Steven M Kogan, Ava J Reck, Biplav Tiwari, Janani Rajbhandari Thapha, Sierra Carter, Assaf Oshri, Kalsea Koss, Sun Joo Ahn, Steven Beach, Sycarah Fisher, Emilie Smith, Linhao Zhang
{"title":"Family-Centered Prevention Attenuates the Association Between Structural Racism Risk and Black Adolescents' Low Self-regulation and Externalizing Behaviors: Secondary Analysis of a Randomized Clinical Trial.","authors":"Steven M Kogan, Ava J Reck, Biplav Tiwari, Janani Rajbhandari Thapha, Sierra Carter, Assaf Oshri, Kalsea Koss, Sun Joo Ahn, Steven Beach, Sycarah Fisher, Emilie Smith, Linhao Zhang","doi":"10.1007/s11121-025-01828-5","DOIUrl":"https://doi.org/10.1007/s11121-025-01828-5","url":null,"abstract":"<p><p>Converging evidence underscores the influence of structural racism on the emergence of externalizing behaviors among Black youth. Recent studies suggest that family-centered prevention may attenuate some of the effects of structural racism on youth mental health. Hypotheses were tested regarding the potential of the Strong African American Families (SAAF) preventive intervention (ClinicalTrials.gov Identifier: NCT03590132) to (a) attenuate the influence of structural racism on low self-regulation, (b) attenuate the influence of low self-regulation on externalizing behaviors, and (c) disrupt the pathway from structural racism to externalizing behaviors via low self-regulation. Hypotheses were tested with data from 472 Black youth (mean age = 11.61 at pre-test) and their caregivers participating in a randomized prevention trial. Structural racism was indexed according to a cumulative risk model based on census-level indicators of Black-White disparities in labor force participation, housing, educational attainment, poverty, and a measure of racial segregation. Consistent with hypotheses, we found that SAAF buffered the influence of structural racism risk on low self-regulation. A significant buffering effect was not detected on the path from low self-regulation to externalizing behaviors. Conditional indirect effect analysis suggested that attending SAAF disrupted the pathway linking structural racism to externalizing behaviors via low self-regulation. Study findings underscore the potential benefits of widespread dissemination of family-centered prevention targeting evidence-based protective processes designed for Black youth. Clinical Trial: Registered at Clinicaltrials.gov, NCT03590132, July 5, 2018.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley C Helle, Joan Masters, Karla T Washington, Kenneth J Sher, Jessica M Cronce, Jason R Kilmer, Kristin M Hawley
{"title":"Adoption and Perceptions of the College Alcohol Intervention Matrix (CollegeAIM) Among Professionals in a Higher Education Statewide Prevention Coalition.","authors":"Ashley C Helle, Joan Masters, Karla T Washington, Kenneth J Sher, Jessica M Cronce, Jason R Kilmer, Kristin M Hawley","doi":"10.1007/s11121-025-01824-9","DOIUrl":"https://doi.org/10.1007/s11121-025-01824-9","url":null,"abstract":"<p><p>Alcohol prevention research for college students has resulted in numerous efficacious approaches, but the timeline from development to implementation is long. The College Alcohol Intervention Matrix (CollegeAIM) is a dissemination and implementation tool developed in 2015 and updated in 2019 to aid in the selection of evidence-based alcohol prevention strategies for higher education settings. The present study is the first to examine the use and perceptions of the CollegeAIM tool. Student affairs professionals (N=142) across 23 campuses in a statewide prevention coalition participated in a survey examining CollegeAIM with a focus on implementation outcomes and areas for actionable change. Campuses also provided their prevention strategic plans. Survey data were analyzed via calculation of descriptive statistics. Strategic plans were analyzed via content analysis techniques. Approximately one-third (38%) of participants had heard of the CollegeAIM, but many reported the tool felt unfamiliar and were largely unaware if their departments used the tool to select strategies (16% reported personal use). Over half considered CollegeAIM to be feasible, appropriate, and acceptable for selecting strategies, and CollegeAIM was largely considered to be comprehensive, helpful, and user-friendly. Content analysis of strategic plans revealed that independent of CollegeAIM use, many strategies listed in CollegeAIM were planned for implementation, including many supported by weak evidence. Within one statewide prevention coalition, the CollegeAIM is well-received though is not as widely used by higher education professionals as it could be and has potential for increased uptake with additional dissemination efforts. Recommendations for CollegeAIM use and training are provided.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren M Berny, Lindsey M Nichols, Maria L Schweer-Collins, Emily E Tanner-Smith
