Igor Francisco Chagas Dos Santos, Alexandre Sampaio Moura, Matheus Marchesotti Dutra Ferraz, Carla Maria Gonçalves de Macedo Moreira, Paula Meireles, Maria das Graças Braga
{"title":"Mutations associated with viral resistance to integrase in individuals initiating dolutegravir-containing antiretroviral therapy: retrospective cohort, Brazil 2017-2019.","authors":"Igor Francisco Chagas Dos Santos, Alexandre Sampaio Moura, Matheus Marchesotti Dutra Ferraz, Carla Maria Gonçalves de Macedo Moreira, Paula Meireles, Maria das Graças Braga","doi":"10.1080/09540121.2025.2474672","DOIUrl":"10.1080/09540121.2025.2474672","url":null,"abstract":"<p><p><b>ABSTRACT</b>Retrospective cohort aimed to analyze viral resistance mutations to integrase in people living with HIV/Aids (PLWHA) in Brazil. Patients receiving first-line therapy with a three-drug antiretroviral (ART) regimen containing dolutegravir (DTG), with HIV-1 genotypic resistance test available after starting treatment, were included. Data from three national databases related to antiretroviral dispensing, LT CD4+ cell count and HIV viral load (VL), and genotyping resistance testing were linked. Ideal adherence was defined as the proportion of days covered (PDC) ≥ 80%. Thirty (7.0%) of the 430 participants had resistance to DTG; five had high and 11 had moderate resistance levels. The N155H (<i>n</i> = 9) and E138K (<i>n</i> = 7) mutations were the most prevalent. DTG mutations were significantly more prevalent among males, whites, and those with HIV-VL count > 100,000 copies/mL, switching to alternative regimens or with resistance mutations to other classes of antiretroviral drugs (<i>p</i> < 0.05). Ideal ART adherence was observed in 52.8% of the participants and it was associated with DTG mutations (<i>p</i> < 0.001). This study described the resistance mutations to DTG in individuals starting treatment with this drug and the characteristics of such individuals. Understanding such a profile is crucial to regions where a DTG-containing regimen is the recommended first-line therapy.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1602-1612"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrating HIV prevention into routine health obstetric and gynecologic care.","authors":"Sneha Thatipelli, Megan Grabill, Kayla Harrell, Nia Bhadra-Heintz, Sara Solomon, Shimrit Keddem, Florence Momplaisir","doi":"10.1080/09540121.2025.2534110","DOIUrl":"10.1080/09540121.2025.2534110","url":null,"abstract":"<p><p>There is low uptake of PrEP for women. This study aims to understand the barriers and facilitators to improving PrEP uptake and integrating PrEP care into obstetric and gynecologic (OBGYN) care. We used the consolidated framework for implementation research (CFIR 2.0) to guide our approach. We conducted semi-structured interviews with OBGYN professionals, medical directors, and PrEP navigators. Participants were recruited via emails and purposeful sampling. Between May and December 2023, we completed 16 interviews. All participants heard of oral PrEP and felt that HIV prevention was within their scope of practice, but very few were prescribing PrEP. On a scale of 1-10 with 10 being most comfortable, the average comfort level identifying PrEP candidates was 6.96 (SD 1.91), but comfort prescribing PrEP was 6.11 (SD 2.51). Barriers to PrEP included insurance considerations, a lack of clinic infrastructure to support PrEP prescription and monitoring, and discomfort with prescribing PrEP (Individual). Key facilitators were PrEP stewards, professional and patient PrEP awareness and knowledge. Proposed strategies to increase PrEP uptake included PrEP education, workflow improvements, and utilizing the electronic medical record for HIV screening and PrEP care. Addressing multilevel barriers and facilitators can help increase PrEP uptake in the OBGYN setting.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1450-1461"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gwang Suk Kim, Sooyoung Kwon, Layoung Kim, Seoyoung Baek
{"title":"Exploring barriers to the HIV care continuum among people living with HIV in South Korea: a cross-sectional descriptive study.","authors":"Gwang Suk Kim, Sooyoung Kwon, Layoung Kim, Seoyoung Baek","doi":"10.1080/09540121.2025.2535469","DOIUrl":"10.1080/09540121.2025.2535469","url":null,"abstract":"<p><p>Despite the importance of care continuum in managing chronic diseases, people living with HIV (PLWH) face multiple challenges. This study explored the multifaceted barriers to the HIV care continuum perceived by PLWH and assessed differences based on individual characteristics. A cross-sectional online survey was conducted with 243 PLWH from five hospital outpatient clinics. Factor analysis identified 