World Journal of Orthopedics最新文献

{"title":"Investigation of clinical outcomes in conservative management of hook fractures: Commentary on recent findings.","authors":"Li-Hu Ding, Pan-Feng Wu, Nian-Zhe Sun","doi":"10.5312/wjo.v16.i5.106881","DOIUrl":"10.5312/wjo.v16.i5.106881","url":null,"abstract":"<p><p>This editorial critically evaluates the landmark study by Tanaka and Yoshii, which demonstrated a 100% union rate with conservative management of hamate hook fractures, challenging the historical preference for surgical intervention. In contrast to Scheufle <i>et al</i>'s report of 90%-100% failure rates with early surgical approaches, Tanaka and Yoshii's protocol achieved universal healing despite delayed diagnoses in 25% of cases. Central to this success is the systematic integration of high-resolution computed tomography for early diagnosis and dynamic monitoring of trabecular bone regeneration, significantly reducing missed diagnoses and guiding personalized immobilization timelines. The patient-centered strategy-allowing temporary splint removal during low-risk activities-balanced fracture stability with joint mobility preservation, avoiding post-treatment stiffness. However, limitations such as small sample size (<i>n</i> = 16), selection bias, and insufficient long-term functional data (<i>e.g.</i>, grip strength, return-to-sport metrics) underscore the need for comparative trials. Emerging trends, including adjunct therapies like low-intensity pulsed ultrasound and biologics (<i>e.g.</i>, teriparatide), are proposed to accelerate healing while minimizing immobilization risks. This work redefines conservative fracture management paradigms, emphasizing innovation without compromising efficacy. Overall, this assessment deepens our understanding of the conservative management of hook fractures and provides evidence-based insights for improved clinical decision-making.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106881"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic exclusion in orthopedic research: Cultural adaptation, multilingual innovations, and pathways to global health equity.","authors":"Qin-Zhi Liu, Lei Zeng, Nian-Zhe Sun","doi":"10.5312/wjo.v16.i5.106951","DOIUrl":"10.5312/wjo.v16.i5.106951","url":null,"abstract":"<p><p>This editorial critically evaluated the recent study by AlMousa <i>et al</i>, which examined the impact of the Arabic version of the American Academy of Orthopedic Surgeons Foot and Ankle Outcomes Questionnaire (AAOS-FAOQ) on postoperative quality of life and recovery in Arabic-speaking patients with traumatic foot and ankle injuries. In the context of systemic linguistic exclusion in orthopedic research-where English-language journals dominated most publications and non-English-speaking populations faced dual barriers of trial underrepresentation and semantic distortions (<i>e.g.</i>, mistranslations of terms like \"joint instability\" in Arabic)-AlMousa <i>et al</i>'s work highlighted the transformative potential of culturally adapted methodologies. Their rigorous four-stage adaptation framework validated the Arabic AAOS-FAOQ as a reliable tool, enhancing ecological validity and reducing bias in patient-reported outcomes. However, limitations such as regional specificity (Gulf-centric sampling) and short follow-up periods (4 months) underscored broader challenges in non-English research: Redundant studies, prolonged hospital stays for limited English proficiency patients, and underrepresentation of certain ethnic groups in trials. To dismantle linguistic hegemony, we proposed semantic reconstruction (<i>e.g.</i>, integrating culturally specific indicators like \"prayer posture\"), dialect-aware neural translation, and World Health Organization led terminology standardization. In line with these proposed solutions, AlMousa <i>et al</i>'s study exemplified how language-sensitive adaptations could bridge equity gaps, while future efforts would need to balance cultural specificity with cross-study comparability through AI-driven multilingual databases and policy mandates for cultural adaptation roadmaps.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106951"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury <i>via</i> the miR-21/PTEN axis.","authors":"Ying-Jie Wang, Zhong-Zheng Zhi, Tao Liu, Jian Kang, Guang-Hui Xu","doi":"10.5312/wjo.v16.i5.106183","DOIUrl":"10.5312/wjo.v16.i5.106183","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) is a severe and permanent trauma that often leads to significant motor, sensory, and autonomic dysfunction. Neuronal apoptosis is a major pathomechanism underlying secondary injury in SCI. Long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression and cellular processes, including apoptosis. However, the role of lncRNA growth arrest-specific transcript 5 (GAS5) in SCI-induced neuronal apoptosis remains unclear.</p><p><strong>Aim: </strong>To investigate the role of lncRNA GAS5 in SCI-induced neuronal apoptosis <i>via</i> its interaction with microRNA (miR)-21 and the phosphatase and tensin homolog (PTEN)/AKT pathway.