Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-11-29DOI: 10.1177/19714009241303127
Tyler M Bielinski, Prateeka Koul, Malie K Collins, Oded Goren, Gregory M Weiner, Christoph J Griessenauer, Clemens M Schirmer, Philipp Hendrix
{"title":"Serial VerifyNow P2Y12 platelet reactivity units in cerebral aneurysm patients treated with ticagrelor surrounding stent-coiling or flow diversion.","authors":"Tyler M Bielinski, Prateeka Koul, Malie K Collins, Oded Goren, Gregory M Weiner, Christoph J Griessenauer, Clemens M Schirmer, Philipp Hendrix","doi":"10.1177/19714009241303127","DOIUrl":"10.1177/19714009241303127","url":null,"abstract":"<p><p>IntroductionPlatelet function testing using serial VerifyNow P2Y12 platelet reactivity units (PRUs) is established for guiding clopidogrel antiplatelet therapy in cerebral aneurysm stenting procedures. However, for ticagrelor, the impact of serial PRU testing and the identification of safe PRU ranges remains unexplored.MethodsFlow diversion stenting (<i>n</i> = 232) and stent-assisted coiling procedures (<i>n</i> = 83) performed 05/2017-12/2021 were reviewed. Out of these, 31 flow diversion and 18 stent-coiling procedures were performed on 44 patients using ticagrelor. Baseline demographics, ticagrelor PRUs, and clinical outcomes were assessed.ResultsCollectively, 257 ticagrelor P2Y12 PRUs were obtained. PRUs were <100 in 192/257 (74.7%) tests. Only 11/257 (4.3%) PRUs were >200. The overall median ticagrelor PRU was 38 (IQR 11-101). Among the 49 procedures, median PRUs before the procedure (25, IQR 10-67), on the day of the procedure (68, IQR 44-117), and on the day after the procedure (37, IQR 21-79) did not show the significant differences between the groups. A total of seven thromboembolic complications occurred. Median PRUs surrounding the thromboembolic complications (median 182, IQR 148-235) were significantly higher than preprocedural (<i>p</i> < .001), day of surgery (<i>p</i> < .01), and postprocedural PRUs (<i>p</i> < .01). All seven procedures harbored demographic, anatomic, or procedural features increasing the risk for thromboembolic complications.DiscussionThe majority of periprocedural ticagrelor PRUs were <100. PRUs at the time point of thromboembolic complications were >120. Despite procedure-complicating features in each thromboembolic case, it raises the question whether safe ticagrelor PRU levels might be lower than those commonly applied for clopidogrel.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"331-336"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-08-07DOI: 10.1177/19714009241269462
Sneh Brahmbhatt, Amit Agarwal, Dhruv Shetty, Amit Desai, Alok A Bhatt
{"title":"\"Genetic tumor syndromes of the head and neck: Update in the genomic era\".","authors":"Sneh Brahmbhatt, Amit Agarwal, Dhruv Shetty, Amit Desai, Alok A Bhatt","doi":"10.1177/19714009241269462","DOIUrl":"10.1177/19714009241269462","url":null,"abstract":"<p><p>Genetic tumor syndromes are due to inherited genetic mutations, which have recently come to the attention of clinicians due to the widespread adoption of DNA sequencing, ultimately leading to imaging for surveillance. As a result, radiologists must be familiar with the clinical, genetic, and radiologic features of these syndromes. This article reviews genetic tumor syndromes of the head and neck according to the recently updated WHO's 5th edition.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"277-290"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-05-02DOI: 10.1177/19714009241247468
Raman Singh, Uttam Verma, Hakeem J Shakir, Shyian Jen
{"title":"Thrombectomy using Zoom Reperfusion System in pediatric acute ischemic strokes: Case series and literature review.","authors":"Raman Singh, Uttam Verma, Hakeem J Shakir, Shyian Jen","doi":"10.1177/19714009241247468","DOIUrl":"10.1177/19714009241247468","url":null,"abstract":"<p><p>IntroductionZoom reperfusion system (Imperative Care, CA) has proven to be promising for use in adult mechanical thrombectomies (MTs) but has not been described in pediatrics. We present two cases of a 14-year-old with acute right middle cerebral artery (MCA) syndrome and a 10-year old with acute left MCA syndrome who underwent MT using Zoom Reperfusion System safely with TICI 2B and TICI 3 recanalization, respectively.MethodCase report and literature review.ResultsA 14-year-old healthy boy with right supraclinoid internal carotid artery (ICA) occlusion (case 1) and a 10-year-old boy with left hypoplastic heart syndrome and left ICA terminus occlusion (case 2) were taken for MT after receiving alteplase at our institution. Through femoral access, an 8-French sheath was introduced into the right femoral artery through which a Zoom 88 catheter was introduced and parked at the right petrous ICA segment in case 1 and left ophthalmic ICA segment in case 2. Angiogram demonstrated complete ICA occlusion just past the ophthalmic artery origin in case 1 and at the ICA terminus in case 2. Zoom system (88 and 71) was then navigated to the face of clot with vacuum manifold engaged with the clot. TICI 2B (with the help of Trevo stent retriever [Stryker]) and TICI 3 recanalization were achieved in cases 1 and 2, respectively.ConclusionThe use of Zoom reperfusion system could potentially be feasible for use in pediatric age group. Larger pediatric patient population is needed to establish its safety.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"349-353"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-08-01DOI: 10.1177/19714009241269501