26 items clustered into five subdomains of barriers to the HIV care continuum: \"unfriendly healthcare service\", \"life and environmental factors distracting from treatment\", \"internal and social stigma\", \"difficulties in adhering to medication\", and \"denial and fear of diagnosis\". Descriptive analysis showed that total barrier scores were significantly higher among individuals with college-level education or higher, unemployment, single marital status, non-receipt of National Medical Aid, and high self-efficacy in managing their healthcare (all <i>p</i> < .05). Regarding barrier subdomains, internal and social stigma was more prominent in the early stage of HIV diagnosis, while unfriendly healthcare service and difficulties in medication adherence were greater in the later stage. The identified barriers spanned diagnosis, treatment, healthcare services, and stigma, and vary by individual characteristics and stage of diagnosis. These findings emphasize the need for tailored, stage-specific interventions to enhance continuity of HIV care.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1482-1492"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonia Poteat, Yi Liu, Darya Adams, L Leigh-Ann van der Merwe, Allanise Cloete, Lauren E Howard, Janice McCarthy
{"title":"Social determinants of HIV status and viral load suppression among transgender women in South Africa: a cross-sectional analysis.","authors":"Tonia Poteat, Yi Liu, Darya Adams, L Leigh-Ann van der Merwe, Allanise Cloete, Lauren E Howard, Janice McCarthy","doi":"10.1080/09540121.2025.2535471","DOIUrl":"10.1080/09540121.2025.2535471","url":null,"abstract":"<p><p>Transgender women in South Africa face a heavy HIV burden, but data on key psychosocial and structural factors remain limited. This cross-sectional study examined associations between HIV outcomes and psychosocial (substance use, alcohol use, medical distrust, community connectedness) and structural (education, homelessness, income, sex work, violence) factors. We conducted interviewer-administered surveys with 213 transgender women in Cape Town, Johannesburg, and East London between June and November 2018. Of the 213 participants, 196 knew their HIV status and 67 reported living with HIV. Multivariable logistic regression found homelessness (aOR 4.50 [95%CI: 1.67, 12.23]), sex work (aOR 5.90 [95%CI: 2.14, 16.29]), and earning above the poverty level (aOR 3.08 [95%CI: 1.37, 6.94]) were significantly associated with living with HIV. Among participants with HIV, sex work (aOR 13.39 [95%CI: 1.17, 153.67]) was the only significant predictor of viral suppression. South Africa's provision of financial support specifically for PHIV may account for associations between income and HIV; while South Africa's sex-worker specific clinics, tailored to this population's needs, may account for their higher viral suppression. Study findings highlight the importance of context-specific HIV research with key populations to identify locally relevant strategies to improve HIV outcomes.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1507-1520"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bingyi Wang, Xin Peng, Yong Lu, Leiwen Fu, Xinyi Li, Zhen Lu, Tian Tian, Weijie Zhang, Xin Xiao, Lin Ouyang, Ying Wang, Maohe Yu, Guohui Wu, Yoshiko Sakuma, Yong Cai, Dan Wu, Weiming Tang, Joseph D Tucker, Huachun Zou
{"title":"Association between frailty and low sexual function among sexually active older adults living with HIV in China: a multi-centre cross-sectional study in China.","authors":"Bingyi Wang, Xin Peng, Yong Lu, Leiwen Fu, Xinyi Li, Zhen Lu, Tian Tian, Weijie Zhang, Xin Xiao, Lin Ouyang, Ying Wang, Maohe Yu, Guohui Wu, Yoshiko Sakuma, Yong Cai, Dan Wu, Weiming Tang, Joseph D Tucker, Huachun Zou","doi":"10.1080/09540121.2025.2480151","DOIUrl":"10.1080/09540121.2025.2480151","url":null,"abstract":"<p><p>The expanding ageing population increases the importance of understanding frailty and related impacts on health. Our objectives were to examine the sexual function and its association with frailty among sexually active older adults aged 50+ living with HIV (OALHIV). A multi-centre cross-sectional study was conducted between September 2021 and July 2022. We enrolled OALHIV from specialized infectious disease hospitals providing HIV care in four cities in China. Data were collected through an investigator-administered questionnaire. Logistic regression was used to assess correlates of lower sexual function. 239 sexually active OALHIV (40 women and 199 men) were included in the present analyzes. 53 (22.2%) participants had frailty. About two-fifths (37.7%) reported at least one sexual difficulty lasting 3 months or more in the past year. Lack of interest in having sex was the most commonly reported sexual response problem (27.2%). 