Neuroradiology Journal最新文献

{"title":"Edaravone dexborneol for the treatment of acute ischemic stroke: A systematic review and meta-analysis.","authors":"Ali Mortezaei, Mohamed Emara, Mohammad Amin Habibi, Forough Yazdanian, Ibrahim Mohammadzadeh, Adam A Dmytriw, Redi Rahmani, David S Liebeskind","doi":"10.1177/19714009251340319","DOIUrl":"https://doi.org/10.1177/19714009251340319","url":null,"abstract":"<p><p>BackgroundEdaravone dexborneol has been developed as a novel neuroprotective agent and showed a promising result in treatment of stroke. The current meta-analysis aimed to assess the feasibility and efficacy of the edaravone dexborneol in the treatment of stroke.MethodWe performed a systematic review and meta-analysis of literature in four electronic databases. Binary outcomes were analyzed through the risks ratio (RR) and 95% confidence interval (CI), while the continuous outcomes were analyzed through the standardized mean difference (SMD) and 95% CI. Also, we did a subgroup analysis to show more feasibility and safety dimensions.ResultsFive studies with a total of 2415 patients were included. There were 1119 patients in edaravone dexborneol group and 1216 patients in control group. The 90-mRS 0-1 (RR 1.17 [95% CI 1.09-1.25]; <i>p</i> < 0.0001) and 90-day mRS 0-2 (RR 1.12 [95% CI 1.07-1.18]; <i>p</i> < 0.0001) were statistically significant higher in intervention group compared with control group. There was no significant difference between intervention group and control group concerning 90-day mRS 0-3 (RR 1.03 [95% CI 0.99-1.06]; <i>p</i> = 0.07), 90-day mortality rate (RR 0.71 [95% CI 0.45-1.11]; <i>p</i> = 0.13), serious adverse events (RR 0.91 [95% CI 0.72-1.16]; <i>p</i> = 0.45), and NIHSS score ≤1 at days 14 (RR 0.96; <i>p</i> = 0.69), 30 (RR 1.08; <i>p</i> = 0.18), and 90 (RR 1.06; <i>p</i> = 0.15). No heterogeneity in treatment effect was seen in the analysis, and any potential discrepancies were addressed by sensitivity analysis.ConclusionEdaravone dexborneol can be a favorable treatment option for patients with stroke. However, more randomized controlled trials are required to confirm our findings.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251340319"},"PeriodicalIF":1.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forearm-only transarterial and transvenous approach for endovascular intervention of dural arteriovenous fistula.","authors":"Kento Tsuburaya, Hidemichi Ito, Toshihiro Ueda, Gaku Hidaka, Yuichiro Kushiro, Taigen Sase, Masashi Uchida, Hidetoshi Murata","doi":"10.1177/19714009251340312","DOIUrl":"https://doi.org/10.1177/19714009251340312","url":null,"abstract":"<p><p>BackgroundTransradial arterial access has become widely used as a less invasive approach in neuroendovascular therapy, but the forearm venous approach has rarely been reported.ObjectivesThis study aimed to assess the safety and efficacy of forearm transvenous neurointervention for intracranial lesions. We present our experience with a simultaneous forearm-only transarterial and venous approach (fTAVA) for dural arteriovenous fistulas (dAVFs).MethodsWe retrospectively reviewed a prospective database of consecutive patients who underwent fTAVA for dAVFs between 2021 and 2024. fTAVA was performed using the right radial artery and superficial forearm vein as puncture sites. Arterial closure was achieved using a radial compression device, whereas bandage compression was used for venous closure. Procedural success, angiographic results, procedure-related complications and patient satisfaction were evaluated.ResultsOverall, 13 (8 carotid-cavernous sinus and 5 transverse-sigmoid sinus fistulas) procedures using fTAVA were successfully performed with favorable outcomes. Arterial puncture was performed at the distal radial artery in nine cases. The venous puncture site was the median cubital vein in nine cases and the forearm cephalic vein in four cases. The targeted fistulas were distal to the right jugular vein in four cases and the left jugular vein in nine cases. They were successfully accessed in all cases. The angiographic result was total occlusion in eleven cases and subtotal occlusion in two cases. There was one patient with minor access-site complication in distal radial artery.ConclusionsThe fTAVA is a safe and effective method for the endovascular treatment of dAVFs and is associated with reduced patient discomfort.