JOURNAL OF MEDICAL INVESTIGATION最新文献_第4页

Composition of Gut Microbiota and Its Relationship with Inflammatory Markers in Healthy Individuals and Patients with Ulcerative Colitis or Crohn's Disease. 健康人群和溃疡性结肠炎或克罗恩病患者肠道菌群组成及其与炎症标志物的关系

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.92

Hideo Watanabe, Yoshito Ono, Taro Oshikiri, Koichiro Tsuchiya

{"title":"Composition of Gut Microbiota and Its Relationship with Inflammatory Markers in Healthy Individuals and Patients with Ulcerative Colitis or Crohn's Disease.","authors":"Hideo Watanabe, Yoshito Ono, Taro Oshikiri, Koichiro Tsuchiya","doi":"10.2152/jmi.73.92","DOIUrl":"10.2152/jmi.73.92","url":null,"abstract":"Background: The gut microbiota plays an important role in inflammatory bowel disease (IBD). However, its relationship with inflammatory markers remains unclear, especially in Asian populations.Methods: This prospective observational study examined the gut microbiota composition and its association with systemic inflammatory markers in Japanese patients with ulcerative colitis (UC) and Crohn's disease (CD) compared to healthy controls. Bacterial diversity, short-chain fatty acid-producing bacteria, and key genera were analyzed via 16S rRNA gene sequencing.Results: Patients with CD exhibited reduced bacterial diversity. Clostridium cluster IV was decreased in CD and showed a negative correlation with fecal calprotectin levels in UC. Clostridium cluster XIVa was negatively correlated with fecal calprotectin levels in both UC and CD, and with C-reactive protein (CRP) levels in CD. Oscillibacter positively correlated with CRP levels in CD. These findings suggest that a reduction in butyrate-producing bacteria is associated with increased inflammation in patients with IBD.Conclusion: To our knowledge, this is the first study to demonstrate a significant association between specific bacterial taxa and inflammatory markers in Japanese patients with IBD. Clostridium clusters IV and XIVa may serve as biomarkers, although potential confounders such as age, sex, and concurrent medication use should be recognized as study limitations. J. Med. Invest. 73 : 92-100, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"92-100"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influences of ampicillin exposure in early life on the murine gut microbiota and steatotic liver disease associated with western diet. 早期氨苄西林暴露对小鼠肠道微生物群和与西方饮食相关的脂肪变性肝病的影响

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.186

Ryuji Ishikawa, Maki Nakamura, Akiko Sakurai, Haruyuki Nakayama-Imaohji, Tomomi Kuwahara, Mayuko Ichimura-Shimizu, Masami Shishibori, Keiko Kataoka

{"title":"Influences of ampicillin exposure in early life on the murine gut microbiota and steatotic liver disease associated with western diet.","authors":"Ryuji Ishikawa, Maki Nakamura, Akiko Sakurai, Haruyuki Nakayama-Imaohji, Tomomi Kuwahara, Mayuko Ichimura-Shimizu, Masami Shishibori, Keiko Kataoka","doi":"10.2152/jmi.73.186","DOIUrl":"10.2152/jmi.73.186","url":null,"abstract":"Dysbiosis of gut microbiota is one of the important factors associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Antibiotic use, especially in early life, could profoundly disrupt an establishing process of stable gut microbiota, and the influence on gut environment may persist throughout life. In this study, we examined effects of ampicillin exposure (AMP) in early life on the temporal changes of fecal microbiota and severity of MASLD in western diet-fed C57BL/6J mice. Histological evaluation of MASLD showed that steatosis in female mice and lobular inflammation was significantly influenced with AMP, and that NAS (MASLD activity score constituting from score of steatosis, lobular inflammation, and ballooning degeneration) tended to be high in female of AMP-treated group. 16S metagenome analyses of fecal microbiota showed significant decrease of α-diversity and remarkable shift to normally minor bacterial species at 4 weeks of age in AMP-treated mice, and the influence was continuously observed even after finishing the western diet feeding period. α-Diversity at 4weeks of age negatively correlated with combined scores of steatohepatitis and fibrosis. These results suggest that AMP in early life induced dysbiosis of gut microbiota and could promote the development of western diet-associated steatotic liver disease. J. Med. Invest. 73 : 186-207, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"186-207"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in the impact of structured education together with isCGM in individuals with type 1 diabetes:post hoc analysis of the ISCHIA study. 结构化教育和isCGM对1型糖尿病患者影响的性别差异：ISCHIA研究的事后分析

