中药治疗炎症性骨病的潜力:阐明分子机制和见解。

IF 2.3 Q2 ORTHOPEDICS
Jing-Shun Lu, Min Yang, Zeng-Gao Han, Chen-Yu Song, Nurjamal Sarbay, Kai-Yang Wang
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引用次数: 0

摘要

炎症性骨病是慢性炎症性疾病的一类,其主要病理特征是慢性炎症对骨代谢和骨重塑的影响。它会导致疼痛、脊柱关节畸形和功能障碍。常见的炎性骨病临床类型包括类风湿关节炎、强直性脊柱炎和骨关节炎。然而,炎症性骨病缺乏有效的临床治疗方法,而且药物干预常常伴有难以忍受的副作用。中医(TCM)在治疗炎症性骨病方面有着悠久的历史和被证明的功效。近年来,越来越多的研究强调了中医在这方面的潜力。本文系统评价中医药治疗炎性骨病的应用,重点探讨其抗炎作用的分子机制。通过阐明中医药治疗类风湿关节炎、强直性脊柱炎和骨关节炎的具体靶点,为进一步探索中医药在炎症性骨病临床应用中的作用提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potential of traditional Chinese medicine for inflammatory bone diseases: Elucidating molecular mechanisms and insights.

Inflammatory bone diseases constitute a category of chronic inflammatory disorders, with the primary pathological characteristic being the impact of chronic inflammation on bone metabolism and remodeling. It leads to pain, spinal joint deformities, and functional impairments. Common clinical types of inflammatory bone diseases include rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. However, there is a paucity of effective clinical treatments for inflammatory bone diseases, and pharmacological interventions are frequently associated with intolerable side effects. Traditional Chinese medicine (TCM) has a long-standing history and proven efficacy in managing inflammatory bone diseases. In recent years, an increasing number of studies have highlighted the potential of TCM in this context. This article systematically evaluates the application of TCM in treating inflammatory bone diseases, emphasizing the underlying molecular mechanisms of its anti-inflammatory effects. By elucidating the specific targets of TCM in the treatment of rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis, we aim to provide novel insights into the further exploration of TCM's role in clinical application for inflammatory bone diseases.

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CiteScore
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