Journal of Natural Products 最新文献_第6页

Structure-Guided Discovery of Neuroprotective Kromycin-Type Macrolides from Streptomyces narbonensis sp. 以结构为导向发现纳邦链霉菌中具有神经保护作用的克霉素型大环内酯类化合物。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-06-19 DOI: 10.1021/acs.jnatprod.6c00302

Ziheng Jing, Bingya Jiang, Weikang Li, Chenhui Zhang, Jingwen Xu, Tianxiang Zhang, Donglin Liu, Liyan Yu, Duqiang Luo, Zhengyan Guo

{"title":"Structure-Guided Discovery of Neuroprotective Kromycin-Type Macrolides from Streptomyces narbonensis sp.","authors":"Ziheng Jing, Bingya Jiang, Weikang Li, Chenhui Zhang, Jingwen Xu, Tianxiang Zhang, Donglin Liu, Liyan Yu, Duqiang Luo, Zhengyan Guo","doi":"10.1021/acs.jnatprod.6c00302","DOIUrl":"10.1021/acs.jnatprod.6c00302","url":null,"abstract":"Sixnew kromycin-type macrolides, kromycins B–G(1–6), and with the known kromycinA (7), were isolated from Streptomyces narbonensis sp. CPCC 206470 guided by the Global NaturalProducts Social MolecularNetworking (GNPS) analysis. Their structures were comprehensivelyestablished by extensive spectroscopic analyses, time-dependent densityfunctional theory electronic circular dichroism (TDDFT-ECD) comparison,and single-crystal X-ray diffraction analysis. These compounds representa structurally distinct subclass of 14-membered macrolides. Compound 7 exhibited substantial neuroprotective activity by inhibitingAβ42 aggregation and ameliorating oxidative stress and neuroinflammationin N2a neuronal cells. It enhanced antioxidant enzyme activities (SODand CAT) and suppressed nitric oxide production. Genomic analysisidentified a pikromycin-related biosynthetic gene cluster in the producingstrain. This study expands the chemical diversity of kromycin-typenatural products and highlights their potential as multitarget therapeuticagents for neurodegenerative diseases.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2083–2092"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Stereochemical Revision of Violaceoid E, a Polyoxygenated Cyclohexanoid Natural Product Isolated from Aspergillus violaceofuscus Gasperini 紫曲霉天然多氧环己酸产物Violaceoid E的合成及立体化学修正。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-02 DOI: 10.1021/acs.jnatprod.6c00630

Yuki Kubo, Yusuke Ogura, Hirosato Takikawa, Hironori Okamura

引用次数: 0

Nucleoside Analog Natural Products: Over a Decade of Advances in Isolation, Biological Activity, and Synthesis 核苷类似物天然产物：在分离、生物活性和合成方面的十多年进展。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-10 DOI: 10.1021/acs.jnatprod.6c00624

Malvika Raj, Sabrina Y. Harada, Emma K. Davison

{"title":"Nucleoside Analog Natural Products: Over a Decade of Advances in Isolation, Biological Activity, and Synthesis","authors":"Malvika Raj, Sabrina Y. Harada, Emma K. Davison","doi":"10.1021/acs.jnatprod.6c00624","DOIUrl":"10.1021/acs.jnatprod.6c00624","url":null,"abstract":"Nucleoside analogs represent one of the largest classesof anticancerand antiviral therapies, many of which have been directly or indirectlydeveloped as a result of nucleoside natural product discovery. Overthe past decade, renewed interest in this class has led to the discoveryof diverse nucleoside analog natural products from microbial, marine,and fungal sources, often featuring unprecedented modifications tothe nucleobase, and/or the ribose sugar 2′, 3′, 4′,and 5′ positions. This review provides a comprehensive updateof novel nucleoside natural products reported between January 2015and January 2026, encompassing their isolation, structural elucidation,biological activities, and synthetic and biosynthetic studies. Expansionsto key families such as muraymycins, pseudouridimycin, tunicamycins,and puromycin analogs are discussed alongside structural revisionsand unique metabolites that expand the chemical space of nucleosides.By consolidating recent advances and highlighting emerging structuraland biological trends, this review aims to provide a resource forresearchers in natural product chemistry, chemical biology, and medicinalchemistry, and to inspire new nucleoside drug discovery programs.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2031–2061"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Structure and Absolute Configuration of Diterpenoids from Hymenaea stigonocarpa” 修正“土果膜属二萜类化合物的结构和绝对构型”。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-05 DOI: 10.1021/acs.jnatprod.6c00679