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251340312"},"PeriodicalIF":1.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of tube voltage on image quality in non-contrast photon-counting computed tomography of the head: Comparison of 120 kVp and 140 kVp.","authors":"Denise Schoenbeck, Jan Robert Kroeger, Matthias Michael Woeltjen, Julius Henning Niehoff, Christoph Moenninghoff, Lukas Goertz, Jan Borggrefe, Arwed Elias Michael","doi":"10.1177/19714009251339079","DOIUrl":"https://doi.org/10.1177/19714009251339079","url":null,"abstract":"<p><p>PurposeNon-contrast cerebral computed tomography (NCCT) is one of the most frequently performed CT examinations. Photon-counting CT (PCCT) offers advantages in terms of noise reduction, higher spatial resolution, and inherent spectral information. PCCT available today allows NCCT to be performed with tube voltage of 120 or 140 kVp. This study evaluates the impact of tube voltage on image quality at an equivalent dose.Methods76 patients with an NCCT with 120 kVp, 76 with 140 kVp, and 56 patients with slightly different effective tube current per group were included. Signal, noise, signal-to-noise ratio, gray-white contrast, and contrast-to-noise ratio were determined using several regions of interest for different virtual monoenergetic image (VMI) levels and compared between dose-equivalent groups. An image quality rating of the clinically used virtual monoenergetic images (VMIs) 65 keV was performed.ResultsThe VMI 65 keV images at 120 kVp exhibited reduced noise, improved gray-white contrast, and improved contrast-to-noise ratio compared to 140 kVp (<i>p</i> < .001). The density differences between cortical gray matter at different distances from calvaria were also lower with 120 kVp (<i>p</i> < .001). The rating of image quality showed no difference between 120 kVp and 140 kVp.ConclusionsCurrently, NCCT with a tube voltage of 120 kVp versus 140 kVp seems to achieve better image quality. However, further studies are required to evaluate possible advantages of 140 kVp, for example artifact reduction in the case of dense foreign materials or enhanced spectral possibilities, and regarding imaging of special intracranial pathologies.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251339079"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis and rapid thrombectomy with stent placement in distal vertebral artery stenosis (Mori Type C) with mild symptoms.","authors":"Gregor Richter, Ali Hammed, Omar Ismail, Safwan Omran, Dina Rishan, Sara Hirsch, Christian Tanislav","doi":"10.1177/19714009251339091","DOIUrl":"https://doi.org/10.1177/19714009251339091","url":null,"abstract":"<p><p><b>Background:</b> Vertebrobasilar artery occlusion (VBAO) is a life-threatening condition with often nonspecific symptoms, making early diagnosis challenging. Timely intervention is crucial, especially in cases involving distal vertebral artery stenosis. <b>Case Report:</b> A 65-year-old male presented with acute vertigo, dizziness, and visual disturbances, along with ipsilateral sixth cranial nerve palsy. His medical history included a treated abdominal aortic aneurysm, hypercholesterolemia, and hypertension. CT angiography (CTA) revealed an occlusion in the V4 segment of the right vertebral artery. CT perfusion imaging showed minimal perfusion delay in the right brainstem. The patient received intravenous thrombolysis (IVT) with tenecteplase, followed by mechanical thrombectomy (MT), partial recanalization was achieved. However, digital subtraction angiography (DSA) identified a critical stenosis (>90%) responsible for the occlusion, consistent with arteriosclerotic disease. Following intravenous administration of 500 mg acetylsalicylic acid, a Biotronik Orsiro 2.25 × 9 mm drug-eluting stent was placed, achieving complete recanalization (eTICI 3). Neurologic symptoms resolved completely post-intervention, and the patient received 300 mg clopidogrel. He was discharged with an MRS score of 0 within 3 days. <b>Conclusion:</b> This case highlights the effectiveness of a multimodal approach (IVT, MT, and stenting) in treating distal vertebral artery occlusion (Mori Type C). Early diagnosis and timely endovascular intervention led to rapid symptom resolution and complete neurological recovery. Follow-up ultrasound at 4 months confirmed good bilateral vertebral artery perfusion without restenosis, supporting the potential long-term benefits of this multimodal treatment approach. This case underscores the importance of advanced imaging for early detection and the role of thrombectomy and stenting in optimizing patient outcomes.