Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv最新文献

Development of a home-based pre-exposure prophylaxis care delivery system for long-acting injectable cabotegravir: a formative exploration of patient preferences. 为长效注射卡博替拉韦开发基于家庭的暴露前预防护理系统：对患者偏好的形成性探索。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-09-08 DOI: 10.1080/09540121.2024.2397128

Janelly Gonzalez, Paulina A Rebolledo, Aaron J Siegler, Wenting Huang, Kenneth H Mayer, Valeria D Cantos

{"title":"Development of a home-based pre-exposure prophylaxis care delivery system for long-acting injectable cabotegravir: a formative exploration of patient preferences.","authors":"Janelly Gonzalez, Paulina A Rebolledo, Aaron J Siegler, Wenting Huang, Kenneth H Mayer, Valeria D Cantos","doi":"10.1080/09540121.2024.2397128","DOIUrl":"10.1080/09540121.2024.2397128","url":null,"abstract":"Cabotegravir (CAB-LA), the only Food and Drug Administration-approved injectable pre-exposure prophylaxis (PrEP), is effective and may address PrEP uptake disparities among Black and Latino sexual and gender minority (SGM) men. Uptake of CAB-LA may require developing innovative non-clinic-based care delivery strategies in home-based settings. We explored SGM men's opinions on a future home-based CAB-LA PrEP care service to guide the adaptation of PrEP@Home, an existing home-based PrEP system for oral PrEP. Through 14 in-depth interviews with current or former SGM male participants in the PrEP@Home study, we explored the acceptability of a home-based injectable PrEP system and examined visit and communication-related preferences. All participants considered home-based CAB-LA care to be acceptable and 8/14 would utilize the system if available. Convenience and comfort with using a home-based system impacted the overall acceptance of the approach. Factors influencing acceptability included clinical teams' affiliation with healthcare systems, a credentialed two-person team, and staff identity verification methods. Logistical preferences included communicating pre-visit patient instructions, allowing flexible scheduling hours, and the use of text, phone calls, or mobile app communication methods based on urgency. Conclusively, a home-based CAB-LA PrEP delivery system was acceptable among the interviewed SGM men, guiding its development and future implementation.Trial registration: ClinicalTrials.gov identifier: NCT03569813.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1882-1890"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining HIV pre-exposure prophylaxis (PrEP) acceptability among rural people who inject drugs: predictors of PrEP interest among syringe service program clients. 研究农村注射吸毒者对艾滋病毒暴露前预防疗法（PrEP）的接受程度：注射器服务计划客户对 PrEP 感兴趣的预测因素。

IF 16.4 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-13 DOI: 10.1080/09540121.2024.2390067

Hilary L Surratt, Sarah Brown, Abby L Burton, Will Cranford, Christie Green, Stephanie M Mersch, Rebecca Rains, Philip M Westgate

{"title":"Examining HIV pre-exposure prophylaxis (PrEP) acceptability among rural people who inject drugs: predictors of PrEP interest among syringe service program clients.","authors":"Hilary L Surratt, Sarah Brown, Abby L Burton, Will Cranford, Christie Green, Stephanie M Mersch, Rebecca Rains, Philip M Westgate","doi":"10.1080/09540121.2024.2390067","DOIUrl":"10.1080/09540121.2024.2390067","url":null,"abstract":"Rural communities in the US have increasing HIV burden tied to injection drug use, yet engagement in pre-exposure prophylaxis (PrEP) care has been low among people who inject drugs (PWID). Syringe service programs (SSPs) are widely implemented in Kentucky's Appalachian region, presenting an important opportunity to scale PrEP services. This paper examines PrEP awareness, interest and preferences among PWID attending community-based SSPs in Appalachia. Eighty participants were enrolled from two SSP locations. Eligibility included: ≥ 18 years old, current injection drug use and SSP use, and an indication for PrEP as defined by CDC guidelines. Participants completed a structured baseline interview. Predictors of PrEP awareness, interest and formulation preferences were examined. 38.8% reported baseline awareness of PrEP, 50% expressed high interest in PrEP, and 48.1%reported a preference for injectable PrEP. Significant bivariate predictors of PrEP interest included: current worry about health, higher perceived HIV risk, higher community HIV stigma, and higher enacted substance use stigma in the past year; in the adjusted model, enacted substance use stigma remained significant. Findings demonstrate substantial interest in PrEP among rural PWID. Intrapersonal and social determinant factors were associated with PrEP interest, which suggests the importance of multi-level intervention targets to increase PrEP uptake.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1858-1868"},"PeriodicalIF":16.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scoping review of interventions targeting HIV stigma in women living with HIV. 对针对女性艾滋病病毒感染者的艾滋病污名化干预措施进行范围界定审查。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1080/09540121.2024.2408682