{"title":"Brief Drug Interventions Delivered in General Medical Settings: a Systematic Review and Meta-analysis of Cannabis Use Outcomes.","authors":"Lauren M Berny, Lindsey M Nichols, Maria L Schweer-Collins, Emily E Tanner-Smith","doi":"10.1007/s11121-025-01826-7","DOIUrl":"https://doi.org/10.1007/s11121-025-01826-7","url":null,"abstract":"<p><p>There is consistent evidence that brief interventions can be effective in preventing and reducing alcohol use, but support for their effects on illicit drug use is more limited. This meta-analysis expands prior research by testing whether brief drug interventions (BDIs) delivered in general medical settings reduce cannabis consumption and severity across post-intervention follow-up periods and explores potential heterogeneity in these effects. Findings from 17 randomized controlled trials were synthesized to compare short- and long-term cannabis use outcomes between intervention and control groups. Mixed effects meta-regression models were estimated to examine variability in effects across four intervention characteristics: booster session delivery, delivery setting, intervention target, and target population. Sensitivity tests were also conducted for both main effects and moderation analyses. There was no evidence that BDIs yielded significant short-term reductions in cannabis use (OR = 1.20, 95% CI [0.90, 1.62]), consumption level (g = 0.01, 95% CI [- 0.07, 0.09]), or severity (g = 0.13, 95% CI [- 0.07, 0.33]). Similarly, there was no evidence of effects on long-term cannabis use (OR = 1.19, 95% CI [0.73, 1.86]) or consumption level (g = 0.04, 95% CI [- 0.05, 0.12]). Although the primary analyses did not provide evidence of effect moderation, sensitivity tests revealed BDIs delivered in emergency departments evidenced small but significant reductions in long-term cannabis consumption levels. While these findings do not provide support for the overall effectiveness of BDIs on cannabis consumption or severity in general medical settings, they offer suggestive evidence that BDIs may perform more favorably when delivered in emergency departments. Thus, high-quality trials evaluating the effects of BDIs in emergency departments are needed. Given the importance of preventing adverse health outcomes and consequences of cannabis use, more research is needed to improve and evaluate BDI outcomes. Further, developing and testing alternative prevention and intervention approaches are essential to comprehensively address cannabis use.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick O'Neill, Whitney Becker, Casey A Cunningham, Damon E Jones, Ashley N Linden-Carmichael
{"title":"The Role of Policy in Preventing Discrimination-Based Suicide and Substance Use Coping Outcomes Within the Transgender Community.","authors":"Patrick O'Neill, Whitney Becker, Casey A Cunningham, Damon E Jones, Ashley N Linden-Carmichael","doi":"10.1007/s11121-025-01825-8","DOIUrl":"https://doi.org/10.1007/s11121-025-01825-8","url":null,"abstract":"<p><p>Individuals who identify as transgender/gender diverse face an increased risk of discrimination, particularly in health care settings. This discrimination has been associated with higher odds of substance use coping and attempting suicide. However, risk and protective factors that can moderate this relationship remain under-evaluated. The present study examines the role of LGBTQ-friendly state policy climates in preventing discrimination-based outcomes of substance use coping and attempting suicide in the transgender/gender diverse community. Data from the 2008-2009 National Transgender Discrimination Survey were merged with state policy climate scores. Policy climate scores were derived from the tracking of legislation through the Movement Advancement Project. Participants were asked about using substances to cope, prior suicide attempts, and three types of discrimination at mental health clinics (denied equal treatment, verbal harassment/disrespect, physical assault). Being denied equal treatment or service and being verbally harassed or disrespected were both associated with increased odds of using substances to cope and attempting suicide. Residing in a more LGBTQ-friendly policy climate moderated the relationship between being denied equal treatment and a prior suicide attempt as well as the relationship between verbal harassment and both suicide attempt and use of substances to cope. Findings underscore the potential of LGBTQ-friendly policy climates to serve as a protective factor against discrimination faced by the transgender/gender diverse community. A greater understanding of the role of policies in the relationship between discrimination and adverse outcomes can help form policy-based prevention in an effort to improve the lives of individuals in the transgender/gender diverse community.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevention SciencePub Date : 2025-07-01Epub Date: 2025-04-14DOI: 10.1007/s11121-025-01803-0
