Respiratory Medicine and Research最新文献

{"title":"Analysis of Exhaled Breath and Serum Markers Following a Single Bout of Exercise in COPD Patients - a Case-Control Study.","authors":"Rembert Koczulla, Tobias Boeselt, Albrecht Sitte Zoellner, Rainer Gloeckl, Daniela Kroll, Inga Jarosch, Tessa Schneeberger, Julia Held, Sabina Janciauskiene","doi":"10.1016/j.resmer.2025.101193","DOIUrl":"https://doi.org/10.1016/j.resmer.2025.101193","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"101193"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Remdesivir on long-term outcomes in lung transplant recipients with SARS-CoV-2 infection: a retrospective cohort analysis.","authors":"Damiana-Maria Vulturar, Gaëlle Dauriat, Anne Gigandon, Pauline Pradère, Pierre Gazengel, Samuel Dolidon, Chahine Medraoui, Amir Hanna, Adrian Crutu, Liviu-Stefan Moaca, Laurène Cachera, Delphine Mitilian, Dominique Fabre, Elie Fadel, Olaf Mercier, Alban Le Monnier, Jérôme Le Pavec, Benoît Pilmis","doi":"10.1016/j.resmer.2025.101192","DOIUrl":"https://doi.org/10.1016/j.resmer.2025.101192","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has presented considerable challenges for lung transplant (LTx) recipients, a population inherently at high risk for severe complications. Although early data from the pandemic indicated worrisome outcomes for these patients, understanding the current context of SARS-CoV-2 infections is essential to inform ongoing management strategies. The efficacy of anti-viral treatments, including Remdesivir (RDV), remains uncertain. This study aims to evaluate the effect of RDV on clinical outcomes in LTx recipients infected with SARS CoV-2, primarily those with a clinically significant disease course.</p><p><strong>Methods: </strong>A single-center retrospective cohort study was conducted, including LTx recipients with confirmed SARS-CoV-2 infection diagnosed between January 2022 and December 2023. Patients were classified as treated with RDV if they received at least three consecutive days of therapy, typically initiated in the context of symptomatic infection with increased oxygen requirements (RDV group). The primary outcome was all-cause mortality. Secondary outcomes were ICU admission, longitudinal changes in lung function, at 3-, 6-, and 12-months post-infection, incidence of COVID-19-associated pulmonary aspergillosis (CAPA) and bacterial co-infections. A multivariable logistic regression model was used to control for cofounding factors.</p><p><strong>Results: </strong>Among the 130 LTx infected with SARS CoV-2, 61% (80/130) received at least 3 days of RDV. All cause of mortality was lower in the RDV group (4% 2/50) compared to the non-RDV group (15%, 12/80) (p= 0.05). Non-RDV group experienced a significant decline in forced expiratory volume in 1 second (FEV1) at 3 months post-infection compared to those in the RDV group (6% vs 3%, p = 0.04). ICU admission rates, bacterial coinfection, and CAPA were similar between groups.</p><p><strong>Conclusion: </strong>RDV treatment appears to improve survival and may mitigate the long-term deterioration of lung function in lung transplant recipients infected with SARS CoV-2. These findings underscore the potential of RDV as a beneficial therapy in this high-risk population and highlight the need for further investigation in larger studies.</p>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"101192"},"PeriodicalIF":1.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and extensive calcification of pulmonary arteries","authors":"Sahbi Guezara ,&nbsp;Vincent Cottin ,&nbsp;Giulia Francese ,&nbsp;Mohamed Bakloul ,&nbsp;Sara Boccalini ,&nbsp;Ségolène Turquier","doi":"10.1016/j.resmer.2025.101189","DOIUrl":"10.1016/j.resmer.2025.101189","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101189"},"PeriodicalIF":1.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-synthetase syndrome: A focus on interstitial lung disease as a diagnostic criteria","authors":"Jessica A. Peterson ,&nbsp;Caroline Cook ,&nbsp;Hanzhi Gao ,&nbsp;Raju Reddy ,&nbsp;Bruno Hochhegger ,&nbsp;Diana Gomez-Manjarres ,&nbsp;Faye Pais","doi":"10.1016/j.resmer.2025.101190","DOIUrl":"10.1016/j.resmer.2025.101190","url":null,"abstract":"<div><h3>Background</h3><div>Anti-synthetase syndrome (ASyS) is an autoimmune disorder with clinical manifestations that often include interstitial lung disease (ILD), myositis, and arthritis. Although it shares features with other idiopathic inflammatory myopathies, ILD is more prevalent and often more severe in this syndrome. The aim of this study was to compare Connors and Solomon diagnostic criteria for ASyS and investigated whether the presence of no additional symptoms, one additional symptom, or two or more symptoms, in addition to ILD and relevant antibodies, would indicate a worse prognosis.