Zhongfang Yang, Qianqian Hu, Weijie Xing, Zheng Zhu, Michael V Relf, Dalmacio Dennis Flores, Yan Hu

{"title":"A scoping review of interventions targeting HIV stigma in women living with HIV.","authors":"Zhongfang Yang, Qianqian Hu, Weijie Xing, Zheng Zhu, Michael V Relf, Dalmacio Dennis Flores, Yan Hu","doi":"10.1080/09540121.2024.2408682","DOIUrl":"10.1080/09540121.2024.2408682","url":null,"abstract":"Since its initial detection in the 1980s, AIDS has become a significant global health threat, disproportionately affecting women. Stigma constitutes the substantial barrier to accessing healthcare for women living with HIV (WLWH). This scoping review based on the Population, Concept, and Context (PCC) framework aimed to provide evidence-based guidance for clinical caregivers to develop intervention strategies and assess their effectiveness. From database inception to May 2023, research on stigma interventions for WLWH was searched in databases including Embase (OVID), MEDLINE (OVID), CINAHL (EBSCO), ProQuest, Scopus, WANFANG, VIP, CNKI, and SinoMed. Literature was screened based on inclusion and exclusion criteria, and results were extracted for scoping review. Twelve studies were included featuring information-based, skills-based interventions, and a combination of both, targeting individuals and institutions. Six studies reported significant reduction in stigma. Assessment tools used included the 7-item Questionnaire on Attitudes toward AIDS Victims (AQAV-7), the 40-item HIV Stigma Scale (HSS-40), the 14-item Chronic Illness Stigma Scale (SSCI-14), the 28-item Internalization HIV-Related Stigma Scale (IHSS-28), the 57-item Internalized Stigma Scale (IS-57), and the 6-item Internalized AIDS-Related Stigma Scale (IA-RSS-6). Validation of existing intervention and the development of mechanisms linking interventions to stigma reduction are needed.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1719-1730"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital technology for HIV self-management in low- and middle-income countries: a scoping review of adolescents' preferences. 中低收入国家艾滋病毒自我管理的数字技术：青少年偏好范围审查。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1080/09540121.2024.2383868

Leonie Weyers, Talitha Crowley, Lwandile Tokwe

{"title":"Digital technology for HIV self-management in low- and middle-income countries: a scoping review of adolescents' preferences.","authors":"Leonie Weyers, Talitha Crowley, Lwandile Tokwe","doi":"10.1080/09540121.2024.2383868","DOIUrl":"10.1080/09540121.2024.2383868","url":null,"abstract":"Digital health technology interventions have shown promise in enhancing self-management practices among adolescents living with Human Immunodeficiency Virus (ALHIV). The objective of this scoping review was to identify the preferences of ALHIV in low- and middle-income countries (LMICs) concerning the use of digital health technology for the self-management of their chronic illness. Electronic databases, including PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL) (Plus with Full Text), Central (Cochrane Library), Epistemonikos, and Medline (EbscoHost), were searched. The review focused on English articles published before June 2023, that described a technology intervention for ALHIV specifically from LMIC. The screening and data extraction tool Covidence facilitated the scoping review process. Of the 413 studies identified, 10 were included in the review. Digital health technology interventions can offer enhanced support, education, and empowerment for ALHIV in LMICs. However, barriers like limited access, stigma, and privacy concerns must be addressed. Tailoring interventions to local contexts and integrating technology into healthcare systems can optimize their effectiveness.Review registration: OSF REGISTRIES (https://archive.org/details/osf-registrations-eh3jz-v1).","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1805-1814"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to antiretroviral therapy and its association with quality of life among people with HIV in the United States. 美国艾滋病病毒感染者坚持抗逆转录病毒疗法及其与生活质量的关系。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI: 10.1080/09540121.2024.2391439

