World Journal of Orthopedics最新文献

{"title":"Comparative efficacy of proximal femoral nail <i>vs</i> dynamic condylar screw in treating unstable intertrochanteric fractures.","authors":"Ahmed Mohamed Yousif Mohamed, Monzir Salih, Mohanad Abdulgadir, Ayman E Abbas, Duha Lutfi Turjuman","doi":"10.5312/wjo.v15.i8.796","DOIUrl":"10.5312/wjo.v15.i8.796","url":null,"abstract":"<p><strong>Background: </strong>Among the most frequent hip fractures are trochanteric fractures, which usually occur from low-energy trauma like minor falls, especially in older people with osteoporotic bones.</p><p><strong>Aim: </strong>To evaluate the treatment efficacy of dynamic condylar screws (DCS) and proximal femoral nails (PFN) for unstable intertrochanteric fractures.</p><p><strong>Methods: </strong>To find pertinent randomized controlled trials and retrospective observational studies comparing PFN with DCS for the management of unstable femoral intertrochanteric fractures, a thorough search was carried out. For research studies published between January 1996 and April 2024, PubMed, EMBASE, Scopus, Web of Science, Cochrane Library, and Google Scholar were all searched. The complete texts of the papers were retrieved, vetted, and independently examined by two investigators. Disputes were settled by consensus, and any disagreements that persisted were arbitrated by a third author.</p><p><strong>Results: </strong>This study included six articles, comprising a total of 173 patients. Compared to the DCS, the PFN had a shorter operation time [mean difference (MD): -41.7 min, 95% confidence interval (95%CI): -63.04 to -20.35, <i>P</i> = 0.0001], higher success rates with closed reduction techniques [risk ratio (RR): 34.05, 95%CI: 11.12-104.31, <i>P</i> < 0.00001], and required less intraoperative blood transfusion (MD: -1.4 units, 95%CI: -1.80 to -1.00, <i>P</i> < 0.00001). Additionally, the PFN showed shorter fracture union time (MD: -6.92 wk, 95%CI: -10.27 to -3.57, <i>P</i> < 0.0001) and a lower incidence of reoperation (RR: 0.37, 95%CI: 0.17-0.82, <i>P</i> = 0.01). However, there was no discernible variation regarding hospital stay, implant-related complications, and infections.</p><p><strong>Conclusion: </strong>Compared to DCS, PFN offers shorter operative times, reduces the blood transfusions requirements, achieves higher closed reduction success, enables faster fracture healing, and lowers reoperation incidence.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronal plane stability of cruciate-retaining total knee arthroplasty in valgus gonarthrosis patients: A mid-term evaluation using stress radiographs.","authors":"Pruk Chaiyakit, Pichayut Wattanapreechanon","doi":"10.5312/wjo.v15.i8.764","DOIUrl":"10.5312/wjo.v15.i8.764","url":null,"abstract":"<p><strong>Background: </strong>Total knee arthroplasty (TKA) using implants with a high level of constraint has generally been recommended for patients with osteoarthritis (OA) who have valgus alignment. However, studies have reported favorable outcomes even with cruciate-retaining (CR) implants.</p><p><strong>Aim: </strong>To evaluate the coronal plane stability of CR-TKA in patients with valgus OA at the mid-term follow-up.</p><p><strong>Methods: </strong>Patients with primary valgus OA of the knee who underwent TKA from January 2014 to January 2021 were evaluated through stress radiography using a digital stress device with 100 N of force on both the medial and lateral side. Gap openings and degrees of angulation change were determined. Descriptive statistical analysis was performed for both continuous and categorical variables. Inter-rater reliability of the radiographic measurements was evaluated using Cronbach's alpha.</p><p><strong>Results: </strong>This study included 25 patients (28 knees) with a mean preoperative mechanical valgus axis of 11.3 (3.6-27.3) degrees. The mean follow-up duration was 3.4 (1.04-7.4) years. Stress radiographs showed a median varus and valgus gap opening of 1.6 (IQR 0.6-3.0) mm and 1.7 (IQR 1.3-2.3) mm and varus and valgus angulation changes of 2.5 (IQR 1.3-4.8) degrees and 2.3 (IQR 2.0-3.6) degrees, respectively. No clinical signs of instability, implant loosening, or revision due to instability were observed throughout this case series.</p><p><strong>Conclusion: </strong>The present study demonstrated that using CR-TKA for patients with valgus OA of the knee promoted excellent coronal plane stability.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needle arthroscopic-assisted repair of tibio-fibular syndesmosis acute injury: A case report.","authors":"Blazej G Wojtowicz, Marcin Domzalski, Jedrzej Lesman","doi":"10.5312/wjo.v15.i8.820","DOIUrl":"10.5312/wjo.v15.i8.820","url":null,"abstract":"<p><strong>Background: </strong>Acute injuries to the tibiofibular syndesmosis, often associated with high ankle sprains or malleolar fractures, require precise diagnosis and treatment to prevent long-term complications. This case report explores the use of needle arthroscopy as a minimally invasive technique for the repair of tibiofibular syndesmosis injuries.