Christopher Gasparis, Hannah Travers, Justin Turpin, Christian Ferreira, Katherine Stark, Derek R Brinster, David J Langer, Ahmad A Ballout
{"title":"Staged cerebral and brachiocephalic bypass in a patient with MCA and brachiocephalic steno-occlusion.","authors":"Christopher Gasparis, Hannah Travers, Justin Turpin, Christian Ferreira, Katherine Stark, Derek R Brinster, David J Langer, Ahmad A Ballout","doi":"10.1177/19714009241269501","DOIUrl":"10.1177/19714009241269501","url":null,"abstract":"<p><p><b>Background:</b> Brachiocephalic steal is a rare phenomenon that may lead to hemodynamic abnormalities in the ipsilateral vertebral and carotid arteries. Current treatment includes management of vascular risk factors, endovascular stenting, and surgical management depending on the severity of symptoms. <b>Case Information:</b> We describe a patient with multiple vascular risk factors who presented with mild neurological symptoms and chronic right arm weakness associated with concurrent brachiocephalic steal and right MCA M1 stenosis on neuroimaging. Use of right superficial temporal artery to middle cerebral artery bypass and aorta-right subclavian bypass resulted in improved flow to the right hemisphere on quantitative magnetic resonance angiography and single-photon emission computed tomography, significantly lowering the risk of catastrophic ischemic stroke. <b>Conclusion:</b> Complex steal phenomena increase stroke risk. In cases of high-grade occlusion or advanced symptoms, endovascular or surgical management should be considered for optimal stroke prevention.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"372-376"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-07-31DOI: 10.1177/19714009241269487
Niklas Lützen, Charlotte Zander, Rick Dersch, Jürgen Beck, Horst Urbach
{"title":"Cerebrospinal fluid-venous fistula visualisation by intrathecal pressurization: A technical note and illustrative case.","authors":"Niklas Lützen, Charlotte Zander, Rick Dersch, Jürgen Beck, Horst Urbach","doi":"10.1177/19714009241269487","DOIUrl":"10.1177/19714009241269487","url":null,"abstract":"<p><p>CSF-venous fistulas (CVFs) are an important cause of spontaneous intracranial hypotension and challenging to diagnose. Lateral decubitus positioning during myelography and a technique called \"resisted inspiration\" has shown to improve CVF detection. However, the impact of intrathecal pressurization to improve visualization of CVF has mostly been speculated on. In this brief report, we demonstrate how a CVF became progressively more visible only after stepwise intrathecal pressurization: An indication of the importance of pressurization for CVF detection.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"368-371"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-08-05DOI: 10.1177/19714009241269526
Mohammad Amin Habibi, Ali Dinpazhouh, Aliakbar Aliasgary, Mohammad Sina Mirjani, Mehdi Mousavinasab, Mohammad Reza Ahmadi, Poriya Minaee, SeyedMohammad Eazi, Milad Shafizadeh, Muhammet Enes Gurses, Victor M Lu, Chandler N Berke, Michael E Ivan, Ricardo J Komotar, Ashish H Shah
{"title":"Predicting telomerase reverse transcriptase promoter mutation in glioma: A systematic review and diagnostic meta-analysis on machine learning algorithms.","authors":"Mohammad Amin Habibi, Ali Dinpazhouh, Aliakbar Aliasgary, Mohammad Sina Mirjani, Mehdi Mousavinasab, Mohammad Reza Ahmadi, Poriya Minaee, SeyedMohammad Eazi, Milad Shafizadeh, Muhammet Enes Gurses, Victor M Lu, Chandler N Berke, Michael E Ivan, Ricardo J Komotar, Ashish H Shah","doi":"10.1177/19714009241269526","DOIUrl":"10.1177/19714009241269526","url":null,"abstract":"<p><p>BackgroundGlioma is one of the most common primary brain tumors. The presence of the telomerase reverse transcriptase promoter (pTERT) mutation is associated with a better prognosis. This study aims to investigate the TERT mutation in patients with glioma using machine learning (ML) algorithms on radiographic imaging.MethodThis study was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The electronic databases of PubMed, Embase, Scopus, and