World Journal of Orthopedics最新文献

{"title":"Retrieval analysis in total knee arthroplasty.","authors":"Emerito Carlos Rodriguez-Merchan, William J Ribbans","doi":"10.5312/wjo.v16.i3.102160","DOIUrl":"10.5312/wjo.v16.i3.102160","url":null,"abstract":"<p><p>Retrieval analysis in total knee arthroplasty (TKA) has been little studied in the literature. A narrative review of the literature to understand the current importance of retrieval analysis in TKA has been conducted. On August 27, 2024, a literature search was performed in PubMed using \"TKA retrieval analysis\" as keywords. A total of 160 articles were found, of which only 19 were analyzed because they were directly related to the subject of this article. Rotating-platform (mobile-bearing) TKA has no surface damage advantage over fixed-bearing TKA. TKAs with central locking mechanisms are more prone to debond from the cement mantle. No major wear of the polyethylene (PE) component in TKA using oxidized zirconium components occurs. Femoral components of cobalt-chromium roughen more than oxidized zirconium femoral components. The use of a polished tibial tray over an unpolished design is advised. At short-run assessment (15 months on average), antioxidant-stabilized highly crosslinked PE components are not clinically different in surface damage, density of crosslinking, or oxidation compared to standard remelted highly crosslinked PE components. A correlation between implant position and PE component surface damage has been reported. It shows the importance of optimizing component position to reduce PE component damage. Contemporary knee tumor megaendoprostheses show notable volumetric metal wear originated at the rotating hinge. Retrieval analysis in TKA renders relevant data on how different prosthetic designs described in the literature perform. Such information can help to improve future prosthetic designs to increase prosthetic survival.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"102160"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of refractory thoracolumbar spine infection by thirteen times of vacuum sealing drainage: A case report.","authors":"Jun-Jie Wu, Zheng-Qi Chang","doi":"10.5312/wjo.v16.i3.101073","DOIUrl":"10.5312/wjo.v16.i3.101073","url":null,"abstract":"<p><strong>Background: </strong>A case study of multiple distinct levels of skipped thoracolumbar spine infection was reported in which 13 successful vacuum sealing drainage (VSD) surgeries were treated.</p><p><strong>Case summary: </strong>The patient underwent a total of 13 procedures within our medical facility, including five performed under local anesthesia and eight performed under general anesthesia. The source of the ailment was ultimately identified as <i>Enterobacter cloacae</i>. After the last procedure, the patient's symptoms were alleviated, and the recovery process was satisfactory. Three months post-operation, the Japanese Orthopaedic Association scores had improved to 100%. Imageological examination revealed a satisfactory position of internal fixation, and the abnormal signals in the vertebral body and intervertebral space had been eliminated when compared to the pre-operative results.</p><p><strong>Conclusion: </strong>The study demonstrates that the extreme lateral approach debridement combined with multiple VSD operations is a secure and successful method of treatment for recurrent spinal infection, providing an alternative to traditional surgery.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"101073"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denosumab regimens in the treatment of giant cell tumor of bone: A systematic review with meta-analysis.","authors":"Bruno G Barreto, Claudio Santili, Alex Guedes, Fernando D Moreira, Claudio Luiz Dsl Paz","doi":"10.5312/wjo.v16.i3.102520","DOIUrl":"10.5312/wjo.v16.i3.102520","url":null,"abstract":"<p><strong>Background: </strong>Giant cell tumor of bone (GCTB) is a rare, locally aggressive neoplasm that should be treated surgically, whenever possible. This treatment approach may be linked with greater morbidity besides functional impairment. Denosumab is a human monoclonal antibody. Its administration inhibits bone resorption and has become part of the therapeutic armamentarium against GCTB, as it allows local control with a view to downstaging for a more conservative surgical procedure. However, there is no consensus in the literature regarding the optimal denosumab regimen for GCTB. Therefore, a wide discussion of denosumab regimen is necessary.</p><p><strong>Aim: </strong>To assess the effectiveness of various therapy protocols employing denosumab in individuals with GCTB.</p><p><strong>Methods: </strong>A broad and systematic literature search was carried out using the PRISMA guidelines. We analyzed studies that reported skeletally mature patients with GCTB regardless of sex or ethnicity treated with denosumab. Articles with fewer than five patients and in languages except Spanish, Portuguese and English were excluded. Statistical analysis with proportion meta-analysis was performed due to the dichotomous nature of the data.</p><p><strong>Results: </strong>1005 articles were screened, of which 26 articles met the inclusion criteria and were selected, totaling 1742 patients, 51.8% women and 48.2% men, with an average of 35 years of age. Treatment with denosumab was associated with high rates of clinical benefit (CB) and imaging response (IR), without changing local recurrence rates when compared to patients treated without denosumab, regardless of the therapeutic regimen adopted and the number of doses applied. The adverse events (AE) presented were mostly mild, with the exception of a malignant transformation to osteosarcoma.