Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv最新文献

{"title":"Risk of hepatitis C virus reinfection after direct-acting antiviral treatment among HIV-positive men who have sex with men and people who inject drugs: a systematic review and meta-analysis.","authors":"Pi-Lien Hung, Chih-Chen Chou, Susan Shin-Jung Lee, Pei-Chin Lin","doi":"10.1080/09540121.2025.2536178","DOIUrl":"https://doi.org/10.1080/09540121.2025.2536178","url":null,"abstract":"<p><p>The incidence of hepatitis C virus (HCV) reinfection following successful direct-acting antiviral therapy in HIV/HCV co-infected individuals remains a significant public health concern. This study aimed to estimate the reinfection incidence in high-risk groups, particularly people who inject drugs and men who have sex with men (MSM). A systematic review and meta-analysis was conducted by searching PubMed, Embase, and the Cochrane Library through March 2022. Studies reporting HCV reinfection following sustained virologic response after direct-acting antiviral therapy among HIV/HCV co-infected patients were included. Ten studies involving 5,632 individuals were analyzed. The incidence rate ratio of reinfection was significantly higher in MSM (<i>n</i> = 1,681) than in people who inject drugs (<i>n</i> = 2,490) (incidence rate ratio = 3.56; 95% CI: 1.26-10.09; I² = 77%). Subgroup and meta-regression analyses showed a higher reinfection rate in MSM from studies published on or before 2020 and among individuals with chronic HCV infection. Additionally, time to reinfection was shorter in MSM, with a pooled mean difference of -0.57 years. These findings highlight a consistently higher reinfection risk in HIV-positive MSM. Targeted behavioral counseling and routine HCV RNA surveillance are essential strategies to detect reinfection early and to support long-term control of HCV.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-14"},"PeriodicalIF":1.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where did they go? Describing and reengaging people with HIV lost to follow-up in the PISCIS Cohort Study.","authors":"Jorge Palacio-Vieira, Sergio Moreno-Fornés, Yesika Díaz, Andreu Bruguera, Josep M Llibre, Hernando Knobel, Iván Chivite, Josep M Miró, Pere Domingo, Paula Suanzes, Antoni Campins, Gemma Navarro, Lizza Macorigh, Arantzazu Mera, Jordi Casabona, Arkaitz Imaz, Juliana Reyes-Urueña","doi":"10.1080/09540121.2025.2534111","DOIUrl":"https://doi.org/10.1080/09540121.2025.2534111","url":null,"abstract":"<p><p>Reengaging patients lost to follow-up (LTFU) is crucial to achieving the UNAIDS 95-95-95 targets. This study analyses an intervention aimed at identifying and reengaging LTFU individuals in the PISCIS Cohort in Catalonia. The cohort included 28,033 people living with HIV (PLWH) across 17 hospitals in Catalonia and two in the Balearic Islands as of 2021. LTFU was defined as no contact with HIV care in any Catalan hospital for ≥12 months between June 2021 and January 2010. At four hospitals, suspected LTFU cases were confirmed through clinical records and followed up via phone calls, text messages and emails. Confirmed cases were invited to reengage in care. A total of 1,411 suspected LTFU individuals were studied. Compared to those in regular follow-up, LTFU individuals were more often male, aged 30-39, born outside Spain (64.8%) and men who have sex with men (70.4%). Of these, 27.3% could not be located, with a higher proportion born outside Spain (74.8% vs. 61.0%). Reengagement rates were low, though older individuals and women were more likely to reengage. These findings underscore the importance of accurate cohort records, systematic tracking and targeted strategies to reengage hard-to-reach LTFU patients.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-12"},"PeriodicalIF":1.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sexual minority men's perspectives and benefits of long-acting injectable antiretroviral therapy in South Africa.","authors":"Lindsey de Vos, Albert Manyuchi, Dawie Nel, Joseph Daniels","doi":"10.1080/09540121.2025.2534535","DOIUrl":"https://doi.org/10.1080/09540121.2025.2534535","url":null,"abstract":"<p><p>In South Africa, sexual minority men (SMM) face high HIV rates and challenges with antiretroviral therapy (ART) adherence, hindering viral suppression. Factors, such as non-disclosure, stigma, and partner dynamics, complicate adherence. Long-acting ART options, like injectables, could help address these challenges; however, their acceptability among SMM in South Africa remains unclear. Between April and June 2024, qualitative interviews were conducted with 21 SMM who participated in the Speaking Out & Allying Relationships (SOAR) a video- and skills-based HIV intervention, supporting SMM's communication and coping skills for status-sharing and treatment adherence in South Africa, to explore their initial impressions of injectable ART. Interviews explored disclosure, adherence, partner dynamics, and attitudes toward injectable ART. Participants viewed injectables as a major improvement over daily pills, citing benefits, such as reduced mental burden and increased privacy and safety. They felt that injectables could give them more control over disclosure, and flexibility to manage treatment during social interactions. These findings suggest that long-acting ART could improve adherence and reduce stigma, aligning with SMMs dynamic lifestyle. Further research is necessary to evaluate the effectiveness and accessibility of injectable ART for SMM in South Africa, emphasizing supportive healthcare systems and training providers in this emerging treatment landscape.