Web of Science were searched from inception to August 1, 2023. The statistical analysis was performed using the MIDAS package of STATA v.17.ResultsA total of 22 studies involving 5371 patients were included for data extraction, with data synthesis based on 11 reports. The analysis revealed a pooled sensitivity of 0.86 (95% CI: 0.78-0.92) and a specificity of 0.80 (95% CI 0.72-0.86). The positive and negative likelihood ratios were 4.23 (95% CI: 2.99-5.99) and 0.18 (95% CI: 0.11-0.29), respectively. The pooled diagnostic score was 3.18 (95% CI: 2.45-3.91), with a diagnostic odds ratio 24.08 (95% CI: 11.63-49.87). The Summary Receiver Operating Characteristic (SROC) curve had an area under the curve (AUC) of 0.89 (95% CI: 0.86-0.91).ConclusionThe study suggests that ML can predict TERT mutation status in glioma patients. ML models showed high sensitivity (0.86) and moderate specificity (0.80), aiding disease prognosis and treatment planning. However, further development and improvement of ML models are necessary for better performance metrics and increased reliability in clinical practice.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"265-276"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroradiology JournalPub Date : 2025-06-01Epub Date: 2024-11-20DOI: 10.1177/19714009241303077
John C Benson, Alex B Pais, Ian T Mark, William O Tobin, John J Chen, Frederic B Meyer, Christopher H Hunt, Caterina Giannini
{"title":"Radiology-pathology correlation: Rosai-Dorfman disease.","authors":"John C Benson, Alex B Pais, Ian T Mark, William O Tobin, John J Chen, Frederic B Meyer, Christopher H Hunt, Caterina Giannini","doi":"10.1177/19714009241303077","DOIUrl":"10.1177/19714009241303077","url":null,"abstract":"<p><p>Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare non-Langerhans cell histiocytic neoplasm. Although the disease classically presents as massive painless lymphadenopathy in young adults, RDD can also involve the central nervous system in some patients. CNS lesions, can cause headaches, neurologic deficits, and even neurologic deficits. The imaging appearance of CNS RDD typically mimics that of meningiomas: well-circumscribed dural-based lesions that often have dural tails. However, some imaging clues also exist that might help a radiologist recognize RDD, even before histopathologic confirmation. This radiology-pathology report of a patient with CNS RDD highlights the most pertinent clinical, imaging, and pathologic features of CNS RDD, and discusses what the neuroradiologist needs to know about the disease.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"299-303"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhairya A Lakhani, Aneri B Balar, Vaibhav Vagal, Subtain Ali, Hamza Salim, Janet Mei, Musharaf Khan, Manisha Koneru, Sijin Wen, Hanzhang Lu, Richard Wang, Argye E Hillis, Jeremy J Heit, Greg W Albers, Adam A Dmytriw, Tobias Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli
{"title":"The relative cerebral blood volume (rCBV) <42% is independently associated with prolonged hospitalization in anterior circulation large vessel occlusion.","authors":"Dhairya A Lakhani, Aneri B Balar, Vaibhav Vagal, Subtain Ali, Hamza Salim, Janet Mei, Musharaf Khan, Manisha Koneru, Sijin Wen, Hanzhang Lu, Richard Wang, Argye E Hillis, Jeremy J Heit, Greg W Albers, Adam A Dmytriw, Tobias Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli","doi":"10.1177/19714009251348621","DOIUrl":"10.1177/19714009251348621","url":null,"abstract":"<p><p>BackgroundThe pretreatment rCBV <42% lesion volume on CT Perfusion (CTP) has recently been shown to predict 90-day functional outcomes in stroke patients. However, its association with length of stay (LOS) has not yet been explored. This study aims to assess the relationship between rCBV <42% and prolonged LOS, defined as 7 days or longer.MethodsIn this retrospective evaluation of our prospectively collected database, we analyzed patients with confirmed anterior circulation large vessel occlusion on CT angiography who also received CT perfusion between 9/1/2017 and 10/01/2023. We used Student's t-test, Mann-Whitney U test, and Chi-Square test to assess differences. Logistic regression and ROC analyses were employed to evaluate the relationship between rCBV <42% and length of stay (LOS). A <i>p</i>-value of ≤0.05 was considered statistically significant.ResultsA total of 268 patients met our inclusion criteria. Of these, 85 (31.7%) received intravenous thrombolysis (IVT), and 221 (82.5%) underwent mechanical thrombectomy (MT). After adjusting for several variables, logistic regression analysis revealed that an rCBV <42% lesion volume was independently associated with prolonged length of stay (LOS) (aOR = 0.98, <i>p</i> < .001). ROC analysis indicated an area under the curve (AUC) of 0.66 (<i>p</i> < .001) for predicting prolonged LOS.ConclusionrCBV <42% lesion volume is independently associated with prolonged LOS. This parameter may serve as a useful adjunct tool in prognostication of AIS-LVO patients.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251348621"},"PeriodicalIF":1.3,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahriar Faghani, Mana Moassefi, Jennifer S McDonald, Bradley J Erickson, John C Benson
