Respiratory Medicine and Research最新文献

{"title":"Evaluating the correspondence between the EQ-5D-5L and disease severity and quality of life in adults and adolescents with cystic fibrosis","authors":"Rana Altabee ,&nbsp;Siobhan B. Carr ,&nbsp;Janice Abbott ,&nbsp;Rory Cameron ,&nbsp;Daniel Office ,&nbsp;Nicholas J. Simmonds ,&nbsp;Jennifer A. Whitty ,&nbsp;David Turner ,&nbsp;Garry Barton","doi":"10.1016/j.resmer.2024.101137","DOIUrl":"10.1016/j.resmer.2024.101137","url":null,"abstract":"<div><h3>Background</h3><p>The EQ-5D is the recommended measure to capture health-related quality of life (HRQoL), recognised for use in health technology appraisal bodies. In order to assess whether it is appropriate to use the EQ-5D for making decisions about the cost-utility of treatments in cystic fibrosis (CF), this study assesses the performance of the EQ-5D-5L in adults and adolescents with CF.</p></div><div><h3>Method</h3><p>This was a cross-sectional observational survey study of patients with CF attending a single large CF centre. Participants were asked to complete a survey that included two HRQoL measures; the EQ-5D-5L and CF Quality of Life (CFQoL) questionnaires.</p></div><div><h3>Results</h3><p>Among 213 participants, the median EQ-5D-5L index score was 0.76 (IQR 0.66 – 0.84) and the visual analogue (EQ-VAS) was 70 (60 – 80). Both the EQ-5D index and EQ-VAS discriminated between disease severity based on lung function (<em>p</em> = 0.01 and <em>p</em> &lt; 0.01, respectively) and pulmonary exacerbation (<em>p</em> = 0.02 and <em>p</em> &lt; 0.01, respectively); however, EQ-VAS differentiated between more lung function severity groups compared to EQ-5D index. The EQ-5D-5L demonstrated convergent validity as its dimensions, index score, and EQ-VAS had significant correlations with most CFQoL domains. Though, EQ-VAS significantly predicted more domains of CFQoL (4 domains) compared to EQ-5D index (only 1 domain).</p></div><div><h3>Conclusion</h3><p>The generic EQ-5D-5L performed adequately in discriminating between CF disease severity, and its index score and EQ-VAS had moderate correlations with CFQoL. However, using a complementary condition-specific measure alongside the EQ-5D-5L can provide better insight of HRQoL in CF and benefit the process of cost-utility analysis.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101137"},"PeriodicalIF":2.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000539/pdfft?md5=b71da58ca67010b88f93e6e2d262327d&pid=1-s2.0-S2590041224000539-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Description, clinical impact and early outcome of S. maltophilia respiratory tract infections after lung transplantation, A retrospective observational study","authors":"Benoît Pilmis ,&nbsp;Claire Rouzaud ,&nbsp;Deborah To-Puzenat ,&nbsp;Anne Gigandon ,&nbsp;Gaelle Dauriat ,&nbsp;Séverine Feuillet ,&nbsp;Delphine Mitilian ,&nbsp;Justin Issard ,&nbsp;Alban Le Monnier ,&nbsp;Olivier Lortholary ,&nbsp;Elie Fadel ,&nbsp;Jérôme Le Pavec","doi":"10.1016/j.resmer.2024.101130","DOIUrl":"10.1016/j.resmer.2024.101130","url":null,"abstract":"<div><h3>Background and research question</h3><p><em>S. maltophilia</em> infections are associated with significant morbidity and mortality. Little is known regarding its presentation, management, and outcome in lung transplant recipients.</p></div><div><h3>Study design and Methods</h3><p>This retrospective case control study reviewed <em>S. maltophilia</em> respiratory tract infection in lung transplant recipients (01/01/2011-31/01/2020) and described the clinical, microbiological and outcome characteristics matched with lung transplant recipients without respiratory tract infection.</p></div><div><h3>Results and interpretation</h3><p>We identified 63 <em>S. maltophilia</em> infections in lung transplant recipients. Among them none were colonized before transplantation. Infections occurred a median of 177 (IQR: 45- 681) days post transplantation. Fifty-four (85.7 %) patients received trimethoprim-sulfamethoxazole (400/80 mg three times a week) to prevent <em>Pneumocystis jirovecii</em> pneumonia (PJP). <em>S. maltophilia</em> strains were susceptible to trimethoprim-sulfamethoxazole, levofloxacin, minocycline and ceftazidime in respectively 85.7 %, 82.5 %, 96.8 % and 34.9 % of cases. Median duration of treatment was 9 days (IQR 7–11.5). Clinical and microbiological recurrence were observed in respectively 25.3 % and 39.7 % of cases. Combination therapy was not associated with a decrease in the risk of recurrence and did not prevent the emergence of resistance. <em>S. maltophilia</em> respiratory tract infection was associated with a decline in FEV-1 at one year.