Afif F. Monteiro, João M. Batista, Jr., Michelle A. Machado, Richele P. Severino, Ewan W. Blanch, Vanderlan S. Bolzani, Paulo C. Vieira, Vanessa G. P. Severino

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Oribatid Mites Supply Tetrodotoxin to Poisonous Newts 甲螨为毒蝾螈提供河豚毒素。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-04-24 DOI: 10.1021/acs.jnatprod.6c00280

Yuto Nakazawa, Satoshi Shimano, Tadachika Miyasaka, Masaatsu Adachi, Toshio Nishikawa, Kazutoshi Yoshitake, Masafumi Amano, Shigeru Sato, Kentaro Takada

{"title":"Oribatid Mites Supply Tetrodotoxin to Poisonous Newts","authors":"Yuto Nakazawa, Satoshi Shimano, Tadachika Miyasaka, Masaatsu Adachi, Toshio Nishikawa, Kazutoshi Yoshitake, Masafumi Amano, Shigeru Sato, Kentaro Takada","doi":"10.1021/acs.jnatprod.6c00280","DOIUrl":"10.1021/acs.jnatprod.6c00280","url":null,"abstract":"Tetrodotoxin(TTX) is a potent neurotoxin widely distributed amongmarine and terrestrial animals, yet how terrestrial vertebrates acquirethis toxin has been debated for decades. Here, we identify oribatidmites as the primary dietary sources of TTX for the Japanese fire-belliednewt, Cynops pyrrhogaster. We detectTTX and its analogs in the mites Scheloribates processus and Galumna sp. KM1, which are preferentiallyconsumed by terrestrial newts. In a controlled toxification experiment,juvenile newts accumulated TTX after consuming TTX-bearing mites,directly demonstrating dietary acquisition. Our results support thatthe early terrestrial stage is critical for lifelong TTX acquisitionin the C. pyrrhogaster. Notably, wealso detect pumiliotoxin, a poison-frog alkaloid, in S. processus, suggesting that newts and poison frogshave convergently evolved to exploit toxin-bearing microarthropodsfor chemical defense. We propose a “terrestrial toxic web”hypothesis in which oribatid mites act as a shared environmental reservoirlinking putative microbial toxin production to vertebrate chemicaldefense, highlighting microarthropods as potential key mediators interrestrial toxin flow.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2062–2072"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147757477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus Trichoderma harzianum 内生真菌哈茨木霉产生的具有抗肝纤维化活性的多环融合细胞松弛素。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-03 DOI: 10.1021/acs.jnatprod.6c00375

Yan-Jiang Zhang, Yi-Ling Liao, Lu Gan, Long Jiang, Tao Yuan, Sheng Yin, Gui-Hua Tang