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.74

Shuichiro Saito, Yushi Hirota, Akane Yamamoto, Mariko Ueda, Shu Meguro, Kiminori Hosoda, Arata Itoh, Ken Kato, Noriko Kodani, Akio Kuroda, Munehide Matsuhisa, Junnosuke Miura, Akira Shimada, Atsuhito Tone, Masao Toyoda, Naoki Sakane, Takashi Murata

{"title":"Sex differences in the impact of structured education together with isCGM in individuals with type 1 diabetes:post hoc analysis of the ISCHIA study.","authors":"Shuichiro Saito, Yushi Hirota, Akane Yamamoto, Mariko Ueda, Shu Meguro, Kiminori Hosoda, Arata Itoh, Ken Kato, Noriko Kodani, Akio Kuroda, Munehide Matsuhisa, Junnosuke Miura, Akira Shimada, Atsuhito Tone, Masao Toyoda, Naoki Sakane, Takashi Murata","doi":"10.2152/jmi.73.74","DOIUrl":"10.2152/jmi.73.74","url":null,"abstract":"Background: The ISCHIA study demonstrated that intermittently scanned continuous glucose monitoring (isCGM) combined with structured education effectively reduced the time below range (TBR) in individuals with type 1 diabetes. Given that the influence of sex on CGM metrics has remained unclear, we performed a post hoc analysis of the ISCHIA study to evaluate the impact of isCGM together with structured education on TBR and other parameters in men and women separately.Methods: Data for 93 individuals who completed the ISCHIA study were analyzed. Baseline characteristics and intervention outcomes, including CGM indices and quality of life (QOL) scores, were stratified by sex for comparative analysis.Results: Age, body mass index, disease duration, and insulin dosage at baseline did not differ significantly between men and women. Intervention outcomes including TBR (9.9±6.2% vs 10.3±7.6% for men vs women, respectively), time in range (61.5±11.2% vs 59.7±10.9%), and time above range (28.6±12.7% vs 30.0±13.4%) as well as QOL scores also did not show any significant sex differences.Conclusion: The use of isCGM together with structured education was suggested to be effective in reducing TBR among individuals with type 1 diabetes regardless of sex. J. Med. Invest. 73 : 74-79, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"74-79"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the efficacy of sublingual immunotherapy and prophylactic treatment with antihistamines on allergic rhinitis symptoms and quality of life in small and large Japanese cedar pollen dispersal years. 舌下免疫治疗与抗组胺预防治疗对小、大杉木花粉散布年变应性鼻炎症状及生活质量的疗效比较

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.55

Tatsuya Fujii, Seiichiro Kamimura, Keisuke Ishitani, Yoshiaki Kitamura

{"title":"Comparison of the efficacy of sublingual immunotherapy and prophylactic treatment with antihistamines on allergic rhinitis symptoms and quality of life in small and large Japanese cedar pollen dispersal years.","authors":"Tatsuya Fujii, Seiichiro Kamimura, Keisuke Ishitani, Yoshiaki Kitamura","doi":"10.2152/jmi.73.55","DOIUrl":"10.2152/jmi.73.55","url":null,"abstract":"Background: It remains to be elucidated that the differences in treatment effects on allergic rhinitis (AR) symptoms and quality of life (QOL) in patients with Japanese cedar (JC) pollinosis during different pollen dispersal seasons.Objectives: We compared the effects of sublingual immunotherapy (SLIT) with JC pollen tablets and prophylactic treatment with antihistamines on AR symptoms and QOL during different JC pollen dispersal seasons.Material and methods: 106 and 129 patients with JC pollinosis were enrolled during the small and large JC pollen dispersal seasons, respectively. They were categorized into the SLIT, antihistamine, and untreated groups. AR symptoms and QOL scores were evaluated.Results: The SLIT group showed significant improvement in all AR symptoms and QOL scores compared with the untreated group during both the small and large pollen dispersal seasons. The antihistamine group showed significantly improved nasal symptoms and higher QOL scores than the untreated group during the small pollen dispersal season, but it did not show any improved QOL scores, during the large pollen dispersal season.Conclusions: These findings suggested that JC pollen SLIT was more effective in suppressing AR symptoms than prophylactic treatment with antihistamines, resulting in improved QOL during the large JC pollen dispersal season. J. Med. Invest. 73 : 55-61, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"55-61"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exiting nerve root injury during full-endoscopic trans-Kambin's triangle lumbar interbody fusion (FE-KLIF) and how to avoid it:a multicenter study. 全内窥镜下经kambin三角腰椎椎体间融合术（FE-KLIF）中存在神经根损伤及如何避免：一项多中心研究。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.26

