Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv最新文献_第6页

Humanising the law: harnessing science and community voices to end HIV criminalisation. 使法律人性化：利用科学和社区的声音结束对艾滋病毒的刑事定罪。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-20 DOI: 10.1080/09540121.2025.2562458

Edwin J Bernard

{"title":"Humanising the law: harnessing science and community voices to end HIV criminalisation.","authors":"Edwin J Bernard","doi":"10.1080/09540121.2025.2562458","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562458","url":null,"abstract":"HIV criminalisation is a global phenomenon undermining both public health and human rights. Although scientific advances have transformed HIV into a manageable condition, legal systems have not kept pace. This paper traces the evolution of community-led responses to HIV criminalisation over nearly two decades, demonstrating how science, advocacy, and storytelling have collectively reshaped legal and policy frameworks. It describes the formation and strategic interventions of the HIV Justice Network and, later, the HIV JUSTICE WORLDWIDE coalition; highlights methodological innovations such as legal monitoring and community-based documentation; and emphasises the centrality of human rights principles. Case examples - including the legacy of Ugandan nurse Rosemary Namubiru - illustrate the impact of HIV criminalisation and the power of resilience. While challenges persist amidst growing authoritarianism and disinformation, coordinated global efforts continue to advance evidence-informed, rights-based alternatives. This paper calls for a humanisation of the law that centres lived experiences, elevates scientific understanding, and fosters justice for people living with HIV. Ultimately, this paper argues for a paradigm shift from punitive legal responses to approaches rooted in care, dignity, and justice.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness of HIV among Bangladeshi women: evidence from the MICS dataset. 孟加拉国妇女对艾滋病毒的认识：来自多指标集数据集的证据。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-19 DOI: 10.1080/09540121.2025.2560100

Sayed Jubair Bin Hossain, Fariha Kadir, Muhammad Ihsan-Ul- Kabir, Maruf Hasan Rumi

{"title":"Awareness of HIV among Bangladeshi women: evidence from the MICS dataset.","authors":"Sayed Jubair Bin Hossain, Fariha Kadir, Muhammad Ihsan-Ul- Kabir, Maruf Hasan Rumi","doi":"10.1080/09540121.2025.2560100","DOIUrl":"https://doi.org/10.1080/09540121.2025.2560100","url":null,"abstract":"Bangladesh exhibits a low prevalence of HIV; however, socioeconomic and gender disparities contribute to an increased vulnerability among women, primarily due to limited awareness of transmission methods, preventive measures, and testing services. This study employs data from the Multiple Indicators Cluster Survey (MICS) 2019, utilizing descriptive statistics, Chi-square tests, and logistic regression analyses to examine the influence of socio-demographic factors, educational attainment, and media exposure on HIV awareness. The findings indicate a moderate level of awareness, albeit accompanied by widespread misconceptions; only 27.5% of women knew where to access testing services. Women residing in urban areas, possessing higher education levels, belonging to wealthier households, and with media exposure demonstrated significantly higher awareness levels. Disparities are evident across different regions, notably in Barishal and Mymensingh. Futhermore, women with higher secondary education exhibited a 17.5-fold increase in HIV knowledge compared to those with primary education. The study underscores the importance of targeted educational initiatives, media campaigns, and enhanced testing acessibility, particularly in underserved regions, to improve awareness and mitigate stigma.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV risk perception through unprotected sex after traditional male circumcision (the practice of sifon) using the health belief model in West Timor, Indonesia. 在印度尼西亚西帝汶，利用健康信念模型，在传统男性包皮环切术（割礼）后通过无保护的性行为认识艾滋病毒风险。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-19 DOI: 10.1080/09540121.2025.2562246

Gregorius Abanit Asa, Nelsensius Klau Fauk, Hailay Abrha Gesesew, Paul Russell Ward