</p><p><strong>Case summary: </strong>We report on a 40-year-old male patient who presented with a trimalleolar fracture and ankle subluxation following a high ankle sprain. Due to significant swelling and poor soft tissue quality, initial management involved external stabilization. Subsequently, needle arthroscopy was employed to assess and treat the tibiofibular syndesmosis injury. The procedure, performed under spinal anesthesia and fluoroscopic control, included nanoscopic evaluation of the ankle joint and reduction of the syndesmosis using a suture button. Follow-up assessments showed significant improvement in pain levels, range of motion, and functional scores. At 26 weeks post-procedure, the patient achieved full range of motion and pain-free status. Needle arthroscopy offers a promising alternative for the management of acute tibiofibular syndesmosis injuries, combining diagnostic and therapeutic capabilities with minimal invasiveness.</p><p><strong>Conclusion: </strong>This technique may enhance clinical outcomes and reduce recovery times, warranting further investigation and integration into clinical practice.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Native and prosthetic septic arthritis in a university hospital in Saudi Arabia: A retrospective study.","authors":"Reham Kaki","doi":"10.5312/wjo.v15.i8.722","DOIUrl":"10.5312/wjo.v15.i8.722","url":null,"abstract":"<p><strong>Background: </strong>Septic arthritis, whether native or prosthetic, poses a significant challenge in clinical practice due to its potentially devastating consequences. Despite its clinical importance, there remains a dearth of comprehensive studies and standardized diagnostic criteria, particularly in the Kingdom of Saudi Arabia.</p><p><strong>Aim: </strong>To investigate the epidemiology, microbiological profiles, and clinical characteristics of native and prosthetic septic joints in the Saudi Arabian population.</p><p><strong>Methods: </strong>Medical records of patients diagnosed with septic arthritis between January 1, 2015, and December 31, 2022, were retrospectively reviewed. Data regarding patient demographics, clinical presentation, microbiological cultures, treatment modalities, and outcomes were analyzed.</p><p><strong>Results: </strong>In a retrospective review of 52 cases of septic arthritis, a balanced gender distribution was observed (1:1 ratio), with the knee being the most commonly affected joint (80.8%). Methicillin-resistant <i>Staphylococcus aureus</i> predominated in native joints (24.2%), while <i>Brucella spp.</i> was more prevalent in prosthetic joints (21.1%). Joint preservation was achieved in most cases (84.6%), with no significant difference in clinical features between native and prosthetic joints. However, certain comorbidities were more common in native joint cases, including renal impairment (<i>P</i> = 0.002), hemodialysis (<i>P</i> = 0.004), heart disease (<i>P</i> = 0.013), and chronic liver disease (<i>P</i> = 0.048). At the same time, osteoarthritis was more prevalent in prosthetic joint cases (<i>P</i> = 0.013). Vancomycin was the most frequently used antibiotic (26.9%), and most patients received antibiotics before joint aspiration (57.7%). Surgical intervention, predominantly arthrotomy, was required in most cases (32.7%). Notably, a significant association was found between joint type and mortality (odds ratio = 0.587, <i>P</i> = 0.048), as well as the Charlson comorbidity index and mortality (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This study highlighted distinctive microbiological profiles and etiological factors in septic arthritis cases in the Saudi Arabian population.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neglected congenital bilateral knee dislocation treated by quadricepsplasty with semitendinosus and sartorius transfer: A case report.","authors":"Osama M Qasim, Abdulaziz A Abdulaziz, Nibras K Aljabri, Khalid S Albaqami, Rayan M Suqaty","doi":"10.5312/wjo.v15.i8.807","DOIUrl":"10.5312/wjo.v15.i8.807","url":null,"abstract":"<p><strong>Background: </strong>Congenital knee dislocation (CKD) is a rare condition, which accounts for 1% of congenital hip dislocations. It can present as an isolated condition or coexist with other genetic disorders. Treatment options include serial casting, percutaneous quadriceps recession, and V-Y quadricepsplasty (VYQ). The pathogenesis and hereditary patterns of CKD are not fully understood, with most cases being familial. CKD is usually managed immediately after birth. However, in this report, the patient was neglected for 2 years.</p><p><strong>Case summary: </strong>A 2-year-old girl with bilateral CKD after birth presented to our hospital after failed serial casting; the patient had seizures and limited access to healthcare because of her family's low socioeconomic status. Her birth was noted for a breech presentation accompanied by oligohydramnios. The delivery took a long time, requiring immediate medical interventions. As an infant, she had chronic diseases, including a small patent ductus arteriole, multicystic dysplastic kidney disease, and epilepsy. She was found to have a bilateral knee dislocation of approximately -90° on hyperextension. A multidisciplinary team was involved, and medical care was optimized. She underwent VYQ plus semitendinosus and sartorius transfer. After four postoperative follow-ups, her knees were regaining mobility, and she could walk for 2-3 steps without assistance.