Sharon M Kelly, Annice Brown, Tracy Agee, Jeffrey Hsu, Nicholas Schweizer, Larry W Chang, Sheree Schwartz, Oluwaseun Falade-Nwulia
{"title":"HIV provider perspectives on opioid use disorder care integration into outpatient HIV care in Baltimore, Maryland: a mixed-methods RE-AIM analysis.","authors":"Sharon M Kelly, Annice Brown, Tracy Agee, Jeffrey Hsu, Nicholas Schweizer, Larry W Chang, Sheree Schwartz, Oluwaseun Falade-Nwulia","doi":"10.1080/09540121.2025.2534538","DOIUrl":"10.1080/09540121.2025.2534538","url":null,"abstract":"<p><p>Despite the high prevalence of opioid use disorders (OUD) among people with HIV (PWH), treatment among PWH remains low. Integrating OUD care into HIV care may improve OUD outcomes; however, adoption is limited due to multilevel barriers. RESTORE is a low-threshold substance use disorder (SUD) care program integrated into an outpatient HIV-care clinic that provides training and ongoing support for SUD care adoption by HIV providers. This mixed-methods study explored providers' perspectives on barriers and facilitators to RESTORE implementation and adoption of OUD treatment in HIV care. Repeated cross-sectional surveys were administered pre-RESTORE (2019; <i>N</i> = 42) and post-RESTORE implementation (2021; <i>N</i> = 48). In-depth interviews (<i>N</i> = 18) were completed post-implementation. Chi-square analysis assessed differences between pre- and post-implementation responses. Interviews were analyzed using thematic analysis guided by RE-AIM. Acceptability (Acceptability of Intervention Measure [range 4-20], mean = 16.4) and appropriateness (Intervention Appropriateness Measure, mean = 17.9) were high. Adoption of buprenorphine prescribing was high (29.2% post-implementation vs. 4.8% pre-implementation). Comfort managing OUD increased twofold (21.4% to 45.8%; <i>p</i> = 0.02). Inexperience with buprenorphine initiation and time were barriers to adopting OUD treatment. Ongoing mentoring in OUD care was a facilitator. Future research on the integration of OUD care into HIV care should incorporate task-shifting to increase provider-level support for OUD care.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1332-1345"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deborah Ekusai-Sebatta, Agnes N Kiragga, Eva Laker Agnes Odongpiny, Ritah Shanice Namugenyi, Pauline Byakika-Kibwika, Janet Seeley, Rachel King
{"title":"Health worker' perceptions of risks, barriers to and facilitators of long-acting injectable antiretroviral therapy delivery to women for prevention of vertical transmission programs.","authors":"Deborah Ekusai-Sebatta, Agnes N Kiragga, Eva Laker Agnes Odongpiny, Ritah Shanice Namugenyi, Pauline Byakika-Kibwika, Janet Seeley, Rachel King","doi":"10.1080/09540121.2025.2532600","DOIUrl":"10.1080/09540121.2025.2532600","url":null,"abstract":"<p><p>This study examines the perceptions and experiences of health workers and caregivers regarding the delivery of long-acting antiretroviral therapy (LA-ART) in Uganda, especially for preventing vertical transmission of HIV. Using a qualitative implementation research design informed by the Health Belief Model, the researchers conducted 17 key informant interviews with clinicians, nurses, peer mothers, social workers, department heads, and lead researchers across six study centers between May 2022 and September 2023. The interviews were recorded and transcribed verbatim into English language and analyzed thematically using NVivo 14. Five key themes emerged: perceived benefits, perceived barriers, facility readiness, and recommendations for implementation. Health workers highlighted benefits such as treatment convenience, improved adherence, and patient acceptance. However, they also identified major barriers, including stigma, limited staff training, and financial constraints. Concerns about health facility readiness particularly cold chain storage for the injectable medication were also noted. The findings underscore the importance of addressing these challenges to support effective LA-ART delivery. The study recommends comprehensive training for healthcare workers, patient education, and a phased rollout strategy. Understanding the views of frontline workers is crucial for the successful integration of LA-ART into HIV care and improving health outcomes for people living with HIV.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1355-1365"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madelyn Carlson, Melvin Livingston, Ameeta S Kalokhe, Jessica M Sales