</div></div><div><h3>Methods</h3><div>This retrospective single-center study examined patients who were previously diagnosed with ASyS based on Connors or Solomon criteria and were further categorized using the 273rd ENMC International workshop criteria and post-hoc. The patients were then stratified based upon how many “defining” signs and symptoms that they had in addition to ILD and antibodies. Demographic characteristics, pulmonary function tests (PFT), chest CT’s—along with clinical outcomes were assessed.</div></div><div><h3>Results</h3><div>No differences in demographic factors and PFT’s were found between those who were diagnosed using Solomons versus Connors criteria. No differences in demographic, PFT’s and chest CT’s between those with ILD and antibodies only, with 1 additional criteria, and with 2+ additional criteria groups, although those with two or more additional criteria had a longer duration since diagnosis.</div></div><div><h3>Discussion</h3><div>Key findings from the study suggest that there are no differences in diagnostic outcomes, therapeutic interventions, or mortality rates when using different criteria to diagnose ASyS. This study suggests a reevaluation of diagnostic criteria for ASyS to prioritize ILD and relevant antibodies rather than a focus of additional criteria, supporting the new ASyS defining criteria from 273rd ENMC International Workshop (2024).</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101190"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging respiratory challenges in space and long-duration missions","authors":"Benjamin Pequignot ,&nbsp;Seamus Thierry ,&nbsp;G Kim Prisk ,&nbsp;Mickael Lescroart","doi":"10.1016/j.resmer.2025.101188","DOIUrl":"10.1016/j.resmer.2025.101188","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101188"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of complementary medicines and self-medication practices in cystic fibrosis – MUCAUTOMED study","authors":"Sophie Lemagner ,&nbsp;Isabelle Récoché ,&nbsp;Frédéric Eyvrard ,&nbsp;Remy Chambault ,&nbsp;Marie Mittaine ,&nbsp;Marlène Murris","doi":"10.1016/j.resmer.2025.101186","DOIUrl":"10.1016/j.resmer.2025.101186","url":null,"abstract":"<div><h3>Background</h3><div>Cystic fibrosis (CF) patients often undergo treatment with CFTR modulators, which have demonstrated high efficacy but also potential involvement in drug interactions. Inquiries regarding the risks of drug interactions with complementary and alternative medicine products (CAMp) and self-medication drugs have become frequent among patients and prescribers at Toulouse University Hospital. Currently, there is lack of literature on these practices within CF patients, particularly in France, and more so since the advent of CFTR modulators.</div></div><div><h3>Methods</h3><div>This observational monocentric study (MUCAUTOMED) aimed to characterize and quantify the prevalence of CAMp utilization among CF patients under our hospital's care. A secondary objective was to assess and describe the prevalence of self-medication practices. Surveys were administered to outpatients during visits from January 10 to June 6, 2022.</div></div><div><h3>Results</h3><div>Out of 171 included patients, responses from 64 adults and 69 children were analyzed (response rate 133/171 = 77.8 %). CAMp usage was reported by 56.3 % of adults and 46.4 % of children. Most patients use CAMp for enhancing wellness, addressing digestive concerns, and managing respiratory issues. Remarkably, 71.4 % of participants were unaware of potential drug interactions with CAMp, and 48.9 % initiated such use without consulting healthcare professionals. Notably, a significant correlation between CAMp utilization and self-medication was identified within the pediatric population.</div></div><div><h3>Conclusion</h3><div>Our investigation underscores a notably high prevalence of CAMp use among the CF population. Given these findings, it is imperative to routinely discuss CAMp utilization and self-medication practices when initiating CFTR modulator therapy. A multidisciplinary approach is recommended to address potential interactions that may impact overdosing and underdosing, ensuring patients and families are informed of associated risks.</div><div>Registration number 2021-A02593-38.