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251339091"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the Contour Neurovascular System for the treatment of intracranial aneurysms.","authors":"Sebastian Johannes Müller, Eya Khadhraoui, Roland Schwab, Elie Diamandis, Daniel Behme","doi":"10.1177/19714009251336321","DOIUrl":"https://doi.org/10.1177/19714009251336321","url":null,"abstract":"<p><p>BackgroundThis systematic review aims to reflect the current state of the literature on use and efficacy of the Contour Neurovascular System (CNS), an endovascular implant specifically developed for the treatment of intracranial wide-neck aneurysms.MethodsWe included manuscripts from a PubMed search with the terms \"contour AND aneurysm.\" Manuscripts that did not refer to the CNS were excluded via screening.The number of interventions from included studies was calculated and, where possible, occlusion rates of aneurysms, used CNS sizes, and complications were recorded.ResultsWe found a total number of 23 studies with 625 patients and 661 aneurysms treated with CNS (122 ruptured). The number of studies with low bias and sufficient randomization is very small. Only two prospective studies with 43 patients could be identified. The mean aneurysm size was 6.4 mm (height), 5.5 mm (dome size), and 3.9 mm (neck size). Most used CNS sizes were \"7\" and \"9.\" A complete occlusion result was achieved in 61% of patients in the long-term controls; in 28%, an adequate occlusion with a small neck rest was reported.ConclusionsThe preliminary results of the CNS are promising. However, these findings need to be proven in larger, prospective studies.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251336321"},"PeriodicalIF":1.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed FLAIR-enhancement of benign notochordal remnant (ecchordosis physaliphora).","authors":"Jeroen Peels, Christof Vulsteke, Michael Boedts, Eline Marin, Laurens J L De Cocker","doi":"10.1177/19714009241303131","DOIUrl":"10.1177/19714009241303131","url":null,"abstract":"<p><p>Ecchordosis physaliphora (EP) is a benign notochordal remnant most commonly encountered in the skull base. In opposition to typical cases of its invasive counterpart, that is, chordoma, EP does not show T1-enhancement. Now, we describe three patients with EP, discovered on delayed contrast-enhanced 3D FLAIR performed for endolymphatic hydrops imaging in suspected Menière's disease. All EP cases demonstrated intense, delayed FLAIR-enhancement of the notochordal remnant. The importance of this new observation of FLAIR-enhancement in EP is threefold: (1) it may increase the detection rate of EP, (2) FLAIR-enhancement in EP should not be mistaken for T1-enhancement in chordoma, and (3) it may open a new window for future imaging studies aiming to better differentiate EP from chordoma.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"220-223"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Epidural Hematoma Expansion in Traumatic Brain Injury: A Machine Learning Approach.","authors":"Mohammad Hasanpour, Danial Elyassirad, Benyamin Gheiji, Mahsa Vatanparast, Ehsan Keykhosravi, Mehdi Shafiei, Shirin Daneshkhah, Arya Fayyazi, Shahriar Faghani","doi":"10.1177/19714009241303052","DOIUrl":"10.1177/19714009241303052","url":null,"abstract":"<p><p>IntroductionTraumatic brain injury (TBI) is a leading cause of disability and mortality worldwide, with epidural hematoma (EDH) being a severe consequence. This study focuses on identifying factors predicting EDH volume changes in TBI patients and developing a machine learning (ML) model to predict EDH expansion.MethodsThe study includes patients with