{"title":"HIV risk perception through unprotected sex after traditional male circumcision (the practice of sifon) using the health belief model in West Timor, Indonesia.","authors":"Gregorius Abanit Asa, Nelsensius Klau Fauk, Hailay Abrha Gesesew, Paul Russell Ward","doi":"10.1080/09540121.2025.2562246","DOIUrl":"https://doi.org/10.1080/09540121.2025.2562246","url":null,"abstract":"This study aimed to explore the HIV risk perception of having unprotected sexual intercourse following traditional male circumcision (TMC), a practice known as sifon, in West Timor, Indonesia. Guided by the Health Belief Model, we interviewed 34 men who underwent TMC, 7 traditional practitioners and 13 women who had engaged and analysed them thematically. The result showed that most of the participants had low HIV risk perception towards sifon practice and had low perceived severity of the impact of HIV/AIDS, which was supported by a strong cultural belief in sifon practice and lack of knowledge of HIV/AIDS. Similarly, most of the participants who underwent sifon did not see the benefit of using condoms when performing sifon. The findings showed that participants are at high risk of acquiring HIV infection due to performing sifon without protection. The findings indicated the need for open, detailed and consistent health education on the risk of HIV transmission through sifon practice in communities practising TMC and sifon irrespective of their status.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-13"},"PeriodicalIF":1.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contraceptive method continuation among a prospective cohort study of Malawian women on antiretroviral treatment initiating the Levonorgestrel Implant or the Depot Medroxyprogesterone Acetate Injectable for pregnancy prevention (the FP-ART study). 在一项马拉维妇女抗逆转录病毒治疗的前瞻性队列研究中继续使用避孕方法，开始使用左炔诺孕酮植入物或Depot醋酸甲孕酮注射剂预防妊娠（FP-ART研究）。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-17 DOI: 10.1080/09540121.2025.2556694

Jill Hagey, Xingyan Liu, Katie Mollan, Karen Diepstra, Clara Lemani, John Chapola, Agatha Bula, Jennifer Winston, Lameck Chinula, Mina Hosseinipour, Sam Phiri, Ashley Appiagyei, Michael Hudgens, Jennifer H Tang

{"title":"Contraceptive method continuation among a prospective cohort study of Malawian women on antiretroviral treatment initiating the Levonorgestrel Implant or the Depot Medroxyprogesterone Acetate Injectable for pregnancy prevention (the FP-ART study).","authors":"Jill Hagey, Xingyan Liu, Katie Mollan, Karen Diepstra, Clara Lemani, John Chapola, Agatha Bula, Jennifer Winston, Lameck Chinula, Mina Hosseinipour, Sam Phiri, Ashley Appiagyei, Michael Hudgens, Jennifer H Tang","doi":"10.1080/09540121.2025.2556694","DOIUrl":"10.1080/09540121.2025.2556694","url":null,"abstract":"Limited prospective data exist for long-term hormonal contraceptive continuation rates among women living with HIV. We conducted a prospective cohort study of women living with HIV in Lilongwe, Malawi from 2017 to 2021 and evaluated their contraceptive method continuation and ART regimens. Participants initiating either depot medroxyprogesterone acetate (DMPA) injection or levonorgestrel (LNG) implant were followed every 24 weeks for up to 192 weeks. 1,359 participants enrolled in the study; 689 initiated the DMPA injection, and 670 initiated the LNG implant. At enrollment, DMPA and implant users had similar age, body mass index, educational levels, number of children, breastfeeding status, future pregnancy intention, CD4 count, and HIV viral load. 1,179 participants (86.8%) usedefavirenz-based therapy at enrollment, with 874 (74.1%) switching to dolutegravir-based therapy by their last study visit. During study follow-up, 225 (32.7%) DMPA and 141 (21.0%) implant users discontinued their initial contraceptive method. Time to method discontinuation differed between the two contraceptive groups (log-rank p < 0.001). The time by which 25% of women had discontinued their initial contraceptive also differed markedly: 76.0 weeks for the DMPA group and 142.7 weeks for the implant group. Future studies can evaluate the factors that lead to contraceptive continuation versus discontinuation among WLWH.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1-13"},"PeriodicalIF":1.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective analysis of factors influencing immunologic failure among people living with HIV on antiretroviral therapy. 艾滋病病毒感染者抗逆转录病毒治疗免疫功能衰竭影响因素的回顾性分析。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1080/09540121.2025.2534541