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101186"},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of hemi-cannula in patients with high risk of recannulation in an intermediate respiratory care unit. A descriptive analysis and study of the predictor variables of the use of posterior non-invasive mechanical ventilation","authors":"Sergio Lopez-Ruz,&nbsp;Alba Fernández-Boza,&nbsp;Maria Andrea Jaimes-Castaño,&nbsp;Carlos Carrera-Cueva,&nbsp;Belen Muñoz-Sánchez,&nbsp;Emilio Garcia-Díaz,&nbsp;Demetrio González-Vergara,&nbsp;Javier Toral-Marin,&nbsp;Maria Barca-Hernando","doi":"10.1016/j.resmer.2025.101185","DOIUrl":"10.1016/j.resmer.2025.101185","url":null,"abstract":"<div><h3>Background</h3><div>Information about the decannulation process in patients with high risk of recannulation is limited. However, devices such as the hemi-cannula, which maintain airway permeability for a controlled period, may enhance the safety of this process.</div></div><div><h3>Aims</h3><div>Describe and analyze the variables in the decannulation process of patients with high risk of recannulation, who have used a hemi-cannula and correlate these variables with the posterior need for Non-Invasive Mechanical Ventilation (NIMV).</div></div><div><h3>Methods</h3><div>Unicentric study analyzing a retrospective cohort of consecutive patients admitted to the Intermediate Respiratory Care Unit (IRCU) to continue the decannulation process from April 2022 to April 2024. Sociodemographic and clinical variables were described and analyzed. SPSS software was used to analyze the data with T student for independent data and Chi-square with Fischer correction.</div></div><div><h3>Results</h3><div>The final cohort included 19 patients, whom most of them had no previous respiratory pathology, but a 47.4 % had some cardiovascular risk factors. All of the patients had polyneuropathy at the admission to the IRCU. No 30-day mortality was observed in any patient. The recannulation rate was 10.5 %. 21 % of the patients required subsequent NIMV. Statistical significance at the analysis of the correlation between the mean number of days of Invasive Mechanical Ventilation (IMV) and the need for subsequent NIMV was found. However, there was not with the remaining variables.</div></div><div><h3>Conclusions</h3><div>The use of devices such as the hemi-cannula can enhance safety during the complex decannulation process in patients with high risk of recannulation, reducing the likelihood of reintubation or readmission to the Intensive Care Unit (ICU).</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101185"},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does occupational exposure affect the surgical management of patients with non-small cell lung cancer? A single-center retrospective experience","authors":"Matthieu Thumerel ,&nbsp;Camille Carles ,&nbsp;Hugues Begueret ,&nbsp;Quentin Thomas ,&nbsp;Jacques Jougon ,&nbsp;Carine Audoin ,&nbsp;Jean-François Bernaudin ,&nbsp;Patrick Brochard ,&nbsp;Yaniss Belaroussi","doi":"10.1016/j.resmer.2025.101183","DOIUrl":"10.1016/j.resmer.2025.101183","url":null,"abstract":"<div><h3>Objective</h3><div>Non-small-cell lung cancer (NSCLC) remains a major public health concern, with tobacco and environmental exposures to carcinogens (such as asbestos, radon, and silica) recognized as major risk factors. This study investigates the impact of occupational exposure, particularly to crystalline silica on peri‑ and postoperative outcomes in patients undergoing surgery for NSCLC.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 251 patients who underwent lobectomy or segmentectomy between 2018 and 2021, with occupational exposure data collected postoperatively.</div></div><div><h3>Results</h3><div>Our findings suggest that patients with occupational exposure, particularly to silica, asbestos, or multiple carcinogens, have more complex surgical courses, including longer operative times, higher rates of conversion from minimally invasive to open surgery, and increased postoperative complications (Clavien-Dindo grade II or higher). Preoperative lymph node staging was less accurate in exposed patients, in part because of inflammatory changes such as fibro-hyaline lesions, which can cause false-positive PET/CT findings.</div></div><div><h3>Conclusions</h3><div>The study highlights the need for tailored surgical strategies and accurate lymph node staging in exposed individuals. Future research should focus on prospective studies to refine perioperative management and explore the biological mechanisms driving these complications.