World Journal of Orthopedics最新文献

{"title":"Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis.","authors":"Usama Ismaeil Hagag, Fatma Mohamed Halfaya, Hessah Mohammed Al-Muzafar, Suhailah Saud Al-Jameel, Kamal Adel Amin, Wael Abou El-Kheir, Emad A Mahdi, Gamal Abdel-Nasser Ragab Hassan, Osama Mohamed Ahmed","doi":"10.5312/wjo.v15.i11.1056","DOIUrl":"10.5312/wjo.v15.i11.1056","url":null,"abstract":"<p><strong>Background: </strong>No effective treatment guarantees full recovery from osteoarthritis (OA), and few therapies have disadvantages.</p><p><strong>Aim: </strong>To determine if bone marrow mesenchymal stem cells (BMMSCs) and hyaluronic acid (HA) treat ankle OA in Wistar rats.</p><p><strong>Methods: </strong>BMMSCs were characterized using flow cytometry with detection of surface markers [cluster of differentiation 90 (CD90), CD105, CD34, and CD45]. Fifty male Wistar rats were divided into five groups of 10 rats each: Group I, saline into the right tibiotarsal joint for 2 days; Group II, monosodium iodate (MIA) into the same joint; Groups III, MIA + BMMSCs; Group IV, MIA + HA; and Group V, MIA + BMMSCs + HA. BMMSCs (1 × 10⁶ cells/rat), HA (75 µg/rat), and BMMSCs (1 × 10⁶ cells/rat) alongside HA (75 µg/rat) were injected intra-articularly into the tibiotarsal joint of the right hind leg at the end of weeks 2, 3, and 4 after the MIA injection.</p><p><strong>Results: </strong>The elevated right hind leg circumference values in the paw and arthritis clinical score of osteoarthritic rats were significantly ameliorated at weeks 4, 5, and 6. Lipid peroxide significantly increased in the serum of osteoarthritic rats, whereas reduced serum glutathione and glutathione transferase levels were decreased. BMMSCs and HA significantly improved OA. The significantly elevated ankle matrix metalloproteinase 13 (MMP-13) mRNA and transforming growth factor beta 1 (TGF-β1) protein expression, and tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) serum levels in osteoarthritic rats were significantly downregulated by BMMSCs and HA. The effects of BMMSCs and HA on serum TNF-α and IL-17 were more potent than their combination. The lowered serum IL-4 levels in osteoarthritic rats were significantly upregulated by BMMSCs and HA. Additionally, BMMSCs and HA caused a steady decrease in joint injury and cartilage degradation.</p><p><strong>Conclusion: </strong>BMMSCs and/or HA have anti-arthritic effects mediated by antioxidant and anti-inflammatory effects on MIA-induced OA. MMP-13 and TGF-β1 expression improves BMMSCs and/or HA effects on OA in Wistar rats.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1056-1074"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-derived stem cells and knee osteoarthritis: New perspectives, old concerns.","authors":"Eduardo B de Sousa, José Paulo A Gabbi Filho, Vinicius S Gameiro, Leandra S Baptista","doi":"10.5312/wjo.v15.i11.1001","DOIUrl":"10.5312/wjo.v15.i11.1001","url":null,"abstract":"<p><p>In this editorial, we comment on the paper by Muthu <i>et al</i> published in the recent issue of the journal. This editorial review focusses on the use of adipose-derived stem cells (ADSCs) in knee osteoarthritis treatment. We discuss the differences between the stromal vascular fraction and microfragmented adipose tissue and highlight the results of clinical studies comparing both treatments and the use of hyaluronic acid, platelet-rich plasma, and bone marrow aspirate concentrate. The use of expanded ADSCs is also discussed; moreover, concerns regarding treatment with ADSCs, particularly the heterogeneity of published studies and the need to standardize protocols to explore clinical potential is explored.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1001-1006"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction.","authors":"Tian-Wang Zhu, Xian-Xiang Xiang, Chun-Hui Li, Rui-Xin Li, Nan Zhang","doi":"10.5312/wjo.v15.i11.1036","DOIUrl":"10.5312/wjo.v15.i11.1036","url":null,"abstract":"<p><strong>Background: </strong>Meniscus extrusion occurs in most elderly individuals and most patients after meniscus allograft transplantation. The risk factors and correlative factors of meniscus extrusion have been extensively studied. However, for using tendon autograft for meniscus reconstruction, both graft type and surgical method are different from those in previous studies on meniscus extrusion.</p><p><strong>Aim: </strong>To identify predictive factors for coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction.</p><p><strong>Methods: </strong>Ten patients who underwent medial meniscus reconstruction with tendon autograft were selected for this retrospective observational study. The graft extrusions and potential factors were measured and correlation and regression analyses were performed to analyze their relationships.