Beni-Suef University Journal of Basic and Applied Sciences最新文献

{"title":"Effects of red clover (Trifolium pratense L.) on type 2 diabetes mellitus parameters: a systematic review","authors":"Atefeh Amerizadeh,&nbsp;Fatemeh Rafieian,&nbsp;Mohammad Hossein Paknahad,&nbsp;Fatemeh Moslemi,&nbsp;Hooria Seyedhosseini-Ghaheh","doi":"10.1186/s43088-026-00820-4","DOIUrl":"10.1186/s43088-026-00820-4","url":null,"abstract":"<div><h3>Background</h3><p>Red clover (<i>Trifolium pratense</i>) and its isoflavones (formononetin, biochanin A) have been investigated for their potential effects on glucose metabolism and related metabolic outcomes.</p><h3>Methods</h3><p>A comprehensive systematic search was conducted according to PRISMA guidelines by searching PubMed, Web of Science, Embase, Scopus, and Google scholar for studies evaluating the effects of red clover extracts or isolated isoflavones on glycemic outcomes. Human, animal, and in vitro studies were included.</p><h3>Results</h3><p>Sixteen studies (18 datasets) met eligibility criteria, including 3 human studies, 11 animal studies, and 4 in-vitro studies. The in vitro studies consistently demonstrated favorable effects of red clover on glucose metabolism, including enhanced β-cell viability, reduced apoptosis, increased insulin secretion, and activation of metabolic pathways such as PPAR-α. Animal studies generally reported improvements in glycemic control and insulin sensitivity, including reductions in fasting glucose and HbA1c and modulation of metabolic regulators such as SIRT1. In contrast, evidence from human trials was limited and inconsistent. Only one randomized controlled trial reported a significant improvement in fasting insulin, whereas no consistent effects were observed for fasting glucose or HbA1c across studies. Interpretation of the clinical evidence is limited by the small number of trials, small sample sizes, and heterogeneity in study populations, interventions, and outcome measures.</p><h3>Conclusion</h3><p>Preclinical findings suggest that red clover may exert glucose-lowering and insulin-sensitizing effects; however, these findings have not been consistently confirmed in human studies. High-quality, adequately powered randomized controlled trials using standardized red clover preparations are required to establish its efficacy and safety in metabolic disease management.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00820-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148751724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry and biological effects of aquatic plants from Danube Delta Biosphere Reserve (Iris spp. and Nymphaea spp.):an update review","authors":"Maria Daniela Ionica Mihaila,&nbsp;Mihaela Dragoi Cudalbeanu,&nbsp;Bianca Furdui,&nbsp;Rodica Mihaela Dinica","doi":"10.1186/s43088-026-00814-2","DOIUrl":"10.1186/s43088-026-00814-2","url":null,"abstract":"<div><h3>Background</h3><p>Among the native flora of the Danube Delta Biosphere Reserve in Romania, there are two beautiful aquatic flowering plants, the Yellow Flag Iris (<i>Iris pseudacorus</i>) and the White Waterlily <i>(Nymphaea alba</i>), which are part of the <i>Iris</i> and <i>Nymphaea</i> species, respectively. These two species, known mainly as ornamental plants, also have numerous bioactive properties, their extracts being recorded since the medieval era for the prevention and treatment of various diseases.</p><h3>Main body of the abstract</h3><p>This systematic review presents an update of the specialized literature on <i>Iris</i> spp. and <i>Nymphaea</i> spp. aiming to illustrate the chemical composition of the plant and a synthetic presentation of the most common biological applications of the extracts of these plants, but also regarding their traditional uses. Therefore, continued knowledge in this field is useful because there are few studies that reveal the toxicity of these plants at low doses.</p><h3>Conclusions</h3><p>The reviewed studies indicate that Iris and Nymphaea from the Danube Delta Biosphere Reserve contain a variety of bioactive compounds such as polyphenols, flavonoids and terpenoids that have supported many of their applications in traditional medicine, such as strong antioxidants, anti-inflammatory, antidiabetic, antitumor, antibacterial, antihepatotoxic, and antiviral activities.