Donglan Chen, Qiuhua Chen, Manzhou Lin

引用次数: 0

Assessment of targeted intervention programs on STI symptoms among Hijra and transgender in India: analysis of national level integrated biological and behavioral surveillance. 印度海吉拉和跨性别者性传播感染症状针对性干预方案评估：国家层面综合生物和行为监测分析

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1080/09540121.2025.2534109

Nishakar Thakur, Shreya Jha, Sanjay Rai, Shashi Kant, Yujwal Raj, M Kalaivani, Puneet Misra, Partha Haldar, Kiran Goswami, Chinmoyee Das

{"title":"Assessment of targeted intervention programs on STI symptoms among Hijra and transgender in India: analysis of national level integrated biological and behavioral surveillance.","authors":"Nishakar Thakur, Shreya Jha, Sanjay Rai, Shashi Kant, Yujwal Raj, M Kalaivani, Puneet Misra, Partha Haldar, Kiran Goswami, Chinmoyee Das","doi":"10.1080/09540121.2025.2534109","DOIUrl":"10.1080/09540121.2025.2534109","url":null,"abstract":"We aimed to evaluate the effectiveness of a Targeted Intervention (TI) program on Sexually Transmitted Infection (STI) symptoms among Hijra and Transgender (H/TG) persons in India. We analyzed the H/TG data from the national Integrated Biological and Behavioral Surveillance (IBBS) Survey for the years 2014-2015. The IBBS was a cross-sectional survey of 4,966 H/TG. Descriptive analysis was employed to delineate the socio-demographic profile of H/TG, along with program exposure components. Bivariate and multivariate logistic regression were utilized to compute unadjusted and adjusted odds ratios, along with their 95% confidence intervals. The Propensity Score Matching (PSM) method was employed to evaluate the effectiveness of the TI program on STI symptoms. All statistical analyses were performed using STATA version 16.0 (STATA Corp., College Station, TX, USA). H/TG who had received information on STI/HIV/AIDS from Peer Educators/Outreach Workers (PEs/ORWs) were 3.03 times more likely to have STI symptoms (aOR: 3.03, CI: 2.44-3.76), than the H/TG who did not receive the information. H/TG who had received condoms from PEs/ORWs were 0.57 times less likely to report STI symptoms (aOR: 0.57, CI: 0.47-0.71) than the H/TG who did not receive the condom. H/TG who had seen a demonstration on correct use of condom from PEs/ORWs were 0.67 times less likely to report STI symptoms (aOR: 0.67, CI: 0.57-0.80) than the H/TG who had not seen the demonstration. The TI program intervention among H/TG was effective in reducing the reported prevalence of STI symptoms.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1568-1575"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-adherence to antiretroviral therapy in pregnant women with HIV in Brazil, 2014-2019: a spatial analysis. 2014-2019年巴西感染艾滋病毒的孕妇不坚持抗逆转录病毒治疗的空间分析

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-07-21 DOI: 10.1080/09540121.2025.2534540

Luana Andrade Simões, Tércia Moreira Ribeiro da Silva, Matheus Marchesotti Dutra Ferraz, Guilherme Augusto Veloso, Maria das Graças Braga

