Respiratory Medicine and Research最新文献

{"title":"Chest wall motion symmetry during breathing – a systematic review with meta-analysis providing normative value in healthy subjects","authors":"Laurent GAILLARD ,&nbsp;Laurent STUBBE ,&nbsp;Damien RIQUET ,&nbsp;Nicolas HOUEL","doi":"10.1016/j.resmer.2025.101244","DOIUrl":"10.1016/j.resmer.2025.101244","url":null,"abstract":"<div><h3>Background</h3><div>The physical examination of the respiratory system looks for evidence of asymmetrical breathing motion that is considered as pathologic. Optoelectronic plethysmography (OEP) is a non-invasive technic that uses motion capture to measure breathing volumes.</div></div><div><h3>Objective</h3><div>The aim of this systematic review is to research the progress made using OEP with a segmentation allowing the comparison of left and right parts of total and compartmental chest wall motion both in pathology and healthy condition.</div></div><div><h3>Methods</h3><div>Systematic research was conducted using Pubmed, ScienceDirect, Scopus and Cochrane databases. A meta-analysis was performed on the relative contribution of the right side to the total and compartmental chest wall motion in healthy subjects during quiet breathing.</div></div><div><h3>Results</h3><div>Twenty studies met the inclusion criteria. OEP accurately diagnosed pathologies that would typically be diagnosed through invasive procedures. OEP is suitable for the assessment of the effects of thoracic surgeries and pulmonary rehabilitation. The meta-analysis results show that the total chest wall motion is symmetrical with the right side contributing 50.00% ([49.24: 50.76], <em>p</em> &lt; 0.05). Compartmental chest wall motion is affected by slight asymmetries. The right part of the pulmonary rib cage (RCP) accounts for 51.02% ([49.56 : 52.47], <em>p</em> &lt; 0.05) of the RCP motion. The right part of the abdominal rib cage and the abdomen compensate with a contribution of 49.25% ([47.74 : 50.77], <em>p</em> &lt; 0.05 and 49.33% ([48.34 : 50.32], <em>p</em> &lt; 0.05) respectively.</div></div><div><h3>Conclusion</h3><div>OEP’s ability to compare left and right sides of chest wall motion during breathing is relevant to diagnose and to follow-up pathologies causing breathing asymmetries.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101244"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of systemic sclerosis on outcomes of patients hospitalized for influenza: Evidence from the US nationwide inpatient sample","authors":"Ang-Jun Liu ,&nbsp;Hen-Hong Chang ,&nbsp;Hsueh-Ting Chu ,&nbsp;Tai-Hua Yang ,&nbsp;Yu-Pei Chen","doi":"10.1016/j.resmer.2025.101232","DOIUrl":"10.1016/j.resmer.2025.101232","url":null,"abstract":"<div><h3>Background</h3><div>Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and immune dysregulation, often involving pulmonary and cardiovascular systems. Limited data exist regarding its impact on outcomes among patients hospitalized with influenza.</div></div><div><h3>Methods</h3><div>Using the US Nationwide Inpatient Sample (2016–2020), we identified adults hospitalized with a principal diagnosis of influenza using ICD-10 codes. Patients were categorized into SSc and non-SSc groups. Propensity score matching (1:4) was applied to balance baseline characteristics. Logistic and linear regression analyses estimated adjusted odds ratios (aORs) or coefficients with 95% confidence intervals (CIs) for in-hospital mortality, complications, length of stay (LOS), and adverse discharge outcomes.</div></div><div><h3>Results</h3><div>After matching, 1,265 patients (253 with SSc, 1,012 without SSc) were included, representing 6,248 hospitalizations nationwide after weighting. Compared with non-SSc patients, those with SSc had significantly higher risks of secondary bacterial or fungal infections (aOR = 1.42; 95% CI: 1.05–1.92; p = 0.025) and bronchiectasis (aOR = 3.91; 95% CI: 1.77–8.65; p &lt; 0.001). Among patients aged ≥60 years, SSc was associated with increased risks of bronchiectasis (aOR = 4.67; 95% CI: 2.13–10.24) and respiratory failure requiring mechanical ventilation (aOR = 1.47; 95% CI: 1.06–2.02). Smokers with SSc had a higher risk of shock, while non-smokers with SSc remained at elevated risk for secondary infections, bronchiectasis, and respiratory failure.</div></div><div><h3>Conclusions</h3><div>SSc was associated with excess risks of severe in-hospital complications among influenza patients, particularly in older adults and smokers, underscoring the need for targeted prevention and early intervention strategies.