</p></div><div><h3>Conclusion</h3><p><em>S. maltophilia</em> is an important cause of lower respiratory tract infection in lung transplant recipients. Trimethoprim-sulfamethoxazole use as prophylaxis for PJP doesn't prevent <em>S. maltophilia</em> infection among lung transplant recipients. Levofloxacin and trimethoprim-sulfamethoxazole appear to be the two molecules of choice for the treatment of these infections and new antibiotic strategies (cefiderocol, aztreonam/avibactam) are currently being evaluated for multi-resistant <em>S. maltophilia</em> infections.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101130"},"PeriodicalIF":2.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive hemoptysis: A normal platelet count may not be enough","authors":"Thibaud Soumagne,&nbsp;Dominique Helley,&nbsp;Sébastien Eymieux,&nbsp;Laurent Frenzel,&nbsp;Anne Vincenot,&nbsp;Alessandro Di Gaeta,&nbsp;Olivier Pellerin,&nbsp;Benjamin Planquette,&nbsp;Nicolas Gendron","doi":"10.1016/j.resmer.2024.101134","DOIUrl":"10.1016/j.resmer.2024.101134","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101134"},"PeriodicalIF":2.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus with poor glycemic control is a risk factor for pneumonia in COPD","authors":"Rafael Golpe ,&nbsp;Juan-Marco Figueira-Gonçalves ,&nbsp;Laura Arias-Zas ,&nbsp;David Dacal-Rivas ,&nbsp;Nagore Blanco-Cid ,&nbsp;Olalla Castro-Añón","doi":"10.1016/j.resmer.2024.101135","DOIUrl":"10.1016/j.resmer.2024.101135","url":null,"abstract":"<div><h3>Background</h3><p>Pneumonias are events of great prognostic significance in COPD, so it is important to identify predictive factors.</p></div><div><h3>Objective</h3><p>To determine whether poor glycemic control is related to an increased risk of pneumonia in COPD.</p></div><div><h3>Method</h3><p>A historical cohort study conducted in a COPD clinic. The first severe exacerbation after the first visit was analyzed. Exacerbations that presented with pulmonary infiltrates were identified. A Cox proportional hazards analysis was performed including the values of glycosylated hemoglobin (Hb1Ac) in patients with diabetes mellitus (DM) and variables that could plausibly be related to the risk of pneumonia. The best Hb1Ac value to predict pneumonia was assessed using receiver-operating characteristics analysis.</p></div><div><h3>Results</h3><p>There were 1124 cases included in the study. A total of 411 patients were admitted to the hospital at least once and 87 were diagnosed with pneumonia. Variables associated with the risk of pneumonia were previous admissions due to COPD and Hb1Ac values (HR: 2.33, 95% CI: 1.06 – 5.08, <em>p</em> = 0.03). A higher body mass index (BMI) was associated with a lower risk of pneumonia. The optimal cutoff point for Hb1Ac to predict pneumonia risk was 7.8 %. The patients were classified into 3 groups: (1) no DM, (2) controlled DM (Hb1AC &lt; 7.8 %), (3) uncontrolled DM (Hb1AC ≥ 7.8 %). The risk of pneumonia for group 2 was not different from group 1, while the risk for group 3 was significantly higher than for groups 1 and 2 (HR: 4.52, 95 % CI: 1.57 – 13.02).</p></div><div><h3>Conclusions</h3><p>Poor control of DM is a predictor of the risk of pneumonia in COPD. The cutoff point of 7.8 % for this variable seems to be the most useful to identify patients at risk.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101135"},"PeriodicalIF":2.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis-like disease probably induced by apremilast: A case report","authors":"Paul Hannetel,&nbsp;Audrey Courdurie,&nbsp;Michael Levraut,&nbsp;Jacques Boutros,&nbsp;Alice Gaudart,&nbsp;Frederic Vandenbos","doi":"10.1016/j.resmer.2024.101131","DOIUrl":"10.1016/j.resmer.2024.101131","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101131"},"PeriodicalIF":2.