previous decades in Finland and appears to be higher than previously reported, particularly in elderly men.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101132"},"PeriodicalIF":2.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000485/pdfft?md5=86148589ae8c4061d2cfb25f9ad609c8&pid=1-s2.0-S2590041224000485-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An « endo-tracheal customization » of a tracheobronchial silicone stent","authors":"Martin Boussuges,&nbsp;Aurélie Kienlen","doi":"10.1016/j.resmer.2024.101129","DOIUrl":"10.1016/j.resmer.2024.101129","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101129"},"PeriodicalIF":2.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis Diagnostic Score (SDS) system: Impact of race, sex, organ involvement and duration of symptoms prior to diagnosis","authors":"Ying Zhou ,&nbsp;Florence Jeny ,&nbsp;Violetta Vucinic ,&nbsp;Deepak Talwar ,&nbsp;Ogugua Ndili Obi ,&nbsp;Marc A Judson ,&nbsp;Irina Strambu ,&nbsp;Parathasarathi Bhattacharyya ,&nbsp;Dominique Valeyre ,&nbsp;Alexandra N Bickett ,&nbsp;Elyse E Lower ,&nbsp;Robert P Baughman","doi":"10.1016/j.resmer.2024.101127","DOIUrl":"10.1016/j.resmer.2024.101127","url":null,"abstract":"<div><h3>Background</h3><p>The Sarcoidosis Diagnostic Score (SDS) system has been established for sarcoidosis patients based on the WASOG organ involvement criteria. We evaluated modifications of the SDS system to determine if they improved its the diagnostic accuracy.</p></div><div><h3>Methods</h3><p>Biopsy-confirmed patients with sarcoidosis seen during a 7-month period at 9 sarcoidosis centers across the world. Patients with non-sarcoidosis seen at the same sites were served as control patients. Comparing the SDS-biopsy and SDS-clinical values of five groups: duration of symptoms prior to evaluation (≤1 years vs.&gt;1 years, ≤2 years vs.&gt;2 years), organ involvement (lung, eye, or cardiac), race, and sex.</p></div><div><h3>Results</h3><p>A total of 990 patients with sarcoidosis and 1011 controls were included in this study. The SDS-clinical was significantly more discriminating for those undergoing assessment with symptoms for more than one year (z-statistic=2.570, <em>p</em> = 0.0102) or two years (z-statistic=2.546, <em>p</em> = 0.0109). However, the addition of two points for both &gt;1 years and &gt;2 years since onset of symptoms did not increase sensitivity and specificity of diagnosis with the SDS system. The SDS-clinical cut-off for patients with ocular or cardiac disease was two points higher than that for lung disease. There was no difference in SDS-clinical or biopsy AUC values based on gender or race.</p></div><div><h3>Conclusions</h3><p>The longer the duration of symptoms prior to diagnosis, the more likely the diagnosis of sarcoidosis was correct. For patients presenting with ocular or cardiac symptoms, evidence of multi-organ involved can improve the diagnostic accuracy of the SDS-clinical.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101127"},"PeriodicalIF":2.2,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual inhaled antibiotics for treatment of pulmonary exacerbations in cystic fibrosis – A real life pilot study","authors":"Moshe Heching ,&nbsp;Liora Slomianksy ,&nbsp;Huda Mussaffi ,&nbsp;Dario Prais ,&nbsp;Joel Weinberg ,&nbsp;Mordechai R. Kramer","doi":"10.1016/j.resmer.2024.101128","DOIUrl":"10.1016/j.resmer.2024.101128","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101128"},"PeriodicalIF":2.2,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000448/pdfft?md5=21329279a017f62b30a76be47a37bb3c&pid=1-s2.0-S2590041224000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary nodules and the psychological harm they can cause: A scoping review","authors":"Grace C. Hillyer ,&nbsp;Nicole Milano ,&nbsp;William A. Bulman","doi":"10.1016/j.resmer.2024.101121","DOIUrl":"10.1016/j.resmer.2024.101121","url":null,"abstract":"<div><p>More than 1.6 million pulmonary nodules are diagnosed in the United States each year. Although the majority of nodules are found to be benign, nodule detection and the process of ruling out malignancy can cause patients psychological harm to varying degrees. The present study undertakes a scoping review of the literature investigating pulmonary nodule-related psychological harm as a primary or secondary outcome. Online databases were systematically searched to identify papers published through June 30, 2023, from which 19 publications were reviewed. We examined prevalence by type, measurement, associated factors, and behavioral or clinical consequences. Of the 19 studies reviewed, 11 studies investigated distress, anxiety (<em>n</em> = 6), and anxiety and depression (<em>n</em> = 4). Prevalence of distress was 24.0 %-56.7 %; anxiety 9.9 %-42.1 %, and 14.6 %-27.0 % for depression. A wide range of demographic and social characteristics and clinical factors were associated with nodule-related psychological harm. Outcomes of nodule-related harms included experiencing conflict when deciding about treatment or surveillance, decreased adherence to surveillance, adoption of more aggressive treatment, and lower health-related quality of life. Our scoping review demonstrates that nodule-related psychological harm is common. Findings provide evidence that nodule-related psychological harm can influence clinical decisions and adherence to treatment recommendations. Future research should focus on discerning between nodule-related distress and anxiety; identifying patients at risk; ascertaining the extent of psychological harm on patient behavior and clinical decisions; and developing interventions to assist patients in managing psychological harm for better health-related quality of life and treatment outcomes.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101121"},"PeriodicalIF":2.2,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000370/pdfft?md5=e00898e97cc43b0153d798a4860670ad&pid=1-s2.0-S2590041224000370-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}