Neuroradiology Journal最新文献

{"title":"Non-contrast magnetic resonance evaluation of active multiple sclerosis lesions: Emerging role of quantitative synthetic magnetic resonance imaging.","authors":"Sachin Girdhar, Sruthi S Nair, Bejoy Thomas, Chandrasekharan Kesavadas","doi":"10.1177/19714009241269541","DOIUrl":"10.1177/19714009241269541","url":null,"abstract":"<p><p>PurposeThe current study aims to explore the utility of novel synthetic MRI-derived quantitative parameters including myelin-correlated volume (MyC) in identifying active MS lesions without injecting gadolinium contrast.Methods43 MS patients underwent institutional MS protocol including 3D FLAIR and post-contrast 3D T1VIBE sequence on a 1.5 T MR Scanner in addition to synthetic MRI sequence. MS plaques were categorised into enhancing (C) and non-enhancing (N) lesions. They were also sub-categorised based on location into periventricular WM lesions (P), deep WM lesions (D), infratentorial lesions (I) and cortical-juxtacortical (C) lesions. ROIs were placed on Synthetic FLAIR images in MS lesions and quantitative parameters of R1, R2, PD and myelin-correlated volume (MyC) obtained. Sensitivity and specificity for various cut-off values to differentiate enhancing from non-enhancing multiple sclerosis lesions were calculated by performing ROC curve analysis and logistic regression analysis.ResultsContrast enhancing lesions demonstrated significantly higher mean R1, R2 values and lower mean PD values in comparison to non-enhancing lesions (<i>p</i> < 0.05) but with limited specificity. Region-wise analysis revealed high AUC values for mean R1 and R2 at cortical-juxtacortical lesions (<i>p</i> < 0.001) followed by periventricular lesions (<i>p</i> < 0.003) for differentiating enhancing from non-enhancing lesions with no significant contribution from MyC and PD values.ConclusionSynthetic MRI-derived quantitative parameters of mean R1, R2, MyC and PD hold value in differentiating contrast enhancing and non-enhancing MS lesions without administering gadolinium-based contrast agent. However, the current study did not achieve significant specificity for establishing the same.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"176-184"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact on mortality at 90 days of acute kidney injuries in endovascularly treated stroke: A systematic review, meta-analysis, and meta-regression.","authors":"Gianluca De Rubeis, Michele Alessiani, Sebastiano Fabiano, Luca Bertaccini, Andrea Wlderk, Francesca Romana Pezzella, Sabrina Anticoli, Peter Alan Barber, Luca Saba, Enrico Pampana","doi":"10.1177/19714009241303134","DOIUrl":"10.1177/19714009241303134","url":null,"abstract":"<p><p>AimTo investigate the prognostic implication (mortality at 3 months) of acute kidney injury (AKI) in acute ischemic stroke treated with mechanical thrombectomy (MT).Material and MethodsA literature search was performed using PubMed/OVID/Cochran's CENTRAL database (time frame: inception to January 2023). Study characteristics, patient status, clinical outcomes, AKI incidence, and sample size were recorded. The exclusion criteria were non-English literature, no human subjects, and <10 patients as the sample size. Studies were assessed using the MINORS/GRADE system. Meta-analysis and meta-regression with a random-effects model were performed.Results3314 studies were retrieved. After applying the exclusion criteria, the final population included of 18/3314 studies (0.5%). Among them, only 6/18 (33.3%) studies reported results in two separate groups (AKI vs non-AKI), allowing for inference statistics for a total population of 3229 (538.6 ± 403.7). The I^2 was 34.6 and Q's Cochrane was 7.80. The pooled odds ratio (OR) for mortality at 3 months in patients with AKI was 5.8 (95% confidence interval [95% CI] 95% CI 3.62 to 9.52). Leave-one-out meta-analysis showed no significant sources of heterogeneity. In the meta-regression, diabetes prevalence was associated with a higher mortality rate (OR 1.14, 95% CI 1.03 to 1.28), and lower age and a small amount of contrast media were negatively correlated (0.91 [95% CI 0.83 to 0.99] and OR 0.97 [95% CI 0.94 to 1.00], respectively).ConclusionAKI was significantly associated with the mortality rate in MT-treated stroke patients (OR 5.8 [95% CI 3.62 to 9.36]).