</p><p><strong>Conclusion: </strong>Treatment of GCTB with denosumab is effective, showing high rates of CB and IR. The AE that occurred were mostly mild. We found no differences between the articles considering the researched outcomes regardless of the therapeutic regimen adopted.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"102520"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional outcomes of peroneus longus tendon autograft for posterior cruciate ligament reconstruction: A meta-analysis.","authors":"Ahmed Mohamed Yousif Mohamed, Monzir Salih, Mugahid Mohamed, Ayman E Abbas, Maysara Elsiddig, Mazin Abdelsalam, Basil Elhag, Nujud Mohamed, Souzan Ahmed, Deena Omar, Samah Ahmed, Duaa Mohamed","doi":"10.5312/wjo.v16.i3.101841","DOIUrl":"10.5312/wjo.v16.i3.101841","url":null,"abstract":"<p><strong>Background: </strong>The posterior cruciate ligament (PCL) is vital for regulating posterior tibial translation in relation to the femur, which is critical for knee stability. PCL tears are infrequently isolated in knee injuries; however, the absence of the PCL results in abnormal knee kinematics, which may cause injuries to other ligaments. The ideal tendon source for PCL reconstruction is still a subject of debate.</p><p><strong>Aim: </strong>To evaluate the results of employing the peroneus longus tendon (PLT) in PCL reconstruction.</p><p><strong>Methods: </strong>A comprehensive search was conducted to identify relevant randomized controlled trials and retrospective observational studies discussing the outcomes of using the PLT for PCL reconstruction. Studies published up to August 2024 were searched across multiple databases, including PubMed, EMBASE, Scopus, Web of Science, Cochrane Library, and Google Scholar. Full texts of the selected articles were retrieved, reviewed, and independently assessed by the investigators. Discrepancies were resolved by consensus, with any remaining disagreements being arbitrated by a third author.</p><p><strong>Results: </strong>This meta-analysis included five studies on PLT use for PCL reconstruction: (1) Four prospective studies with 104 patients; and (2) One retrospective study with 18 patients. Most studies followed up participants for 24 months, while one had a shorter follow-up of 18 months. Lysholm and modified cincinnati scores improved by pooled means of 32.2 (95%CI: 29.3-35.1, <i>I</i> ² = 0%) and 31.1 (95%CI: 27.98-34.22, <i>I</i> ² = 0%), respectively. Postoperative American Orthopaedic Foot and Ankle Society and Foot and Ankle Disability Index scores were 94.5 (<i>I</i> ² = 61.5%) and 94.5 (<i>I</i> ² = 80.09%), respectively. Single-hop and triple-hop test scores averaged 95.5 (95%CI: 94.5-96.5) and 92.4 (95%CI: 91.9-92.9) respectively. No significant differences were observed in thigh circumference at 10 cm and 20 cm between the injured and healthy sides.</p><p><strong>Conclusion: </strong>Evidence supports PLT autografts for PCL reconstruction, improving knee function and patient outcomes. Larger randomized trials are needed to confirm efficacy and compare graft options.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"101841"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the quality of life after anterior minimally invasive total hip arthroplasty: Commentary on recent findings.","authors":"Qin-Zhi Liu, Nian-Zhe Sun","doi":"10.5312/wjo.v16.i3.105318","DOIUrl":"10.5312/wjo.v16.i3.105318","url":null,"abstract":"<p><p>This editorial critically evaluated the recent study by Ishikura <i>et al</i>, which examined the impact of anterior minimally invasive total hip arthroplasty (MIS-THA) on postoperative quality of life, with a specific focus on the timeline and influencing factors for return to work and resumption of driving. Ishikura <i>et al</i>'s research demonstrated that anterior MIS-THA could shorten recovery time, reduce postoperative pain, and significantly enhance patients' quality of life and productivity. Their findings identified occupational type and work intensity as key determinants of postoperative recovery. By synthesizing evidence from multiple studies, this analysis systematically evaluated the clinical advantages of anterior MIS-THA-including reduced soft tissue trauma and accelerated functional recovery-while acknowledging its limitations, such as a steep surgical learning curve and early postoperative complication risks. The discussion emphasized the necessity of designing personalized rehabilitation protocols that accounted for patients' occupational demands. Notably, while current findings primarily derived from retrospective analyses, the article highlighted the need for prospective cohort studies to validate these observations. The commentary also addressed ongoing debates in the field, particularly the elevated complication rates associated with the direct anterior approach compared to posterior techniques, thereby underscoring the critical role of surgeon expertise in optimizing procedural safety. Collectively, this evaluation advanced our understanding of postoperative recovery dynamics in anterior MIS-THA and provides evidence-based insights to refine clinical rehabilitation frameworks.