</p><p><strong>Results: </strong>The medial graft extrusion correlated with the preoperative bilateral hip-knee-ankle angle difference, preoperative Kellgren-Lawrence grade, preoperative relative joint space width, and preoperative bilateral medial edge incline angle difference. The anterior graft correlated with the anterior tunnel edge distance at 1 week after operation. The posterior graft extrusion correlated with the preoperative bilateral hip-knee-ankle angle difference, preoperative relative joint space width, and posterior tunnel edge distance at 1 week after operation. The mean graft extrusion correlated with the preoperative bilateral hip-knee-ankle angle difference and preoperative relative joint space width. The preoperative joint space width and anterior and posterior tunnel edge distance at 1 week can be used to predict the medial, anterior, posterior, and mean graft extrusion length.</p><p><strong>Conclusion: </strong>The preoperative joint space width and tunnel position can be used to predict the coronal and sagittal graft extrusion length after using tendon autograft for medial meniscus reconstruction.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1036-1046"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of negative pressure wound therapy in complex surgical treatment of necrotizing fasciitis of the upper limb.","authors":"Konstantin V Lipatov, Arthur Asatryan, George Melkonyan, Aleksandr D Kazantcev, Ekaterina I Solov'eva, Denis V Krivikhin, Irina V Gorbacheva, Urii E Cherkasov","doi":"10.5312/wjo.v15.i11.1015","DOIUrl":"10.5312/wjo.v15.i11.1015","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing fasciitis (NF) of the upper extremities is a severe surgical pathology, and the incidence of this disease has been steadily increasing in recent decades. Surgical treatment is accompanied by the formation of extensive wounds, which can be treated with significant difficulties. In recent years, negative pressure wound therapy (NPWT) has proven to be highly effective. It is also promising for the treatment of NF.</p><p><strong>Aim: </strong>To explore the effectiveness of NPWT in the treatment of NF of the upper extremities.</p><p><strong>Methods: </strong>The results of the treatment of 36 patients with NF of the upper extremities in two groups (NPWT group and control group; 2022-2023) were retrospectively analyzed. In the NPWT group, the NPWT method (120 mmHg; constant mode) was used after surgical treatment. The number of vacuum-assisted dressings in patients ranged from 1 to 3, depending on the dynamics of the wound process. The duration of fixation of one bandage was up to 2-3 d. In the control group, conventional methods of local wound treatment were used. The following indicators were analyzed: The treatment delay, the prevalence of inflammation, the microbial landscape, the number of debridements, the duration of wound preparation for surgical closure, and the nature of skin plastic surgery.</p><p><strong>Results: </strong>Most patients experienced a significant treatment delay [4 d, interquartile range (IQR): 2-7 d], which led to the spread of the pathological process to the forearm and shoulder. The most common pathogens were <i>Staphylococcus aureus</i> (14; 38.9%) and <i>Streptococcus pyogenes</i> (22; 61.1%). The average number of debridements <i>per</i> patient was 5 (IQR: 3-7), with no difference between groups. The average time to prepare wounds for surgical closure was 11 ± 4 d in the NPWT group and 29 ± 10 d (<i>P</i> = 0.00001) in the control group. In the NPWT group, the wounds were more often closed with local tissues (15; 83.3%), and in the control group, split-thickness skin grafts were more often used (4; 50%).</p><p><strong>Conclusion: </strong>The predominant isolation of <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i> from the lesions allowed us to classify these patients as NF type II. Multiple debridement procedures have become a feature of this disease treatment. The use of NPWT has significantly reduced the time required to prepare wounds for surgical closure. Early closure of wounds allows for more frequent use of local tissue repair, which ensures better results. NPWT is a highly effective way to prepare wounds for early surgical closure in patients with upper extremity NF.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1015-1022"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by <i>Mycobacterium houstonense</i>: A case report.","authors":"Hong-Yin Lin, Quan-Hui Tan","doi":"10.5312/wjo.v15.i11.1095","DOIUrl":"10.5312/wjo.v15.i11.1095","url":null,"abstract":"<p><strong>Background: </strong><i>Mycobacterium houstonense</i> (<i>M. houstonense</i>) belongs to the nontuberculous mycobacterium group. Infection caused by <i>M. houstonense</i> is prone to recurrence.</p><p><strong>Case summary: </strong>We present a patient who was diagnosed with osteomyelitis caused by <i>M. houstonense</i> and treated with a combination of cefoxitin, and amikacin combined with linezolid.