</p><p><strong>Methods: </strong>SCI rat models and hypoxic neuronal cell models were established. Motor function was assessed using the Basso-Beattie-Bresnahan score. Expression levels of GAS5, miR-21, PTEN, caspase 3, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and AKT were measured using quantitative PCR or Western blot analysis. Neuronal apoptosis was determined by TUNEL staining. Dual-luciferase reporter assays validated GAS5-miR-21 binding. Knockdown and overexpression experiments explored the functional effects of the GAS5/miR-21 axis.</p><p><strong>Results: </strong>GAS5 was significantly upregulated in the spinal cord following SCI, coinciding with increased neuronal apoptosis and decreased AKT activation. <i>In vitro</i> experiments demonstrated that GAS5 acted as a molecular sponge for miR-21, leading to increased PTEN expression and inhibition of the AKT signaling pathway, thereby promoting apoptosis. <i>In vivo</i>, GAS5 knockdown attenuated neuronal apoptosis, enhanced AKT activation, and improved motor function recovery in SCI rats.</p><p><strong>Conclusion: </strong>GAS5 promotes neuronal apoptosis in SCI by binding to miR-21 and upregulating PTEN expression, inhibiting the AKT pathway. Targeting GAS5 may represent a novel therapeutic strategy for SCI.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106183"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of primary total knee arthroplasty operative reports in a tertiary teaching hospital.","authors":"Sulaiman A Almousa","doi":"10.5312/wjo.v16.i5.104438","DOIUrl":"10.5312/wjo.v16.i5.104438","url":null,"abstract":"<p><strong>Background: </strong>Operative reports (OP-Rs) are essential for communication among healthcare providers. They require accuracy and completeness to serve as a quality indicator of patient care. Objective assessment of primary total knee replacement (TKR) OP-Rs has never been reported. Therefore, a standardized benchmark for assessment and factors affecting the completeness of TKR OP-Rs needs to be evaluated.</p><p><strong>Aim: </strong>To evaluate the completeness rate of primary TKR OP-Rs in a teaching hospital and to assess the factors affecting completeness.</p><p><strong>Methods: </strong>A retrospective review of 58 consecutive primary TKR OP-Rs in a tertiary teaching hospital were included in this study. We used document analysis to review the OP-Rs against a standardized list of six subsets of mandatory variables. The correlation between the percentage of completeness and the specific variables was determined.</p><p><strong>Results: </strong>After analyzing 58 cases, we found that the time to documentation was 1.5 hours. Out of the 52 mandatory variables, a median of 30 variables were documented yielding a completeness of 58%. Administrative, procedural, exposure, and implant variables were documented the most often, whereas clinical and process variables were most frequently left uncompleted. The documentation of the operative maneuver was variable. There was no association between the completeness of the reports and the time to documentation, documenter level, complication rate, operative duration, or length of hospital stay.</p><p><strong>Conclusion: </strong>Multiple variables were left undocumented on the unstructured primary TKR OP-Rs. The completeness percentage will likely improve after the implementation of a standardized structured OP-R.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"104438"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of neutrophil to lymphocyte ratio in osteoarthritis: A systematic review and meta-analysis.","authors":"Maryam Salimi, Shokoufeh Khanzadeh, Brandon Lucke-Wold, Arshin Ghaedi, Austin V Stone","doi":"10.5312/wjo.v16.i5.106145","DOIUrl":"10.5312/wjo.v16.i5.106145","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) involves low-grade inflammation. The neutrophil-to-lymphocyte ratio (NLR) may serve as a simple biomarker, but its role in OA remains unclear.</p><p><strong>Aim: </strong>To review the existing scientific literature on the role of NLR in OA, a classic age-related disorder, to perform a meta-analysis of the available data.</p><p><strong>Methods: </strong>The electronic databases PubMed, ProQuest, and Scopus were systematically searched from inception to March 1, 2024. The inclusion criteria were retrospective and prospective case-control studies involving human subjects with OA and healthy controls. The included studies needed to provide NLR levels for both OA patients and healthy controls and perform a comparative analysis of NLR levels between these groups.</p><p><strong>Results: </strong>According to the PRISMA guidelines, fifteen articles were included in the meta-analysis after multiple screenings. The pooled results demonstrated a significant overall elevation of NLR in OA patients compared to healthy controls. (standardized mean difference = 0.39, 95% confidence interval: 0.03-0.75, <i>P</i> = 0.03). However, the subgroup analysis shows no significant differences in NLR levels when considering study design (retrospective <i>vs</i> prospective) and OA severity (severe <i>vs</i> mild-moderate). This suggests variability and potential limitations in using NLR as a consistent marker across different study types and OA severity.