Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv最新文献_第5页

Anal cancer in people living with HIV: 36 years' experience of a Greek reference center. 艾滋病毒感染者的肛门癌：希腊参考中心36年的经验。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-29 DOI: 10.1080/09540121.2025.2562240

Ioanna A Paschou, Eleni Paparizou, Anastasia Politi, Anastasios Skliris, Theodora Douvali, Vassilios Paparizos, Alexander J Stratigos, Varvara Vasalou

{"title":"Anal cancer in people living with HIV: 36 years' experience of a Greek reference center.","authors":"Ioanna A Paschou, Eleni Paparizou, Anastasia Politi, Anastasios Skliris, Theodora Douvali, Vassilios Paparizos, Alexander J Stratigos, Varvara Vasalou","doi":"10.1080/09540121.2025.2562240","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562240","url":null,"abstract":"This retrospective study examines the incidence and characteristics of anal cancer among people living with HIV over a 36-year period at a Greek reference center. A total of 3,105 patients followed at the Special Infectious Diseases Unit of \"Andreas Sygros\" Hospital were evaluated for demographic and clinical data, including CD4 counts and outcomes. Thirty-one cases of anal cancer were identified, predominantly among males (29/31). The mean age at diagnosis was 48.81 years, and CD4 counts were low at diagnosis (mean 378.6 cells/mm³). 14 patients died from anal cancer, 4 from other causes, 10 remain under follow-up, and 3 were lost to follow-up. These findings highlight that people with HIV, especially those with low CD4 counts, face an increased risk of anal cancer even with effective antiretroviral therapy. Persistent HPV co-infection exacerbates this risk. Regular screening, early detection, and preventive measures such as vaccination and behavioral interventions are essential to reduce disease burden and mortality. Psychosocial factors - including HIV-related stigma, anal sex stigma, and limited social support - may also affect healthcare engagement and willingness for anal cancer screening. Addressing these factors alongside medical interventions is crucial for prevention and early diagnosis.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Religiosity, gender and knowledge gaps: factors influencing HIV/AIDS discrimination among medical interns. 宗教信仰、性别和知识差距：影响医务实习生对艾滋病毒/艾滋病歧视的因素。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-29 DOI: 10.1080/09540121.2025.2562244

Adil Bahadir, Alperen Baki, Sude Bakkal, Omer Baran Bali, Aslı Davas

{"title":"Religiosity, gender and knowledge gaps: factors influencing HIV/AIDS discrimination among medical interns.","authors":"Adil Bahadir, Alperen Baki, Sude Bakkal, Omer Baran Bali, Aslı Davas","doi":"10.1080/09540121.2025.2562244","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562244","url":null,"abstract":"Discrimination against people living with HIV/AIDS remains a pervasive problem among medical trainees. This cross-sectional study aimed to identify factors influencing discriminatory attitudes among sixth-year medical trainees at Turkey's largest medical school during the 2023-2024 academic year. Data were collected from 295 participants, with a response rate of 83.3%. Discriminatory attitudes were assessed using a validated 16-item scale, while independent variables included gender, religiosity and participation in HIV/AIDS training. Knowledge was measured with 23 questions in five categories, including legal rights and prevention methods. Significant knowledge gaps, including legal and preventive domains, were revealed. For instance, 30.2% of participants incorrectly believed HIV cannot be transmitted via breastfeeding, and 26.4% thought physicians could legally refuse to treat people living with HIV/AIDS. The mean discrimination score was 28.2 ± 12.3 (range: 16-80), indicating stronger stigmatizing attitudes in certain subgroups. Male trainees and those reporting strong religiosity exhibited significantly higher discrimination scores (p = 0.0001). Participation in HIV/AIDS-specific training was associated with lower discrimination scores in bivariate analysis (p = 0.033). A strong negative association between HIV knowledge and discriminatory attitudes remained significant. These findings underscore the immediate need to integrate structured, evidence-based, sensitively designed HIV education into medical training.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-11"},"PeriodicalIF":1.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