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101232"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving towards COPD control: Lessons, challenges, and the role of CONDOR, a new French respiratory research network","authors":"Bruno Ribeiro-Baptista ,&nbsp;Pierre-Olivier Girodet ,&nbsp;Olivier Le Rouzic ,&nbsp;Maéva Zysman ,&nbsp;Nicolas Roche ,&nbsp;Lucile Regard","doi":"10.1016/j.resmer.2025.101224","DOIUrl":"10.1016/j.resmer.2025.101224","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101224"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial lung disease mortality rates and disparities across U.S. states","authors":"Eva Ma ,&nbsp;Pengyi Zhu ,&nbsp;Niranjan Jeganathan","doi":"10.1016/j.resmer.2026.101252","DOIUrl":"10.1016/j.resmer.2026.101252","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101252"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for an underlying myeloproliferative neoplasm in patients with chronic thromboembolic pulmonary hypertension","authors":"Stephen E. Langabeer","doi":"10.1016/j.resmer.2025.101235","DOIUrl":"10.1016/j.resmer.2025.101235","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101235"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organising pneumonia following amivantamab treatment: a case report","authors":"Gaspard Naulleau ,&nbsp;Lise Matton ,&nbsp;Ioana Hutuca ,&nbsp;Xavier Fremand ,&nbsp;Florence Jeny ,&nbsp;Boris Duchemann","doi":"10.1016/j.resmer.2025.101227","DOIUrl":"10.1016/j.resmer.2025.101227","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101227"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary nodules in a histoplasmosis-endemic area: Diagnostic challenges and lessons from a case series","authors":"Sylvain Neveu ,&nbsp;Quentin Lafarge ,&nbsp;Marwan Haboub ,&nbsp;Audrey Mansuet-Lupo ,&nbsp;Milène Chaptal ,&nbsp;Chantal Raherison-Semjen","doi":"10.1016/j.resmer.2026.101275","DOIUrl":"10.1016/j.resmer.2026.101275","url":null,"abstract":"<div><h3>Introduction</h3><div>In histoplasmosis-endemic regions, pulmonary nodules often raise concern for malignancy. Distinguishing benign infectious granulomas from neoplastic lesions while limiting invasiveness is a major diagnostic challenge.</div></div><div><h3>Materials and methods</h3><div>We report a case series of 11 patients diagnosed with nodular pulmonary histoplasmosis at the University Hospital of Guadeloupe, a French West Indies institution located in an endemic area. Clinical, radiologic, microbiologic, and histopathologic data were retrospectively reviewed.</div></div><div><h3>Results</h3><div>All 11 patients presented with solid pulmonary nodules associated with mediastinal and/or hilar lymphadenopathy, mimicking locally advanced lung cancer. Among the nine patients who underwent 18F-FDG PET/CT, all but one showed hypermetabolic activity in the nodule. Five patients were immunocompromised, and notably, four of the eleven patients were treated for rheumatoid arthritis. Diagnosis was established through surgical resection in five cases, percutaneous or lymph node biopsy in another five, and bronchoalveolar lavage (BAL) alone in one patient. Serologic testing was positive in all five patients tested, and <em>H. capsulatum</em> PCR on BAL was positive in two of the four cases tested. Exposure history and clinical context supported the diagnosis in several cases, but noninvasive tests alone were generally insufficient to exclude malignancy.</div></div><div><h3>Conclusion</h3><div>This series illustrates the diagnostic difficulty of pulmonary nodules in histoplasmosis-endemic areas and the frequent need for invasive procedures. The development of improved, noninvasive diagnostic strategies is essential to avoid unnecessary surgery while ensuring timely cancer diagnosis.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101275"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of having pulmonary embolism response team (PERT) on outcome of pulmonary embolism: A systematic review and meta-analysis","authors":"Sagun Dawadi ,&nbsp;Dhan Bahadur Shrestha ,&nbsp;Prakash Raj Oli ,&nbsp;Raj Kumar Thapa ,&nbsp;Jurgen Shtembari ,&nbsp;Amit Bhandari ,&nbsp;Daniel H. Katz","doi":"10.1016/j.resmer.2025.101245","DOIUrl":"10.1016/j.resmer.2025.101245","url":null,"abstract":"<div><h3>Introduction</h3><div>Pulmonary embolism (PE) continues to pose a significant challenge in clinical practice. Selecting the optimal management approach is complicated by conflicting societal guidelines, which can hinder the care team's ability to deliver effective therapies in timely fashion. To address this complexity, the Pulmonary Embolism Response Team (PERT) was introduced in 2012. This study evaluates the effectiveness of PERT and explores its integration as a standard of care for PE management.