{"title":"Experiences of recent hate-related violence and their association with mental and physical health among people living with HIV in Atlanta, Georgia.","authors":"Madelyn Carlson, Melvin Livingston, Ameeta S Kalokhe, Jessica M Sales","doi":"10.1080/09540121.2025.2532598","DOIUrl":"10.1080/09540121.2025.2532598","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) are disproportionately affected by violence. The majority of violence research has focused on intimate partner violence, childhood abuse, gender-based violence, and sexual violence more generally. Less research has examined community violence among PWH. In this analysis, we test the association between hate crime experience and mental and HIV outcomes in a sample of adults with HIV, majority of whom are Black/African American, living in Atlanta, Georgia.</p><p><strong>Setting: </strong>PWH were recruited from HIV service settings (<i>N</i> = 285) to participate in a cross-sectional study.</p><p><strong>Methods: </strong>Primary association was tested using logistic regression models with the following outcomes: anxiety, depression, PTSD, ever virally suppressed, continuous viral suppression, and engagement in HIV care. A two-way interaction term examined gender as potential effect measure modifier of the association between hate crime experience and health outcomes.</p><p><strong>Results: </strong>Roughly half the sample (<i>N</i> = 125) experienced a hate crime in the past 12 months. In the multivariate model adjusted for covariates, hate crime survivors had 4.02 higher odds of experiencing PTSD symptoms over the last four weeks compared to persons who did not suffer hate violence (95% CI 2.06, 7.85).</p><p><strong>Conclusion: </strong>HIV treatment interventions and care practices treating PWH with hate violence experience should respond to PTSD symptoms.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1233-1243"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evan L Eschliman, Yuexuan Liu, Asri A Rahmah, Briyanna Philip, Dung T Hoang, Haruka Kokaze, Nasim Khoshnam, Emily Dunkel, Vivian R Ye, Karen Choe, Ohemaa B Poku, Gloria Alvarez, Trang Nguyen, Nam Truong Nguyen, Donna Shelley, Lawrence H Yang
{"title":"Development and psychometric properties of three scales employing \"what matters most\" to assess cultural aspects of intersectional HIV-related and cancer stigma among people living with HIV in Hanoi, Vietnam.","authors":"Evan L Eschliman, Yuexuan Liu, Asri A Rahmah, Briyanna Philip, Dung T Hoang, Haruka Kokaze, Nasim Khoshnam, Emily Dunkel, Vivian R Ye, Karen Choe, Ohemaa B Poku, Gloria Alvarez, Trang Nguyen, Nam Truong Nguyen, Donna Shelley, Lawrence H Yang","doi":"10.1080/09540121.2025.2521801","DOIUrl":"10.1080/09540121.2025.2521801","url":null,"abstract":"<p><p><b>ABSTRACT</b>People living with HIV have disproportionate cancer risk and are a priority population for cancer prevention and control efforts globally, including in Vietnam. HIV-related and cancer stigma independently and intersectionally hinder access to and uptake of prevention and treatment. Using formative qualitative research that used the \"What Matters Most\" theoretical framework and cognitive interviewing, we developed three culturally-tailored stigma scales for people living with HIV in Hanoi, Vietnam (i.e., for anticipated intersectional HIV-related and cancer stigma, internalized HIV-related stigma, and public cancer stigma [i.e., negative community attitudes]). Scales were administered to 100 people living with HIV alongside existing widely-used stigma scales and measures of cancer prevention-related constructs. This initial psychometric validation supported that each scale has two subscales reflecting how cultural aspects both shape and protect against stigma, strong reliability (ranging from <i>α </i>= 0.76-0.91, <i>ω </i>= 0.78-0.91), and strong convergent validity with corresponding existing scales for internalized HIV-related stigma and public cancer stigma. The culturally-tailored intersectional and cancer-only scales were correlated at least as highly with the measured cancer prevention-related constructs compared to the existing public cancer stigma scale. Culturally-tailored, intersectional scales could help monitor and address stigma, ultimately promoting HIV and cancer prevention, control, and treatment.