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00814-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148751396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical distribution, ethnobotanical uses, phytochemical composition, and biological activities of Syagrus species from Northeastern Brazil","authors":"Meykson Alexandre da Silva,&nbsp;José Rivaldo de Lima,&nbsp;Jeanderson Marcelino da Silva,&nbsp;João Victor de Oliveira Alves,&nbsp;Marcia Vanusa da Silva,&nbsp;Hércules Melo Diógenes,&nbsp;Sarah Mikaella Silva de Brito,&nbsp;Roberta Jeane Bezerra Jorge,&nbsp;Maria Tereza dos Santos Correia","doi":"10.1186/s43088-026-00817-z","DOIUrl":"10.1186/s43088-026-00817-z","url":null,"abstract":"<div><p>This study aimed to perform an integrative review of ethnobotanical uses, biological activities, and phytochemical profiles of <i>Syagrus</i> species found in northeastern Brazil, and to assess their geographic distribution. The review was conducted using PubMed, Scopus, SciELO, and ScienceDirect, and selected studies published between 2011 and September 2025. The search strategy included scientific names of 25 species and hybrids. Peer-reviewed articles were included when <i>Syagrus</i> appeared in the title, abstract, or keywords, while duplicates and unrelated studies were excluded. Ethnobotanical reports, phytochemical data, and biological activities were analyzed systematically. Geographic distribution records from GBIF were processed in QGIS 3.22.1 to generate updated maps and identify new potential occurrence points. A total of 1,068 publications were identified, and after removing duplicates and applying eligibility criteria, 55 articles were included. Less than 15% of Brazilian <i>Syagrus</i> species (<i>n</i> = 9) have been scientifically investigated, indicating a significant knowledge gap. The fatty-acid profile of <i>Syagrus</i> oils is dominated by triacylglycerols containing medium- and long-chain fatty acids (C8–C24), with lauric acid (C12:0) frequently exceeding 40%. This composition underscores their pharmacological and industrial relevance, particularly for surfactant and detergent production. <i>Syagrus</i> species exhibit notable antioxidant, antimicrobial, antibiofilm, nematocidal, larvicidal, antiparasitic, analgesic, anti-inflammatory, anti-arthritis, and neuroprotective activities. Overall, <i>Syagrus</i> species from northeastern Brazil display strong ethnobotanical relevance and diverse bioactivities. However, research remains scarce, highlighting the need for further studies to isolate bioactive compounds and to support sustainable and safe therapeutic applications.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00817-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148751395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in point-of-care diagnostics for Acinetobacter baumannii: a review of novel detection and sensing strategies","authors":"Hanne Altın,&nbsp;Duygu Nuhoglu,&nbsp;Ozge Boga,&nbsp;Seyma Soykan,&nbsp;Beyza Cepeci Ata","doi":"10.1186/s43088-026-00818-y","DOIUrl":"10.1186/s43088-026-00818-y","url":null,"abstract":"<div><h3>Background</h3><p><i>Acinetobacter baumannii</i> [<i>A. baumannii</i>] is recognized as a critical pathogen in the global dissemination of antibiotic resistance and is associated with severe infections affecting various anatomical sites, often leading to significant morbidity and mortality. Prompt and accurate identification of <i>A. baumannii</i> is essential for the effective management of healthcare-associated infections, particularly in hospital settings. However, the prolonged turnaround time of conventional microbiological diagnostic techniques poses a major barrier to timely therapeutic intervention.</p><h3>Main body</h3><p>As a result, there is increasing emphasis on the development of point-of-care [POC] diagnostic platforms that enable rapid, sensitive, and specific detection of <i>A. baumannii</i>. This review examines biosensing technologies suitable for field deployment, focusing on systems designed for the detection of antibiotic-resistant <i>A. baumannii</i>, both at the genomic and cellular levels. The first section discusses isothermal nucleic acid amplification methods targeting resistance-associated genes in <i>A. baumannii</i>, along with the corresponding signal readout and analysis strategies.