traumatic EDH between 2019 and 2021. Data were gathered from CT scans performed at the time of admission and 6 hours later, and subsequently analyzed. The data was divided into three cohorts: all cases, adults, and pediatrics. To predict EDH volume changes, we used Logistic Regression (LR), Random Forest (RF), XGBoost, and K-Nearest Neighbors (KNN) models. Data was divided into an 80% training set and a 20% test set. Through a rigorous process of parameter optimization and K-fold cross-validation, focusing on the area under the receiving operating curve (AUROC), we identified the best models in all cohorts. The best models were evaluated on the test sets, reporting AUROC, recall, precision, and accuracy using the youden index threshold.ResultsResults show that age, initial EDH volume, swirl sign, intra-hematoma air bleb, contusion, otorrhagia, subarachnoid hemorrhage, location, and other side extra-axial hematoma have significant effects on changing EDH volume. Based on test AUROC, the best models were RF for adults (82.4%), KNN for pediatrics (90%), and LR for all cases (81.6%).DiscussionIn this study, we identified key features for predicting EDH expansion as well as developing ML models. Using high sensitive models, can assist clinicians in identifying high-risk patients early. This allows for enhanced monitoring and timely intervention, improving patient outcomes by facilitating quicker decisions for follow-up imaging or treatment.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"200-206"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pipeline versus non-pipeline flow diverter treatment for M1 aneurysms: A systematic review and meta-analysis.","authors":"Yigit Can Senol, Atakan Orscelik, Cem Bilgin, Hassan Kobeissi, Sherief Ghozy, Santhosh Arul, David F Kallmes, Ramanathan Kadirvel","doi":"10.1177/19714009241260805","DOIUrl":"10.1177/19714009241260805","url":null,"abstract":"<p><p>BackgroundThe flow diversion treatment of aneurysms located distal to the Circle of Willis has recently increased in frequency. We conducted a systematic review and meta-analysis of the clinical and radiological outcomes of flow diverter (FD) embolization in treating M1 aneurysms.MethodsPubMed, Web of Science, Ovid Medline, Ovid Embase, and Scopus were searched up to May 2024 using the Nested Knowledge platform. We included studies assessing the long-term clinical and radiological outcomes for M1 aneurysms. Results of FDs classified as Pipeline Embolization Devices (PED) versus other types of FDs. Angiographic occlusion rates, ischemic and hemorrhagic complications, and favorable clinic outcomes were included. All data were analyzed using R software version 4.2.2.ResultsThirteen studies with 112 total patients (58 patients for PED and 54 patients for other FD devices) were included in our meta-analysis. The overall adequate (complete + near-complete) occlusion rates were 85.1%. The complete occlusion rate was higher with PED than with other FD devices (72.9% PED and 41.6% for non-PED FDs, respectively, <i>p</i>-value <.01). The ischemic complications were 9.9% and 9.0% for the PED and non-PED groups, respectively (<i>p</i>-value = .89). The overall modified Rankin Scale 0-2 was 100% for the non-PED and 97.1% for the PED group (<i>p</i>-value = .51). In-stent stenosis rate was 7.5% for PED devices compared to 2.6% in the non-PED group (<i>p</i>-value = .35).ConclusionsThis relatively small meta-analysis showed high rates of adequate and complete occlusion in FD treatment of M1 segment aneurysms, with favorable safety profiles. PEDs were associated with higher rates of complete aneurysm occlusion compared to other types of FDs.