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1393-1409"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bekana K Tadese, Fritha Hennessy, Tim Holbrook, Girish Prajapati
{"title":"Weight gain and health-related quality of life in people living with HIV on antiretroviral therapy in the United States.","authors":"Bekana K Tadese, Fritha Hennessy, Tim Holbrook, Girish Prajapati","doi":"10.1080/09540121.2025.2534116","DOIUrl":"10.1080/09540121.2025.2534116","url":null,"abstract":"<p><p>Adverse weight gain has been reported to be associated with certain antiretroviral drugs. This study evaluated the association between weight gain and health-related quality of life (HRQoL) among people living with HIV (PLWH) using real-world data. Data were derived from the Adelphi HIV Disease Specific Programme (DSP)™, a real-world, cross-sectional survey of physicians and virologically suppressed PLWH under their treatment, conducted in the U.S. between June 2021 and July 2022. Physicians reported demographic and clinical characteristics of PLWH, including weight. Health-related quality of life was assessed using the Impact of Weight on Quality of Life-Lite-Clinical Trials (IWQoL-Lite-CT) questionnaire. Propensity score matching (PSM) and weighted regression was utilized to compare health-related quality of life in PLWH with 12-month weight gain of ≥5% and <5%. Among 225 PLWH (≥5%: 54 and <5%:171) analysed, mean age was 46.3 years, 80.1% were male, 31.0% Black, mean Charlson Comorbidity Index was 4.2 (SD = 0.5). After PSM and regression adjustment, PLWH with ≥5% weight gain had on average, a lower IWQoL-Lite-CT composite score (65.8 vs 74.4; <i>p</i> < 0.001) and sub-domain scores, indicating poorer quality of life. The study findings demonstrate the humanistic impact of weight gain in PLWH, highlighting the need to consider weight gain in the management of HIV, including selection of appropriate antiretroviral therapy.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1283-1291"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of first-line antiretroviral therapy choice on adverse drug reactions in children with HIV infection: a retrospective cohort study in southwest China.","authors":"Qiuli Chen, Yanyan Liao, Peijiang Pan, Chunyan Lu, Chuanyi Ning, Hailong Wang, Junjun Jiang, Li Ye, Lijuan Zhou, Shanfang Qin, Hao Liang","doi":"10.1080/09540121.2025.2532601","DOIUrl":"10.1080/09540121.2025.2532601","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) is essential in managing children with human immunodeficiency virus (HIV) infection, but is often complicated by adverse drug reactions (ADRs), which can significantly impact therapeutic outcomes. This study investigates ADRs in 375 children with HIV receiving zidovudine (AZT)- or abacavir (ABC)-based ART regimens, using Kaplan-Meier, Cox regression analyses to evaluate ADR incidences, and propensity score matching (PSM) to address confounders. We found ADRs occurred in 21.9% of the cohort. Incidence was significantly higher with the ABC-based regimen (31.2%) versus the AZT-based regimen (17.2%). Most ADRs-primarily gastrointestinal-emerged within the first month of ART. Cox regression analysis confirmed ABC-based regimen nearly tripled the ADR risk (adjusted hazard ratio [aHR] = 2.987, <i>P</i> < 0.001). Notably, children at advanced WHO clinical stages (III-IV) on the ABC-based regimen faced even greater risk (aHR = 3.190, <i>P</i> = 0.005) compared to earlier stages (I-II). These results underscore the need for regimen customization based on disease severity to improve safety and efficacy in pediatric HIV treatment, informing optimized ART protocols and personalized strategies.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1346-1354"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad Chehab, Kim Engler, Tibor Schuster, David Lessard, Esli Osmanlliu, Abdul Cadri, Bertrand Lebouché