</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"185-191"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of flow redirection endoluminal device (FRED) for treatment of intracranial aneurysm; A systematic review and meta-analysis.","authors":"Mohammad Amin Habibi, Mohammad Sina Mirjani, Amir Mahmoud Ahmadzadeh, Mohammad Taha Akbari Javar, Shaghayegh Karami, Muhammad Hussain Ahmadvand","doi":"10.1177/19714009241269460","DOIUrl":"10.1177/19714009241269460","url":null,"abstract":"<p><p>BackgroundPrevious research has shown promising results for treating intracranial aneurysms (IAs) with a flow redirection endoluminal device (FRED). In this systematic review and meta-analysis, we aimed to assess the safety and efficacy of this device by providing pooled estimates using the data from previous studies.MethodsA systematic literature search of Web of Sciences, PubMed, Scopus, and Embase was performed until October 8th, 2023. After selecting the final articles, relevant data were extracted. Parameters relating to safety and efficacy were pooled using STATA software. Heterogeneity was assessed using I-squared and Cochran's Q. Funnel plots and Egger's regression methods were used to evaluate publication bias. Sensitivity analysis was also performed using the leave-one-out method.ResultsThe data of 37 studies were used for meta-analysis. The rates of immediate adequate occlusion and complete occlusion were 0.51 (95% CI: 0.31-0.71) and 0.34 (95% CI: 0.16-0.53), respectively, while the rates of the adequate and complete occlusion at the latest follow-up were 0.90 (95% CI: 0.84-0.94) and 0.75 (95% CI: 0.65-0.84), respectively. The periprocedural complications rate was 0.04 (95% CI: 0.03-0.06), and the overall complications rate was 0.12 (95% CI: 0.09-0.15). The rate of good functional outcome was 0.99 (95% CI: 0.99-1.00) and the successful implantation rate was 1.00 (95% CI: 1.00-1.00). There was substantial heterogeneity among the reports for most of the evaluated parameters.ConclusionFRED had high safety and efficacy in treating IAs, as evidenced by its high occlusion and low complication rates.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"142-175"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneously occurring diabetic striatopathy and osmotic demyelination syndrome: A rare case report.","authors":"Michael J Christensen, Trevor J Huff, Austin M Pickrell, Samuel N Rogers","doi":"10.1177/19714009251324311","DOIUrl":"10.1177/19714009251324311","url":null,"abstract":"<p><p>Diabetic striatopathy (DS), also known as non-ketotic hyperglycemic hemichorea, is a rare condition that arises from uncontrolled hyperglycemia. It is characterized by new onset movement disorders, changes in the striatum on imaging, or both. DS can occur as a complication of long-standing non-ketogenic hyperglycemia or be the first presentation of previously undiagnosed diabetes mellitus (DM). Additionally, uncontrolled or rapidly corrected hyperglycemia can, in rare cases, lead to osmotic demyelination syndrome (ODS). Although ODS typically occurs after the rapid correction of hyponatremia, the same effects and symptoms can manifest in patients with diabetes when hyperglycemia is corrected too quickly. We present a 59-year-old male with a history of uncontrolled diabetes mellitus and cerebrovascular accident who was brought to the emergency department by EMS with a new onset movement disorder. This case demonstrates a rare example of a patient presenting with classic imaging findings of both DS and ODS. Specifically, the patient demonstrated unilateral basal ganglia hyperdensity on CT, indicative of DS, alongside central pontine diffusion restriction and T2/FLAIR hyperintensity, consistent with ODS. This report discusses a rare case of the simultaneous occurrence of diabetic striatopathy and osmotic demyelination syndrome in a patient with uncontrolled diabetes mellitus, highlighting the intricate neurological complications of hyperglycemia. These findings stress the importance of timely recognition and management of hyperglycemia-related conditions, with imaging playing a pivotal role in diagnosis.