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"105318"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patellar resurfacing in knee arthroplasty: A comprehensive review and meta-analysis.","authors":"Yuri Klassov","doi":"10.5312/wjo.v16.i3.102031","DOIUrl":"10.5312/wjo.v16.i3.102031","url":null,"abstract":"<p><strong>Background: </strong>Patellar resurfacing in knee arthroplasty remains a contentious issue, with various strategies including routine, selective, and non-resurfacing approaches. This review and meta-analysis aim to assess the incidence of patellar resurfacing, revision rates, patient satisfaction, and relevant knee scores associated with each method.</p><p><strong>Aim: </strong>To determine the comparative effectiveness of routine, selective, and non-resurfacing strategies in patellar resurfacing within knee arthroplasty by evaluating incidence rates, revision rates, patient satisfaction, and knee function scores.</p><p><strong>Methods: </strong>A systematic review spanning from 1990 to 2024 was conducted using PubMed, Embase, and Cochrane Library databases. Studies reporting on the incidence of patellar resurfacing, revision rates, patient satisfaction, and relevant knee scores were included. Data from esteemed world registries such as the Australian Orthopaedic Association National Joint Replacement Registry, the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man and Danish Knee Arthroplasty Registry among others, were meticulously examined. Meta-analysis was employed to derive pooled estimates and 95% confidence intervals.</p><p><strong>Results: </strong>Analysis of data sourced from diverse world registries and literature sources unveiled significant disparities in the incidence of patellar resurfacing across different geographic regions and healthcare institutions. For instance, the incidence of routine patellar resurfacing ranged from 60% to 90% in some regions, while in others, it was as low as 30% to 50%. The meta-analysis indicated that routine resurfacing was associated with a lower revision rate of 3.5% (95%CI: 2.8%-4.2%) compared to non-resurfacing approaches, which exhibited a higher revision rate of 6.8% (95%CI: 5.5%-8.1%). Patient satisfaction outcomes showed variability, with routine resurfacing demonstrating higher mean satisfaction scores in functionality, pain relief, and stability categories.</p><p><strong>Conclusion: </strong>The findings underscore the complexity of patellar resurfacing in knee arthroplasty and highlight the need for continued research to refine clinical practice. Future studies should prioritize prospective randomized controlled trials comparing different patellar resurfacing techniques using standardized outcome measures. Longitudinal studies with extended follow-up periods are necessary to evaluate the long-term outcomes and durability of various patellar resurfacing strategies. Collaborative efforts among multidisciplinary teams will be essential to conduct high-quality research that can provide actionable insights and improve patient outcomes.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"102031"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative imaging adequacy and its impact on unplanned return-to-theatre rates in pedicle screw instrumentation.","authors":"Ramy Sherif, Ella Clifford Spence, Jessica Smith, Michael John Haydon McCarthy","doi":"10.5312/wjo.v16.i3.103955","DOIUrl":"10.5312/wjo.v16.i3.103955","url":null,"abstract":"<p><strong>Background: </strong>Pedicle screw instrumentation is a critical technique in spinal surgery, offering effective stabilization for various spinal conditions. However, the impact of intraoperative imaging quality-specifically the use of both anteroposterior (AP) and lateral views-on surgical outcomes remains insufficiently studied. Evaluating whether the adequacy of these imaging modalities affects the risk of unplanned returns to theatre (URTT) within 90 days due to screw malplacement is essential for refining surgical practices and improving patient care.</p><p><strong>Aim: </strong>To evaluate how intraoperative imaging adequacy influences unplanned return-to-theatre rates, focusing on AP and lateral fluoroscopic views.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 1335 patients who underwent thoracolumbar and sacral pedicle screw instrumentation between January 2013 and December 2022. Data on intraoperative imaging adequacy, screw placement, and URTT events were collected and statistically analyzed using IBM SPSS v23. Imaging adequacy was assessed based on the presence of both AP and lateral views, and outcomes were compared between imaging groups.</p><p><strong>Results: </strong>A total of 9016 pedicle screws were inserted, with 82 screws identified as malplaced in 52 patients. Of these, 46 patients required URTT due to screw malplacement, with 37 returning within 90 days (URTT90). Patients with both AP and lateral imaging saved intraoperatively had significantly lower URTT90 rates compared to those with only lateral imaging saved, demonstrating the critical role of imaging adequacy in improving surgical outcomes.</p><p><strong>Conclusion: </strong>This study underscores that comprehensive intraoperative imaging with both AP and lateral views reduces unplanned returns, improves outcomes, enhances precision, and offers a cost-effective approach for better spinal surgery results.