</p><h3>Conclusion</h3><p>This is followed by an overview of recent advancements in electrochemical biosensors, including their design principles and diagnostic applications for <i>A. baumannii</i>. The final section highlights nanoparticle-based detection methodologies, emphasizing their potential to enhance diagnostic performance through improved sensitivity, specificity, and assay speed.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00818-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148750920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating bioengineering with solar-powered traps for sustainable fruit fly management","authors":"Adhan Efendi,&nbsp;Abdulfatah Abdu Yusuf,&nbsp;Muhammad Imam Ammarullah","doi":"10.1186/s43088-026-00813-3","DOIUrl":"10.1186/s43088-026-00813-3","url":null,"abstract":"<div><p>Control of fruit flies remains a major challenge in chili cultivation, as infestations can significantly reduce crop yield and quality. Conventional pest control methods are often ineffective, energy-dependent, or environmentally unsustainable. This study developed a solar-powered fruit fly trap that integrates bioengineering principles with renewable energy technology to provide a sustainable pest management solution. The trap was designed using Autodesk Inventor to produce detailed 2D and 3D models and fabricated from hollow iron through cutting, welding, and assembly processes. The electrical system consists of solar panels, a solar charge controller, a step-down converter, and a high-voltage module that powers the trapping mechanism. Bioengineering principles were incorporated by integrating a methyl eugenol attractant with a high-voltage electrocuting system, enabling selective attraction and effective capture of fruit flies while utilizing renewable solar energy as the primary power source. Preliminary field testing demonstrated that the prototype operated reliably under agricultural conditions and successfully captured fruit flies, indicating its technical feasibility as an environmentally friendly and energy-efficient pest management system for chili cultivation.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00813-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of electronic cigarette aerosol, conventional cigarette smoke, and cannabis smoke on the cellular properties of osteogenically induced gingival fibroblasts/gingival mesenchymal stem cells","authors":"Abir Tarek Mansour El-Mouelhy,&nbsp;Sherine Adel Nasry,&nbsp;Omnia Aboul Dahab,&nbsp;Dina Sabry,&nbsp;Karim Mohamed Fawzy El-Sayed","doi":"10.1186/s43088-026-00811-5","DOIUrl":"10.1186/s43088-026-00811-5","url":null,"abstract":"<div><h3>Background</h3><p>Tobacco smoking remains a major global health burden. Although electronic cigarettes (EC) are considered less harmful than conventional cigarette, their effects on oral health are not fully defined. Cannabis use is increasing worldwide, yet its impact on oral tissues is poorly understood. This investigation evaluated the effects of EC aerosol, conventional cigarettes smoke and cannabis smoke on cellular viability, mitochondrial integrity and gene expression in osteogenically induced gingival fibroblast/gingival mesenchymal stem cells (GF/GMSCs).</p><h3>Methods</h3><p>Isolation and characterization of human GF/GMSCs (<i>n</i> = 32) were performed, followed by osteogenic induction using (BMP-2) and aerosol/smoke application. Osteogenically induced GF/GMSCs were assessed via MTT-assay, mitochondrial depolarization assessed using JC-1 dye, ATM, p21, Oct4 and Nanog gene expression, and osteogenic differentiation.</p><h3>Results</h3><p>Viability (OD450nm) was significantly reduced in the cannabis/BMP- (mean ± SD: 1.02 ± 0.24) and cigarettes/BMP-(1.05 ± 0.39;<i>p</i> &lt; 0.05), with no reduction in viability in the EC/BMP-(1.78 ± 0.47) and BMP-group (1.74 ± 0.59;<i>p</i> &gt; 0.05). Upregulated expression of ATM, Oct4, and Nanog (gene copies/GAPDH) was significant with cannabis/BMP-(2.23 ± 0.34, 1.73 ± 0.53 and 2.04 ± 0.33 respectively), cigarettes/BMP-(2.58 ± 0.69, 1.91 ± 1.03 and 2.26 ± 0.6; <i>p</i> &lt; 0.05 respectively), with no significant upregulation in EC/BMP-(0.72 ± 0.37; 0.91 ± 0.56; 1.11 ± 0.49) compared to BMP-group (0.51 ± 0.17, 0.64 ± 0.2, and 1.01 ± 0.58; <i>p</i> &gt; 0.05 respectively). p21 expression was significantly downregulated in EC/BMP-(1.97 ± 0.52), cannabis/BMP-(1.26 ± 0.29) and cigarettes/BMP-(1.38 ± 0.74) compared to BMP-group (4.24 ± 0.69; <i>p</i> &lt; 0.05). Osteogenic differentiation was impeded with reduced Alizarin-red straining and significant downregulation of osteopontin expression in EC/BMP-(2.12 ± 0.47), cannabis/BMP-(1.48 ± 0.99), and cigarettes/BMP- -(1.36 ± 0.38) compared to BMP-group (3.95 ± 0.88;p˂0.05).