{"title":"Studied factors and metrics of patient portal use among people with HIV: a rapid scoping review.","authors":"Mohamad Chehab, Kim Engler, Tibor Schuster, David Lessard, Esli Osmanlliu, Abdul Cadri, Bertrand Lebouché","doi":"10.1080/09540121.2025.2532596","DOIUrl":"10.1080/09540121.2025.2532596","url":null,"abstract":"<p><p>For people living with HIV (PLHIV), patient portals could facilitate access to personal health records while promoting self-management and retention in care. Given the apparent heterogeneity in the studied factors influencing portal use among PLHIV and the metrics used in research, we conducted a rapid scoping review to inventory them. Two databases were searched (Medline and Embase on the Ovid platform) from conception until 15 September 2023. Two reviewers screened all records and full texts. Studies published in English, employing quantitative methods, including a portal usage metric, and involving PLHIV were included. Influencing factors and metrics were classified based on categorizations generated from previous relevant reviews. From 1421 records, 188 full-text studies were assessed, and 18 were included. Published between 2010 and 2022 and mostly from the USA (94%), these studies identified 35 portal usage metrics in five categories (e.g., patient use/adoption, frequency, duration). Similarly, 35 influencing factors were identified, mainly health-related (e.g., HIV viral load) or demographic (e.g., race/ethnicity). This review confirmed the heterogeneity of metrics and influencing factors concerning patient portal use among PLHIV. Developing a conceptual framework of influencing factors and a taxonomy of use metrics could help orient and harmonize future research in this area.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1366-1379"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios Nikolopoulos, Ashley Buchanan, Natallia Katenka, Elli Bonova, Katerina Pantavou, Daniele Piovani, Ke Zhang, Stefanos Bonovas, Samuel R Friedman, Konstantinos Fokianos
{"title":"Evaluation of spill-over effects of antiretroviral treatment on sharing injecting equipment in a sociometric network of people who inject drugs.","authors":"Georgios Nikolopoulos, Ashley Buchanan, Natallia Katenka, Elli Bonova, Katerina Pantavou, Daniele Piovani, Ke Zhang, Stefanos Bonovas, Samuel R Friedman, Konstantinos Fokianos","doi":"10.1080/09540121.2025.2530411","DOIUrl":"10.1080/09540121.2025.2530411","url":null,"abstract":"<p><p>The evidence on risk compensation due to antiretroviral treatment (ART) use for people, who inject drugs (PWID), is limited. Moreover, interventions, including ART administration, frequently have spill-over effects, i.e., individuals who were not exposed themselves possibly benefit from their connections to those who were exposed. This work aimed to evaluate the causal effects in the presence of spill-over of ART uptake on sharing injecting equipment. Data were obtained from the Transmission Reduction Intervention Project, a network-based intervention among PWID in 2013-2015 in Athens, Greece. An inverse probability weighted estimator (IPWE) was used to assess spill-over effects. The analysis included 218 individuals, with 17% of them being on ART, corresponding to 32% of those living with HIV. The adjusted estimated risk differences (RD) between those on ART and those without ART (direct effects) ranged from 0.105 to 0.155 and were not statistically significant. Comparing participants, who did not receive ART across different levels of ART exposure among their first-degree contacts in the network (spill-over effects), the estimated RDs indicated a protective but not statistically significant spill-over effect of ART. The analyses of PWID-related network data, using a novel estimator, detected no statistically significant effects of ART on sharing injection equipment.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1380-1392"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciana Cardoso Martins, Ana Célia Oliveira Dos Santos, Marcelo Palmares Oliveira E Silva, Paulo Sérgio Ramos de Araújo