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of preexisting interstitial lung disease on outcomes of lung cancer surgery: A monocentric retrospective study","authors":"Alice Goga ,&nbsp;Alex Fourdrain ,&nbsp;Paul Habert ,&nbsp;Anh Thu Nguyen Ngoc ,&nbsp;Julien Bermudez ,&nbsp;Alice Mogenet ,&nbsp;Eléonore Simon ,&nbsp;Etienne Gouton ,&nbsp;Pascale Tomasini ,&nbsp;Pascal Alexandre Thomas ,&nbsp;Laurent Greillier ,&nbsp;Johan Pluvy","doi":"10.1016/j.resmer.2024.101126","DOIUrl":"10.1016/j.resmer.2024.101126","url":null,"abstract":"<div><h3>Introduction</h3><p>Interstitial lung disease (ILD) is a known risk factor for lung cancer (LC). However, the surgical risk of LC in patients with ILD remains unclear. Therefore, we conducted a single-center retrospective study to assess clinical features and outcomes of LC population who underwent surgery with or without ILD.</p></div><div><h3>Methods</h3><p>Patients who underwent surgery for LC between January 2006 and June 2023 in our center were assessed using data extracted from the nationwide EPITHOR thoracic surgery database. Suspicion of ILD was based on patients’ records. Confirmation of ILD was then made on the patient's medical and radiological history. Patients were classified according to the pattern of ILD. The study aimed to describe the outcomes after lung cancer resection in patients with confirmed LC-ILD group compared to those without ILD (LC-non-ILD): post-operative complications, disease-free survival (DFS) and overall survival (OS). A subgroup analysis was also performed on patients with idiopathic pulmonary fibrosis and lung cancer (LC-IPF).</p></div><div><h3>Results</h3><p>4073 patients underwent surgery for LC at Assistance Publique des Hôpitaux de Marseille between January 2006 and June 2023. Of these, 4030 were in the LC-non-ILD group and 30 were LC-ILD patients. In the LC-ILD group, the predominant CT scan pattern was probable UIP (50 %). OS was not significantly lower in the LC-ILD group (45 months versus 84 months, <em>p</em> = 0.068). Dyspnea and tumor size were identified as potential univariate predictors of OS. No significant differences were observed on post-operative complications or their severity. The most common post-operative complications in the LC-ILD group were prolonged air leak, respiratory failure, or pneumonia. 13 patients had cancer recurrence in the LC-ILD group.</p></div><div><h3>Conclusion</h3><p>Our study provides a comprehensive analysis of a LC-ILD population features and outcome when undergoing surgery for LC. Patients with LC-ILD appeared to have a reduced OS compared with LC-non-ILD. Further investigation<del>s</del> with larger prospective studies could be useful to confirm and develop these preliminary findings.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101126"},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000424/pdfft?md5=913718c8afc4cffa8ff0a0aea61d1b69&pid=1-s2.0-S2590041224000424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An underrecognized phenotype of pulmonary emphysema with marked pulmonary gas exchange but with mild or moderate airway obstruction","authors":"Gaelle Weisenburger ,&nbsp;Vincent Bunel ,&nbsp;Cendrine Godet ,&nbsp;Mathilde Salpin ,&nbsp;Domitille Mouren ,&nbsp;Charlotte Thibaut de Menonville ,&nbsp;Tiphaine Goletto ,&nbsp;Armelle Marceau ,&nbsp;Raphael Borie ,&nbsp;Marie-Pierre Debray ,&nbsp;Hervé Mal","doi":"10.1016/j.resmer.2024.101086","DOIUrl":"10.1016/j.resmer.2024.101086","url":null,"abstract":"<div><p>In patients with pulmonary emphysema and mild to moderate airflow limitation, one does not expect the features marked exertional dyspnea and hypoxemia as well as a profound decrease in diffusing capacity of the lung for carbon monoxide (DLCO). Here we describe this phenotype and its prognosis. From our database, we retrospectively selected cases associating emphysema, exertional breathlessness, O₂ requirement at least upon exercise, forced expiratory volume in 1 sec (FEV₁) ≥ 50% predicted, and DLCO ≤ 50% predicted, without associated combined pulmonary fibrosis and emphysema, right-to-left shunt, or severe pulmonary hypertension<del>.