俾斯麦海新褐藻中含有抗炎的2-氨基咪唑类甾体。
IF 3.3
2区 生物学
Q2 CHEMISTRY, MEDICINAL
Journal of Natural Products
Pub Date : 2025-05-23
Epub Date: 2025-03-07
DOI:10.1021/acs.jnatprod.5c00118
引用次数: 0
摘要
海绵属的海绵以生产多种生物活性代谢物而闻名。从俾斯麦海（Bismarck Sea）收集的海绵Neopetrosia cfr . rava的主要代谢物中分离出contignasterine A(1)和B(2)，以及已知的具有高度生物活性的类固醇contignasterol(3)，它们具有类似的氧化苷元。共轭胆碱的特点是在氧化类固醇的侧链上分支了一个2-氨基咪唑，并且在C-7上还含有一个不寻常的磷酸基团。对这些化合物的抗炎活性进行了研究，发现这三种化合物都抑制了促炎介质的产生。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea.
Sponges of the genus Neopetrosia are known for the production of a large diversity of bioactive metabolites. Contignasterines A (1) and B (2) were isolated as major metabolites of the sponge Neopetrosia cf. rava collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol (3) possessing a similar oxidized aglycone. Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidized steroid, and 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities of these compounds were investigated and revealed that all three compounds inhibited the production of pro-inflammatory mediators.
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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