Neuroradiology Journal最新文献

{"title":"Pre-stroke functional status and prognosis following mechanical thrombectomy: Systematic review and meta-analysis.","authors":"Rudolfh Batista Arend, Bruno Zilli Peroni, Daniel Marchi Kieling, Lucca Tamara Alves Carretta, Henrique Gnoatto, Nícolas Oliveira Moura, Martina Bassolli, Natan Lucca Lima, Anderson Silva Corin, Gabriel Cambruzzi, Rafael Torres Fonseca Dos Santos, Cleiton Formentin, Antonio Delacy Martini Vial, Herika Negri Britto, Guilherme Gago, Alex Roman","doi":"10.1177/19714009261500713","DOIUrl":"https://doi.org/10.1177/19714009261500713","url":null,"abstract":"<p><p>IntroductionMechanical thrombectomy (MT) is an endovascular approach applicable to large- and medium-vessel occlusion in the context of ischemic stroke (IS), with recanalization rates superior to 80% and favorable clinical outcomes. However, its benefits in patients with pre-existing functional disability remain unclear because these individuals are typically excluded from randomized controlled trials (RCTs). This systematic review and meta-analysis therefore aimed to assess how pre-stroke functional status influences key prognostic outcomes after MT.MethodologyPubMed, Embase, Scopus, Web of Science, and Cochrane Library databases were searched for English studies published from inception to September 2025. Observational cohorts and RCTs were included if they evaluated patients with IS treated with MT, comparing outcomes (functional outcomes, recanalization, complications, and mortality) between patients with and without pre-stroke disability (PD and NPD, respectively). Disability was mainly defined as a pre-stroke modified Rankin Scale (mRS) ≥2 or ≥3, and analyses were stratified accordingly. Data were pooled using a random-effects model, and heterogeneity was explored with Baujat plots and leave-one-out analyses.ResultsThis review included 12 studies comprising 26,444 patients, of whom 2,837 had PD and 23,607 had NPD. Most studies defined PD as a pre-stroke mRS ≥3. Patients with PD had higher rates of diabetes (28.9% vs 18.5%), hypertension (78.9% vs 66.0%), and atrial fibrillation (46.7% vs 29.4%). In contrast, NIHSS, ASPECTS, occlusion site, and time to treatment were similar between groups. Intravenous thrombolysis was less frequently administered in the PD group (33.8% vs 46.9%). No significant difference was observed in favorable functional outcomes between patients with PD and NPD (OR = 0.68; 95% CI: 0.39-1.16). Otherwise, 90-day mortality was higher in PD patients (OR = 2.75; 95% CI: 2.38-3.18). Finally, the risk of symptomatic intracranial hemorrhage and the rate of successful recanalization did not differ significantly between groups (OR = 1.19; 95% CI: 0.98-1.43, and OR = 0.89; 95% CI: 0.71-1.11, respectively).ConclusionPre-stroke disability was not significantly associated with functional outcomes or reduced recanalization rates after mechanical thrombectomy, although the substantial heterogeneity in functional outcomes warrants cautious interpretation. Pre-stroke disability was associated with higher 90-day mortality, which may be related to a greater baseline comorbidity burden and clinical vulnerability. These results support considering thrombectomy in selected patients with prior disability, while highlighting the need for individualized assessment. High-quality prospective studies are still required to confirm these findings.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009261500713"},"PeriodicalIF":1.2,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and metabolic imaging after mechanical thrombectomy for acute ischemic stroke: A hybrid 18F-FDG PET/MRI pilot study.","authors":"Fernando Aparici-Robles, Josep Puig, Lluis Morales-Caba, Pablo Sopena-Novales, Begoña Martínez-Sanchís, Juan Manuel Sanchís-García, Víctor Vázquez-Añón, Regina Teruel, Marc Comas-Cufí, Sonia Ginés, Amadeo Ten, José Miguel Carot-Sierra, Luis Martí-Bonmatí","doi":"10.1177/19714009261494962","DOIUrl":"10.1177/19714009261494962","url":null,"abstract":"<p><p>Hybrid 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) enables simultaneous, single-session assessment of structural and metabolic stroke damage. We prospectively studied 10 consecutive patients (6 women; mean age 71.6 ± 11.2 years) with anterior-circulation stroke due to middle cerebral artery (MCA) occlusion who underwent successful mechanical thrombectomy (MT). Structural damage was graded with the Alberta Stroke Program Early CT Score (ASPECTS) on admission and 24-h non-contrast CT and on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) at 72 hours; metabolic damage was graded with a PET-adapted ASPECTS on simultaneously acquired 18F-FDG PET at 72 hours. A between-modality difference of ≥3 ASPECTS points was considered significant. Baseline ASPECTS was 10 in 9 patients, and all achieved successful recanalization (modified Thrombolysis in Cerebral Infarction 2c-3). 