{"title":"Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus Trichoderma harzianum","authors":"Yan-Jiang Zhang, Yi-Ling Liao, Lu Gan, Long Jiang, Tao Yuan, Sheng Yin, Gui-Hua Tang","doi":"10.1021/acs.jnatprod.6c00375","DOIUrl":"10.1021/acs.jnatprod.6c00375","url":null,"abstract":"A molecularnetworking-guided investigation of extracts from thegrowth medium of the endophytic fungus Trichoderma harzianum MLJ-4 resulted in the isolation of eightnew polycyclic-fused cytochalasins (CYTs), triharziachalasins A–H(1–8), along with six known analogues(9–14). Their structures, includingabsolute configurations, were elucidated by comprehensive spectroscopicanalysis, NMR calculations with DP4+ analysis, theoretical ECD simulations,and single-crystal X-ray diffraction. Compounds 1–3 feature a rare 5/6/5/8-fused tetracyclic system, while 4–8 possess a novel 5/6/6/7/5-fused pentacyclicscaffold. Compound 1 is the first cytochalasin analoguecontaining a cis-fused 5/8 ring within the 5/6/5/8framework. All CYTs were evaluated for antiliver fibrosis activityin TGF-β1-stimulated LX-2 cells using high-content screeningassays. The most promising compound, triharziachalasin H (8), dose-dependently suppressed the expression of key fibrotic markers,including fibronectin (FN), collagen I, and α-smooth muscleactin (α-SMA). Mechanism studies revealed that its antiliverfibrosis effect is mediated via inhibition of the NF-κB signalingpathway. This work expands the structural diversity of bioactive CYTsand reveals the antiliver fibrosis activity of this novel polycyclic-fusedarchitecture, highlighting its potential as a lead compound for antiliverfibrosis drug development.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2093–2105"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148373839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of Ribosomally Synthesized and Post-translationally Modified Knottins from the Deep-Sea Sponge Stryphnus fortis 深海海绵Stryphnus fortis核糖体合成和翻译后修饰的结蛋白的发现。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-06-09 DOI: 10.1021/acs.jnatprod.6c00501

Lakmini N. Kosgahakumbura, Blazej Slazak, Norelle L. Daly, Rein Fadoul, Samia Mohamed, Erik Jacobsson, Ruisheng Xiong, Björn Hellman, Ulf Göransson, Chamari M. Hettiarachchi, Paco Cárdenas, Sunithi Gunasekera

{"title":"Discovery of Ribosomally Synthesized and Post-translationally Modified Knottins from the Deep-Sea Sponge Stryphnus fortis","authors":"Lakmini N. Kosgahakumbura, Blazej Slazak, Norelle L. Daly, Rein Fadoul, Samia Mohamed, Erik Jacobsson, Ruisheng Xiong, Björn Hellman, Ulf Göransson, Chamari M. Hettiarachchi, Paco Cárdenas, Sunithi Gunasekera","doi":"10.1021/acs.jnatprod.6c00501","DOIUrl":"10.1021/acs.jnatprod.6c00501","url":null,"abstract":"Knottins are stable, structurally constrained mini-proteinswithdiverse bioactivities. This work presents the first report of a novelfamily of knottins, ‘stryphnines’, from the deep-seasponge Stryphnus fortis. Peptidomicand transcriptomic analysis revealed a rich peptide repertoire andconfirmed their ribosomal and sponge origin. This led to the isolationof two novel knottins containing a side-chain to side-chain esterlinkage between serine 10/11 and glutamic acid 29/30, respectively,alongside one of their counterpart peptides devoid of the ester bond.The cryptic ester linkage was difficult to resolve due to β-eliminationoccurring at the serine side-chain ester. However, a combination ofNMR, pH incubation studies, and MS/MS analysis facilitated their completeidentification. Both stryphnines with and without the ester linkageexhibited no cytotoxicity and genotoxicity to mammalian cells. Incontrast, stryphnines with the ester linkage strongly inhibited biofoulingby barnacle larvae Amphibalanus improvisus and inhibited bacterial sialidase from Clostridium perfringens. The core knottin framework remained extremelystable in human serum at physiological conditions, despite ester bondhydrolysis occurring at high temperature and different pH treatments.The positive attributes of nontoxicity and biological stability, alongsidedemonstrated bioactivities, open up opportunities to further investigatethe true ecological role and biosynthetic mechanisms of stryphnines.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2118–2132"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Goyangamins A–C, Three Pairs of Enantiomeric 2(1H)-Quinolinone Alkaloid Dimers with Antisenescent Activity from Tetradium daniellii 具有抗衰老活性的三对对映体2(1H)-喹啉酮生物碱二聚体

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-04 DOI: 10.1021/acs.jnatprod.6c00589

Van-Hieu Mai, Thi Tuyet Minh Le, Seri Choi, Gi-Hyeon Seong, Hyunuk Cha, Yun-Sil Lee, Won Keun Oh