</div></div><div><h3>Methods</h3><div>A systematic search of databases was conducted from inception to April 2024. Relevant references were identified and imported for analysis. Statistical evaluation was performed using RevMan Web, using odds ratios (OR) for dichotomous outcomes and mean differences (MD) for continuous outcomes.</div></div><div><h3>Results</h3><div>The analysis included 23 studies, comprising 15,621 patients in two groups: patient managed by PERT, n=5,555 and patient managed with standard treatment without PERT, n=10,066. The use of PERT significantly lowered odds of 30-day or in-hospital mortality (OR 0.76, CI 0.59-0.99) but significantly increased the utilization of advanced therapeutic strategies (OR 3.45, CI 1.95-6.09). Although PERT demonstrated favorable odds for reduced major bleeding events and earlier achievement of therapeutic anticoagulation but could not achive statistcal significance. Also, while PERT was associated with higher odds of ICU admission (OR 2.41, CI 1.33-4.34)but significantly reduced the length of ICU stay (MD -0.67, CI -1.28 to -0.05).</div></div><div><h3>Conclusion</h3><div>PERT implementation has been associated with reduced mortality, shorter ICU stays, at cost of higher utilization of advanced therapies. However, given that most studies are observational, these findings should be interpreted cautiously, and higher-quality research is needed to establish definitive benefit.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101245"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty in COPD hospitalized patients: Associated factors from a multicentre cohort study","authors":"Cristóbal Esteban ,&nbsp;María Gascón ,&nbsp;Eva Tabernero ,&nbsp;Patricia Sobradillo ,&nbsp;Monica Rayón ,&nbsp;Ignacio García-Talavera ,&nbsp;Amaia Aramburu ,&nbsp;Leyre Chasco ,&nbsp;José M. Quintana ,&nbsp;the ReEPOC-REDISSEC group","doi":"10.1016/j.resmer.2025.101239","DOIUrl":"10.1016/j.resmer.2025.101239","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the study was to determine the association between frailty and hospitalizations, mid-term mortality and medical readmissions, and to evaluate the relationship between frailty and other variables, such as dependence, anxiety, depression and health-related quality of life in a cohort of COPD patients after admission due to exacerbation (eCOPD).</div></div><div><h3>Methods</h3><div>Prospective observational cohort study conducted across nine Spanish hospitals. Patients were recruited consecutively. Variables relating to the patients' clinical baseline status were recorded, including the Tilburg Frailty Indicator (TFI), EuroQol EQ-5D, the COPD Assessment Test (CAT), Yale Physical Activity Survey (YPAS); the mMRC Dyspnea Scale, Hospital Anxiety and Depression Scale (HAD), and the Duke-UNC scale.</div></div><div><h3>Results</h3><div>1638 COPD patients were studied, with a mean age of 72.4 (SD 10.3), 77 % male, mean FEV1 49.4 % (SD 19.2), median Charlson index 2; mean CAT 21.3 (SD 9.1). In the multivariate analysis, the variables independently associated with frailty were older age, female sex, comorbidities, health-related quality of life, dyspnea, dependence, anxiety, depression, and physical activity. Multivariable survival regression analysis identified TFI, sex, and previous hospitalizations as predictors of one-year mortality. These variables, together with comorbidities, were associated with the risk of readmission due to any medical condition during the 1-year follow-up.</div></div><div><h3>Conclusions</h3><div>Frailty was associated with admission due to eCOPD and to the number of hospitalizations. In COPD, a single hospitalization should be considered a warning sign for frailty. Variables such as dependence, anxiety, depression and HRQoL were independent predictors of frailty. Additionally, frailty was associated with mortality and medical readmissions in the following year.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101239"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive peptides in therapeutic α1-Antitrypsin preparations modulate neutrophil chemokine receptors: Implications for augmentation therapy","authors":"Julia Held ,&nbsp;Jing Liu ,&nbsp;Friedemann R. Börner ,&nbsp;Michael Kiehntopf ,&nbsp;Sabine Wrenger ,&nbsp;Sabina Janciauskiene","doi":"10.1016/j.resmer.2026.101249","DOIUrl":"10.1016/j.resmer.2026.101249","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101249"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}