Bekana K Tadese, Fritha Hennessy, Phoebe Salmon, Tim Holbrook, Girish Prajapati

{"title":"Adherence to antiretroviral therapy and its association with quality of life among people with HIV in the United States.","authors":"Bekana K Tadese, Fritha Hennessy, Phoebe Salmon, Tim Holbrook, Girish Prajapati","doi":"10.1080/09540121.2024.2391439","DOIUrl":"10.1080/09540121.2024.2391439","url":null,"abstract":"Adherence to antiretroviral therapy (ART) is critical for people with HIV (PWH) to achieve and maintain virologic suppression and minimize drug resistance. This study aimed to use real-world data to characterize ART adherence and its effect on quality of life (QoL) in PWH. Data were drawn from the Adelphi HIV Disease Specific Programme™, a cross-sectional survey of physicians and PWH in the United States, conducted June-October 2021. Demographic and clinical characteristics, ART adherence and treatment satisfaction for PWH were reported by physicians. PWH completed standardized QoL questionnaires. Adherence level was categorized into completely, mostly and less adherent. Regression analysis was used to investigate factors associated with adherence and the association between adherence and QoL measures. Of 578 PWH, 189 (32.7%) were not completely adherent. Having AIDS-defining illnesses, anxiety/depression or being symptomatic was significantly associated with lower adherence. Reasons for poor adherence included forgetting, difficulties integrating into routine and side effects. QoL scores were significantly higher in the completely adherent group. These findings highlight the strong association between suboptimal adherence and QoL among PWH and key factors and PWH reasons that may lead to suboptimal adherence. Interventions aimed at improving the QoL of PWH by understanding these factors are warranted.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1869-1881"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of determinants of health on the relationship between stigma and health in people living with HIV. 健康决定因素对艾滋病毒感染者污名化与健康之间关系的影响。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-09-17 DOI: 10.1080/09540121.2024.2401379

Jason M Lo Hog Tian, James R Watson, Janet A Parsons, Robert G Maunder, Michael Murphy, Lynne Cioppa, A McGee, Wayne Bristow, Anthony R Boni, Monisola E Ajiboye, Sean B Rourke

{"title":"The impact of determinants of health on the relationship between stigma and health in people living with HIV.","authors":"Jason M Lo Hog Tian, James R Watson, Janet A Parsons, Robert G Maunder, Michael Murphy, Lynne Cioppa, A McGee, Wayne Bristow, Anthony R Boni, Monisola E Ajiboye, Sean B Rourke","doi":"10.1080/09540121.2024.2401379","DOIUrl":"10.1080/09540121.2024.2401379","url":null,"abstract":"Determinants of health are important drivers of health states, yet there is little work examining their role in the relationship between HIV stigma and health. This study uses moderation analysis to examine how determinants of health affect the relationship between enacted, internalized, and anticipated stigma and mental health. Quantitative data was collected on 337 participants in Ontario, Canada at baseline (t1) between August 2018 and September 2019 and at follow-up (t2) between February 2021 and October 2021. Separate moderation models were created with each determinant of health (age, gender, sexual orientation, ethnicity, geographic region, education, employment, and basic needs) acting as the moderator between types of stigma at t1 and mental health at t2. Age was a significant moderator for the relationship between internalized and enacted stigma at t1 and mental health at t2. Region was a moderator for enacted and anticipated stigma and mental health. Sexual orientation was a moderator for anticipated stigma and mental health. Lastly, having basic needs was a moderator for enacted and anticipated stigma and mental health. Our findings suggest that intervention strategies may be more effective by incorporating supports for these determinants of health in addition to stigma reduction to improve mental health.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1902-1911"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceptions of the attributes of new long-acting HIV pre-exposure prophylaxis formulations compared with a daily, oral dose among South African young women: a qualitative study. 南非年轻女性对新型长效艾滋病暴露前预防制剂与每日口服制剂的属性比较：一项定性研究。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-06 DOI: 10.1080/09540121.2024.2383878