Kozaburo Mizutani, Masatoshi Morimoto, Seiji Yamaya, Kiyoshi Yagi, Kazuya Kishima, Takashi Inokuchi, Shutaro Fujimoto, Takahiro Ogawa, Tomoya Terai, Nobutoshi Takamatsu, Kazuta Yamashita, Fumitake Tezuka, Kosuke Sugiura, Masashi Kumon, Yutaro Kanda, Saori Soeda, Naoki Morozumi, Hideki Murakami, Toshiya Tachibana, Atsushi Teramoto, Toshinori Sakai, Hiroshi Ito, Haruhiko Akiyama, Junzo Fujitani, Koichi Sairyo

{"title":"Exiting nerve root injury during full-endoscopic trans-Kambin's triangle lumbar interbody fusion (FE-KLIF) and how to avoid it:a multicenter study.","authors":"Kozaburo Mizutani, Masatoshi Morimoto, Seiji Yamaya, Kiyoshi Yagi, Kazuya Kishima, Takashi Inokuchi, Shutaro Fujimoto, Takahiro Ogawa, Tomoya Terai, Nobutoshi Takamatsu, Kazuta Yamashita, Fumitake Tezuka, Kosuke Sugiura, Masashi Kumon, Yutaro Kanda, Saori Soeda, Naoki Morozumi, Hideki Murakami, Toshiya Tachibana, Atsushi Teramoto, Toshinori Sakai, Hiroshi Ito, Haruhiko Akiyama, Junzo Fujitani, Koichi Sairyo","doi":"10.2152/jmi.73.26","DOIUrl":"10.2152/jmi.73.26","url":null,"abstract":"Full-endoscopic trans-Kambin's lumbar interbody fusion (FE-KLIF) is a type of minimally invasive fusion surgery that requires only a 14-mm skin incision for cage insertion. The only surgery-related complication of concern with FE-KLIF is exiting nerve root injury (ENRI). We investigated the incidence of ENRI in 131 cases that underwent FE-KLIF at 10 hospitals. After encountering 5 cases of ENRI, all of which occurred during insertion of an open cannula, we devised a novel type of open cannula, which we call a rescue cannula, to avoid ENRI. There were 5 cases of ENRI (5.7%) in the 88 patients who underwent FE-KLIF before use of the rescue cannula. We have put the rescue cannula in the FE-KLIF system, and one can use the rescue cannula when electromyography alarms. Under such strategy to avoid the ENRI for using the rescue cannula, none of these 43 cases developed ENRI. FE-KLIF is a minimally invasive fusion surgery in which ENRI is the only worrisome complication. Use of a rescue cannula could be the solution to avoiding ENRI. J. Med. Invest. 73 : 26-31, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"26-31"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of exercise intervention according to functional decline risk before and after the study among community-dwelling older adults. 运动干预对社区老年人功能衰退风险研究前后的影响。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.143

Yuya Nakajima, Hidenori Onishi, Yasutaka Mizukami, Yuki Niida, Tomoko Okamoto, Naohiro Konoshita, Tokuharu Tanaka, Masafumi Kubota, Hideaki Hori, Akiko Matsunaga, Masamichi Ikawa, Yasutaka Kobayashi, Hiroyuki Hayashi, Osamu Yamamura