</p><h3>Conclusion</h3><p>Cannabis smoke and cigarette smoke negatively influence the viability, gene expression, and cause DNA damage in osteogenically induced GF/GMSCs, with a lesser effect of EC-aerosol on these findings. Still, all tested exposures negatively affected the differentiation of osteogenically induced GF/GMSCs.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00811-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148628729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threshold dynamics and Gaussian stationary distribution of a stochastic SIQR epidemic model with spatial diffusion: a semigroup approach","authors":"Panumart Sawangtong,&nbsp;Mozhgan Akbari,&nbsp;Alireza Najafi","doi":"10.1186/s43088-026-00808-0","DOIUrl":"10.1186/s43088-026-00808-0","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;The spread of infectious diseases is strongly influenced by environmental variability, random disturbances, and population mobility across geographical regions. These factors can significantly affect disease transmission and progression, making purely deterministic models insufficient for capturing realistic epidemic dynamics. Environmental noise may modify transmission rates, recovery processes, and other epidemiological parameters, while the movement of individuals contributes to the spatial propagation of infections. Reaction-diffusion epidemic models provide an effective mathematical framework for describing the spatial spread of diseases, whereas stochastic modeling captures the influence of random fluctuations. Combining stochastic effects with spatial diffusion allows epidemic models to represent more realistic biological and environmental conditions. Despite these advantages, rigorous analytical studies for stochastic reaction-diffusion epidemic models that incorporate quarantine strategies are still relatively limited in the existing literature.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;In this work, we formulate a stochastic SIQR reaction-diffusion epidemic model to describe the spatio-temporal dynamics of four interacting populations: susceptible &lt;span&gt;((S),)&lt;/span&gt; infected &lt;span&gt;((I),)&lt;/span&gt; quarantined &lt;span&gt;((Q),)&lt;/span&gt; and recovered &lt;span&gt;((R).)&lt;/span&gt; Diffusion terms are included to represent the spatial movement of individuals, while stochastic perturbations account for environmental randomness influencing disease transmission. Using stochastic transformations together with linear semigroup theory, we establish the existence and uniqueness of a global positive solution to the nonlinear stochastic system. Two threshold parameters, &lt;span&gt;(R_{0}^{e})&lt;/span&gt; and &lt;span&gt;(R_{0}^{s},)&lt;/span&gt; are introduced to characterize the extinction and strong persistence of the infection. For the special case of a constant transmission rate &lt;span&gt;(beta,)&lt;/span&gt; the endemic equilibrium &lt;span&gt;(E^{*})&lt;/span&gt; is derived, and the asymptotic behavior of the system in a neighborhood of this equilibrium is investigated using linear algebra methods and Lyapunov matrix equations.