<b>Abbreviations:</b> ART: antiretroviral therapy; SMM: sexual minority men; U = U: undetectable = untransmittable (HIV campaigns and messaging).</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory mixed-methods questionnaire study investigating motivators for and reservations about clinical research participation in people living with HIV.","authors":"Claire Petersen, M Wood, F Dransfield, M Grundy-Bowers, G Clunie, A Winston","doi":"10.1080/09540121.2025.2534531","DOIUrl":"https://doi.org/10.1080/09540121.2025.2534531","url":null,"abstract":"<p><p>Clinical research in healthcare settings offers substantial benefits, including reduced mortality rates in research-active hospitals and access to novel treatments for participants. Despite these advantages, research often faces recruitment challenges, particularly under-representation of women and ethnic minorities. This study explores the views of people living with HIV regarding research participation. This mixed-methods study was conducted at a central London hospital's HIV outpatient clinic and Clinical Trials Centre from April 2018 to January 2019. Using the COM-B models as a theoretical framework, questionnaires were designed for individuals currently or previously involved in research, and for those with no prior research involvement. Questions included demographics, motivators and reservations about research participation, and the importance of information sources when deciding to participate in research. Quantitative data were analysed descriptively, and a framework analysis of qualitative data was completed. Of the 155 respondents, 50 were participating in research, and 105 were not. Key motivators included advancing medical knowledge, altruism and access to new treatments. Major barriers were time commitments and concerns about side effects. 80% of people participating in research, and 74% of those not participating rating rated discussions with regular clinicians to be very important when deciding to participate in research. Women faced similar barriers to the overall cohort, particularly related to time commitments and care-giving responsibilities. Research participation is influenced by the therapeutic relationship with, and input from regular clinicians. Addressing barriers such as time commitments through flexible scheduling, integrating research and clinical visits, and utilising remote visits could improve recruitment. Involving patients in research design via Patient and Public Involvement and Engagement (PPIE) ensures protocols are acceptable and tailored to participant needs. Effective collaboration between researchers and clinicians is essential to optimise research recruitment. Clear, empathetic communication and flexible study designs can address participant concerns, ultimately enhancing involvement in clinical research.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-13"},"PeriodicalIF":1.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characteristics of people with HIV who had late, delayed and timely HIV diagnoses in Florida, 2015-2021.","authors":"Christina E Parisi, Shantrel S Canidate, Awewura Kwara, Zhigang Li, Zhi Zhou, Colby Cohen, Robert L Cook, Natalie Chichetto","doi":"10.1080/09540121.2025.2484299","DOIUrl":"10.1080/09540121.2025.2484299","url":null,"abstract":"<p><p>Different definitions of late HIV diagnosis are used to represent people diagnosed at an advanced stage of their illness. How well varying definitions represent those at risk for poor outcomes is unclear. Our aim was to examine proportions of late, delayed and timely HIV diagnoses in Florida and identify factors associated with diagnosis status. Using the first laboratory test in the Enhanced HIV/AIDS Reporting System, we determined annual proportions of late (CD4 < 200 cells/μL), delayed (200 ≤ CD4 < 350 cells/μL) and timely (CD4 ≥ 350 cells/μL) diagnoses in Florida between 2015 and 2021 and assessed characteristics associated with diagnosis status using multinomial logistic regression models. Among 30,411 individuals (20% female, 39% non-Hispanic Black, 34% Hispanic, mean age 37.1 years), 22% had a late and 17% had a delayed diagnosis. Non-Hispanic Black race, older age, and diagnosis at an inpatient facility were associated with greater odds of having a late or delayed diagnosis compared with having a timely diagnosis. There was no change in the prevalence of late, delayed, and timely diagnoses each year during the study period. Nearly 40% of HIV diagnoses in Florida were late or delayed. Given those with late and delayed diagnoses were similar, strategies to improve timeliness of diagnosis among these groups are needed.