End-user preferences for biomedical HIV prevention products and service delivery models: a mixed methods study with female university students in Zambia. 最终用户对生物医学艾滋病毒预防产品和服务提供模式的偏好：对赞比亚女大学生的混合方法研究

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-26 DOI: 10.1080/09540121.2025.2560096

Twaambo Euphemia Hamoonga, Karen Hampanda, Madeleine Sehrt, Lillian Nayame, Inyambo Mumbula, Julia Thorne, Mulanda Joseph Mulawa, Oliver Mweemba

{"title":"End-user preferences for biomedical HIV prevention products and service delivery models: a mixed methods study with female university students in Zambia.","authors":"Twaambo Euphemia Hamoonga, Karen Hampanda, Madeleine Sehrt, Lillian Nayame, Inyambo Mumbula, Julia Thorne, Mulanda Joseph Mulawa, Oliver Mweemba","doi":"10.1080/09540121.2025.2560096","DOIUrl":"https://doi.org/10.1080/09540121.2025.2560096","url":null,"abstract":"Adolescent girls and young women in sub-Saharan Africa are disproportionately affected by HIV. We determined acceptability and desirability of pre-exposure prophylaxis products and delivery modalities among female university students in Zambia. In 2022, we conducted an online survey (n = 806) and focus group discussions (n = 34) with female students at a public university in Zambia, focused on PrEP products and service delivery preferences. Descriptive statistics and qualitative themes were integrated, compared, and synthesized. The most preferred PrEP products were once-a-month oral pills (35%); a one-time vaccine (33%); and 2-monthly or 3-monthly injection (20%). Few (<5%) preferred the implant, vaginal gel, or vaginal ring. Qualitative themes confirmed preferences for longer-acting PrEP options. However, some participants were hesitant to use an injection and expressed desire for an oral pill that could be taken after sex. Any product that required insertion into the vagina was generally unacceptable and least desired. Most (54%) participants wanted to access PrEP in a non-clinical setting due to anticipated stigma of being seen at an HIV clinic/service area. Expanding PrEP choices, specifically longer-acting and on-demand products, along with differentiated service delivery models beyond the traditional HIV clinic are desirable attributes to female university students in Zambia.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-11"},"PeriodicalIF":1.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depressive symptomatology and their correlates among caregivers of children and adolescents living with HIV in KwaZulu-Natal, South Africa. 南非夸祖鲁-纳塔尔省感染艾滋病毒的儿童和青少年照料者的抑郁症状及其相关性

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-25 DOI: 10.1080/09540121.2025.2562235

Reuben Christopher Moyo, Eugene Lee Davids, Lovemore Sigwadi Nyasha, Stanley Carries, Audrey Moyo, Andrew Gibbs, Nwabisa Shai, Kalysha Closson, Laura Washington, Nokwanda Sithole, Arvin Bhana, Nelly Mwandacha, Angela Kaida, Darshini Govindasamy