29.7% expressed satisfaction with their sex life. 49 participants were categorized as having a low sexual function. Frailty (aOR 3.03, 95%CI 1.22-7.53) was associated with low sexual function. OALHIV with frailty should be screened for sexual function problems. More efforts should be made to integrate sexual health services into geriatric services, ensuring comprehensive care that addresses their specific sexual concerns.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1539-1550"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph Kirabira, Naume Akello, Keng-Yen Huang, Madrine Nakawuki, Edith Wakida, Celestino Obua, Scholastic Ashaba, Brian C Zanoni, Godfrey Zari Rukundo
{"title":"Lived experiences and coping mechanisms among children and adolescents living with HIV after HIV disclosure in Eastern Uganda.","authors":"Joseph Kirabira, Naume Akello, Keng-Yen Huang, Madrine Nakawuki, Edith Wakida, Celestino Obua, Scholastic Ashaba, Brian C Zanoni, Godfrey Zari Rukundo","doi":"10.1080/09540121.2025.2534117","DOIUrl":"10.1080/09540121.2025.2534117","url":null,"abstract":"<p><strong>Purpose: </strong>To understand the experiences and coping mechanisms of children and adolescents living with HIV (CALH) after HIV disclosure.</p><p><strong>Methods: </strong>We conducted a qualitative study among CALH after HIV disclosure receiving care from two referral hospitals in eastern Uganda. In-depth interviews were conducted using an interview guide during routine outpatient visits to HIV clinics until data saturation was achieved. All interviews were audiotaped, and the collected data were analyzed using an inductive thematic approach.</p><p><strong>Results: </strong>We conducted 23 interviews with CALH aged 11-17 years. Participants' experiences of disclosure were categorized into two major themes: (1) negative experiences, including HIV-related stigma, loss of social support and trust, and emotional and behavioral challenges, and (2) positive experiences, including improved self-efficacy and adherence. Coping mechanisms after disclosure were categorized into two themes (1) healthy (adherence to treatment, distraction, guidance and counseling, social support, and cognitive restructuring) and (2) non-healthy (alcohol and other substance use) coping mechanisms.</p><p><strong>Conclusion: </strong>The above experiences and coping mechanisms highlight the need to develop interventions that promote planned early disclosure of HIV status to children, supported by trained healthcare workers with rigorous counseling for better physical and mental health outcomes.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1462-1474"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction.","authors":"","doi":"10.1080/09540121.2025.2529645","DOIUrl":"10.1080/09540121.2025.2529645","url":null,"abstract":"","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1613"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina E Hill, Leslie Pierce, Hannah Chew, Ashley Sellers, David Schlundt, Neerav Desai, Aima A Ahonkhai
{"title":"Evaluating patient outcomes and stakeholder perspectives in a novel healthcare transition clinic for young people living with HIV: a mixed methods study.","authors":"Nina E Hill, Leslie Pierce, Hannah Chew, Ashley Sellers, David Schlundt, Neerav Desai, Aima A Ahonkhai","doi":"10.1080/09540121.2025.2534124","DOIUrl":"10.1080/09540121.2025.2534124","url":null,"abstract":"<p><p>Patients transitioning from pediatric to adult HIV care have lower rates of retention in care and viral suppression. Health system interventions can improve outcomes in adolescents and young adults living with HIV (AYA-HIV). We designed and implemented an Adolescent Young Adult Healthcare Transition (AYAHCT) clinic in a U.S.-based healthcare system. We present a mixed-method (quantitative and qualitative) evaluation. The quantitative analysis included retrospective clinical outcomes between 2017-2023. Qualitative analysis included stakeholder interviews in pediatric, AYAHCT, and adult HIV clinics. The pilot cohort included 18 patients. Patients attended 4.4 visits/year, and retention in care was 100% in the first year in the AYAHCT clinic. However, only 70% of patients were virally suppressed. Seven patients (38.8%) transitioned to adult care, with 85.7% retention in care and 96.8% viral suppression. Stakeholders identified strengths including Ryan White funding, institutional support, and program adaptability. Stakeholders identified barriers, including HIV stigma and political climate in the Southern U.S., with resources needed for mental health, disclosure, and case management. We describe the initial outcomes of the AYAHCT cohort with a qualitative evaluation of clinical implementation. The pilot cohort demonstrated excellent retention across HIV care transitions but low viral suppression. Qualitative analysis revealed opportunities for program improvement.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1493-1506"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria da Conceição Saraiva, Juliana Lauar Gonçalves, Mariana Dias Lula, Simone Caivano, Simone Furtado Dos Santos, Patrícia Ferreira Gomes, Emmanuelle Dutra Oliveira, Maria das Graças Braga