Patience Shamu, Saiqa Mullick, Nicola J Christofides

{"title":"Perceptions of the attributes of new long-acting HIV pre-exposure prophylaxis formulations compared with a daily, oral dose among South African young women: a qualitative study.","authors":"Patience Shamu, Saiqa Mullick, Nicola J Christofides","doi":"10.1080/09540121.2024.2383878","DOIUrl":"10.1080/09540121.2024.2383878","url":null,"abstract":"Oral PrEP is highly effective against the acquisition of HIV but is underutilised by young women. New options, like the monthly dapivirine vaginal ring (DVR) and injectable long-acting cabotegravir (CAB-LA), are emerging. However, little is known about young women's perceptions of these alternatives. This qualitative study explored perceptions of the attributes of PrEP technologies in South Africa. Young women accessing sexual health services were purposively selected to participate in 22 in-depth interviews, five focus group discussions and two workshops using the nominal group technique, between August 2022 and March 2023. A thematic approach guided by the diffusion of innovation attributes, including relative advantage, compatibility with the student's lives, complexity of the technology, and trialability, was used for data analysis. The DVR was the least preferred because of lower efficacy, the perceived complexity of inserting it in the vagina and some safety concerns. Oral PrEP, which some had tried and discontinued, was least compatible with students' busy schedules. Integrating PrEP and contraceptives with similar return visit patterns could enhance service delivery. Intensive demand creation campaigns will be needed to increase PrEP utilisation and dispel myths about the vaginal ring.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1815-1825"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood sexual trauma and opioid use among older adults living with HIV. 感染艾滋病毒的老年人童年时期的性创伤与阿片类药物的使用。

IF 16.4 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI: 10.1080/09540121.2024.2390066

Monique J Brown, Sravya Sunkara, Amandeep Kaur, Prince Nii Ossah Addo, Daniel Amoatika, Elizabeth Crouch

{"title":"Childhood sexual trauma and opioid use among older adults living with HIV.","authors":"Monique J Brown, Sravya Sunkara, Amandeep Kaur, Prince Nii Ossah Addo, Daniel Amoatika, Elizabeth Crouch","doi":"10.1080/09540121.2024.2390066","DOIUrl":"10.1080/09540121.2024.2390066","url":null,"abstract":"Childhood sexual abuse (CSA) has been linked to substance use and substance use disorders in adulthood. However, there have been limited studies examining the relationship between CSA and opioid use among older adults living with HIV (OALH). Therefore, the aim of this study was to determine the association between CSA and opioid use among OALH (n = 91). Data were obtained from an HIV clinic population in South Carolina using paper-and-pen, and online questionnaires. CSA was operationalized using six questions from the Early Trauma Inventory-Self Report Form (Yes vs. No). Opioid use was self-report of the use of opioids including: heroin, fentanyl, Oxycontin, Vicodin, codeine, morphine (used vs. never used). Nested crude and multivariable logistic regression models adjusting for sociodemographic confounders were used to determine the association between CSA and opioid use. After adjusting for race, gender, age, and education, OALH who were CSA survivors were 21 times more likely to currently use opioids compared to OALH who were not exposed to CSA (adjusted OR: 21.1; 95% CI: 1.78-250.0). The association seen between CSA history and opioid use may be due to unresolved trauma among OALH. Trauma-informed interventions addressing CSA may help to reduce opioid use among OALH.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1852-1857"},"PeriodicalIF":16.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of the Alcohol Use Disorder Inventory Test in determining caseness for alcohol use disorder among persons receiving antiretroviral therapy. 酒精使用障碍量表测试在确定接受抗逆转录病毒治疗者是否患有酒精使用障碍方面的实用性。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-06-13 DOI: 10.1080/09540121.2024.2365853