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324311"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation of left internal and external carotid arteries via right brachial artery approach in cerebral angiography.","authors":"Tomonori Orito, Naoya Imai, Takamasa Kinoshita, Shigenobu Sawada, Katsuhiko Hayashi","doi":"10.1177/19714009251324300","DOIUrl":"10.1177/19714009251324300","url":null,"abstract":"<p><p>Cerebral angiography is essential for diagnosing cerebrovascular diseases and crucial to separate the internal and external carotid arteries during angiography. The femoral artery approach is more invasive than the brachial artery approach. In some cases, guiding the catheter through the right brachial artery to the left internal and external carotid arteries is feasible. This study retrospectively investigated factors influencing successful catheter guidance to the left carotid arteries. We studied 30 patients (17 men; mean age 64.9 years) in whom catheter guidance to the left internal and external carotid arteries was attempted via the right brachial artery. A 4Fr Simmons-type catheter and a 0.035-inch diameter guidewire were used. We retrospectively analyzed patient characteristics and aortic arch anatomy. Guidance was successful in 20 patients (66.7%). There were no significant differences in sex, age, height, weight, BMI, aorta type, or bifurcation type between the brachiocephalic and left common carotid arteries between the successful and unsuccessful cases. However, a significant difference was observed in the angle formed by the Simmons catheter during insertion into the left common carotid artery (45.7° vs 19.3° <i>p</i> < .01). The rising angles of the catheter entering the aortic arch from the brachiocephalic artery were 64.2° versus 84.8°, respectively (<i>p</i> < .01). Cut-off values were 30.9° (AUC = 0.985) and 77.5° (AUC = 0.9). Safe guidance to the left internal and external carotid arteries was achievable when the angle of the Simmons catheter curve was 30.9° or greater and the rising angle of the catheter entering the aortic arch from the brachiocephalic artery was 77.5° or less.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324300"},"PeriodicalIF":1.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment of intracranial aneurysms with silk vista baby flow diverter: A systematic review and meta-analysis.","authors":"Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Rana Hashemi, Mohammad Amin Habibi, Arman Hasanzade, Sara Bana, Mahdi Hooshmand, Fatemeh Ghorbanpouryami, Dorsa Najari, Ehsan Bahrami Hezaveh","doi":"10.1177/19714009251324324","DOIUrl":"10.1177/19714009251324324","url":null,"abstract":"<p><strong>Background: </strong>The Silk Vista Baby (SVB) flow diverter (FD) is a stent designed for small vessels ranging from 1.5 to 3.5 mm. It is the only FD deliverable through a 0.017-inch microcatheter. This systematic review and meta-analysis aimed to assess the SVB utilization in intracranial aneurysms (IAs).</p><p><strong>Methods: </strong>Four electronic databases, PubMed, Scopus, Embase, and Web of Science, were searched from inception to November 5^th, 2024.</p><p><strong>Results: </strong>Ten studies with 359 patients with 373 IAs were included. Our results revealed a pooled complete occlusion rate of 65% (95%CI: 43%-83%), a favorable outcome rate of 94% (95%CI: 83%-100%), and a morbidity rate of 4% (95%CI: 0%-11%). Our meta-analysis revealed a pooled in-stent thrombosis rate of 2% (95%CI: 1%-5%), side branch occlusion rate of 2% (95%CI: 0%-3%), intracerebral hemorrhage (ICH) rate of 2% (95%CI: 1%-4%), and device shortening rate of 4% (95%CI: 3%-6%). The subgroup analysis showed that the complete occlusion rate (≤6: 84% [95%CI: 49%-100%] vs >6: 58% [95%CI: 41%-73%], <i>p</i> < .001) was higher in studies with 6-month or lower follow-up duration, and the favorable outcome rate was higher in those with greater than 6-month duration (≤6: 84% [95%CI: 73%-93%] vs >6: 97% [95%CI: 82%-100%], <i>p</i> < .001).</p><p><strong>Conclusion: </strong>SVB is an efficient and safe therapeutic option for managing IAs. We demonstrated that it is associated with promising clinical and radiological outcomes and low rates of complications.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324324"},"PeriodicalIF":1.