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"133-141"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Los Angeles Motor Scale is independently associated with cerebral blood flow < 30% volume in large vessel occlusions.","authors":"Richard Wang, Dhairya A Lakhani, Aneri B Balar, Sadra Sepehri, Licia P Luna, Andrew Cho, Argye E Hillis, Manisha Koneru, Meisam Hoseinyazdi, Hanzhang Lu, Janet Mei, Tobias Faizy, Risheng Xu, Mehreen Nabi, Ishan Mazumdar, Victor C Urrutia, Kevin Chen, Judy Huang, Kambiz Nael, Nathan Hyson, Vivek S Yedavalli","doi":"10.1177/19714009241303140","DOIUrl":"10.1177/19714009241303140","url":null,"abstract":"<p><p>Background and PurposeMechanical thrombectomy (MT) is the treatment standard for large vessel occlusion (LVO) stroke. Under current guidelines, only patients with smaller ischemic core volumes (ICV) are eligible for MT. Thus, it is of interest to quickly estimate ICV in stroke patients. The Los Angeles Motor Scale (LAMS) is a validated tool used to assess stroke severity directly in the field. This study aims to determine whether LAMS score is also associated with ICV, as defined by the CBF <30% volume on CT perfusion imaging.MethodsWe performed a retrospective, multicenter cohort study of consecutive patients presenting with LVO stroke from 9/1/2017 to 10/1/2023. The inclusion criteria were patients with (1) stroke caused by large vessel occlusion confirmed on CTA and (2) diagnostically adequate, multimodal pretreatment CT imaging. Demographic, clinical, and imaging data was collected through manual chart review. Both univariate and multivariate analyses were applied to assess associations. A <i>p</i>-value <.05 was considered significant.ResultsA total of 283 patients (median age: 69, IQR: 61-78) were included in the study. On multivariate logistic regression analysis, we found that lower admission LAMS score (adjusted OR: 0.511, 95% CI: 0.313-0.834, <i>p</i> = .007) was independently associated with a CBF <30% volume of less than 50cc.ConclusionsAdmission LAMS is an independent predictor of a CBF <30% volume of less than 50cc. This demonstrates that LAMS can be used to estimate ICV, which will aid in the early triaging of LVO patients to thrombectomy-capable centers.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"214-219"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The perivascular spaces in young and middle-aged stroke: A single-center analysis integrating clinical and Doppler ultrasound findings.","authors":"Caterina Bernetti, Gianfranco Di Gennaro, Nicoletta Brunelli, Marilena Marcosano, Claudia Altamura, Giorgio Liaci, Desirè Anzalone, Fabrizio Vernieri, Bruno Beomonte Zobel, Carlo A Mallio","doi":"10.1177/19714009241303117","DOIUrl":"10.1177/19714009241303117","url":null,"abstract":"<p><p><b>Purpose:</b> This research seeks to investigate correlations between enlarged Perivascular Spaces (PVSs) and clinical/imaging data, such as information obtained through Doppler analysis, in a population with young and middle-age stroke. <b>Materials and methods:</b> We retrospectively reviewed demographics, clinical and MRI data, of 163 patients, with MRI confirmed stroke. All patients underwent ECD TSA (Eco-Color-Doppler of the Supra-aortic Trunks) and TCCD (Transcranial Eco-color-Doppler), to study extra or intracranial stenosis, presence and composition of plaques. Severity of PVS was evaluated on T2-weighted images according to the Potter scale. To identify potential predictors of PVSs, an exploratory backward stepwise ordinal regression model was developed, including clinical and Doppler US variables. <b>Results:</b> In the stepwise ordered logistic regression analysis with PVSs at BG (Basal Ganglia) as the outcome, hemodynamically significant stenosis in any vessel ipsilateral to the ischemic lesion displayed a significant positive association with a higher outcome value. Similar results were observed for ESUS (Embolic Stroke of Undetermined Source). Fibrolipid plaques in any vase exhibited a significant negative association. At MB (Midbrain), male patients and subjects with hypertension exhibited a higher value of PVSs. Dyslipidemia demonstrated a significant negative effect. When PVSs were investigated in the CS (Centrum Semiovale), no statistically significant association with the extent of PVSs emerged. <b>Conclusion:</b> These insights not only enhance our understanding of the role of PVSs in cerebrovascular health in a young and middle-age population but also highlight the potential of PVSs as a biomarker in neuroimaging studies, warranting further research to elucidate their clinical implications and underlying pathophysiological mechanisms.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"207-213"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}