</p><p><strong>Conclusion: </strong>Our study found that OA patients have higher NLR than healthy individuals. However, NLR did not significantly differ by study type or disease severity, suggesting its limited use in indicating OA severity.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106145"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in research of neutrophil extracellular trap formation in osteoarticular diseases.","authors":"Guan-Jun Sun, Feng Xu, Xiao-Yi Jiao, Yi Yin","doi":"10.5312/wjo.v16.i5.106377","DOIUrl":"10.5312/wjo.v16.i5.106377","url":null,"abstract":"<p><p>Neutrophil extracellular traps (NETs) have been the subject of research in the field of innate immunity since they were first described two decades ago. NETs are fibrous network structures released by neutrophils under specific stimuli, including DNA, histones, and a variety of granular proteins. NETs have been widely studied in the fields of infectious and immune diseases, and new breakthroughs have been made in the understanding of disease pathogenesis and treatment. In recent years, studies have found that NETs play an important role in the occurrence and development of osteoarticular diseases. This article reviews the progress in the research of NETs in common osteoarticular diseases such as rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, osteonecrosis of the femoral head, osteoarthritis, and joint fibrosis, including the formation mechanism of NETs and its role in inflammation, joint destruction, pain and other pathological processes. The problems existing in current research are discussed, along with future research directions, to provide a reference for the in-depth study of osteoarticular diseases and the development of new treatment strategies.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106377"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promising technique for managing nonspecific chronic low back pain using multi angular isometric lumbar exercise.","authors":"Yadulla Syed, Mohamed Abubakr Hassan, Rashmi Muthira Kalayil, Othman Ahmad Othman, Ahammed Mekkodathil, Ayman El-Menyar","doi":"10.5312/wjo.v16.i5.104425","DOIUrl":"10.5312/wjo.v16.i5.104425","url":null,"abstract":"<p><p>Low back pain (LPB) is a common and impactful health concern globally, affecting individuals across various demographics and imposing a significant burden on the health care system. Nonspecific chronic LBP (NCLBP), characterized as pain lasting over 12 weeks without an identifiable cause, leads to notable functional limitations and reduced quality of life. Traditional rehabilitation programs, often focusing on dynamic exercises for lumbar strengthening, typically do not target the deep stabilizing muscles crucial for lumbar support and effective recovery. Multi-angular isometric lumbar exercise (MAILE) offers a low-impact method for strengthening lumbar stabilizers through multi-angular isometric contractions, reducing risks from dynamic movements. This article examines MAILE's potential in addressing motor control dysfunctions in NCLBP, highlighting studies on lumbar muscle activation, core stability, and isometric exercises. The article explores the prevalence and socioeconomic impact of NCLBP in the Middle East, highlighting the need for affordable treatment options in areas like Qatar and Saudi Arabia. This article aims to validate the efficacy of MAILE in reducing pain, enhancing mobility, and improving lumbar stability, offering a valuable option for NCLBP management. Future research should focus on large-scale clinical trials to substantiate these findings and guide clinical practice.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"104425"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of elbow radiographic measurements in patients with supracondylar humerus fractures and healthy controls.","authors":"Nuri K Ülgen, Batuhan Gencer, Özgür Doğan","doi":"10.5312/wjo.v16.i5.105734","DOIUrl":"10.5312/wjo.v16.i5.105734","url":null,"abstract":"<p><strong>Background: </strong>Supracondylar humeral fractures (SCHF) are the second most common fractures in childhood and can lead to short- and long-term complications. Despite their prevalence, the anatomical factors that predispose children to SCHF remain unclear. This study aimed to determine whether there are significant morphological differences in the elbow by comparing the radiographic angular measurements of the contralateral elbows of patients with SCHF to those of patients with distal radius fractures (DRF) and a healthy control group. We sought to explore if these morphological variations contribute to the occurrence of SCHF.</p><p><strong>Aim: </strong>To determine radiological parameters that may predispose to pediatric elbow fractures.</p><p><strong>Methods: </strong>Radiographs of 78 SCHF patients were analyzed for angular measurements of the contralateral elbow. Two control groups were used: 98 healthy children and 40 patients with DRF. Angular measurements included Baumann angle (BA), humeroulnar angle (HUA), humerus metaphysis-diaphysis angle (HMDA), humerus shaft-condylar angle (HSCA), and lateral capitellohumeral angle. Only BA, HUA, and HMDA were measured in the DRF group. Statistical analysis was performed to compare differences among groups.