18F-FDG PET showed severe hypometabolism in every infarcted territory, often extending beyond structural changes: ASPECTS differences were present in 7/10 patients for CT, 6/10 for DWI and 6/10 for FLAIR versus 18F-FDG PET/MRI, reaching the predefined 3-point threshold in 3/10 for CT versus PET/MRI. Because DWI, FLAIR and PET were acquired simultaneously at 72 hours (CT at 24 hours), the DWI/FLAIR-versus-PET comparisons are free of temporal confounding. Ipsilateral thalamic and crossed cerebellar diaschisis were each identified in 4/10 patients at 72 hours. Despite this more extensive hypometabolism, 9/10 patients achieved a favorable outcome (modified Rankin Scale ≤2) at 3 months. Hybrid 18F-FDG PET/MRI maps metabolic abnormality and remote network dysfunction invisible to structural imaging alone, adding a physiological dimension to ASPECTS-based evaluation of the reperfused brain.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009261494962"},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological DESH score cannot predict outcome after shunt surgery: A Swedish prospective follow-up study.","authors":"Clara Constantinescu, Mia Emgård, Karin Sundström, Dan Farahmand, Mats Tullberg, Doerthe Ziegelitz, Per Hellström","doi":"10.1177/19714009261494951","DOIUrl":"10.1177/19714009261494951","url":null,"abstract":"<p><p>BackgroundDisproportionately enlarged subarachnoid-space hydrocephalus (DESH) has been proposed as a radiological predictor of shunt responsiveness in idiopathic normal pressure hydrocephalus (iNPH), but previous studies have reported inconsistent results. We investigated the association between preoperative DESH score and postoperative outcome after shunt surgery in a prospective iNPH cohort.MethodsThis prospective study included 101 consecutive patients with iNPH from the Gothenburg Prediction of Outcome in iNPH (POiNT) study. Preoperative DESH scores were assessed on MRI using previously published criteria. Clinical outcomes included the Gothenburg iNPH scale, modified Rankin Scale (mRS), Mini-Mental State Examination (MMSE), and Timed Up and Go test (TUG-t). The primary outcome was improvement of ≥5 points on the iNPH scale.ResultsMean preoperative DESH score was 6.3 ± 1.7. At follow-up, the mean iNPH scale score improved from 50.8 ± 19.8 to 63.3 ± 20.0 (<i>p</i> < .001), with 70% improving by ≥5 points. Preoperative DESH score was not associated with postoperative change in iNPH scale score (<i>r</i> = -0.123, <i>p</i> = .219) or with responder status for any outcome. In multivariable analysis, DESH score was not independently associated with postoperative iNPH scale score after adjustment for baseline iNPH scale score, age, and disease duration. DESH score and Evans' index decreased and callosal angle increased after surgery (all <i>p</i> < .001).ConclusionsPreoperative DESH score was not associated with postoperative clinical improvement after shunt surgery in patients with iNPH. Although DESH-related imaging markers changed significantly after surgery, baseline DESH score had limited value as an independent predictor of shunt responsiveness.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009261494951"},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment for basilar artery occlusion: A Bayesian network meta-analysis comparing time-to-treatment windows and medical management.","authors":"Lucca Tamara Alves Carretta, Ocilio Ribeiro Gonçalves, Luciano Falcão, Mariana Letícia de Bastos Maximiano, Lucas Pari Mitre, Rudolfh Batista Arend, João Vitor Andrade Fernandes, Pedro Rodrigues Teixeira, Leonardo Di Cosmo, Tassiane Cristina Morais, Leandro de Assis Barbosa, Ahmet Günkan","doi":"10.1177/19714009261429231","DOIUrl":"10.1177/19714009261429231","url":null,"abstract":"<p><p>Background and objectivesBasilar artery occlusion accounts for a small fraction of ischemic strokes but carries a disproportionally poor natural history, with high rates of death and disability under best medical therapy (BMT). Endovascular treatment is used to treat these patients, though evidence of its safety and efficacy in different time windows compared to BMT remains conflicted. To address this, this Bayesian meta-analysis evaluates the outcomes of endovascular treatment for basilar artery occlusion performed in early (0-6 h) and late (>6 h) windows versus BMT.Materials and methodsFollowing PRISMA guidelines, databases were searched through for studies comparing endovascular versus BMT in patients with basilar artery occlusion. Randomized controlled trials, prospective, and retrospective studies reporting at least one clinical outcome were included. A Bayesian random-effects network meta-analysis was performed to compare