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1131-1139"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of stigma in people living with HIV, its effect on treatment adherence and psychiatric comorbid disease.","authors":"Salaar Ahmed, Meeral Nasir, Aleena Arshad, Hamza Ahmed Farooqi, Syed Faisal Mahmood","doi":"10.1080/09540121.2025.2486571","DOIUrl":"10.1080/09540121.2025.2486571","url":null,"abstract":"<p><p>HIV has become a rising healthcare issue in Pakistan in recent years with new outbreaks and spillover to traditionally low-risk groups. We studied the stigma around HIV, its relation to psychiatric comorbidities such as depression and anxiety, and adherence to treatment in people living with HIV (PLHIV). A hospital-based cross-sectional study was conducted over six months at a tertiary care hospital in Karachi, Pakistan. Self-administered digital questionnaires containing basic demographics, PHQ9, GAD7, HSS12, and GMAS scales were used to assess depression, anxiety, stigma, and medical adherence respectively. A total of 66 participants were included, with a mean age of 39.97 ± 14.32 years. The mean stigma score was 25.67 ± 9.46, with 9 participants (13.85%) experiencing severe stigma. Among the different stigma components, disclosure concerns had the highest mean score (7.91 ± 2.91). Most participants had no depression and a no-to-low risk for anxiety. No relationship was found between medical adherence and either stigma scores or psychiatric comorbidities. Patients identified as from key populations (<i>n</i> = 35) had significantly increased risk of depression (<i>p</i> = 0.0493), anxiety (<i>p</i> = 0.023), and HIV-associated stigma (<i>p</i> = 0.0166). Stigma continues to affect mental well-being and hinders early diagnosis and treatment of PLHIV. A comprehensive approach, cannot be complete without addressing this stigma and its effect on disease burden, diagnosis, and treatment.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1167-1174"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma and other correlates of self-esteem and depression in cisgender men and transfeminine persons with HIV who have sex with men in Kenya, Malawi, and South Africa (HPTN 075).","authors":"Erica L Hamilton, Xu Guo, Sufia Dadabhai, Ravindre Panchia, Arthur Ogendo, Doerieyah Reynolds, Ying Chen, Theo G M Sandfort","doi":"10.1080/09540121.2025.2488874","DOIUrl":"10.1080/09540121.2025.2488874","url":null,"abstract":"<p><p><b>ABSTRACT</b>HIV-related stigma profoundly impacts individuals living with HIV, hindering self-esteem and access to treatment. Few studies, if any, have assessed the effects of stigma on depression and self-esteem among men who have sex with men (MSM) and transfeminine persons (TFP) with HIV in African settings. We explored factors, including various forms of stigma, contributing to low self-esteem and poor mental health among 71 MSM and TFP in Kenya, Malawi, and South Africa, using data from the HPTN (HIV Prevention Trials Network) 075 study. Lower self-esteem was associated with moderate to severe depression and was significantly lower among those who experienced HIV as a stigma. Moreover, participants who had encountered MSM-related stigma in healthcare settings were more likely to exhibit moderate to severe depression. Being employed was a protective factor against depression. These results suggest that interventions aimed at reducing MSM-related stigma in healthcare settings and enhancing self-esteem through employment opportunities for MSM and TFP living with HIV might contribute toward ending the HIV epidemic.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1181-1193"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who could benefit the most from long-acting antiretroviral therapy? perspectives of HIV care providers and people with HIV in Florida.","authors":"Rebecca J Fisk-Hoffman, Abigail Gracy, Sashaun S Ranger, Preeti Manavalan, Maya Widmeyer, Robert L Cook, Shantrel S Canidate","doi":"10.1080/09540121.2025.2510915","DOIUrl":"10.1080/09540121.2025.2510915","url":null,"abstract":"<p><p>Injectable cabotegravir/rilpivirine (CAB/RPV) is now available, and other long-acting antiretroviral therapy (ART) regimens are in development. The present study describes the factors that HIV care providers and people with HIV (PWH) in Florida (a high HIV incidence and prevalence setting) consider when assessing populations of PWH who could benefit from long-acting ART. We conducted semi-structured qualitative interviews with 11 providers (27% non-Hispanic Black, 27% Hispanic, 73% cis women) and 16 PWH (31% non-Hispanic Black, 19% Hispanic, 50% cis men, 69% aged 50+) from five sites in Florida. Participants were asked about the groups of PWH who they thought could benefit the most from long-acting ART. Responses were analyzed using a reflexive thematic approach. Seven populations of PWH who could benefit from long-acting ART were identified: 1) younger PWH, 2) PWH with co-occurring conditions, 3) PWH who use substances, 4) PWH experiencing housing instability, 5) PWH with frequent travel, 6) PWH experiencing stigma, and 7) PWH who reliably take medication and engage in care. Many groups who may be excluded from injectable CAB/RPV based on the current guidelines were seen as potentially benefiting from such an option.