</p><p><strong>Conclusion: </strong>The emergence of metagenomic next-generation sequencing (NGS) has brought new hope for the diagnosis and treatment of listeria meningitis. NGS can analyze a large number of nucleic acid sequences in a short time and quickly determine the pathogen species in the sample. Compared with traditional cerebrospinal fluid culture, NGS can greatly shorten the diagnosis time and provide strong support for the timely treatment of patients. Regarding treatment, NGS can also play an important role. Rapid and accurate diagnosis can enable patients to start targeted treatment as soon as possible and improve the treatment effect. At the same time, by monitoring the changes in pathogen resistance, the treatment plan can be adjusted in time to avoid treatment failure.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1095-1100"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic synovectomy for synovial hyperplasia in chronic knee gouty arthritis: A case report.","authors":"Ghuna A Utoyo, Calvin Calvin","doi":"10.5312/wjo.v15.i11.1101","DOIUrl":"10.5312/wjo.v15.i11.1101","url":null,"abstract":"<p><strong>Background: </strong>Chronic synovitis due to chronic knee gouty arthritis (KGA) resulting in synovial hyperplasia has not been documented in the current literature, and thus the optimal management for this condition remains unclear. This case report discusses a 34-year-old man with a history of chronic KGA who presented with recurrent knee effusion resulting from synovial hyperplasia.</p><p><strong>Case summary: </strong>A 34-year-old man presented to our outpatient clinic with a 5-year recurrent knee effusion and a history of chronic KGA. Symptoms persisted despite serial aspiration and urate-lowering medication (febuxostat 80 mg once daily) for 2 months. Diagnostic arthroscopy was performed due to the recalcitrant symptoms. Intraoperatively, tophi deposition and excessive thickening of the synovial membrane were observed. Synovial biopsy and partial synovectomy were performed, revealing chronic synovitis with synovial hyperplasia that was consistent with chronic KGA. At follow-up after 6 months, the patient reported no further episode of knee effusion.</p><p><strong>Conclusion: </strong>Arthroscopic synovectomy for synovial hyperplasia in chronic KGA sufficiently eradicates the symptoms of recurrent knee effusion.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1101-1108"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation and management outcome of foot drop with tibialis posterior tendon transfer.","authors":"Muhammad Saaiq","doi":"10.5312/wjo.v15.i11.1047","DOIUrl":"10.5312/wjo.v15.i11.1047","url":null,"abstract":"<p><strong>Background: </strong>Foot drop causes considerable disability. The ankle-dorsiflexion is either weak or lost completely. Additionally, the ankle eversion and toe extensions are also impaired. This results in a high steppage gait while walking. Overall, the gait is awkward; there is greater energy consumption; increased proneness to sustain injury of the forefoot; and more frequent falling during walking.</p><p><strong>Aim: </strong>To document the clinical and epidemiological profile of foot drop patients in our population and evaluate the outcome of tibialis posterior (TP) tendon transfer for restoring the lost dorsiflexion in foot drop.</p><p><strong>Methods: </strong>The study was carried out at the National Institute of Rehabilitation Medicine in Islamabad over a period of 7 years. It included patients of all sexes and ages who presented with foot drop and had no contraindications for the procedure of TP tendon transfer. Exclusion criteria were patients who had contraindications for the operation. For instance, paralyzed posterior leg compartment muscles, Achilles tendon contracture, stiff ankle or toes, unstable ankle joint, weak gastrocnemius and scarred skin spanning over the route of planned tendon transfer. Also, patients who had the foot drop as a result of disc prolapses or brain diseases were excluded. Convenience sampling technique was used. The circum-tibial route of TP tendon transfer was employed.</p><p><strong>Results: </strong>Out of 37 patients, 26 (70.27%) were males whereas 11 (29.72%) were females. The mean age was 22.59 ± 8.19 years. Among the underlying causes of foot drop, road traffic accidents constituted the most common cause, found among 20 (54.05%) patients. The share of complications included wound infections in 3 (8.10%) patients and hypertrophic scars in 2 (5.40%) patients. At 1-year postoperative follow-up visits, the outcome was excellent in 8 (21.62%), good in 20 (54.05%) and moderate in 9 (24.31%).</p><p><strong>Conclusion: </strong>The majority of cases of foot drop resulted from road traffic accidents that directly involved the common peroneal nerve. TP tendon transfer through the circumtibial route was found to be an easily executed effective operation which restored good dorsiflexion of the ankle among the majority of patients.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1047-1055"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence awareness and perceptions among pediatric orthopedic surgeons: A cross-sectional observational study.","authors":"Ammar K Alomran, Mohammed F Alomar, Ali A Akhdher, Ali R Al Qanber, Ahmad K Albik, Arwa Alumran, Ahmed H Abdulwahab","doi":"10.5312/wjo.v15.i11.1023","DOIUrl":"10.5312/wjo.v15.i11.1023","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) is a branch of computer science that allows machines to analyze large datasets, learn from patterns, and perform tasks that would otherwise require human intelligence and supervision. It is an emerging tool in pediatric orthopedic surgery, with various promising applications. An evaluation of the current awareness and perceptions among pediatric orthopedic surgeons is necessary to facilitate AI utilization and highlight possible areas of concern.