</p><p><strong>Conclusion: </strong>This report highlights the importance of early intervention and recommends extensive studies of the management in similar cases.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total hip arthroplasty for sequelae of childhood hip disorders: Current review of management to achieve hip centre restoration.","authors":"Anil Thomas Oommen","doi":"10.5312/wjo.v15.i8.683","DOIUrl":"10.5312/wjo.v15.i8.683","url":null,"abstract":"<p><p>Adults requiring total hip arthroplasty (THA) for childhood disorder sequelae present with shortening, limp, pain, and altered gait. THA, which can be particularly challenging due to altered anatomy, requires careful planning, assessment, and computed tomography evaluation. Preoperative templating is essential to establish the appropriate acetabular and femoral size. Information regarding neck length and offset is needed to ensure the proper options are available at THA. Hip centre restoration must be planned preoperatively and achieved intraoperatively with appropriate exposure, identification, and stable fixation with optimum-size components. Identifying the actual acetabular floor is essential as changes include altered anatomy, distortion of the margins and version changes. Proximal femur changes include anatomical variation, decreased canal diameter, cortical thickness, changes in anteversion, and metaphyseal and diaphyseal mismatch. Preoperative assessment should consist of limb assessment for variations due to prior surgical procedures. Evaluation of the shortening pattern with the relationship of the lesser trochanter to the teardrop would help identify and plan for subtrochanteric shortening osteotomy, especially in high-riding hips. The surgical approach must ensure adequate exposure and soft tissue release to achieve restoration of the anatomical hip centre. The femoral components may require modularity to enable restoration of anteversion and optimum fixation.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients.","authors":"Peter C Brennan, Stephanie M Peterson, Thomas J O'Byrne, Mariana L Laporta, Cody C Wyles, Paul J Jannetto, Garvan C Kane, Maria Vassilaki, Hilal Maradit Kremers","doi":"10.5312/wjo.v15.i8.773","DOIUrl":"10.5312/wjo.v15.i8.773","url":null,"abstract":"<p><strong>Background: </strong>There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty (TJA) patients.</p><p><strong>Aim: </strong>To determine the association of commonly used implant metals with echocardiographic measures in TJA patients.</p><p><strong>Methods: </strong>The study comprised 110 TJA patients who had a recent history of high chromium, cobalt or titanium concentrations. Patients underwent two-dimensional, three-dimensional, Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal concentrations. Age and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations (exposure) with echocardiographic measures (outcome).</p><p><strong>Results: </strong>Higher cobalt concentrations were associated with increased left ventricular end-diastolic volume (estimate 5.09; 95%CI: 0.02-10.17) as well as left atrial and right ventricular dilation, particularly in men but no changes in cardiac function. Higher titanium concentrations were associated with a reduction in left ventricle global longitudinal strain (estimate 0.38; 95%CI: 0.70 to 0.06) and cardiac index (estimate 0.08; 95%CI, -0.15 to -0.01).</p><p><strong>Conclusion: </strong>Elevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some patients. Longitudinal studies are warranted to better understand the systemic effects of metals in TJA patients.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional analysis of age and sex differences in femoral head asphericity in asymptomatic hips in the United States.","authors":"Mahad M Hassan, Aliya G Feroe, Brenton W Douglass, Andrew E Jimenez, Benjamin Kuhns, Charles F Mitchell, Robert L Parisien, Daniel A Maranho, Eduardo N Novais, Young-Jo Kim, Ata M Kiapour","doi":"10.5312/wjo.v15.i8.754","DOIUrl":"10.5312/wjo.v15.i8.754","url":null,"abstract":"<p><strong>Background: </strong>The sphericity of the femoral head is a metric used to evaluate hip pathologies and is associated with the development of osteoarthritis and femoral-acetabular impingement.</p><p><strong>Aim: </strong>To analyze the three-dimensional asphericity of the femoral head of asymptomatic pediatric hips. We hypothesized that femoral head asphericity will vary significantly between male and female pediatric hips and increase with age in both sexes.</p><p><strong>Methods: </strong>Computed tomography scans were obtained on 158 children and adolescents from a single institution in the United States (8-18 years; 50% male) without hip pain. Proximal femoral measurements including the femoral head diameter, femoral head volume, residual volume, asphericity index, and local diameter difference were used to evaluate femoral head sphericity.