{"title":"Diet quality and nutritional status in people living with HIV on dolutegravir therapy.","authors":"Maria da Conceição Saraiva, Juliana Lauar Gonçalves, Mariana Dias Lula, Simone Caivano, Simone Furtado Dos Santos, Patrícia Ferreira Gomes, Emmanuelle Dutra Oliveira, Maria das Graças Braga","doi":"10.1080/09540121.2025.2534126","DOIUrl":"10.1080/09540121.2025.2534126","url":null,"abstract":"<p><p>While antiretroviral therapy (ART) has improved life expectancy for people living with HIV (PLWHIV), it has also brought new health challenges, including poor diet quality and excess weight. This cross-sectional study evaluated the diet quality and nutritional status of PLWHIV on dolutegravir (DTG)-based therapy in a Brazilian specialized care service. Adults (≥18 years) who initiated DTG between February 2017 and March 2020 were included. Data on sociodemographic, clinical, anthropometric, and dietary aspects were collected through interviews and medical records. Among the 148 participants (92.6% men, mean age 39.2 years), 48.0% were overweight and 24.3% had abdominal obesity. Overweight and obesity were more common among older individuals and those with higher baseline BMI. Abdominal obesity was also associated with lower education, being single, and lower CD4+ T-cell counts. Most women had abdominal obesity, despite most men being of normal weight. Diet quality was poor or intermediate in nearly all participants, marked by low intake of fresh foods and high consumption of ultra-processed items. No correlation was found between diet quality and nutritional status. The findings highlight the need for nutritional monitoring and interventions that also incorporate psychosocial and structural determinants of health among PLWHIV on DTG.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1587-1601"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Henna Budhwani, Jiaying Hao, Dustin M Long, John Waters, Nelson Varas-Díaz, Sylvie Naar, Laura Nyblade, Christyenne L Bond, Robert Paulino-Ramirez, Janet M Turan
{"title":"Results of a workshop intervention trial to reduce HIV and intersectional stigma among sexual and gender minorities and healthcare workers in the Dominican Republic.","authors":"Henna Budhwani, Jiaying Hao, Dustin M Long, John Waters, Nelson Varas-Díaz, Sylvie Naar, Laura Nyblade, Christyenne L Bond, Robert Paulino-Ramirez, Janet M Turan","doi":"10.1080/09540121.2025.2484311","DOIUrl":"10.1080/09540121.2025.2484311","url":null,"abstract":"<p><p>Eliminating stigmas that harm sexual and gender minorities (SGM) with HIV is necessary to end the epidemic; however, few validated stigma-reducing interventions for healthcare settings exist, and even fewer have been evaluated in Spanish-speaking contexts. Finding Respect and Ending Stigma around HIV (FRESH) is a healthcare setting stigma-reduction intervention that was adapted and tested to address HIV and intersectional stigmas that harm SGM with HIV in the Dominican Republic. Herein, we detail the intervention adaptation process and present feasibility, acceptability, and pre-post preliminary effectiveness results ascertained via paired t-tests. Twenty healthcare workers at HIV clinics and sixteen SGM with HIV received the intervention (N = 36). Among healthcare workers, intervention receipt was associated with reductions in negative opinions about people with HIV (PWH, <i>p</i> < 0.05); among SGM PWH there were significant improvements in healthcare empowerment (<i>p</i> < 0.05) and awareness of clinic-based stigma (<i>p</i> < 0.05). Nearly 100% rated the intervention, content, or quality of information as excellent; 95% reported they would recommend FRESH to friends or colleagues. All participants felt the intervention helped them to \"better understand and deal with stigma.\" The Spanish-language FRESH intervention is a promising stigma-reducing intervention for SGM PWH and healthcare workers. Future directions include intervention full-scale testing in Spanish-language settings.</p>","PeriodicalId":48370,"journal":{"name":"Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv","volume":" ","pages":"1530-1538"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}