Griselda Martinez, Brian H Calhoun, Charles B Fleming, Ashley N Linden-Carmichael, Jessica Acolin, Isaac C Rhew, Jason R Kilmer, Mary E Larimer, Katarina Guttmannova
{"title":"Age-Varying Patterns of Cannabis Use, Related Risk Factors, and their Associations among Young Adults in the Context of Legalized Nonmedical Cannabis.","authors":"Griselda Martinez, Brian H Calhoun, Charles B Fleming, Ashley N Linden-Carmichael, Jessica Acolin, Isaac C Rhew, Jason R Kilmer, Mary E Larimer, Katarina Guttmannova","doi":"10.1007/s11121-025-01803-0","DOIUrl":"10.1007/s11121-025-01803-0","url":null,"abstract":"<p><p>The current study examined age-varying patterns of cannabis use, cannabis-specific risk factors, and their associations across young adulthood. We used repeated cross-sectional data from young adults (N = 15,251; M<sub>age</sub> = 22.02 years, SD<sub>age</sub> = 2.22; 68% female) who enrolled in the annual, statewide Washington Young Adult Health Survey between 2015 and 2022. Logistic time-varying effect models showed that cannabis use increased from ages 18-22 and remained relatively stable through age 26. Most cannabis-specific risk factors increased gradually across young adulthood, although perceptions of cannabis use acceptability (injunctive norms) increased substantially through age 23 followed by decreases. Ease of obtaining cannabis, perceptions about others' use (descriptive norms), and low perceived physical harm were generally associated with any past-month cannabis use with stronger associations around age 18. Injunctive norms and low perceived psychological harm were consistently associated with past-month use across young adulthood. Ease of obtaining cannabis, injunctive norms, descriptive norms, and low psychological harm were associated with frequent cannabis use across young adulthood with associations strongest prior to age 21. Low perceived physical harm was associated with frequent use across young adulthood with associations getting somewhat stronger across ages. Findings underscore the importance of focusing on cannabis-specific risk factors in preventive intervention efforts over the course of young adulthood, including focus on young adults in their mid- 20 s in the context of legalized cannabis.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":"773-784"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevention SciencePub Date : 2025-07-01Epub Date: 2025-06-09DOI: 10.1007/s11121-025-01817-8
Anna Maria Ros, Rachel Ballard, Amanda Burnside, Michael Harries, Aron Janssen
{"title":"Pediatric Suicide Attempt Non-Disclosure: an Analysis of Discrepant Screening Results.","authors":"Anna Maria Ros, Rachel Ballard, Amanda Burnside, Michael Harries, Aron Janssen","doi":"10.1007/s11121-025-01817-8","DOIUrl":"10.1007/s11121-025-01817-8","url":null,"abstract":"<p><p>The Ask-Suicide Screening Questions (ASQ) is a validated tool developed to assess suicidal risk in pediatric medical settings with one item assessing historical attempts. While the psychometric properties of the ASQ are well-established, little is known about how youth respond to this question upon repeated administrations. We conducted a retrospective analysis of electronic medical record data by youth who received the ASQ from December 2019 to November 2023 at an urban academic children's hospital. Youth who disclosed a suicide attempt but denied an attempt history at a subsequent visit were identified. Multivariate regression and manual chart review were utilized to identify demographic and clinical variables related to non-disclosure of a previously disclosed attempt. Of 1861 encounters (1460 unique patients) with a disclosed historic suicide attempt, re-screening occurred in 503 future encounters. One hundred forty instances of nondisclosure occurred (127 unique patients). Encounters were classified into false positives (N = 26), encounters where nondisclosure by patients did not impact clinical response (N = 40), and encounters where nondisclosure resulted in no further suicide risk assessment (N = 74). Of this last group, 47.3% received no risk assessment at the initial visit. Compared to the initial visit, the nondisclosure visit was more likely to have a medical presenting complaint and to have negative responses on ASQ questions related to recent suicidal ideation. Denial of a historic attempt upon repeat administration of the ASQ is not uncommon among pediatric patients, and this is more likely to occur at an encounter for a medical presenting complaint.