{"title":"Depressive symptomatology and their correlates among caregivers of children and adolescents living with HIV in KwaZulu-Natal, South Africa.","authors":"Reuben Christopher Moyo, Eugene Lee Davids, Lovemore Sigwadi Nyasha, Stanley Carries, Audrey Moyo, Andrew Gibbs, Nwabisa Shai, Kalysha Closson, Laura Washington, Nokwanda Sithole, Arvin Bhana, Nelly Mwandacha, Angela Kaida, Darshini Govindasamy","doi":"10.1080/09540121.2025.2562235","DOIUrl":"10.1080/09540121.2025.2562235","url":null,"abstract":"Background: Few studies have examined factors linked to depressive symptomatology among caregivers of children and adolescents living with HIV (CALHIV). This study estimated prevalence of depressive symptoms and identified associated factors among caregivers of CALHIV in KwaZulu-Natal, South Africa.Methods: We used baseline data from a cluster-randomised controlled trial of the impact of a cash transfer program and an economic empowerment intervention on health and well-being caregivers of CALHIV. Depressive symptoms were assessed using 10-item Centre for Epidemiologic Studies Depression Scale (CES-D-10), with score of ≥12 indicating presence depressive symptomatology. Correlates of depressive symptoms were identified using multilevel generalised linear models.Results: The prevalence of depressive symptoms was 57% (95% CI: 51% - 63%). Factors associated with increased odds of depressive symptomatology were residing in peri-urban (OR = 4.80, p = 0.038), having any form of disability (OR = 8.12, p = 0.001), having existing medical condition (OR = 3.27, p = 0.009), experiencing physical abuse in the past 12 months (OR = 3.53, p = 0.020), and low social support (OR = 3.94, p = 0.005).Conclusion: The prevalence of depressive symptoms was high among Caregivers of CALHIV. These findings highlight the need for targeted, context-specific interventions that include mental health screening for caregivers to support their mental health and well-being.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the influence of provider communication and language reframing on HIV pre-exposure prophylaxis (PrEP) engagement with Black African and Caribbean women: a systematic review. 调查提供者沟通和语言重构对非洲和加勒比黑人妇女艾滋病毒暴露前预防（PrEP）参与的影响：一项系统评价。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-24 DOI: 10.1080/09540121.2025.2560097

Maksida Sabackic, Ayeshah Emon, Pamela Menzies-Banton, Renee West

{"title":"Investigating the influence of provider communication and language reframing on HIV pre-exposure prophylaxis (PrEP) engagement with Black African and Caribbean women: a systematic review.","authors":"Maksida Sabackic, Ayeshah Emon, Pamela Menzies-Banton, Renee West","doi":"10.1080/09540121.2025.2560097","DOIUrl":"https://doi.org/10.1080/09540121.2025.2560097","url":null,"abstract":"Patient-provider engagement with HIV pre-exposure prophylaxis (PrEP) continues to exhibit significant disparities, particularly among Black African and Caribbean (BAC) women. In the United Kingdom, cisgender women accounted for one-third of HIV diagnoses in 2022, with 64.1% of these cases occurring among BAC women, underscoring a critical gap in equitable access to PrEP information and services. This systematic review explored health service provider-level communication barriers and facilitators influencing PrEP uptake and engagement with BAC women. A comprehensive search across four databases yielded 31 eligible studies examining provider communication about PrEP with BAC women. Thematic analysis identified two key areas: the role of provider communication in PrEP engagement and the importance of reframing language. Barriers included limited provider-initiated conversations, insufficient medical knowledge about PrEP for women, and medical mistrust driven by racial bias and stigma. Facilitators included culturally sensitive, nonjudgmental communication approaches and the strategic reframing of the language surrounding PrEP as a tool for empowerment rather than solely risk reduction. These findings highlight the need for improved provider communication strategies and support the adoption of more inclusive and affirming dialogue to foster equitable PrEP engagement among BAC women, who remain disproportionately excluded from current PrEP narratives.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-16"},"PeriodicalIF":1.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disclosure concerns moderate the association between internalized stigma and antiretroviral medication adherence among people with HIV in the Dominican Republic. 披露问题缓和了多米尼加共和国艾滋病毒感染者内化耻辱与抗逆转录病毒药物依从性之间的关联。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-24 DOI: 10.1080/09540121.2025.2562253

Ibrahim Yigit, Robert Paulino-Ramírez, John Waters, Janet M Turan, Henna Budhwani