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101183"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should segmentectomy indications be extended to NSCLC smaller than 3 cm without lymph node involvement? A retrospective single-center study","authors":"Damien Leveque ,&nbsp;Soufiane Lebal ,&nbsp;Tristan Goudou ,&nbsp;Mihaela Giol ,&nbsp;Denis Debrosse ,&nbsp;Marielle LE Roux ,&nbsp;Thérésa Khalife-Hocquemiller ,&nbsp;Anna Vayssette ,&nbsp;Juliette Camuset ,&nbsp;Alexandra Rousseau ,&nbsp;Jalal Assouad ,&nbsp;Harry Etienne","doi":"10.1016/j.resmer.2025.101179","DOIUrl":"10.1016/j.resmer.2025.101179","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical resection remains the standard treatment for stage IA non-small cell lung cancers (NSCLC). The dual objective of this study is to compare long-term outcomes of lobectomies and segmentectomies for stage IA NSCLC and to identify prognostic factors for resected stage IA NSCLC.</div></div><div><h3>Materials and Methods</h3><div>This is a retrospective monocentric study including patients diagnosed with NSCLC smaller than 3 cm, without lymph node involvement, from November 2015 to November 2021. The primary endpoint was event-free survival (EFS), defined as time from surgery to recurrence or all-cause death. Secondary endpoints included overall survival, recurrence-free survival, and short-term postoperative outcomes (length of stay, drainage duration, 30-day mortality, and postoperative complications). Prognostic factors were analyzed using multivariate Cox regression adjusted for variables identified in univariate analysis.</div></div><div><h3>Results</h3><div>A total of 457 patients underwent surgery for stage cIA NSCLC during the 11study period. Of these, 176 (38.5 %) had a segmentectomy, and 281 (61.5 %) underwent lobectomy. Among patients with cT1N0 tumors, the 5-year event-free survival did not significantly differ between the segmentectomy and lobectomy groups (adjusted HR = 0.59 (0.32; 1.08), <em>p</em> = 0.086), with 5-year event-free rates of 75.0 % and 83.0 %, respectively (<em>p</em> = 0.054). Multivariate analysis revealed an association between nodule type (solid vs. ground-glass or mixed) and event-free survival (death and/or recurrence) ([adjusted HR =2.07 (1.17–3.66), <em>p</em> = 0.01)]. Vascular and/or lymphatic invasion is associated with a decrease in event-free survival (recurrence or death) [adjusted HR = 2.25 (1.29; 3.92), <em>p</em> = 0.004]. Conversion from segmentectomy to lobectomy occurred in 6 patients (3.4 %), and they were included in the lobectomy group for analysis.</div></div><div><h3>Conclusion</h3><div>For patients with clinical stage cIA NSCLC, segmentectomy appears to offer comparable oncologic outcomes to lobectomy. Tumor characteristics, including radiological appearance and histological factors, should be carefully considered when selecting the appropriate surgical strategy. Prospective multicenter studies are needed to confirm these findings.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101179"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early mobilization and functional outcomes in cystic fibrosis patients after lung transplantation: A single-center retrospective study","authors":"Matthieu Reffienna ,&nbsp;Jeremy Roussel ,&nbsp;Gabor Kalman ,&nbsp;Mathilde Labro ,&nbsp;Charles Cerf ,&nbsp;François Parquin","doi":"10.1016/j.resmer.2025.101184","DOIUrl":"10.1016/j.resmer.2025.101184","url":null,"abstract":"<div><h3>Background</h3><div>Rehabilitation has been shown to enhance patient performance before and after lung transplantation, but limited data exist on its role during the immediate post-transplant phase in critical care units.</div></div><div><h3>Methods</h3><div>We conducted a single-center retrospective study. All adult patients who underwent bilateral transplantation for cystic fibrosis were included. Patients were followed from admission to discharge from critical care. All rehabilitation sessions were recorded. We aimed to evaluate the relationship between the amount of mobilization performed by the patient in critical care, and functional performance at discharge.</div></div><div><h3>Results</h3><div>We included 36 patients (21 males) with a median age of 29 years (IQR: 24.5–35.0) and a median critical care length of stay of 15 days (12.5–20). Patients performed a total of 388 sessions of rehabilitation. Out-of-bed mobilization started at a median of post-operative day 2.5 (IQR: 1.0–4.5), with the first walking session at day 3 (IQR: 2.0–4.5). A strong correlation was found between daily walking distance and functional performance, as measured by the 6-minute walk test, with a Pearson correlation coefficient of 0.70 (95 % CI: 0.48–0.84).</div></div><div><h3>Conclusions</h3><div>After lung transplantation for cystic fibrosis, early initiated rehabilitation in critical care is feasible and can improve patients' functional performance. These findings are promising, but require validation in other lung transplant populations.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101184"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}