</del> Over a 12-year period, we identified 16 patients with emphysema and the above presentation. At the initial evaluation, the median age was 62 years (interquartile range 53.8–68.9). The median FEV₁ and DLCO% predicted and mean pulmonary artery pressure were 86 (65–95)%, 38 (31–41)%, and 20 (17–25) mm Hg, respectively. On room air, the median arterial partial pressure of oxygen and partial pressure of carbon dioxide in arterial blood were 63.5 (55.8–69) mm Hg and 34.5 (31–36) mm Hg with increased median alveolar-arterial oxygen difference (46 [39–51] mm Hg). After the initial evaluation, the respiratory condition worsened in 13 of 14 (92.8%) patients with one or more re-evaluations (median follow-up 2.6 [0.9–5.8] years). In 12, lung transplantation was considered. Four patients died after 5.8, 5.7, 7.1, and 0.8 years of follow-up, respectively. We describe an underrecognized phenotype of pulmonary emphysema featuring a particular profile characterized by marked exertional dyspnea, impaired pulmonary gas exchange with low DLCO and marked oxygen desaturation at least on exercise but with mild or moderate airway obstruction.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101086"},"PeriodicalIF":2.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle size distribution of viable nebulized bacteriophage for the treatment of multi-drug resistant Pseudomonas aeruginosa","authors":"Daniel L Thompson ,&nbsp;Zoe Semersky ,&nbsp;Richard Feinn ,&nbsp;Pamela Huang ,&nbsp;Paul E Turner ,&nbsp;Ben K Chan ,&nbsp;Jonathan L Koff ,&nbsp;Thomas S Murray","doi":"10.1016/j.resmer.2024.101133","DOIUrl":"10.1016/j.resmer.2024.101133","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101133"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of pleural infections in Finland","authors":"Antti Lehtomäki ,&nbsp;Mika Ukkonen ,&nbsp;Vesa Toikkanen ,&nbsp;Jari Laurikka ,&nbsp;Jahangir Khan","doi":"10.1016/j.resmer.2024.101132","DOIUrl":"10.1016/j.resmer.2024.101132","url":null,"abstract":"<div><h3>Background</h3><p>The incidence of pleural infections appears to be increasing in Western countries for unclear reasons. The aim of the study was to describe the incidence and treatment patterns of pleural infections in Finland over three decades.</p></div><div><h3>Methods</h3><p>Data regarding each treatment episode for pleural infections in the Finnish special medical care between January 1994 and December 2016 was obtained from a national database and compared to the demographics of Finnish residents obtained from the national census bureau. The annual incidence rates, type of treatment given, as well as the lengths of the hospitalization were analyzed.</p></div><div><h3>Results</h3><p>A total of 28,463 episodes were reported, of which 55% were inpatient episodes. Of these, 76% concerned males, and the median age of patients was 60 (interquartile range 49–70) years. The overall incidence of pleural infections was 23.4 per 100.000 patient-years, with a male-to-female -ratio of 3.3:1. The annual incidence rates increased throughout the study period with an average annual percentage change of +11.4% (95% CI ±7.4%). The highest incidence rates (&gt;200 per 100.000 patient-years) were observed in men aged 80 or more. Altogether 88% of patients were treated conservatively. The proportion of patients treated by mini-invasive surgery significantly increased during study period (0–5.9%, <em>p</em> &lt; 0.001) and was associated with shorter hospitalization (median 6 [interquartile range 4–12] days) than open surgery (median 7 [4.5–13] days) (<em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The incidence of pleural infections has increased significantly over the previous decades in Finland and appears to be higher than previously reported, particularly in elderly men.</p></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101132"},"PeriodicalIF":2.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590041224000485/pdfft?md5=86148589ae8c4061d2cfb25f9ad609c8&pid=1-s2.0-S2590041224000485-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An « endo-tracheal customization » of a tracheobronchial silicone stent","authors":"Martin Boussuges,&nbsp;Aurélie Kienlen","doi":"10.1016/j.resmer.2024.101129","DOIUrl":"10.1016/j.resmer.2024.101129","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"86 ","pages":"Article 101129"},"PeriodicalIF":2.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}