endovascular treatment within 0-6 h and beyond 6 h with BMT.ResultsSeven studies comprising 4,125 patients were included. EVT demonstrated superior functional outcomes compared to BMT across both time windows, with the late (>6 h) window showing a higher probability of achieving favorable modified Rankin Scale (mRS) scores (0-2). Mortality reduction was not consistent, and both early and late EVT were associated with higher risks of hemorrhagic and overall complications. Despite these safety concerns, the overall benefit-to-risk balance favored EVT as the preferred therapy for BAO.ConclusionThe findings underscore the importance of imaging-based selection and individualized decision-making, suggesting that EVT beyond traditional time windows remains effective when guided by appropriate clinical and radiological criteria.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"620-635"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical prediction of aortic arch anatomy to guide stroke CT angiography protocols: A machine learning study.","authors":"Juan Manuel Marquez-Romero, Svetlana V Doubova, Dulce María Bonifacio-Delgadillo, Angel Eduardo Muñoz-Zavala, Rogelio Salinas-Gutiérrez","doi":"10.1177/19714009261417579","DOIUrl":"10.1177/19714009261417579","url":null,"abstract":"<p><p>BackgroundThe aortic arch (AA) influences catheter navigation during endovascular treatment (EVT) for acute ischemic stroke. Whether routine inclusion of the AA in stroke CT angiography (CTA) protocols is necessary remains debated, particularly in settings aiming to streamline imaging workflows.PurposeTo evaluate whether machine learning algorithms (MLAs) can use routinely available clinical and laboratory data to estimate AA configuration in patients with stroke risk factors.Materials and MethodsIn this retrospective study, 108 patients who underwent CTA, including the AA, were analyzed. Eight MLAs were trained to classify AA anatomy as favorable or unfavorable using clinical and laboratory variables available at presentation. Class imbalance was addressed using the Synthetic Minority Oversampling Technique. Model performance was evaluated using five-fold cross-validation and summarized with seven performance metrics.ResultsAfter class balancing, mean accuracy across classifiers ranged from 0.52 to 0.77. Gaussian copula and Naive Bayes classifiers showed the highest accuracy, while k-nearest neighbors and support vector machines demonstrated higher sensitivity. Specificity was highest for regularized discriminant analysis and the Gaussian copula. AUROC values ranged from 0.49 to 0.80 across models.ConclusionRoutinely available clinical and laboratory data contain a limited yet detectable signal, enabling several machine learning algorithms to estimate AA configuration with moderate accuracy. These findings are exploratory and do not support modification of CTA protocols. However, they suggest that pre-imaging clinical data may provide supportive information for future workflow-oriented decision-support tools. Further validation in larger, externally tested cohorts is required before clinical integration can be considered.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"642-648"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12819123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sexual dysfunction in relapsing-remitting multiple sclerosis and its association with brain and cervical cord MRI findings.","authors":"Behnam Dousty, Saeideh Karimi, Alireza Torabi Jahromi, Forough Alizadeh, Banafsheh Zeinali-Rafsanjani, Parisa Pishdad","doi":"10.1177/19714009261423698","DOIUrl":"10.1177/19714009261423698","url":null,"abstract":"<p><p>Sexual dysfunction (SD), a prevalent yet underreported complication in multiple sclerosis (MS), significantly impacts quality of life. This cross-sectional study at Imam Reza Clinic, Shiraz University of Medical Sciences, evaluated SD prevalence in 80 relapsing-remitting MS (RRMS) patients (65 females and 15 males; mean age 38.7 years) compared to 80 demographically matched controls (61 females and 19 males; mean age 39.1 years). SD was assessed using the Female Sexual Function Index (FSFI) for females and the International Index of Erectile Function (IIEF) for males, alongside brain-focused MRI to examine morphological changes. Female RRMS patients had significantly lower FSFI scores (mean 21.80, SD 7.13) than controls (mean 27.86, SD 4.83; <i>p</i> < .001). FSFI scores negatively correlated with cerebrospinal fluid volume (r = -0.297, <i>p</i> = .016), disease duration (r = -0.319, <i>p</i> = .010), fatigue (r = -0.412, <i>p</i> = .001), and depression (r = -0.387, <i>p</i> = .002). Male RRMS patients showed lower IIEF scores (mean 64.40, SD 8.77) compared to controls (mean 73.21, SD 2.84; <i>p</i> = .0012), with positive correlations between IIEF scores and insular cortex volume (r = 0.576, <i>p</i> = .025), cerebellar grey matter volume (r = 0.727, <i>p</i> = .002), and total grey matter volume (r = 0.846, <i>p</i> < .001). Multivariate regression identified MRI measurements, disease duration, and fatigue as independent SD predictors (<i>p</i> < .05). The high SD prevalence in RRMS, with distinct sex-specific neuroimaging correlates, highlights the need for routine SD screening and tailored interventions in MS care to improve patient outcomes.