Einstein-Sao Paulo最新文献

{"title":"Mild and moderate manifestations of SARS-CoV-2 infection, including hospitalization, in children and adolescents with cystic fibrosis.","authors":"Fábia Regina Dos Santos, Daniela Gois Meneses, Ricardo Queiroz Gurgel, Tatiana Rodrigues de Moura, Camilla Natália Oliveira Santos, Lucas Sousa Magalhães, Alexia Ferreira Rodrigues, Maria Luiza Doria Almeida, Allan Valadão de Oliveira Britto, Angela Maria Silva","doi":"10.31744/einstein_journal/2025AO1312","DOIUrl":"10.31744/einstein_journal/2025AO1312","url":null,"abstract":"<p><strong>Background: </strong>Santos et al. analyzed the clinical characteristics and pulmonary function of children with cystic fibrosis infected with SARS-CoV-2. Infected children showed higher rates of dyspnea, coughing, hospitalization, and pulmonary exacerbations. Despite a temporary decline in pulmonary function, the recovery rates matched those of the uninfected children during follow-up. ■ SARS-CoV-2 infection leads to mild-to-moderate disease in children with cystic fibrosis. ■ No worsening of cystic fibrosis was observed months after infection.</p><p><strong>Objective: </strong>This study aimed to evaluate the clinical manifestations of SARS-CoV-2 in children and adolescents with cystic fibrosis.</p><p><strong>Methods: </strong>This was a case-control analysis of clinical variables and pulmonary function test results in 43 children with cystic fibrosis, 17 (39.5%) of whom tested positive for SARS-CoV-2.</p><p><strong>Results: </strong>The infected children exhibited a higher frequency of dyspnea and cough and a greater need for hospitalization. One infected child died. Pulmonary exacerbations were more frequent among the infected children. Additional data indicated a subsequent reduction in pulmonary function in the infected children, although this was not significantly different from that in the uninfected children.</p><p><strong>Conclusion: </strong>Children with cystic fibrosis who contracted SARS-CoV-2 experienced mild to moderate symptoms and required hospitalization but generally had high recovery rates.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1312"},"PeriodicalIF":1.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Multiple Mini Interviews in medical school admissions: assessment using The Big Five Personality framework.","authors":"João Sampaio Góes, Stefano Ivani de Paula, Durval Aníbal Daniel-Filho, Elda Maria Stafuzza Gonçalves Pires, Ângela Tavares Paes, Eduardo Juan Troster","doi":"10.31744/einstein_journal/2025AO1352","DOIUrl":"10.31744/einstein_journal/2025AO1352","url":null,"abstract":"<p><strong>Background: </strong>This study highlights how the Multiple Mini Interviews can be an effective format to evaluate the socio-emotional competencies of candidates seeking admission to medical school. Candidates with higher levels of conscientiousness, revealing traits of competence and self-discipline, achieved superior performance. These traits are linked to future professional success. ■ Multiple Mini Interviews assess medical school candidates' non-cognitive skills effectively. ■ Conscientiousness is found to strongly correlate with higher Multiple Mini Interviews performance. ■ Multiple Mini Interviews ensure diversity without bias toward irrelevant personality traits. ■ Structured interview formats predict academic success and professional readiness.</p><p><strong>Objective: </strong>To evaluate the effectiveness of Multiple Mini Interviews as a selection method for medical school admissions at the Faculdade Israelita de Ciências da Saúde Albert Einstein by evaluating the relationship between the Big Five personality traits and the performance of candidates in the Multiple Mini Interviews.</p><p><strong>Methods: </strong>All candidates who had completed the NEO PI-R personality test and the socio-demographic questionnaire were the participants of the study. The personality profiles of candidates who participated in the Multiple Mini Interviews process of this cross-sectional descriptive study were analyzed by crossing data to identify significant correlations.</p><p><strong>Results: </strong>Of the 225 candidates, 63% were female and the mean age of the sample was 21 years. Only the domain of Conscientiousness showed significant correlations with higher Multiple Mini Interviews scores (p=0.004). Specifically, traits of Conscientiousness such as Competence (p=0.046), Dutifulness (p=0.043), Achievement-Oriented (p=0.050) and Self-Discipline (p=0.028) were associated with better Multiple Mini Interviews performance. Other domains, like Neuroticism, Extraversion, Openness, and Agreeableness, showed no significant correlation. Additionally, socio-demographic factors had no significant impact on performance.