{"title":"Is retirement a pain in the back? A 23-year population-based study on the impact of age and employment on spinal injections.","authors":"Shahriar Faghani, Mana Moassefi, Jennifer S McDonald, Bradley J Erickson, John C Benson","doi":"10.1177/19714009251345115","DOIUrl":"10.1177/19714009251345115","url":null,"abstract":"<p><p>PurposeSpine-related pain disorders commonly require interventions such as spinal injections, which are often image-guided and increase in demand as populations age. This study investigates the impact of lifestyle changes following retirement on the incidence of these procedures, hypothesizing that retirement significantly influences the requirement for such treatments.MethodsA review of medical records from XXX County between 2000 and 2023 was conducted, focusing on patients who received spinal injections, including epidural steroid, facet, and sacroiliac joint injections. Data were stratified by age, employment status pre- and post-procedure, and type of injection. Statistical analysis, including segmental linear regression and t-tests, was used to assess changes in incidence rates over time and across demographic subsets.ResultsOut of 134,318 patients analyzed, a total of 359,224 spinal injections were performed. There was a significant (<i>p</i>-value <.01) increase in the frequency of procedures among individuals around the age of 60, which coincides with the typical retirement age in the United States. The study also highlighted a subsequent decline in the incidence of these procedures between the ages of 70 and 74, suggesting potential adaptation to chronic conditions or the effectiveness of earlier treatments.ConclusionThe findings of this study confirm the hypothesis that retirement significantly impacts the demand for spinal injections, as evidenced by the marked increase in procedures at typical retirement ages. This underscores the importance of integrating preventive care and personalized medical guidance into healthcare strategies for individuals nearing retirement to effectively manage spine-related pain disorders and reduce the necessity for invasive treatments.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251345115"},"PeriodicalIF":1.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differential diagnosis of intracranial solitary fibrous tumor and high-grade meningioma based on CT and MRI features.","authors":"Zongsheng Pu, Yinfu He, Shilin Qiu, Yinrui Yang, Zhenhui Li, DePei Gao, Dafu Zhang","doi":"10.1177/19714009251345103","DOIUrl":"10.1177/19714009251345103","url":null,"abstract":"<p><p>BackgroundISFT and HGM exhibit similar imaging characteristics, but their distinct behaviors and treatments necessitate accurate preoperative imaging for optimal management.PurposeTo evaluate conventional CT and MRI in differentiating ISFT from HGM.MethodsRetrospective analysis of clinical data, CT, and MRI images from 31 ISFT and 50 HGM patients confirmed by pathology. Various imaging features were examined, including tumor size, shape (lobulated or round), base width (narrow or broad), presence of cystic necrosis, calcification, signal intensity on T1- and T2-weighted MRI, intravascular flowing-void signs, peritumoral edema, CT attenuation values on non-enhanced and enhanced scans, and adjacent bone destruction. Chi-square tests, t-tests, ROC curves, and multivariate logistic regression were used to establish predictive models. A nomogram illustrated the final model.ResultsISFT onset age was ≤48.5 years, with a maximum tumor diameter of ≥4.5 cm. Features included lobulated appearance, narrow base, cystic necrosis, absence of calcification, low T1-weighted MRI signal, intravascular flowing-void signs, peritumoral edema, CT value ≤51.7 Hu on non-enhanced and ≥107.6 Hu on enhanced scans, and adjacent bone destruction. Combining tumor diameter, vascular flowing void, enhanced CT value, and absence of calcification yielded 92.0% sensitivity and 90.3% specificity for ISFT diagnosis.ConclusionAge and imaging characteristics effectively differentiate ISFT from HGM, particularly with a tumor diameter ≥4.5 cm, vascular flowing-void signals, absence of calcification, and enhanced CT value ≥107.6 Hu. A nomogram shows good predictive efficacy.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251345103"},"PeriodicalIF":1.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}