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"658-663"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in the anatomy of the deep cerebral veins: A pediatric magnetic resonance image study.","authors":"Amparo Sáenz, Florencia Rodríguez Basili, Beatriz Mantese, Romina Argañaraz","doi":"10.1177/19714009261429191","DOIUrl":"10.1177/19714009261429191","url":null,"abstract":"<p><p>IntroductionThe deep cerebral venous system plays a critical role in surgical approaches to the pineal and posterior third ventricular regions-areas that are particularly challenging in pediatric neurosurgery. While adult venous anatomy is well described, data on normal pediatric venous development remain scarce. Surgical planning in children often relies on extrapolating adult anatomy, which may not reflect age-related anatomical variations that occur during rapid brain growth.MethodsWe retrospectively analyzed high-resolution 3.0 T contrast-enhanced MRIs from 85 pediatric patients (aged 15 days-17 years) performed at a single tertiary center. Key venous angles (ICV-GV, GV-SS, SS-SSS, BV-GV) and distances (BV-BV, ICV-ICV, ICV-BV) were measured using multiplanar reconstruction. Correlations with age were assessed using Pearson correlation and linear regression. Patients were divided into three age groups (0-3 years, 4-12 years, 13-18 years), and group differences were evaluated with ANOVA and Bonferroni correction.ResultsSignificant age-related variations were identified in the conformation of the deep venous system. The ICV-GV, GV-SS, and SS-SSS angles widened with age (<i>p</i> < .001), while BV-GV angles decreased. BV-BV distance increased progressively from infancy to adolescence (<i>p</i> < .001). The ICV-BV relationship remained stable across age groups. Group comparisons confirmed significant differences between the youngest (0-3 years) and oldest (13-18 years) cohorts for most parameters.ConclusionThe venous anatomy of the pineal region evolves significantly with age. Understanding these changes can optimize preoperative planning and surgical strategies in pediatric patients. These data provide age-specific anatomical references that may support neurosurgeons worldwide, including those working in low-resource settings without routine access to neuronavigation.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"664-670"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal ADC values at term equivalent age in the newborn: Comparison between term and very preterm infants.","authors":"Katsumi Hayakawa, Koichi Tanda, Masakazu Nishimoto, Akira Nishimura, Daisuke Kinoshita, Yuko Sano, Kei Yamada","doi":"10.1177/19714009261417574","DOIUrl":"10.1177/19714009261417574","url":null,"abstract":"<p><p>PurposeOnly limited studies have directly compared apparent diffusion coefficient (ADC) values at term-equivalent age (TEA) between normal term infants and very preterm infants. We hypothesized that regional ADC values at TEA would differ between preterm infants and term infants, even in the absence of MRI-detectable brain injury. The purpose of this study was to compare ADC values at TEA between term infants and preterm infants born at less than 32 weeks of gestation.Subjects and methodsThis retrospective study enrolled consecutive infants who underwent neonatal brain MRI over a 7-year period from 2016 to 2022. From this cohort, very preterm infants were selected after confirmation of normal MRI findings and normal neurodevelopmental outcomes. ADC values were measured at six predefined brain regions. ADC values were compared between term infants and preterm infants, and further subgroup analyses were performed among term, very preterm, and extremely preterm infants.ResultsADC values at the basal ganglia were significantly higher in preterm infants compared with term infants. No significant differences were observed at the other five brain regions. Subgroup analysis among term, very preterm, and extremely preterm infants demonstrated significant differences in basal ganglia ADC values, with both very preterm and extremely preterm infants showing higher ADC values than term infants.ConclusionADC values at the basal ganglia at TEA were significantly higher in preterm infants than in term infants, despite normal conventional MRI findings and favorable neurodevelopmental outcomes. These findings suggest region-specific differences in brain microstructural maturation associated with preterm birth.