</p><p><strong>Conclusion: </strong>The findings validate the Multiple Mini Interviews as an effective method for medical school selection, as they correlate with high-value personality traits such as Conscientiousness, while not favoring irrelevant individualities. These results orient the enhancement of selection methods, ensuring a diverse and competent student body and, overall, improving medical education. The findings thus support the use of structured interviews in admission processes, highlighting their role in identifying candidates with essential qualities for success in medical education and practice, and offer valuable insights for similar educational institutions aiming to refine their selection methods.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1352"},"PeriodicalIF":1.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omission of dexamethasone in prophylaxis for highly emetogenic chemotherapy in patients with breast cancer.","authors":"Camilla Vieira de Rebouças, Rafaela de Brito Alves, Alayne Magalhães Trindade Domingues Yamada, Auro Del Giglio, Felipe José Silva Melo Cruz","doi":"10.31744/einstein_journal/2025AO1124","DOIUrl":"10.31744/einstein_journal/2025AO1124","url":null,"abstract":"<p><strong>Background: </strong>A phase II study evaluated a corticosteroid-free regimen (olanzapine, netupitant, and palonosetron) for the treatment of chemotherapy-induced nausea and vomiting. The results showed control rates comparable to those of standard protocols, demonstrating its feasibility without dexamethasone. ■ Evaluation of a corticosteroid-free antiemetic regimen. ■ Primary endpoint: 46% nausea control. ■ Secondary endpoint: 68% emesis control. ■ Comparable to standard four-drug protocols.</p><p><strong>Objective: </strong>Chemotherapy-induced nausea and vomiting are highly prevalent adverse events that can lead to poor treatment adherence and a decreased quality of life. To the best of our knowledge, the complete omission of dexamethasone from any regimen for preventing nausea and vomiting has not yet been evaluated. This study aimed to evaluate the efficacy of a three-drug protocol without corticosteroids for preventing nausea and vomiting.</p><p><strong>Methods: </strong>This prospective, single-arm, phase II study was designed to evaluate the efficacy of olanzapine, netupitant, and palonosetron in controlling nausea and vomiting induced by emetogenic chemotherapy. Patients were assigned to receive olanzapine on days 1-5 and netupitant and palonosetron on day 1. No corticosteroids were administered. The primary endpoint was complete nausea control during the first 5 days after chemotherapy. Secondary endpoints included complete emesis control (no emesis and no use of rescue medication) and overall complete control (no emesis, no rescue medication, and no nausea).</p><p><strong>Results: </strong>The complete nausea control rate was 46% (95% confidence interval [95%CI] 0.32-0.59). The emesis control rate was 68% (95%CI= 0.55-0.80), and the overall control rate was 46% (95%CI= 0.32-0.59).</p><p><strong>Conclusion: </strong>These findings suggest that omitting dexamethasone in highly emetogenic chemotherapy is feasible and results in nausea and vomiting control rates similar to those of the standard four-drug protocol. However, randomized controlled trials are required to confirm this hypothesis.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1124"},"PeriodicalIF":1.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assessment of clinical practice in neuro-oncology.","authors":"Renata Carolina Acri Nunes Miranda, Suzana Maria Fleury Malheiros, André Felix Gentil, Gisele Sampaio Silva, Fabiana de Campos Cordeiro Hirata, Sérgio Eduardo Alonso Araujo, Luís Otávio Sales Caboclo","doi":"10.31744/einstein_journal/2025AO1343","DOIUrl":"10.31744/einstein_journal/2025AO1343","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this study, we aimed to improve patient care for central nervous system conditions based on the 2021 National Institute for Health and Care Excellence guidelines. Performance measures were used to enhance team accountability and address challenges due to limited evaluate to health insurance and variations in clinical staff decision-making. Rehabilitation and observed variability in surgical costs were not measured in this study. Similar studies were also referenced, and improvements in real-time glioma management were suggested. Performance measures and standardizing practices were recommended to improve cost predictability despite the observed cost variability caused by individualized care. ■ The molecular test according to the WHO classification of CNS tumors (gliomas) was performed in 100% (172) of patients. ■ Education on chemotherapy and informed consent for patients with brain tumors was carried out for 100% (130) of the patients who had an indication for chemotherapy treatment. ■ Approximately 87% of the patients with gliomas underwent postoperative cranial MRI. ■ A multidisciplinary approach, including molecular testing, was used for 35% of patients with glioma. ■ Thromboembolic events after resection of the primary brain tumor occurred in only 0.84% (3) patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the