{"title":"Disclosure concerns moderate the association between internalized stigma and antiretroviral medication adherence among people with HIV in the Dominican Republic.","authors":"Ibrahim Yigit, Robert Paulino-Ramírez, John Waters, Janet M Turan, Henna Budhwani","doi":"10.1080/09540121.2025.2562253","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562253","url":null,"abstract":"HIV-related stigma remains a significant barrier to antiretroviral therapy (ART) adherence among people with HIV (PWH). Internalized stigma has been consistently linked to poorer ART adherence. However, the role of disclosure concerns, worries or fears about revealing one's HIV status, remains unclear. This study examines whether disclosure concerns moderate the relationship between internalized stigma and ART adherence among PWH in the Dominican Republic. Data were drawn from 471 PWH recruited from two HIV clinics as part of a cluster-randomized pilot trial. Using moderation analyses, we found that internalized stigma was significantly associated with lower ART adherence (B = -2.30, p = .002), while disclosure concerns alone were not. However, disclosure concerns significantly moderated the relationship between internalized stigma and adherence (B = 1.68, p = .023), such that internalized stigma was significantly associated with poorer ART adherence at low levels of disclosure concerns (B = -4.18, p = .002, CI [-6.815, -1.546]) but not at high levels (B = -.59, p = .437, CI [-2.076, .898]). These findings suggest that, in certain contexts, higher disclosure concerns may buffer against the adverse effects of internalized stigma on medication adherence, possibly by motivating individuals to maintain viral suppression to avoid disclosure. Stigma-reduction interventions should target internalized stigma while addressing the complex role of disclosure concerns in HIV care.Trial registration: ClinicalTrials.gov identifier: NCT04491539.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceived stigma mediates the relationship between regional gray matter volume and aggressive behavior in children affected by parental HIV/AIDS. 感知耻感在父母感染HIV/AIDS的儿童脑灰质体积与攻击行为之间起中介作用。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-24 DOI: 10.1080/09540121.2025.2559358

Huang Gu, Chunmei Qian, Roger D Newman-Norlund, Junfeng Zhao, Xiaoming Li

{"title":"Perceived stigma mediates the relationship between regional gray matter volume and aggressive behavior in children affected by parental HIV/AIDS.","authors":"Huang Gu, Chunmei Qian, Roger D Newman-Norlund, Junfeng Zhao, Xiaoming Li","doi":"10.1080/09540121.2025.2559358","DOIUrl":"https://doi.org/10.1080/09540121.2025.2559358","url":null,"abstract":"Perceived stigma, the subjective awareness of prejudice, stereotypes, and discrimination against persons living with HIV and their children, is a recognized predictor of behavioral problems. However, the neurobiological basis underlying perceived stigma and its role in influencing aggressive behavior at neural level in children affected by parental HIV/AIDS remain largely unclear. In this study, 112 participants aged 10-17 years from a large neurobiological project were extracted for gray matter volume (GMV) in the prefrontal cortex (PFC) and medial temporal lobe (MTL). The results revealed a significant positive correlation between parahippocampal gyrus volume and perceived stigma, after correcting for multiple comparisons. Mediation analysis further demonstrated that perceived stigma mediated the relationship between GMV in the parahippocampal gyrus and aggressive behavior. These findings support the stress acceleration hypothesis, suggesting children exposed to chronic stress accelerate neurodevelopment, particularly in the stress and emotional processing regions. Our study advances the neurostructural understanding of stigma processing and provides clinical insights for targeted interventions in this high-risk population and other marginalized children.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current situation and correlates of perceived stigma among people living with HIV: a cross-sectional study in China. 中国HIV感染者污名的现状及相关因素：一项横断面研究。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-24 DOI: 10.1080/09540121.2025.2562245

Ben Chen, Yukun Zhang, Shuyu Han, Zhongfang Yang, Yue Zhang, Lin Zhang, Beibei Gong, Hongli Yang, Yanfen Fu, Jing Cao, Yan Hu

引用次数: 0

Patient preferences for violence screening in HIV care settings. 艾滋病毒护理机构中患者对暴力筛查的偏好。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-23 DOI: 10.1080/09540121.2025.2562243

Ameeta S Kalokhe, Katherine M Anderson, Madelyn S Carlson, Celeste K Ellison, Sophia C Garbarino, Selaem Hadera, Caroline W Kokubun, Eve Rose, Jessica M Sales