{"title":"Risk factors related to sarcopenia in people living with HIV/AIDS according to 2010 and 2019 European Working Group on Sarcopenia in Older People.","authors":"Luciana Cardoso Martins, Ana Célia Oliveira Dos Santos, Marcelo Palmares Oliveira E Silva, Paulo Sérgio Ramos de Araújo","doi":"10.1080/09540121.2025.2488875","DOIUrl":"10.1080/09540121.2025.2488875","url":null,"abstract":"<p><p><b>ABSTRACT</b>The European Working Group on Sarcopenia in Older People (EWGSOP) updated its criteria, prioritizing muscle strength as the most reliable measure of muscle function. People living with HIV/AIDS (PLWHA) age prematurely, making it important to understand factors associated with unfavorable outcomes and to promote good health and well-being. This study analyzes factors and the prevalence of sarcopenia in PLWHA using the 2010 (EWGSOP1) and 2018 (EWGSOP2) criteria. Were included PLWHA aged 40 or older, treated at an outpatient clinic of a tertiary hospital between 2019 and 2021. Socio-demographic, clinical, and laboratory data were evaluated. Numerical variables were analyzed using central tendency and dispersion measures, while associations between categorical variables were evaluated using chi-square and Fisher's exact tests. The sample consisted of 218 PLWHA with a mean age of 52 ± 8.3 years. According to EWGSOP1, 11.1% were diagnosed with sarcopenia, with increasing age, male gender, and Body Mass Index (BMI) as associated factors. Using EWGSOP2, only 1.4% were classified as sarcopenic, with no associations found between sarcopenia and the studied variables. The prevalence of sarcopenia in PLWHA was eight times higher using EWGSOP1 than EWGSOP2. From a disease prevention perspective, EWGSOP1 criteria seem more appropriate for PLWHA.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1410-1416"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Van Thi Ngoc Tran, Lam Khanh Phung, Hoa Hong Nguyen, Linh Thi Dan Pham, Diep Thi Ngoc Nguyen, Thao Thi Thu Nguyen, Van Thi Hai Hoang, Le Minh Giang, Le Thi Huong, Bradley Neil Gaynes
{"title":"Evidence-based interventions targeting mental health problems in adolescents living with HIV: a scoping review.","authors":"Van Thi Ngoc Tran, Lam Khanh Phung, Hoa Hong Nguyen, Linh Thi Dan Pham, Diep Thi Ngoc Nguyen, Thao Thi Thu Nguyen, Van Thi Hai Hoang, Le Minh Giang, Le Thi Huong, Bradley Neil Gaynes","doi":"10.1080/09540121.2025.2534534","DOIUrl":"10.1080/09540121.2025.2534534","url":null,"abstract":"<p><p>Adolescents living with HIV are at an increased risk of experiencing mental health challenges, impacting their overall well-being and treatment adherence. Evidence-based interventions are crucial to addressing these issues; however, the effectiveness remains unclear. This scoping synthesised all interventions that tested either the prevention or improvement of mental health for adolescents living with HIV. Potential articles were searched up to September 2024 in PubMed, PsycINFO, CINAHL, Embase and Cochrane to identify RCTs evaluating mental health interventions for HIV-infected adolescents. 13/1015 studies were selected, with diverse sample sizes from 21 to 842 participants aged 15-19 years (females: a maximum of 66%). Follow-up intervention periods ranged from 1 to 48 months. Interventions showed mixed effectiveness in improving mental health outcomes. Six studies reported a reduction in depression symptoms compared to no difference/no favourable results in the remaining studies. The emotional or behavioral symptoms were reduced in four studies, versus no difference in the other studies. Two out of four studies showed the effectiveness of trauma intervention. A mixed result needs to be confirmed in future RCTs. This review provides valuable insights into improving the mental health of HIV-infected adolescents and can guide further research and practice in this area.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1208-1220"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}