quality indicators proposed by the American Academy of Neurology and Neuro-oncology Society in patients with primary intracranial central nervous system tumors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study is a retrospective level I analysis that used electronic medical records from the CERNER system and GDOC-SAME at the tertiary hospital. It was approved by the Research Ethics Committee and followed the Declaration of Helsinki. Data was collected and analyzed confidentially via REDCap. The research focused on patients 18 or older with primary central nervous system tumors who had surgery from August 2015 to August 2021. It excluded surgeries performed elsewhere, reoperations, secondary (metastatic) tumors, and primary central nervous system tumors outside the cranium.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results showed that 48% of the patients had gliomas, whereas 30 and 21.6% had meningiomas and other types of tumors. Quality measures showed that 35% of the patients with grade 2-4 tumors had multidisciplinary care plan discussions. All patients with gliomas underwent molecular testing and those eligible who underwent chemotherapy were educated and provided informed consent. Postoperative magnetic resonance imaging within 72h was performed in 87% of gliomas. The length of hospital stay, postoperative complications, Eastern Cooperative Oncology Group status at discharge, and 30-day status were also potential quality measures. However, for meningioma cases, readmissions were associated with patients in the American Society of Anesthesiologists II (58.33%) and American Society of Anesthesiologists II","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1343"},"PeriodicalIF":1.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of adult patients undergoing coronary artery bypass grafting and valve surgery: a literature review.","authors":"Nair Naiara Barros de Vasconcelos, Veronica Neves Fialho Queiroz, Guilherme Martins de Souza, Sandrigo Mangini, Fernando Morita Fernandes Silva, Luiz Guilherme Villares da Costa, Pedro Paulo Zanella do Amaral Campos, Samuel Padovani Steffen, Flávio Takaoka, Ary Serpa Neto, Adriano José Pereira, Carmen Silvia Valente Barbas, Thiago Domingos Corrêa, Renato Carneiro de Freitas Chaves","doi":"10.31744/einstein_journal/2025RW1353","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025RW1353","url":null,"abstract":"<p><strong>Purpose of review: </strong>Coronary artery bypass grafting, revascularization by percutaneous coronary intervention, and heart valve surgery are crucial therapeutic interventions for patients with various cardiovascular diseases. The objective of this literature review was to present the main evidence and practical aspects of the perioperative management of patients undergoing coronary artery bypass grafting and heart valve surgery.</p><p><strong>Recent findings: </strong>Despite advancements in surgical and anesthetic techniques, coronary artery bypass grafting and heart valve surgery present significant risks for perioperative complications and death. These complications increase morbidity, mortality, and length of hospital stay. Coronary artery bypass grafting is indicated for patients with significant left main or advanced coronary artery disease. Most patients undergoing coronary artery bypass grafting with a reasonable life expectancy are advised to adopt a multiple-arterial graft strategy using two or three arterial grafts. Revascularization by percutaneous coronary intervention is frequently performed to alleviate symptoms in patients with stable angina and coronary artery stenoses causing moderate or severe ischemia. Intraoperative coagulation management should include tranexamic acid after the induction of anesthesia and protamine immediately after the termination of extracorporeal circulation. The prophylactic use of fresh-frozen plasma, desmopressin, recombinant activated factor VII, or fibrinogen to reduce bleeding is not recommended. Inhaled anesthetics have recognized cardioprotective properties; however, it is unclear whether anesthesia with a volatile agent can reduce mortality in patients undergoing elective surgery. Echocardiography plays an important role in the perioperative management of patients by defining myocardial structure, assessing intracardiac blood flow, aiding preoperative evaluation, facilitating intraoperative monitoring, and providing real-time guidance for intervention. The perioperative management of patients undergoing coronary artery bypass grafting, percutaneous coronary intervention, and heart valve surgery is highly complex and involves numerous specific conditions. Effective management requires dedicated multidisciplinary teams skilled in timely recognition, prevention, and treatment to ensure appropriate care.