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aristotle wires for cannulating target vessels in paediatric neuro-interventional procedures: A case-control study.","authors":"K D Bhatia, T Blane, B Giarola, J Vedamuthu, V Carraro Do Nascimento, Y-J Kim, G Olsson, M Dexter","doi":"10.1177/19714009251324302","DOIUrl":"10.1177/19714009251324302","url":null,"abstract":"<p><p>BackgroundPaediatric neuro-interventional (PNI) procedures are markedly different to adult procedures and are more likely to be complicated by vasospasm. Traversing the complex tortuous anatomy in these fragile vessels requires both torque control and distal tip softness of the microwire. The Aristotle wires (Scientia Vascular Inc) are a new family of wires with design features offering both torque control and distal tip softness. We sought to assess the ability of these wires to achieve successful target vessel cannulation in paediatric patients.MethodsThe study design was a single-centre case-control study. We compared a case cohort of PNI procedures performed using the Aristotle wires (2023-24) with a control cohort using other wires (2022-23). The primary study outcome was successful cannulation of the target vessel (Yes/No) with a microcatheter.ResultsThe Aristotle wires cohort consisted of 44 targeted vessels across 40 procedures in 20 patients (F = 8; mean age 6.9, SD 6.53 years). The other wires cohort consisted of 41 targeted vessels across 41 procedures in 19 patients (F = 6; mean age 4.3, SD 4.98 years). Successful cannulation of the target vessel was achieved in 43 of 44 target vessels (97.7%) in the Aristotle wires cohort and 34 of 41 target vessels (82.9%) in the other wires cohort (<i>p</i> = .020). The rate of wire-related complications was significantly lower in the Aristotle wires cohort (0 of 44 vs 6 of 41 target vessels, <i>p</i> = .008).ConclusionAristotle wires were associated with significantly better target vessel cannulation and lower wire-related complications than other wires in PNI procedures.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324302"},"PeriodicalIF":1.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of highly cited articles in cerebral angiography.","authors":"Hafiz Muhammad Sameer, Syed Abdullah Arif, Aribah Bhatti, Faraz Arshad, Khadija Ali","doi":"10.1177/19714009251324292","DOIUrl":"10.1177/19714009251324292","url":null,"abstract":"<p><strong>Objective: </strong>To present and analyze the characteristics of the 100 most cited articles that used cerebral angiography for clinical evaluation and intervention.</p><p><strong>Method: </strong>Two researchers independently extracted articles from multiple databases and ranked them by citation count to create the \"top 100 most-cited\" list.</p><p><strong>Results: </strong>The top 100 articles received a total of 115,243 citations. Twenty-one of the top 100 articles were published between 2006 and 2010. Most studied disorder was ischemic stroke (<i>n</i> = 35), and cerebral angiography was used most frequently for diagnosis (<i>n</i> = 88).The United States was affiliated with the highest number of articles (<i>n</i> = 62), with <i>Stroke</i> publishing most articles (<i>n</i> = 22). Public sources funded 39 articles, private sources funded 35, and 38 articles reported conflicts of interest. Thirty-six studies were randomized controlled trials, and male authors held the majority of both first (<i>n</i> = 90) and senior (<i>n</i> = 88) authorship positions.</p><p><strong>Conclusion: </strong>Within the scope of this study, the following features may define a typical highly cited article-a randomized controlled clinical trial conducted in the United States that studied ischemic stroke, used cerebral angiography for diagnosis, and was published relatively recently in a high-impact journal by male first and senior authors.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324292"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic versus conventional MRI for ring-enhancing brain lesions: A pre- and post-contrast comparison.","authors":"Sanket Dash, Sameer Vyas, Nidhi Bhardwaj, Paramjeet Singh, Chirag K Ahuja, Sarfraj Ahmad","doi":"10.1177/19714009251324314","DOIUrl":"10.1177/19714009251324314","url":null,"abstract":"<p><strong>Purpose: </strong>Synthetic MRI has potential to significantly reduce MR scan time by reconstructing multiple contrast images from a single acquisition. The aim of this study was to compare the image quality of both pre- and post-contrast synthetic MRI in subjects with ring-enhancing brain lesions with conventional images.