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;The theoretical analysis shows that when &lt;span&gt;(R_{0}^{e} &lt; 1,)&lt;/span&gt; the infected population becomes extinct at an exponential rate with probability one. In contrast, if &lt;span&gt;(R_{0}^{s} &gt; 1,)&lt;/span&gt; the disease persists strongly in the population. Furthermore, in the vicinity of the endemic equilibrium &lt;span&gt;(E^{*},)&lt;/span&gt; the joint distribution of the system states can be approximated by a multivariate normal probability density function. An explicit representation of the corresponding covariance matrix is obtained under several parameter conditions. Numerical simulations support the analytical results and demonstrate how stochastic perturbations and diffusion rates influence both the stability properties and probabilistic behavior of the ep","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00808-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reuse of reclaimed wastewater for sustainable irrigation of basil (Ocimum basilicum): effects on plant performance and yield","authors":"Mona F. Ghazal,&nbsp;Walaa H. Ismael,&nbsp;Naeem M. E. Doha,&nbsp;Dina Fathi Ismail Ali,&nbsp;Gehan M. Salem","doi":"10.1186/s43088-026-00801-7","DOIUrl":"10.1186/s43088-026-00801-7","url":null,"abstract":"<div><h3>Background</h3><p>Water scarcity is a major challenge to agriculture, emphasizing the need for innovative solutions such as wastewater reuse. This study evaluates the potential of biologically treated sewage water from the El-Salam Canal (Al-Sharqia, Egypt) for safe irrigation using the microalga <i>Chlorella vulgaris</i> and the bacterium <i>Bacillus megaterium</i> as eco-friendly remediation agents.</p><h3>Methods</h3><p>Biological treatment of wastewater was conducted using <i>Chlorella vulgaris</i> and <i>Bacillus megaterium</i>, and the removal efficiency of nutrients and heavy metals was assessed. A pot experiment was performed using basil (<i>Ocimum basilicum</i>) irrigated with domestic water, untreated wastewater, and bio-treated wastewater. Plant growth parameters, chlorophyll content, proline, antioxidant enzymes, oil production, microbial rhizosphere soil activity, soil properties, and heavy metal accumulation in soil and leaves were evaluated.</p><h3>Results</h3><p>Phycoremediation significantly improved effluent quality, with <i>Chlorella vulgaris</i> reducing nitrogen, phosphorus, and heavy metals by 41.1%, 46.7%, and 37.5%, respectively, while <i>Bacillus megaterium</i> achieved reductions of 32.3%, 39.2%, and 28.4%. In a pot experiment with basil (<i>Ocimum basilicum</i>), untreated wastewater significantly inhibited growth, biomass, and chlorophyll content, and increased proline and antioxidant enzymes. In contrast, plants irrigated with bio-treated wastewater showed rapid growth, with <i>Chlorella</i> <i>vulgaris</i> achieving the highest improvement in height, dry weight, chlorophyll, and oil production. <i>Bacillus megaterium</i> enhanced rhizosphere activity by increasing dehydrogenase activity, indole acetic acid production, and micronutrient levels. Treated wastewater resulted in growth comparable to domestic water and significantly reduced heavy metal accumulation in soil and leaves.</p><h3>Conclusions</h3><p>The results demonstrate that phycoremediation with <i>Chlorella vulgaris</i> and <i>Bacillus megaterium</i> can convert wastewater into a safe and nutrient-rich resource, reducing environmental risks and phytotoxicity. This approach offers a sustainable and climate-resilient strategy for agriculture in water-deficient regions like Egypt.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00801-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148614692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saccharomyces cerevisea yeast mitigates the negative consequences of doxycycline abuse in broilers","authors":"Asmaa M. Abd-Elrahman,&nbsp;Salwa M. Hafez,&nbsp;Ghada H. Ali","doi":"10.1186/s43088-026-00779-2","DOIUrl":"10.1186/s43088-026-00779-2","url":null,"abstract":"<div><h3>Background</h3><p>Research indicates that doxycycline hurts broiler chickens, whereas <i>Saccharomyces cerevisiae</i> yeast (SCY) protects against various types of toxicity. This research aimed to assess the potential of <i>Saccharomyces cerevisiae</i> in enhancing broiler resilience against the negative impacts of doxycycline.</p><h3>Methods</h3><p>The experiment started with sixty broiler chicks on their eighth day of life. Separated into four equal groups: one for the control group, one for the Doxycycline treatment (Doxy), one for the Doxycycline plus <i>Saccharomyces cerevisiae</i> treatment (Doxy + SCY), and one for the <i>Saccharomyces cerevisiae</i> treatment. Each bird specimen had its liver, spleen, thymus, thigh, and breast muscles removed, as well as blood samples; The ultimate weights of the liver, spleen, thymus, and body; measurements of malondialdehyde (MDA) and nitric oxide (NO); and the expression levels of the genes for <i>interleukin-6</i> (IL6), <i>catalase</i>,<i> superoxide dismutase</i> (SD), <i>tumor necrosis factor-alpha</i> (TNFα), and <i>interferon-gamma</i> (IFN γ). Total <i>staphylococcus</i>, fungal, colony, and total <i>psychotropic</i> counts were noted.