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eRW1353"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of autoimmune diseases in patients with type 1 diabetes: a scoping review.","authors":"Carlos Antonio Negrato, Rebecca Zerbinatti Pereira, Livia Domingos de Moraes Pimentel Porto, Ylana Walleska Santos Santana, Aline Kimmy Ikemoto Sato, Vitor Casoto de Melo, Miguel Luz Vilela Engel Vieira, Marilia de Brito Gomes","doi":"10.31744/einstein_journal/2025RW1222","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025RW1222","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prevalence of autoimmune diseases in patients with type 1 diabetes mellitus.</p><p><strong>Methods: </strong>This scoping review was conducted following the Joanna Briggs Institute guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) tool to ensure methodological rigor. We systematically searched PubMed, Embase, Scopus, Lilacs, and Web of Science databases to identify relevant literature published between 2018 and 2023.</p><p><strong>Results: </strong>Twenty-four studies were included, mostly single-center studies from six continents, with varying study designs: 16 cross-sectional, seven retrospective, and one prospective cohort. The most prevalent autoimmune diseases found among patients with type 1 diabetes mellitus enrolled in these studies were autoimmune thyroiditis (5.5-41.2%), celiac disease (0.45-24.8%), rheumatoid arthritis (0.4-5.1%), and primary adrenal insufficiency (0.6-2.6%).</p><p><strong>Conclusion: </strong>Autoimmune thyroiditis and celiac disease were the most prevalent autoimmune diseases in patients with type 1 diabetes mellitus. As the complexity of managing type 1 diabetes mellitus increases in the presence of multiple autoimmune comorbidities, further studies are required to elucidate the relationship between type 1 diabetes mellitus and different autoimmune pathologies. A deeper understanding of these associations will guide the development of public health policies, screening strategies, and educational initiatives tailored to the specific needs of this population.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eRW1222"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic inequities in prostate cancer care: private versus public treatment settings pose a significant impact on overall survival.","authors":"Amanda Caroline de Souza Costa, Fernando Korkes, Jose Augusto Rinck Junior, Frederico Timóteo Silva Cunha, Luciana Holtz de Camargo Barros, Stênio de Cássio Zequi, Maria Nirvana da Cruz Formiga","doi":"10.31744/einstein_journal/2025AO0851","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025AO0851","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of assistance from public and private health systems on the overall survival of patients with metastatic prostate cancer.</p><p><strong>Methods: </strong>A total of 213 patients with metastatic prostate cancer treated at the A.C. Camargo Cancer Center, either in the Unified Health System or a private system, from January 2014 to December 2018 were analyzed. Multivariate analysis of overall survival was performed to adjust for the type of health assistance and other clinical prognostic factors.</p><p><strong>Results: </strong>Of 213 included patients, 147 (69%) were from the private system and 66 (31%) were from the Unified Health System. There was a significant difference in the median age at diagnosis between the systems (63.4 years for patients in the private system versus 67.2 years for patients in the Unified Health System, p=0.027). No significant differences in performance status were observed between the groups (p=0.695). Patients treated in the public system had access to fewer treatment lines (2.59 lines in the public system versus 3.04 lines in the private system, p=0.024). Our data revealed a longer median survival for patients with private health care (115 months for patients with private health care versus 78 months for patients in the Unified Health System, p=0.009). Multivariate analysis revealed that patients in the public system had a 66% higher risk of death than those in the private system.</p><p><strong>Conclusion: </strong>Our data demonstrate that patients in the Unified Health System have access to fewer lines of therapy for metastatic prostate cancer, resulting in shorter median survival than patients treated in the private system.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO0851"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological impact of gestational trophoblastic disease: a cross-sectional study.","authors":"Natália Giovanelli Gaspar, Adrielle Carolina Ferreira Silva, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela","doi":"10.31744/einstein_journal/2025AO1014","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025AO1014","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the psychological repercussions of gestational trophoblastic disease.</p><p><strong>Methods: </strong>A cross-sectional study including 100 women (50 with gestational trophoblastic disease and 50 without) was conducted between September 2020 and October 2021. Socio-demographic characteristics, quality of life, depression, and anxiety were evaluated and follow-up was performed at a referral center.