</p><p><strong>Results: </strong>Significant differences were found in elbow measurements between SCHF and control groups (<i>P</i> < 0.05). However, the mean values for all groups fell within the ranges described in the literature.</p><p><strong>Conclusion: </strong>While statistically significant differences were found in elbow morphology between SCHF patients and controls, these differences don't translate into clinically meaningful morphological deviations.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"105734"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review.","authors":"Bruna Trazzi Pagani, Marcelie Priscila de Oliveira Rosso, Matheus Bento Medeiros Moscatel, Beatriz Flavia de Moraes Trazzi, Marcelo Rodrigues da Cunha, João Paulo Mardegan Issa, Daniela Vieira Buchaim, Rogério Leone Buchaim","doi":"10.5312/wjo.v16.i5.106181","DOIUrl":"10.5312/wjo.v16.i5.106181","url":null,"abstract":"<p><strong>Background: </strong>Bone regeneration is a central focus of regenerative medicine, with applications in orthopedics and dentistry, particularly for treating bone defects caused by trauma, infection, or congenital anomalies. Synthetic biomaterials, often combined with fibrin derivatives, offer promising solutions for bone healing and restoration.</p><p><strong>Aim: </strong>To Explore the increasingly important role of the association of synthetic biomaterials with fibrin in bone regeneration.</p><p><strong>Methods: </strong>Search terms included: \"synthetic biomaterials AND fibrin sealant\", \"hydroxyapatite AND fibrin sealant\", \"tricalcium phosphate AND fibrin sealant\", and \"synthetic biomaterials AND platelet-rich fibrin (PRF)\", resulting in 67 articles. After rigorous screening, 21 articles met the inclusion criteria.</p><p><strong>Results: </strong>The reviewed studies assessed biomaterials like hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and fibrin-based products. Key findings highlighted the enhanced osteoconductivity and biocompatibility of HA and β-TCP, especially when combined with fibrin sealants. These composites show significant potential for improving cellular adhesion, promoting osteogenic differentiation, and accelerating bone regeneration. The antimicrobial properties and structural support for cell growth of certain biomaterials indicate a promising potential for clinical applications.</p><p><strong>Conclusion: </strong>This systematic review emphasizes the growing role of fibrin-based biomaterials in bone regeneration and urges continued research to improve their clinical use for complex bone defects.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"106181"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parallax-free panoramic X-ray imaging combined with minimally invasive plate osteosynthesis for treating proximal humeral shaft fractures.","authors":"Wen-Jing Cheng, Jing-Shun Lu, Zhou-Shan Tao, Jia-Bing Xie, Min Yang","doi":"10.5312/wjo.v16.i5.102916","DOIUrl":"10.5312/wjo.v16.i5.102916","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to evaluate the use of combined parallax-free panoramic X-ray imaging during surgery by enabling the mobile C-arm with minimally invasive plate osteosynthesis (MIPO) in the management of proximal humeral shaft fractures.</p><p><strong>Aim: </strong>To evaluate parallax-free panoramic X-ray images during surgery.</p><p><strong>Methods: </strong>A retrospective series of 17 proximal humeral shaft fractures were treated using combined parallax-free panoramic X-ray imaging during surgery by enabling the mobile C-arm with MIPO. The operating time and radiation exposure time were recorded, and early postoperative physical therapy and partial weight bearing were encouraged. Patients were followed at regular intervals and evaluated radiographically and clinically.</p><p><strong>Results: </strong>The mean operating time and radiation time were 73 (range, 49-95) minutes and 57 (range: 36-98) seconds, respectively. No complications occurred during the operation. All fractures healed at an average of 16.9 (range: 15-23) weeks. The average Constant-Murley score for all the patients was 89.5 (range: 75-100) points. None of the patients showed symptoms of vascular or nerve damage or wound infection. Three months after the operation, none of the patients developed subacromial impingement syndrome. No loosening or fracture of the implants occurred. The frontal and lateral radiographs showed good alignment.</p><p><strong>Conclusion: </strong>We consider that MIPO with combined parallax-free panoramic X-ray imaging during surgery is an efficient method for treating proximal humeral shaft fractures, and could significantly reduce operative morbidity as well as lower the rate of intra- and postoperative complications.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":"16 5","pages":"102916"},"PeriodicalIF":2.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}