</p><p><strong>Aim: </strong>To assess the awareness and perceptions of AI among pediatric orthopedic surgeons.</p><p><strong>Methods: </strong>This cross-sectional observational study was conducted using a structured questionnaire designed using QuestionPro online survey software to collect quantitative and qualitative data. One hundred and twenty-eight pediatric orthopedic surgeons affiliated with two groups: Pediatric Orthopedic Chapter of Saudi Orthopedics Association and Middle East Pediatric Orthopedic Society in Gulf Cooperation Council Countries were surveyed.</p><p><strong>Results: </strong>The pediatric orthopedic surgeons surveyed had a low level of familiarity with AI, with more than 60% of respondents rating themselves as being slightly familiar or not at all familiar. The most positively rated aspect of AI applications for pediatric orthopedic surgery was their ability to save time and enhance productivity, with 61.97% agreeing or strongly agreeing, and only 4.23% disagreeing or strongly disagreeing. Our participants also placed a high priority on patient privacy and data security, with over 90% rating them as quite important or highly important. Additional bivariate analyses suggested that physicians with a higher awareness of AI also have a more positive perception.</p><p><strong>Conclusion: </strong>Our study highlights a lack of familiarity among pediatric orthopedic surgeons towards AI, and suggests a need for enhanced education and regulatory frameworks to ensure the safe adoption of AI.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1023-1035"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling.","authors":"Marina Ribeiro Paulini, Letícia Ferreira Montarele, Dimitrius Leonardo Pitol, Gisele Giannocco, Bruno Fiorelini Pereira, Daniela Vieira Buchaim, Carlos Henrique Bertoni Reis, Rogério Leone Buchaim, Joao Paulo Mardegan Issa","doi":"10.5312/wjo.v15.i11.1075","DOIUrl":"10.5312/wjo.v15.i11.1075","url":null,"abstract":"<p><strong>Background: </strong>In the medical and dental fields, there is a need for studies of new therapeutic approaches for the treatment of bone defects that cause extensive bone loss. Melatonin may be an important endogenous biological factor for bone remodeling, and growth factors may enhance the repair process.</p><p><strong>Aim: </strong>To evaluate the gene expression of cytokines (IL-1β, IL-6, IL-10 and TNF-α), markers of osteoclastogenesis (RANK, RANKL and OPG) and MMPs (MMP-1, MMP-2, MMP-8 and MMP-13) from the treatment of melatonin associated with an osteogenic membrane and rhBMP-2 on the recovery of a bone injury.</p><p><strong>Methods: </strong>Sixty-four rats were used and divided into 9 experimental groups and were formed according to the treatment carried out in the region of the bone lesion, which varied between the combination of 1, 10 and 100 μmol/L of melatonin. Gene Expression analysis was performed using real time-PCR by reading the concentration of total RNA and reverse transcription.</p><p><strong>Results: </strong>There were differences between groups when compared with clot or scaffold control, and improvement with a higher concentration of melatonin or rhBMP-2. The combination melatonin (1 µg) with 5 μg of rhBMP-2, using the guided bone regeneration technique, demonstrated some effects, albeit mild, on bone repair of critical bone defects.</p><p><strong>Conclusion: </strong>This indicates that the approach for administering these substances needs to be reassessed, with the goal of ensuring their direct application to the affected area. Therefore, future research must be carried out, seeking to produce materials with these ideal characteristics.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1075-1087"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiotoxicity concerns in total joint arthroplasty.","authors":"Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.5312/wjo.v15.i11.1007","DOIUrl":"10.5312/wjo.v15.i11.1007","url":null,"abstract":"<p><p>This editorial examines the cardiotoxic effects of elevated metal concentrations in patients who received total joint arthroplasty, as detailed in the study of Brennan <i>et al.</i> The study findings reveal that elevated cobalt and titanium levels may affect the cardiac structure and function, providing crucial insights for clinical practice and research. This editorial suggests that the close monitoring of metal ion levels in patients undergoing arthroplasty is necessary to reduce cardiovascular risk.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"15 11","pages":"1007-1014"},"PeriodicalIF":2.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}