</p><p><strong>Results: </strong>Women with gestational trophoblastic disease had a mean age and body mass index of 28.8±6.4 years and 24.7±5.0kg/m2, respectively; the corresponding values for the Control Group were 30.1±6.9 years (p=0.27) and 28.9±4.6kg/m2 (p<0.001). The Gestational Trophoblastic Disease Group presented a better general health status (p=0.04) than the Control Group. Among women with gestational trophoblastic disease, 62% and 46% had anxiety and depression, respectively; the corresponding percentages for women without gestational trophoblastic disease were 52% and 24% (p=0.64 and 0.08, respectively).</p><p><strong>Conclusion: </strong>Multidisciplinary follow-up at a referral center may improve the mental health and quality of life scores of women with gestational trophoblastic disease.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1014"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified palatal flap via soft palate for skull base reconstruction.","authors":"Rogerio Pezato, Aldo Cassol Stamm, Andrea Santos Dumont Costacurta, Carlos Henrique Amaro Bravo Baptista, Reginaldo Raimundo Fujita, Camila Soares Dassi, Richard Louis Voegels, Andrew Thamboo, Miguel Soares Tepedino","doi":"10.31744/einstein_journal/2025AO1247","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025AO1247","url":null,"abstract":"<p><strong>Objective: </strong>Given the importance of vascularized flaps, this study presents a new technique for reconstructing skull defects using a pedicled palatal flap via the soft palate.</p><p><strong>Methods: </strong>Five preserved cadaveric specimens were used to demonstrate the sequential steps involved in harvesting the palatal flap. In addition, 20 normal paranasal sinus computed tomography scans were analyzed to determine potential measurements of the flap (area, perimeter, greatest anteroposterior distance, and greatest transverse distance).</p><p><strong>Results: </strong>The average flap area in females and males was 11.8cm2 and 12.7cm2, respectively. The average perimeter in females and males was 13.5cm and 14.0cm, respectively. In all cases, the flap reached the infratemporal fossa and lower clivus.</p><p><strong>Conclusion: </strong>The palatal flap via the soft palate described in this study proved to be a metrically viable alternative in cadaveric and tomographic studies for use in endonasal surgeries, as well as for skull base and adjacent regions.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1247"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response relationships in Y90 resin microsphere radioembolization for patients with hepatocellular carcinoma: insights from a Brazilian cohort.","authors":"Marcela Juliano Silva Cunha, Francisco Leonardo Galastri, Felipe Nasser, Breno Boueri Affonso, Leonardo Guedes Moreira Valle, Priscila Mina Falsarella, Bruno Pagnin Schmid, Lilian Yuri Itaya Yamaga, Giovanna Sawaya Torre, Rodrigo Gobbo Garcia, Nelson Wolosker","doi":"10.31744/einstein_journal/2025AO1287","DOIUrl":"https://doi.org/10.31744/einstein_journal/2025AO1287","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between the absorbed dose and radiological response in patients with hepatocellular carcinoma undergoing resin microsphere radioembolization to enhance treatment precision and potentially adjust protocols for better outcomes.</p><p><strong>Methods: </strong>This single-center retrospective study was conducted at a quaternary care center in Brazil and comprised 27 patients with 58 target lesions treated between November 2014 and April 2023. The patients' dosimetric profiles were analyzed using advanced imaging software to assess post-treatment clinical and radiological responses. This study explored the correlation between the absorbed doses and tumor objective responses using statistical analyses to confirm the findings.</p><p><strong>Results: </strong>Higher absorbed doses were significantly associated with improved objective responses in the target lesions. The analysis demonstrated that achieving higher dosimetric thresholds correlated with better clinical outcomes, suggesting that a dose-response relationship is essential to optimize treatment protocols.</p><p><strong>Conclusion: </strong>These findings emphasize the importance of personalized dosimetry in managing hepatocellular carcinoma using resin microsphere radioembolization. By quantifying the absorbed dose and understanding its impact on tumor response, treatment strategies can be tailored to enhance efficacy and potentially shift palliative treatments toward curative outcomes. This study provides a crucial foundation for dosimetric adjustment and highlights the need for further research in this area, particularly in Brazil.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1287"},"PeriodicalIF":1.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}