</p><h3>Results</h3><p>The doxycycline-treated group’s mean body weight and the weight of the immunological organs (liver, spleen, and bursa) both significantly dropped (<i>P</i> ˂ 0.001) as compared to the control group. Compared to the Doxy and control groups, the mean end body and immune organ weights of the Doxy + SCY and SCY treated groups were significantly greater (<i>P</i> ˂ 0.001). The Control, SCY, and Doxy + SCY groups had substantially higher mean serum nitric oxide levels than Doxy (<i>P</i> ˂ 0.001). Additionally, the mean levels of TNFα and IL6 were much lower, as were the mean levels of SOD, <i>Catalase</i>, and IFN γ gene expression alterations. Additionally, compared to the Doxy-treated group, the SCY-treated group showed a substantial improvement in the total colony count, total <i>psychotropic</i> count, total fungal count, and total <i>staph</i> count of the thigh and breast muscles.</p><h3>Conclusion</h3><p>In addition to reducing the hazards associated with overdosing and doxycycline abuse, SCY helps broilers gain weight and strengthen their immune systems, which eventually leads to fewer losses and better end product quality and quantity.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00779-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148614064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effects of Phoenix dactylifera and Saccharomyces cerevisiae probiotics via activation of splenic Annexin-A1 expression in rabbits","authors":"Eman Taha Mohammed,&nbsp;Mohamed A. Kandeil,&nbsp;Omima I. Gad,&nbsp;Asmaa M. Abd-Elrahman,&nbsp;Emtnan M. Hassan","doi":"10.1186/s43088-026-00794-3","DOIUrl":"10.1186/s43088-026-00794-3","url":null,"abstract":"<div><h3>Background</h3><p>The immunosuppressive effects of glucocorticoids on T-cells are caused by the down-regulation of Annexin-A1, a protein essential for T-cell activation and adaptive immunity. Therefore, it is interesting to explore the impact of date palm <i>(Phoenix dactylifera L.)</i> fruits and/or <i>Saccharomyces cerevisiae</i> (<i>S. cerevisiae</i>) probiotics on Annexin-A1 expression in rabbit spleen.</p><h3>Methods</h3><p>White <i>New Zealand</i> male rabbits were divided into five groups: control, Dexamethasone (DXM), Dexamethasone plus Date palm (DXM + Date), Dexamethasone plus <i>Saccharomyces cerevisiae</i> (DXM + <i>S. cerevisiae</i>), and Dexamethasone plus Date palm plus <i>Saccharomyces cerevisiae</i> (DXM + Date + <i>S. cerevisiae</i>) treated groups.</p><h3>Results</h3><p>Dexamethasone caused oxidative stress and immunological suppression, as evidenced by significant increases in catalase and Malondialdehyde (MDA), as well as a notable depletion of reduced Glutathione (GSH) in splenic tissues. The study reported a significant decrease in Annexin-A1 expression, as well as decreases in Interferon gamma (IF-γ), Cyclooxygenase 2 (COX-2), and Interleukin 6 (IL-6) expressions in splenic tissue. However, serum immunoglobulin G (IgG) and immunoglobulin M (IgM) levels are non-significantly decreased. Conversely, co-treatments of DXM-treated rabbits with date palm and/or <i>S. cerevisiae</i> restored nearly all biochemical changes to normal.</p><h3>Conclusion</h3><p>Date palm, alone or in combination with <i>S. cerevisiae</i>, can increase splenic Annexin-A1 expression. Furthermore, the data revealed that date palm may have a more immune-stimulant impact than <i>S. cerevisiae</i> in rabbits, as well as a synergistic effect of both. These treatments present a novel way to increase Annexin-A1 signaling as a potential technique for managing immunological deficits.</p></div>","PeriodicalId":481,"journal":{"name":"Beni-Suef University Journal of Basic and Applied Sciences","volume":"15 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s43088-026-00794-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148614063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}