Ashraf Kagee, Wylene Saal, Adelle Sterley

{"title":"Utility of the Alcohol Use Disorder Inventory Test in determining caseness for alcohol use disorder among persons receiving antiretroviral therapy.","authors":"Ashraf Kagee, Wylene Saal, Adelle Sterley","doi":"10.1080/09540121.2024.2365853","DOIUrl":"10.1080/09540121.2024.2365853","url":null,"abstract":"We sought to determine the utility of the Alcohol Use Disorder Identification Test (AUDIT) in screening for alcohol use disorder (AUD) among 688 users of antiretroviral therapy (ART). We used the receiver operating characteristic (ROC) curve analysis to assess whether the AUDIT reliably detected AUD against the Structured Clinical Interview for the DSM (SCID). Of the samples, 22.09% (CI: 19.05% to 25.38%) of participants met the diagnostic criteria for AUD. Among men (n = 135) and women (n = 553), the prevalence estimates were 31.9% and 19.7%, respectively. For men, a cut-off score of 6 predicted AUD with 88.36% (95%CI: 74.92-96.11) sensitivity and 88.04% (95%CI: 79.61-93.88) specificity. For women, a cut-off score of 4 on the AUDIT yielded an optimal sensitivity of 92.66% (95% CI: 86.05%-96.78%) and a specificity of 93.24% (95% CI: 90.49-95.40%). For men, the AUDIT yielded a positive predictive value (PPV) of 75.55% (95% CI: 66.26%-85.87%) and a negative predictive value (NPV) of 91.49% (95% CI: 87.63-97.37%); for women the PPV and NPV were 77.09% (70.34%-82.68%) and 98.11% (96.37%-99.02%), respectively. The instrument's good sensitivity and specificity indicate it is likely to be useful for screening and referral of ART users who are probably cases of AUD.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1754-1759"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews. 肯尼亚感染艾滋病毒的围产期妇女坚持抗逆转录病毒疗法的情况：一项采用干血斑测量法和叙述性访谈法的解释性混合方法研究。

IF 16.4 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-12-01 Epub Date: 2024-08-06 DOI: 10.1080/09540121.2024.2383885

K Hampanda, H Grubbs, J Castillo-Mancilla, P L Anderson, J Thorne, A Helova, J M Turan, M Onono, L L Abuogi

{"title":"Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.","authors":"K Hampanda, H Grubbs, J Castillo-Mancilla, P L Anderson, J Thorne, A Helova, J M Turan, M Onono, L L Abuogi","doi":"10.1080/09540121.2024.2383885","DOIUrl":"10.1080/09540121.2024.2383885","url":null,"abstract":"ABSTRACTAdherence to antiretroviral therapy (ART) remains sub-optimal among pregnant and postpartum women with HIV (PPWH) in high HIV prevalence low resource settings with few effective behavioral interventions. A large body of qualitative literature has established general barriers and facilitators to ART adherence in PPWH at various levels (individual, interpersonal, structural). However, research exploring the underlying behavioral mechanisms of ART adherence in PPWH with objectively verified adherence biomarkers is extremely limited. We conducted 24 in-depth interviews with postpartum women in western Kenya who had linked ART drug concentrations obtained from three dried blood spot samples across the peripartum period. Among PPWH with a low drug concentration (n = 13) compared to those with continuously high drug concentrations (n = 11), distinct themes emerged related to HIV status disclosure, social support, interactions with the health system, and health beliefs. By combining ART biomarkers with patient reported challenges, there is the potential for real-time interventions to support sustained ART adherence among PPWH and improve maternal and infant health outcomes.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1826-1837"},"PeriodicalIF":16.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0