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":"751-759"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early Effects of Communities That Care on the Adoption and Implementation Fidelity of Evidence-Based Prevention Programs in Communities: Results from a Quasi-experimental Study.","authors":"L Decker, I von Holt, S Ünlü, U Walter, D Röding","doi":"10.1007/s11121-025-01823-w","DOIUrl":"https://doi.org/10.1007/s11121-025-01823-w","url":null,"abstract":"<p><p>To date, few evidence-based prevention programs (EBP) have been implemented in Germany, despite their growing availability. Some prevention researchers have stated that prevention support systems such as Communities That Care (CTC) could contribute to the wider spread of EBP in Germany and improve the fidelity of EBP implementation. Our study aims to investigate whether CTC leads to greater adoption of EBP in German communities. A quasi-experimental study was conducted with 22 intervention communities (IC) and 22 comparison communities (CC). Data collection occurred at two time points (T0: 2021/2022 and T1: 2023/2024), capturing information on which EBP were implemented in these communities during the prior school year, the number of people reached, and the quality of EBP implementation. Data from 17 IC and 12 CC were included in the final analyses. At T0, there were no significant differences between IC and CC in the number of EBP implemented or the number of people reached. In the IC, the average number of EBP implemented was 3.57 per 10,000 residents at T0, which increased significantly to 8.57 at T1 (p = .004). In the CC, the average number rose from 1.88 at T0 to 3.41 at T1, though this change was not statistically significant (p = .089). Regarding reach, an average of 140 people per 10,000 residents were reached with EBP at T0 in IC, increasing to 407 by T1, while in CC, the average increased from 77 at T0 to 300 at T1. Neither group showed a statistically significant increase in reach. Implementation fidelity remained consistently high in both groups at both time points. The results suggest that CTC may encourage communities to implement more EBP. However, the findings may be influenced by confounding factors and the relatively short observation period. Further research with an extended follow-up is therefore recommended.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevention SciencePub Date : 2025-07-01Epub Date: 2025-06-25DOI: 10.1007/s11121-025-01819-6
Sebrina L Doyle Fosco, Deborah L Schussler
{"title":"Unpacking the Black Box: Exploring Differences in Practices, Skills, and Knowledge Taught in School-Based Mindfulness Programs.","authors":"Sebrina L Doyle Fosco, Deborah L Schussler","doi":"10.1007/s11121-025-01819-6","DOIUrl":"10.1007/s11121-025-01819-6","url":null,"abstract":"<p><p>School-based mindfulness programs (SBMPs) have shown a range of academic, emotional, and behavioral outcomes. However, heterogeneity in curricular content obscures accurate interpretation of results. To unpack the \"black box\" of SBMPs and better contextualize intervention outcomes, this investigation examined the practices, skills, and knowledge conveyed in twelve curricula. Required curricular elements (CEs) from the written curricula were coded for mindfulness practices and skills, and lessons were coded for mindfulness knowledge conveyed. Curricula had a different composition of components depending on theoretical foundation and program length. All curricula included intrapersonal (i.e., individual) practices, most often engaging somatic awareness. Interpersonal (i.e., relational) practices were identified in eight curricula and were infrequent, except in two programs that focused on kindness/compassion. All curricula cultivated intrapersonal skills of focused attention, emotion awareness, and emotion regulation at varying levels. Programs derived from MBSR cultivated the highest proportion of skills focused on awareness of mental states. Longer programs had a significantly higher proportion of CEs focused on interpersonal skills compared to shorter programs. Longer programs also had a higher proportion of lessons concentrated on focused attention and on empathy/perspective taking. Knowledge conveyed in lessons did not always correspond to the practices and skills coded, indicating students may be learning about topics even if they are not actively practicing or engaged in skill cultivation. This study offers clarity regarding the curricular content of SBMPs, making it possible to investigate links between active ingredients and program outcomes, refine theories of change, and better prepare teachers facilitating SBMPs.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":"827-838"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevention SciencePub Date : 2025-07-01Epub Date: 2025-06-04DOI: 10.1007/s11121-025-01816-9