{"title":"Non-adherence to antiretroviral therapy in pregnant women with HIV in Brazil, 2014-2019: a spatial analysis.","authors":"Luana Andrade Simões, Tércia Moreira Ribeiro da Silva, Matheus Marchesotti Dutra Ferraz, Guilherme Augusto Veloso, Maria das Graças Braga","doi":"10.1080/09540121.2025.2534540","DOIUrl":"10.1080/09540121.2025.2534540","url":null,"abstract":"This ecological study analyzed spatial patterns of non-adherence to antiretroviral therapy (ART) among pregnant women initiating treatment in Brazil from 2014 to 2019. Data were obtained from national systems: SICLOM, SISCEL, and IBGE. Among 23,757 pregnant women aged 15-49, most were aged 20-29 (54%), identified as brown (37.7%), had 8-11 years of education (7.9%), and lacked a partner (36.7%). The non-adherence rate was 20% (n = 4,742). Higher non-adherence was associated with being aged 20-24 (29%, p < 0.005), brown skin color (39.8%, p < 0.005), low education (0-7 years, 27.2%, p < 0.005), no partner (38%, p < 0.005), and changes in ART regimens (19.9%, p < 0.005). Spatial analysis showed higher non-adherence rates in the North and Northeast and lower rates in the South and Central-West. These findings reveal that social vulnerabilities, particularly in less developed regions, hinder ART adherence. Strengthening social policies and improving health service distribution are crucial to ensuring equitable access and supporting pregnant women living with HIV, especially in rural and remote areas.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1423-1433"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human-centered design of an adapted differentiated service delivery model for pregnant and postpartum women living with HIV in Kenya. 为肯尼亚感染艾滋病毒的孕妇和产后妇女提供适应的差异化服务模式的以人为本的设计。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-04-01 DOI: 10.1080/09540121.2025.2485397

John Humphrey, Bett Kipchumba, James G Carlucci, Roselyne Midiwo, Edwin Were, Alan McGuire, Julia Songok, Winstone Nyandiko, Gregory Zimet, Kara Wools-Kaloustian, Violet Naanyu

{"title":"Human-centered design of an adapted differentiated service delivery model for pregnant and postpartum women living with HIV in Kenya.","authors":"John Humphrey, Bett Kipchumba, James G Carlucci, Roselyne Midiwo, Edwin Were, Alan McGuire, Julia Songok, Winstone Nyandiko, Gregory Zimet, Kara Wools-Kaloustian, Violet Naanyu","doi":"10.1080/09540121.2025.2485397","DOIUrl":"10.1080/09540121.2025.2485397","url":null,"abstract":"Differentiated service delivery (DSD) models for pregnant and postpartum women living with HIV (WLH) are lacking despite guidelines recommending DSD for this population. We used human-centered design (HCD) to develop a DSD model for pregnant and postpartum WLH at the Academic Model Providing Access to Healthcare (AMPATH) in Kenya. We conducted co-creation workshops with 11 postpartum women, 9 male partners and 9 providers from three AMPATH-affiliated facilities to develop a DSD model, refined by program/county health officials. The workshops used WHO building blocks for DSD to determine eligibility criteria and strategies for clinical encounters, antiretroviral therapy (ART) distribution, and psychosocial support. We used nominal group techniques and thematic analyses to identify DSD attributes, themes and preference heterogeneity. Workshops yielded a facility-based DSD model with these attributes: eligibility criteria including age ≥18 years, not primigravida, retention in care, viral load <50 copies/mL, no active maternal/child comorbidities; monthly clinical encounters during pregnancy and 6 months postpartum, then every 2-3 months aligned with immunization/HIV testing schedules; flexible ART refills every 1-6 months; psychosocial counseling by mentor mothers as needed. This model was acceptable to stakeholders with perceived feasibility/scalability. Engaging end-users through HCD generated a person-centered DSD model for integrated MCH clinics in Kenya.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1434-1449"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the digital connections: comprehensive HIV knowledge, awareness of antiretroviral therapy, and digital media use among adolescents and young adults in a middle-income country. 检查数字联系：全面的艾滋病毒知识、抗逆转录病毒治疗的认识以及中等收入国家青少年和年轻人的数字媒体使用情况。