</p><p><strong>Results: </strong>In both sexes, the residual volume increased by age (<i>P</i> < 0.05). Despite significantly smaller femoral head size in older ages (> 13 years) in females, there were no sex-differences in residual volume and aspherity index. There were no age-related changes in mean diameter difference in both sexes (<i>P</i> = 0.07) with no significant sex-differences across different age groups (<i>P</i> = 0.06). In contrast, there were significant increases in local aspherity (maximum diameter difference) across whole surface of the femoral head and all quadrants except the inferior regions in males (<i>P</i> = 0.03). There were no sex-differences in maximum diameter difference at any regions and age group (<i>P</i> > 0.05). Increased alpha angle was only correlated to increased mean diameter difference across overall surface of the femoral head (<i>P</i> = 0.024).</p><p><strong>Conclusion: </strong>There is a substantial localized asphericity in asymptomatic hips which increases with age in. While 2D measured alpha angle can capture overall asphericity of the femoral head, it may not be sensitive enough to represent regional asphericity patterns.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior cruciate ligament reconstruction: Effect of graft tunnel position on early to mid-term clinical outcomes.","authors":"Oliver Mann, Oday Al-Dadah","doi":"10.5312/wjo.v15.i8.744","DOIUrl":"10.5312/wjo.v15.i8.744","url":null,"abstract":"<p><strong>Background: </strong>Patient reported outcome measures (PROMs) can be used to assess knee function following anterior cruciate ligament (ACL) reconstruction. Intra-operatively, femoral and tibial tunnels are created to accommodate the new ACL graft. It is postulated that there is an optimum position and orientation of these tunnels and that outcomes from this procedure are affected by their position.</p><p><strong>Aim: </strong>To evaluate the influence of graft tunnel position on early to mid-term clinical outcomes following ACL reconstruction.</p><p><strong>Methods: </strong>Six PROMs were collected following ACL reconstruction which included the Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee, Lysholm, Tegner, EuroQol-5 Dimension-5 level, and Short Form 12-item Health Survey. A total of 8 radiological parameters were measured from post-operative X-rays relating to graft tunnel positions. This data was analysed to assess for any correlations between graft tunnel position and post-operative PROMs.</p><p><strong>Results: </strong>A total of 87 patients were included in the study with a mean post-operative follow-up of 2.3 years (range 1 to 7 years). Posterior position of tibial tunnel was associated with improved KOOS quality of life (rho = 0.43, <i>P</i> = 0.002) and EQ-5D VAS (rho = 0.36, <i>P</i> = 0.010). Anterior position of EndoButton femoral tunnel was associated with an improved EQ-5D index (rho = -0.38, <i>P</i> = 0.028). There were no other significant correlations between any of the other radiological parameters and PROM scores.</p><p><strong>Conclusion: </strong>Overall, graft tunnel position had very little correlation with clinical outcomes following ACL reconstruction. A few (posterior) tibial tunnel and (anterior) EndoButton femoral tunnel measurements were associated with better PROMs.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophagocytic lymphohistiocytosis triggered by relapsing polychondritis: A case report.","authors":"Mi-Ran Han, Jeong-Hwan Hwang, Seungah Cha, So-Yeon Jeon, Kyu Yun Jang, Namsu Kim, Chang-Hoon Lee","doi":"10.5312/wjo.v15.i8.813","DOIUrl":"10.5312/wjo.v15.i8.813","url":null,"abstract":"<p><strong>Background: </strong>Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder caused by abnormal histiocytes and T cell activation. In adults, it is predominantly associated with infections, cancers, and autoimmune diseases. Relapsing polychondritis (RP), another rare disease, is diagnosed based on symptoms without specific tests, featuring cartilage inflammation characterized by swelling, redness, and pain, rarely inducing HLH.</p><p><strong>Case summary: </strong>A 74-year-old woman visited the emergency room with a fever of 38.6 °C. Blood tests, cultures, and imaging were performed to evaluate fever. Results showed increased fluorescent antinuclear antibody levels and mild cytopenia, with no other specific findings. Imaging revealed lymph node enlargement was observed; however, biopsy results were inconclusive. Upon re-evaluation of the physical exam, inflammatory signs suggestive of RP were observed in the ears and nose, prompting a tissue biopsy for confirmation. Simultaneously, persistent fever accompanied by cytopenia prompted a bone marrow examination, revealing hemophagocytic cells. After finding no significant results in blood culture, viral markers, and tissue examination of enlarged lymph nodes, HLH was diagnosed by RP. Treatment involved methylprednisolone followed by azathioprine. After two months, bone marrow examination confirmed resolution of hemophagocytosis, with normalization of hyperferritinemia and pancytopenia.</p><p><strong>Conclusion: </strong>Thorough physical examination enabled diagnosis and treatment of HLH triggered by RP in patients presenting with fever of unknown origin.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}