Csenge B Bődi, Alyssa Amendola, Melissa A Bright
{"title":"Community-Based Participatory Research: Involving Young People with Lived Experiences of Problematic Sexual Behaviors.","authors":"Csenge B Bődi, Alyssa Amendola, Melissa A Bright","doi":"10.1007/s11121-025-01816-9","DOIUrl":"10.1007/s11121-025-01816-9","url":null,"abstract":"<p><p>Community advisory boards bridge the gap between researchers and community members to yield the most informed and successful implementation of prevention services. Youth community advisory boards demonstrate the same research-community member benefit but forming them presents unique challenges that often limit their use. In this article, we present lessons learned from a participatory research study in which we engage young people with problematic sexual behaviors (PSB) in an anonymous community advisory board and interviews. After completing a survey, 16 interview participants and five advisory board members aged 14-21 with PSB were interviewed about the research process, providing insights into survey clarity and participant experiences. Data were analyzed using content analysis to identify key themes. Seven themes emerged from qualitative data analyses. Young people with PSB strongly support research on PSB and they are willing to discuss about sensitive and stigmatized topics. They are not harmed by engaging in these discussions and are capable of providing consent for their participation. Ensuring confidentiality is vital to creating a safe and ethical research environment. Creative communication methods are valuable for building trust and facilitating engagement, while establishing clear boundaries between researchers and participants is essential to maintaining professionalism and respect throughout. Limitations include small sample size, lack of early advisory board involvement, and constraints about participant verification and demographic data. This study highlights not only how to involve a vulnerable, at-risk community of young people in community-based participatory research on a highly stigmatized topic, but also the many benefits of this approach.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":"814-826"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevention SciencePub Date : 2025-07-01Epub Date: 2025-06-06DOI: 10.1007/s11121-025-01814-x
Alithia Zamantakis, Richard Do, Reiping Huang, Artur A F L N Queiroz, Brian Mustanski
{"title":"Gender-Affirming Care as a Predictor of HIV Pre-Exposure Prophylaxis Use and Adherence Among Young Trans Feminine Adults: A Coincidence Analysis.","authors":"Alithia Zamantakis, Richard Do, Reiping Huang, Artur A F L N Queiroz, Brian Mustanski","doi":"10.1007/s11121-025-01814-x","DOIUrl":"10.1007/s11121-025-01814-x","url":null,"abstract":"<p><p>We used coincidence analysis to explore whether various forms of gender-affirming care (GAC) in the presence or absence of medical mistrust facilitate HIV pre-exposure prophylaxis (PrEP) use and adherence. Using secondary data collected between 2014 and 2024 from the RADAR Cohort Study, we performed two crisp-set coincidence analyses with 86 trans feminine young adults for PrEP use and 24 trans feminine young adults for PrEP adherence. Our final model for PrEP use explained over 90% of participants who had used PrEP in the past 6 months with 60% consistency. This model identified receipt of hormone replacement therapy (HRT) OR being on parental insurance as predictors of PrEP use. We identified two final models for PrEP adherence, which explained 50% of participants with 83% consistency: (1) past receipt of puberty blockers OR high suspicion of medical providers in the absence of parental insurance; (2) current or past receipt of HRT in the absence of barriers to GAC and the absence of parental insurance. Our study highlights the significant role of GAC in facilitating PrEP use and adherence among trans feminine individuals. Specifically, HRT and the absence of parental insurance emerged as key predictors, underscoring the need for integrated and accessible GAC to enhance PrEP uptake and adherence in this population.</p>","PeriodicalId":48268,"journal":{"name":"Prevention Science","volume":" ","pages":"798-813"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}