{"title":"Effects of exercise intervention according to functional decline risk before and after the study among community-dwelling older adults.","authors":"Yuya Nakajima, Hidenori Onishi, Yasutaka Mizukami, Yuki Niida, Tomoko Okamoto, Naohiro Konoshita, Tokuharu Tanaka, Masafumi Kubota, Hideaki Hori, Akiko Matsunaga, Masamichi Ikawa, Yasutaka Kobayashi, Hiroyuki Hayashi, Osamu Yamamura","doi":"10.2152/jmi.73.143","DOIUrl":"10.2152/jmi.73.143","url":null,"abstract":"Introduction: This study aimed to clarify the effects of exercise interventions on the risk of functional decline.Methods: This study included community-dwelling older adults who volunteered to participate in physical fitness measurement sessions and remote exercise classes. The participants were stratified into high-risk (HR) and low-risk (LR) groups based on the cutoff value (16/17 points) of the risk assessment scale for incident functional disability. Body composition and physical function were measured before the exercise intervention, and changes were re-measured 2-3 months after the exercise.Results: The analysis included 65 participants with complete data. Twenty-five had HR, and 40 had LR. In the HR group, significant decreases were observed in leg muscle score, phase angle of the whole body and lower limbs, gait speed, and single-leg stance. After exercise, handgrip strength and gait speed improved significantly in both the HR (p<0.001, p<0.001) and LR (p=0.002, p<0.001) groups. Fat mass and body fat percentage also increased significantly in the HR (p=0.022, p=0.017) and LR (p=0.001, p<0.001) groups.Conclusion: Exercise intervention improves physical function regardless of the risk of functional decline. However, certain challenges in maintaining body composition have been observed, suggesting the need for nutritional interventions. J. Med. Invest. 73 : 143-152, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"143-152"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a staying power scale for nurses. 护士持久力量表的研制。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.153

Saori Kamishirakawa, Reiko Okahisa, Yukie Iwasa

{"title":"Development of a staying power scale for nurses.","authors":"Saori Kamishirakawa, Reiko Okahisa, Yukie Iwasa","doi":"10.2152/jmi.73.153","DOIUrl":"10.2152/jmi.73.153","url":null,"abstract":"Nurse retention is a major concern worldwide, as a shortage of experienced nurses can affect the quality and continuity of patient care;however, a reliable tool for evaluating it needs to be developed. This study aimed to develop a Staying Power Scale for Nurses (SPSN) and evaluate its reliability and validity. Following a pilot study, we developed a 35-item SPSN. SPSN reliability was measured using Cronbach's α, and its validity was tested through exploratory and confirmatory factor analyses. Data from 802 nurses were analyzed (response rate, 38.8%;valid responses, 94.1%);31 items were identified and grouped into four factors:aspiration for nursing development, mission-based team engagement, adaptive thinking, and interpersonal consideration. The overall α coefficient for the SPSN was 0.927;subscale values ranged from 0.871 to 0.901. Confirmatory factor analysis showed that the model had acceptable fit indices. The SPSN showed significant positive correlations with the Nurse Resilience Scale, Nurse Work Motivation Scale, and Trait Self-Efficacy Scale, with high reliability and validity. The SPSN is a novel robust tool for assessing nurses' staying power. J. Med. Invest. 73 : 153-165, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"153-165"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation management for a dysfunctional/non-painful (DN) joint causing low back disorder in an elite athlete: A case report. 康复管理功能障碍/非疼痛性（DN）关节引起的腰背部疾病的精英运动员：一个病例报告。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.274

Takafumi Ohshima, Junzo Fujitani, Ken Tomonari, Naoto Ono, Takayuki Kitahara, Yuji Nagao, Saori Soeda, Kosuke Sugiura, Masatoshi Morimoto, Hiroaki Manabe, Fumitake Tezuka, Hiroshi Kageyama, Kazuta Yamashita, Koichi Sairyo

{"title":"Rehabilitation management for a dysfunctional/non-painful (DN) joint causing low back disorder in an elite athlete: A case report.","authors":"Takafumi Ohshima, Junzo Fujitani, Ken Tomonari, Naoto Ono, Takayuki Kitahara, Yuji Nagao, Saori Soeda, Kosuke Sugiura, Masatoshi Morimoto, Hiroaki Manabe, Fumitake Tezuka, Hiroshi Kageyama, Kazuta Yamashita, Koichi Sairyo","doi":"10.2152/jmi.73.274","DOIUrl":"10.2152/jmi.73.274","url":null,"abstract":"Low back pain in athletes can arise from asymptomatic dysfunctional/non-painful (DN) joints, which cause compensatory stress on adjacent regions. This report highlights the clinical importance of identifying and correcting these underlying 'DN joints,' integrating concepts from the Selective Functional Movement Assessment and the joint-by-joint approach to prevent recurrence. A 25-year-old female professional volleyball player underwent surgery for L5 radiculopathy due to disc herniation. Postoperatively, a functional assessment revealed DN joints:restricted mobility in her right glenohumeral joint and thoracic spine. This dysfunction led to compensatory lumbar lateral flexion during spiking motions and unilateral landing on the left foot after spiking, increasing mechanical stress on her lower back. A rehabilitation program successfully corrected these DN joints. Consequently, the compensatory movement pattern resolved. The patient returned to competition six months post-surgery and remained pain-free at a two-year follow-up, competing at her pre-injury level. This case demonstrates that addressing asymptomatic DN joints as the root cause of symptomatic lumbar disorders is crucial for athletes. This comprehensive approach, which looks beyond the site of pain, is essential for a durable recovery and the prevention of injury recurrence. J. Med. Invest. 73 : 274-280, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"274-280"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Adenosquamous Carcinoma with Direct Gastric Invasion:Preoperative Diagnosis by Endoscopic Biopsy -A Case Report. 直接侵犯胃的胰腺腺鳞癌：术前内镜活检诊断1例。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.286