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1150-1159"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV home testing in Poland - an underappreciated approach despite huge potential : an implementation study.","authors":"Bartosz Szetela, Mateusz Bożejko, Zenon Jasyk, Iwona Krzywicka, Katarzyna Giniewicz, Magdalena Ankiersztejn-Bartczak","doi":"10.1080/09540121.2025.2486570","DOIUrl":"10.1080/09540121.2025.2486570","url":null,"abstract":"<p><p>HIV testing faces barriers worldwide and little progress in systematically implementing new approaches has been made so far, especially in Europe. Testing sites (VCTs) and clubs have been the only large-scale venues in Poland to offer anonymous tests for key populations. They are located exclusively in large cities leaving large areas without any real access. We wanted to see if home tests might fill the gaps. Between November 2022 and February 2023 free Simplitude ByMe HIV home-tests were sent out to parcel lockers with orders made opportunistically by patients on the TyToTu.pl webpage. The clients were asked to fill out a short epidemiological online questionnaire (age, gender, sexual orientation, nationality, residence: provincial city/smaller city/village, previous testing) before the order and were asked to give e-feedback afterwards. Statistical analysis was performed for 887 returned questionnaires. 1473 home tests were dispensed. 76.6% of recipients reported heterosexual, 11.7% homosexual and 10.6% bisexual contacts. 57% came were from large provincial cities (<i>p</i> < 0.0001) and for 80% of them it was their first test ever, especially if they reported heterosexual contacts (<i>p</i> < 0.0001) or were older (OR 0.9736; 95% CI: 0.9507, 0.9971). If heterosexual clients had tested before then in the more distant past by 745 days (95% CI: 411-1096). Five tests were reported back as positive (all among heterosexual clients) translating to 0.34% prevalence, 91 negative (6.17% return rate) and 9 invalid (0.61%). Home testing has been underutilized in Poland despite huge interest. Barriers still exist especially for clients reporting heterosexual contacts. HIV home tests should be freely available, especially among older and heterosexual clients as well as immigrants. We urge local and national bodies to fund such testing as it may help include more people in treatment earlier.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1175-1180"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"People who inject drugs and men who have sex with men living with HIV in India experience low probability of viral rebound and high levels of persistent viremia during the first 12 months of antiretroviral therapy.","authors":"Talia A Loeb, Sunil S Solomon, Mihili P Gunaratne, A K Srikrishnan, C K Vasudevan, Rifa T Khan, Santhanam Anand, Boobalan Jayaseelan, Muniratnam Suresh Kumar, David D Celentano, Gregory M Lucas, Shruti H Mehta, Allison M McFall","doi":"10.1080/09540121.2025.2484635","DOIUrl":"10.1080/09540121.2025.2484635","url":null,"abstract":"<p><p>People who inject drugs (PWID) and men who have sex with men (MSM) in India are disproportionately affected by HIV and experience challenges achieving sustained viral suppression. We evaluated probabilities of suppression over time and characteristics associated with persistent viremia and viral rebound among MSM and PWID living with HIV (PLHIV) using 12 months of data collected between 2017-2019 from a cluster-randomized trial across 16 cities in India. To assessprobabilities of suppression, we fit logistic transition models with generalized estimating equations. To assess correlates of persistent viremia and viral rebound, we fit multivariable multilevel logistic regression models. Of 750 PWID, 88% were male and 14% completed high school. Of 850 MSM, 29% completed high school and 54% were married. 46% of PWID and 67% of MSM maintained viral suppression once achieved. Probabilities of viral rebound decreased over time. The probability of newly achieving suppression decreased, from 33%-12% after six months among PWID and 60%-13% among MSM. Among PWID, correlates of persistent viremia included lower education, employment, homelessness, and active injection. Among MSM, hazardous alcohol use was associated with viremia and viral rebound. Treatment engagement and support efforts need to be intensified to encourage PLHIV to achieve life-long suppression.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1085-1096"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}