{"title":"Goyangamins A–C, Three Pairs of Enantiomeric 2(1H)-Quinolinone Alkaloid Dimers with Antisenescent Activity from Tetradium daniellii","authors":"Van-Hieu Mai, Thi Tuyet Minh Le, Seri Choi, Gi-Hyeon Seong, Hyunuk Cha, Yun-Sil Lee, Won Keun Oh","doi":"10.1021/acs.jnatprod.6c00589","DOIUrl":"10.1021/acs.jnatprod.6c00589","url":null,"abstract":"GoyangaminsA–C (1–3),three 2(1H)-quinolinone alkaloid dimers, were isolatedfrom the roots of Tetradium daniellii. The structures of these dimers were elucidated by HRESIMS, 1D and2D NMR spectroscopy, and ECD analysis. Compounds 1 and 2 feature an sp3–sp2 chiral axis,whereas compound 3 contains an sp2–sp2 chiral axis, giving rise to a pair of interconverting atropisomers.Variable-temperature NMR (VT NMR), in conjunction with computationalpotential energy surface (PES) scans, indicated that compounds 1–3 belong to class I atropisomers thatcan readily interconvert at room temperature. Compound 3 exhibited the most potent antisenescence activity, with an IC50 value of 7.8 ± 2.2 μM and showed a dual modeof action involving inhibition of senescence-associated secretoryphenotype (SASP) markers (IL-6, IL-8, IL-1α, and IL-1β)and suppression of senescence-associated β-galactosidase (SA-β-gal)activity.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2157–2166"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cpumycins A–C, Aminated Benzoic Dimers from Streptomyces sp. CPU-W6, and Their Potential Cardioprotective Activities 链霉菌sp. CPU-W6氨基苯甲酸二聚体Cpumycins A-C及其潜在的心脏保护作用

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-06-30 DOI: 10.1021/acs.jnatprod.6c00572

Ziyue Wang, Yali Du, Danyang Zhang, Yuhan Yang, Cheng Feng, Yuncong Xu, Jun Luo, Xuri Wu

{"title":"Cpumycins A–C, Aminated Benzoic Dimers from Streptomyces sp. CPU-W6, and Their Potential Cardioprotective Activities","authors":"Ziyue Wang, Yali Du, Danyang Zhang, Yuhan Yang, Cheng Feng, Yuncong Xu, Jun Luo, Xuri Wu","doi":"10.1021/acs.jnatprod.6c00572","DOIUrl":"10.1021/acs.jnatprod.6c00572","url":null,"abstract":"Chemical investigation of the soil-derived actinomycete Streptomyces sp. CPU-W6 led to the discovery of three novelaminated benzoic dimers, cpumycins A–C (1–3). Their structures, featuring a distinctive C–N–C-linked heterodimericskeleton, were determined through extensive spectroscopic techniquesand X-ray diffraction. Bioinformatic analysis and targeted gene deletionsidentified a shikimate-derived biosynthetic gene cluster (CPU BGC) responsible for the assembly of these metabolites.Further investigations revealed that the formation of cpumycins 1 and 2 follows a hybrid “enzymatic-plus-spontaneous”biosynthetic paradigm, in which the enzymatic production of shikimate-derivedaromatic precursors is coupled with a pH-dependent, spontaneous dimerization.In biological assays, cpumycins B (2) and C (3) exhibited cytoprotective effects against CoCl2-inducedinjury in undifferentiated H9c2 cells at nanomolar concentrations,while exhibiting negligible cytotoxicity (IC50 > 620μM).These findings significantly expand the chemical diversity of shikimate-derivedmicrobial metabolites and provide promising lead scaffolds for thedevelopment of therapeutics with potential cardioprotective benefits.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"89 7","pages":"2179–2188"},"PeriodicalIF":3.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botryolides F and G from the Fungus Bartalinia robillardoides with Anthelmintic Activity 具有驱虫活性的巴塔利菌中的肉毒素F和G。

IF 3.7 2区生物学

Journal of Natural Products Pub Date : 2026-07-24 Epub Date: 2026-07-08 DOI: 10.1021/acs.jnatprod.6c00508

Coralie Pavesi, Victor Flon, Frederic Fercoq, Chloé Borde, Alexandre Escargueil, Pascal Retailleau, Lili Sun, Coralie Martin, Xavier Franck, Soizic Prado

引用次数: 0