{"title":"Patient preferences for violence screening in HIV care settings.","authors":"Ameeta S Kalokhe, Katherine M Anderson, Madelyn S Carlson, Celeste K Ellison, Sophia C Garbarino, Selaem Hadera, Caroline W Kokubun, Eve Rose, Jessica M Sales","doi":"10.1080/09540121.2025.2562243","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562243","url":null,"abstract":"Experiences of interpersonal- and community-level violence are common among people with HIV (PWH) and associated with poor health outcomes, underscoring a need to implement violence screening and support in HIV care. To inform this implementation, we explored preferences of PWH regarding integration of violence screening into HIV care. From February-December 2022, 64 in-depth interviews were conducted with PWH in Atlanta, Georgia as part of a larger mixed-methods study. Participants were purposively selected for diversity of gender, race/ethnicity, violence exposure history, HIV viral suppression, and retention in care. Themes explored included acceptability of violence screening in HIV care and preferences for doing so (in-person, paper-pencil, computerized), screening item phrasing, screening environment (by whom, where), timing of initial screen, and screening frequency. Violence screening in HIV care was highly acceptable and desirable. Collectively, preference was voiced for initiating screening at first HIV care visit and conducting screening regularly thereafter, in-person, by healthcare providers in a trauma-informed, conversational manner, with supplementation by telehealth or computerized comprehensive screeners to accommodate a variety of needs. This study, the first to detail preferences of PWH across gender and retention/viral suppression status, fills a key gap in evidence informing violence screening recommendations in national HIV care guidelines.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-15"},"PeriodicalIF":1.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A more personalized approach to cervical cancer screening for women with HIV. 对感染艾滋病毒的妇女进行更个性化的宫颈癌筛查。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-23 DOI: 10.1080/09540121.2025.2560098

Babs van der Bruggen, Suzanne De Munnik, Remko Bosgraaf, Heidi Ammerlaan

{"title":"A more personalized approach to cervical cancer screening for women with HIV.","authors":"Babs van der Bruggen, Suzanne De Munnik, Remko Bosgraaf, Heidi Ammerlaan","doi":"10.1080/09540121.2025.2560098","DOIUrl":"10.1080/09540121.2025.2560098","url":null,"abstract":"Women living with HIV (WWH) have an increased risk of invasive cervical cancer due to persistent HPV infection and a weakened immune response. Regular cervical screening is recommended, but compliance is poor. This study aims to identify determinants associated with non-compliance and the risk of high-grade intraepithelial lesions (HSIL) in WWH. The study assessed compliance with the national cervical screening guideline of the Dutch Association of HIV Practitioners (NVHB) in Dutch WWH. Data from the ATHENA National HIV cohort, including WWH from seven HIV centers registered from 2000 through 2021, were analyzed. Descriptive and logistic regression analyses were performed to examine the associations between determinants and guideline adherence, as well as the associations between these determinants and cervical smear results in the study population. The study included 1537 WWH, of whom 1007 (65.5%) had at least one cervical smear, resulting in a compliance rate of 0.28 per three patient-years. Among these 1007 women, 228 (22.6%, 23 per 1,000 p-y) had HSIL and 9 (0.9%, 0.9 per 1,000 p-y) developed cervical cancer. Compliance was associated with hormonal contraceptive use, limited alcohol consumption, a history of STDs (other than HIV), and pregnancy. Non-compliance was more common in WWH born in Africa and Western Europe compared to those born in the Netherlands and in those never treated with cART. HSIL was associated with younger age, drug use, high-risk HPV, low CD4 counts, and detectable viral load. Cervical screening compliance in WWH in the Netherlands is moderate to poor, with HSIL incidence twice as high as in the general population. These findings underscore the importance of cervical screening in this high-risk group. The results can guide the development of personalized strategies to improve screening adherence, leading to earlier HSIL detection and a reduced cervical cancer incidence.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-11"},"PeriodicalIF":1.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0