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-07-20 DOI: 10.1080/09540121.2025.2534121

Xavier Javines Bilon

{"title":"Examining the digital connections: comprehensive HIV knowledge, awareness of antiretroviral therapy, and digital media use among adolescents and young adults in a middle-income country.","authors":"Xavier Javines Bilon","doi":"10.1080/09540121.2025.2534121","DOIUrl":"10.1080/09540121.2025.2534121","url":null,"abstract":"There remains a gap in identifying factors that influence HIV knowledge among younger people in middle-income countries who report higher Internet access and social media use. In this study, the association of use of two types of digital media - Internet media and social media - for information about sex with comprehensive HIV knowledge and ART awareness among youth aged 15-24 was measured. Data from the 2021 Young Adult Fertility and Sexuality Study in the Philippines (n = 10,949) were used, and the adolescent health literacy framework was adopted to obtain parsimonious weighted logistic regression models. Digital media use for information about sex yielded varied results concerning improved comprehensive HIV knowledge and ART awareness. Social media use was only associated with improved comprehensive HIV knowledge (adjusted odds ratio [aOR] = 1.265, p = .002), but not ART awareness (aOR = 1.244, p = .063). Meanwhile, the use of Internet media was not associated with improved comprehensive HIV knowledge (aOR = 1.105, p = .335) nor ART awareness (aOR = 1.025, p = .832). Recommendations on how public health initiatives could maximize the potential of digital media to enhance HIV awareness were discussed.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1576-1586"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutations associated with viral resistance to integrase in individuals initiating dolutegravir-containing antiretroviral therapy: retrospective cohort, Brazil 2017-2019. 开始含曲地韦抗逆转录病毒治疗的个体中与病毒对整合酶耐药性相关的突变：回顾性队列，巴西2017-2019

IF 1.2 4区医学

Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1080/09540121.2025.2474672

Igor Francisco Chagas Dos Santos, Alexandre Sampaio Moura, Matheus Marchesotti Dutra Ferraz, Carla Maria Gonçalves de Macedo Moreira, Paula Meireles, Maria das Graças Braga

{"title":"Mutations associated with viral resistance to integrase in individuals initiating dolutegravir-containing antiretroviral therapy: retrospective cohort, Brazil 2017-2019.","authors":"Igor Francisco Chagas Dos Santos, Alexandre Sampaio Moura, Matheus Marchesotti Dutra Ferraz, Carla Maria Gonçalves de Macedo Moreira, Paula Meireles, Maria das Graças Braga","doi":"10.1080/09540121.2025.2474672","DOIUrl":"10.1080/09540121.2025.2474672","url":null,"abstract":"ABSTRACTRetrospective cohort aimed to analyze viral resistance mutations to integrase in people living with HIV/Aids (PLWHA) in Brazil. Patients receiving first-line therapy with a three-drug antiretroviral (ART) regimen containing dolutegravir (DTG), with HIV-1 genotypic resistance test available after starting treatment, were included. Data from three national databases related to antiretroviral dispensing, LT CD4+ cell count and HIV viral load (VL), and genotyping resistance testing were linked. Ideal adherence was defined as the proportion of days covered (PDC) ≥ 80%. Thirty (7.0%) of the 430 participants had resistance to DTG; five had high and 11 had moderate resistance levels. The N155H (n = 9) and E138K (n = 7) mutations were the most prevalent. DTG mutations were significantly more prevalent among males, whites, and those with HIV-VL count > 100,000 copies/mL, switching to alternative regimens or with resistance mutations to other classes of antiretroviral drugs (p < 0.05). Ideal ART adherence was observed in 52.8% of the participants and it was associated with DTG mutations (p < 0.001). This study described the resistance mutations to DTG in individuals starting treatment with this drug and the characteristics of such individuals. Understanding such a profile is crucial to regions where a DTG-containing regimen is the recommended first-line therapy.","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1602-1612"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0