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"636-641"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12811100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial magnetic resonance imaging findings in methanol poisoning: Systematic review and meta-analysis of radiological prevalence.","authors":"Rebeca Oliveira da Silva, Victor Arthur Ohannesian, Bianca Nobre Aguirre, Beatriz Gonçalves da Silva Miroski Gerente, Othon Trevisan Meira, Cid Soares, Vitória Palazoni, Pedro Lívio Gomes Moura, Felipe Araujo Gouhie, Diogo Haddad Santos","doi":"10.1177/19714009261423701","DOIUrl":"10.1177/19714009261423701","url":null,"abstract":"<p><p>PurposeThis meta-analysis aimed to evaluate the pooled prevalence of key cranial magnetic resonance imaging (MRI) findings in methanol poisoning, including putaminal necrosis, optic nerve injury, and mortality.ObjectiveMethanol intoxication is a potentially fatal condition causing severe neurological deficits, yet the prevalence of MRI-detected brain lesions remains incompletely characterized.MethodsA systematic review and meta-analysis were conducted following PRISMA 2020 and Cochrane Handbook guidelines. Studies reporting MRI findings in patients with confirmed methanol poisoning were retrieved from Medline, Scopus, and Web of Science. A random-effects model was used to pool proportions, and heterogeneity was assessed using the I² statistic.ResultsThirteen studies were included in the systematic review. Of these, eight studies contributed data on putaminal necrosis (<i>n</i> = 163), four on optic nerve injury (<i>n</i> = 108), and seven on in-hospital mortality (<i>n</i> = 154). Patients were predominantly male, aged 17-77 years, with oral ingestion as the main exposure route. Mortality showed a pooled prevalence of 7.8% (95% CI 2.2-24.1; I² = 53.9%). Optic nerve injury had a pooled prevalence of 36.1% (95% CI 9.2-75.8; I² = 84.0%). Putaminal necrosis was the most frequent MRI finding, with a pooled prevalence of 47.6% (95% CI 30.3-65.6; I² = 75.0%).ConclusionMRI abnormalities are highly prevalent in methanol poisoning. Putaminal necrosis is the hallmark radiologic feature, while optic nerve injury affects approximately one-third of cases. These findings support MRI as a key tool for assessing methanol-induced neurotoxicity.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"599-610"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative and morphological effects of age, body mass index, and sex on the peroneal nerve: A 3 tesla magnetic resonance imaging study.","authors":"Osman Anil Keküllüoglu, Edzard Wiener","doi":"10.1177/19714009261417568","DOIUrl":"10.1177/19714009261417568","url":null,"abstract":"<p><p>PurposeTo characterize demographic variation in quantitative MR neurography parameters of the peroneal nerve and to assess the methodological impact of epineurium inclusion on signal intensity-based measurements.Materials and MethodsThis retrospective single-center study included 114 screened, presumably healthy subjects undergoing routine 3-T knee MRI. Cross-sectional area (CSA), signal intensity (SI), and nerve-to-muscle SI ratios of the peroneal nerve were measured at three predefined levels, with and without epineurium inclusion. Associations with age, body mass index (BMI), and sex were evaluated using univariable linear regression. Agreement between SI measurements with and without epineurium was assessed using cubic spline regression. Exploratory fuzzy c-means clustering was applied to visualize demographic trends.ResultsSI ratios measured with and without epineurium showed excellent agreement without evidence of a clinically relevant systematic bias. Increasing age was significantly associated with larger CSA (<i>p</i> < .05). In contrast, SI ratios showed no significant age-related association and only weak trends. BMI demonstrated no significant association with either CSA or SI, and no relevant sex-related differences were observed. Fuzzy clustering corroborated regression findings, demonstrating gradual demographic trends with substantial overlap between clusters.ConclusionQuantitative MR neurography parameters of the peroneal nerve exhibit small, gradual variations with age and body mass index, primarily affecting cross-sectional area, while signal-intensity ratios remain largely stable. Measurements with and without epineurium inclusion show strong agreement, indicating that demographic-related variability is modest and should be interpreted as physiological variation rather than pathological change.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"649-657"},"PeriodicalIF":1.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}