研究肩袖愈合的动物模型。

IF 2.3 Q2 ORTHOPEDICS
Qi-Long Jiang
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引用次数: 0

摘要

肩袖撕裂非常普遍,迫切需要了解其愈合机制以改善患者的治疗效果。这篇社论旨在总结常见动物模型(包括啮齿动物、兔子、羊、狗和灵长类动物)和二次关节镜在肩袖愈合研究中的作用和局限性。不同的动物模型具有不同的优点和缺点。例如,啮齿类动物模型具有成本效益,适合基因研究,但与人类在解剖学上存在差异。兔模型因其相对较大的肌腱大小和易于手术操作而受到青睐,但在某些方面仍偏离人类肩部的解剖结构。像羊和狗这样的大型动物的肩膀结构与人类更相似,但在保持一致的实验条件方面成本高昂,而且面临挑战。二次关节镜研究为当前手术技术的有效性提供了证据。动物模型将继续在进一步探索肌腱套局部微环境方面发挥关键作用,这有望帮助制定更有效的策略来促进愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Animal models for study on rotator cuff healing.

Rotator cuff tears are highly prevalent, and there is an urgent need to understand their healing mechanisms to improve treatment outcomes for patients. This editorial aims to summarize the roles and limitations of common animal models (including rodents, rabbits, sheep, dogs, and primates) and second-look arthroscopy in rotator cuff healing research. Different animal models offer distinct advantages and disadvantages. For example, rodent models are cost-effective and suitable for genetic studies but have anatomical differences from humans. Rabbit models are favored for their relatively large tendon size and ease of surgical manipulation, yet they still deviate from human shoulder anatomy in some aspects. Larger animals like sheep and dogs have more similar shoulder structures to humans but come with high costs and challenges in maintaining consistent experimental conditions. Second-look arthroscopic studies have provided evidence for the effectiveness of current surgical techniques. Animal models will continue to play a crucial role in further exploring the local microenvironment of the rotator cuff, which is expected to help develop more effective strategies to promote healing.

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CiteScore
3.10
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发文量
814
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