两种不同碳骨架的Alstonia alstarsines A-E，吲哚类生物碱

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-03-14 DOI:10.1021/acs.jnatprod.5c0002710.1021/acs.jnatprod.5c00027

Xu-Xin Zhu, Yao-Yue Fan, Cheng-Yu Zheng, Hong-Ying Yang, Kun Gao* and Jian-Min Yue*,

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引用次数: 0

摘要

alstolarsines A-E（1-5）具有6/5/5/7/6/6(5)融合多环体系的碳骨架。利用光谱数据、ECD光谱和单晶x射线衍射等方法对其结构进行了表征。alstolarsines A-D（1-4）对DRAK2磷酸化和atp -柠檬酸裂解酶的抑制活性均为无活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alstolarsines A–E, Indoline Alkaloids with Two Different Carbon Skeletons from Alstonia scholaris

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Alstolarsines A–E, Indoline Alkaloids with Two Different Carbon Skeletons from Alstonia scholaris

Five complex indoline alkaloids, alstolarsines A–E (1–5) possessing two unprecedented carbon skeletons of 6/5/5/7/6/6(5) fused polycyclic systems, were isolated from Alstonia scholaris. Their structures were characterized using various methods including spectroscopic data, ECD spectra, and single-crystal X-ray diffraction. The inhibitory activities of alstolarsines A–D (1–4) on DRAK2 phosphorylation and ATP-citrate lyase were evaluated, but all of them were inactive.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.