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"103955"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rates of return to sport following suture button fixation for ligamentous Lisfranc injuries: A systematic review.","authors":"Ragul Rajivan, James J Butler, Rachel Lf Fur, Wendell Cole, Brittany DeClouette, Luilly Vargas, Sebastian Krebsbach, John G Kennedy","doi":"10.5312/wjo.v16.i3.97830","DOIUrl":"10.5312/wjo.v16.i3.97830","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this systematic review was to evaluate the clinical and radiological outcomes at short-term follow-up following suture button fixation for the management of ligamentous Lisfranc injuries.</p><p><strong>Aim: </strong>To assess the effectiveness of suture button fixation in managing ligamentous Lisfranc injuries through a systematic evaluation of short-term clinical and radiological outcomes.</p><p><strong>Methods: </strong>During March 2024, the PubMed, EMBASE, and Cochrane library databases were systematically reviewed to identify clinical studies examining outcomes following suture button fixation for the management of ligamentous Lisfranc injuries. Data regarding patient demographics, pathological characteristics, subjective clinical outcomes, radiological outcomes, complications, and failure rates were extracted and analyzed.</p><p><strong>Results: </strong>Eight studies were included. In total, 94 patients (94 feet) underwent suture button fixation for the management of ligamentous Lisfranc injuries at a weighted mean follow-up of 27.2 ± 10.2 months. The American Orthopaedic Foot and Ankle Society score improved from a weighted mean pre-operative score of 39.2 ± 11.8 preoperatively to a post-operative score of 82.8 ± 5.4. The weighted mean visual analogue scale score improved from a weighted mean pre-operative score of 7.7 ± 0.6 preoperatively to a post-operative score of 2.0 ± 0.4. In total, 100% of patients returned to sport at a mean time of 16.8 weeks. The complication rate was 5%, the most common complication of which was residual midfoot stiffness (3.0%). No failures nor secondary surgical procedures were recorded.</p><p><strong>Conclusion: </strong>This systematic review demonstrated that suture button fixation for ligamentous Lisfranc injuries produced improved clinical outcomes at short-term follow-up. In addition, there was an excellent return-to-sport rate (100%) at a weighted mean time of 16.8 weeks. This review highlights that suture button fixation is a potent surgical treatment strategy for ligamentous Lisfranc injuries; however, caution should be taken when evaluating this data in light of the lack of high quality, comparative studies, and short-term follow-up.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"97830"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization and advances in negative pressure wound therapy for the management of necrotizing fasciitis in the upper limb.","authors":"Peng Wang, Zhi-Peng Li, Yu-Hua Ruan, Peng Yan, Wei-Ping Fu, Chang-Jiang Zhang","doi":"10.5312/wjo.v16.i3.105130","DOIUrl":"10.5312/wjo.v16.i3.105130","url":null,"abstract":"<p><p>Necrotizing fasciitis (NF) is a rapidly progressing, life-threatening soft tissue infection, with upper limb NF posing a particularly serious threat to patient survival and quality of life. Negative pressure wound therapy (NPWT) has shown considerable advantages in accelerating wound healing and mitigating functional impairment. A retrospective study by Lipatov <i>et al.</i> demonstrated that NPWT significantly reduced the time needed for wound closure preparation while enhancing the success rate of local repair. Despite its benefits, certain limitations highlight the need for further optimization. This paper investigates the potential for personalized dynamic regulation of NPWT, its integration with adjunctive therapies, and the role of multidisciplinary collaboration. Furthermore, it explores the incorporation of advanced technologies such as artificial intelligence, imaging modalities, and biomaterials, presenting novel pathways for the personalized management and global standardization of NF treatment.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"105130"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Requirements for standardizing the assessment of mesenchymal stem cell therapy and its effects on osteoarthritis.","authors":"Yu-Chen Wang, Jing-Bo Cheng, Ming-Li Feng","doi":"10.5312/wjo.v16.i3.104451","DOIUrl":"10.5312/wjo.v16.i3.104451","url":null,"abstract":"<p><p>Publications of Soufan <i>et al</i> and Kristjánsson <i>et al</i> in the <i>World Journal of Orthopedics</i> on mesenchymal stem cell (MSC) therapy for osteoarthritis (OA) represent a significant exploration of regenerative medicine's potential in OA treatment. In their research, it is highlighted that MSCs can alleviate OA symptoms and even regenerate cartilage, potentially reversing the disease. They also compared the efficacy of three MSC subtypes, emphasizing the therapeutic advantages of adipose-derived MSCs. MSC injections, a novel and less invasive alternative to traditional treatments such as chondrocyte transplantation or arthroplasty, have a low cost, low risks, and favorable outcomes, presenting a promising approach for OA patients. Additionally, we stressed that the efficacy evaluation criteria, heterogeneity, safety, and other factors must be carefully considered to further advance the clinical translation of MSC therapy for OA.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 3","pages":"104451"},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}