</p><p><strong>Methods: </strong>50 patients with radiologically confirmed ring-enhancing brain lesions underwent TSE_MDME sequence before and after gadolinium administration along with conventional MRI sequences. Image quality was compared between synthetic and conventional sequences on a 4-point scale across 5 parameters, that is, grey white matter differentiation, demarcation of caudate nucleus, lentiform nucleus, demarcation of sulci, and SNR. Also, the artefacts, lesion conspicuity, and ability to diagnose on synthetic images were studied.</p><p><strong>Results: </strong>Image quality of synthetic MRI was relatively similar across all sequences except for FLAIR. The image quality comparison between synthetic and conventional images showed an agreement in 70.7% of the cases (Weighted Kappa = 0.043, <i>p</i> = <0.001). Artefacts were maximum in synthetic FLAIR sequence (52%). 50% cases showed a discordant enhancement pattern in post contrast synthetic images. Despite a higher occurrence of artefacts in synthetic post contrast images, diagnostic ability was comparable across pre- and post-contrast synthetic and conventional images.</p><p><strong>Conclusion: </strong>Synthetic MRI provides comparable diagnostic quality of images with acceptable rate of artefacts in both pre and post contrast sequences. However, needs a careful interpretation especially when diagnosis is heavily relied on the enhancement pattern of lesions.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324314"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the diagnostic ability of treatment response assessment maps (TRAMs)/contrast clearance analysis (CCA) in predicting the presence of active brain tumors.","authors":"Hassan Alkhatatneh, Yu-Han Chen, Santiago Imhoff, Lindsay Fogel, Kevin Yao, David Dubin, Mei Zhang, Paul Chen, Ajay Nemade, Marc Herman, Ala Khatatneh, Tanganyika Barnes, Michael Speiser, Maxwell Janosky","doi":"10.1177/19714009251324305","DOIUrl":"10.1177/19714009251324305","url":null,"abstract":"<p><strong>Introduction: </strong>Brain tumors pose significant diagnostic and therapeutic challenges due to their diverse treatment responses and complex imaging characteristics. Traditional MRI techniques often struggle to differentiate between tumor recurrence and post-treatment changes such as pseudoprogression and necrosis, highlighting the need for more accurate diagnostic tools.</p><p><strong>Material and methods: </strong>This retrospective study conducted at a single tertiary care center and evaluated the diagnostic efficacy of Treatment Response Assessment Maps (TRAMs), also known as Contrast Clearance Analysis (CCA), in distinguishing between tumor recurrence and post-treatment changes in patients who underwent initial treatment for brain tumors. Data from 27 patients were analyzed, including 10 who underwent surgical resection (Group 1) and 17 who had serial images and TRAMs/CCA assessment (Group 2).</p><p><strong>Result: </strong>In Group 1, TRAMs/CCA demonstrated nine positive results, with 8 cases of tumor recurrence confirmed via biopsy. A biopsy also confirmed one negative result after a discussion with the patient. In Group 2, where patients did not undergo biopsy, TRAMs/CCA results varied but correlated with clinical outcomes, underscoring the potential utility of TRAMs/CCA in guiding treatment decisions. These findings suggest that TRAMs/CCA may have superior diagnostic performance compared to traditional MRI in differentiating between tumors.</p><p><strong>Conclusion: </strong>TRAMs/CCA represents a promising advancement in the imaging assessment of brain tumor treatment response, offering higher sensitivity than conventional MRI methods. While implementing TRAMs/CCA could potentially improve diagnostic accuracy and optimize therapeutic strategies for patients with brain tumors, the final decision remains highly dependent on patient-centered discussions.</p>","PeriodicalId":47358,"journal":{"name":"Neuroradiology Journal","volume":" ","pages":"19714009251324305"},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}