Masako Shiba, Kenichi Yoneda, Tatsunao Sueuchi, Miwako Kagawa, Ryo Shinomiya, Takanori Miyake, Yasushi Sato, Masahiro Sogabe, Toshiya Okahisa, Tetsuji Takayama

{"title":"Pancreatic Adenosquamous Carcinoma with Direct Gastric Invasion:Preoperative Diagnosis by Endoscopic Biopsy -A Case Report.","authors":"Masako Shiba, Kenichi Yoneda, Tatsunao Sueuchi, Miwako Kagawa, Ryo Shinomiya, Takanori Miyake, Yasushi Sato, Masahiro Sogabe, Toshiya Okahisa, Tetsuji Takayama","doi":"10.2152/jmi.73.286","DOIUrl":"10.2152/jmi.73.286","url":null,"abstract":"Pancreatic adenosquamous carcinoma (PASC) is a rare and highly aggressive subtype of pancreatic cancer with a dismal prognosis, and its preoperative diagnosis remains challenging. We report the case of an 82-year-old man who presented with epigastric pain and appetite loss. Imaging studies revealed a large, partially necrotic mass in the tail of the pancreas that was contiguous with the posterior gastric wall, accompanied by multiple metastases to the liver, lungs, regional lymph nodes, and peritoneum. Upper gastrointestinal endoscopy identified a large, excavated ulcer within a submucosal tumor-like elevation, and biopsies from the ulcer margin confirmed the presence of squamous cell carcinoma. The pathological findings showed PASC. The patient was diagnosed with Stage Ⅳ PASC, and palliative care was selected in view of advanced dementia and disease extent. This case shows that PASC can present with direct gastric penetration, and it highlights the value of direct endoscopic biopsy of the invaded gastric site to secure a definitive preoperative histopathologic diagnosis. PASC should be considered in the differential diagnosis of pancreatic masses that exhibit gastric invasion and marked internal necrosis on imaging. J. Med. Invest. 73 : 286-290, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"286-290"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of advanced rectal cancer treated with chemotherapy after developing short bowel syndrome following emergency surgery for superior mesenteric artery embolism. 晚期直肠癌肠系膜上动脉栓塞急诊手术后发生短肠综合征，化疗治疗1例。

IF 0.9

JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2026-01-01 DOI: 10.2152/jmi.73.260

Yuta Iizuka, Takuya Shiraishi, Arisa Yamaguchi, Yuta Shibasaki, Takuhisa Okada, Katsuya Osone, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki

{"title":"A case of advanced rectal cancer treated with chemotherapy after developing short bowel syndrome following emergency surgery for superior mesenteric artery embolism.","authors":"Yuta Iizuka, Takuya Shiraishi, Arisa Yamaguchi, Yuta Shibasaki, Takuhisa Okada, Katsuya Osone, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki","doi":"10.2152/jmi.73.260","DOIUrl":"10.2152/jmi.73.260","url":null,"abstract":"Introduction: While venous thrombosis is often associated with malignancy, arterial thromboembolisms are rare. We report a case of unresectable rectal cancer complicated by superior mesenteric artery (SMA) embolism, resulting in short bowel syndrome (SBS), but was successfully treated with chemotherapy.Case presentation: A 60-year-old woman with unresectable rectal cancer presented to our hospital with abdominal pain. Computed tomography revealed contrast defects originating from the SMA. In addition, CT demonstrated small intestinal wall disruption and free air. She was diagnosed with small intestinal ischemia and gastrointestinal perforation due to SMA embolism. Emergency small intestinal resection and jejunostomy were performed (operative time, 77 min; blood loss, 80 mL). The stoma was created 60 cm from the ligament of Treitz, resulting in the development of SBS. After stabilization with fluid management, a central venous port was placed. Chemotherapy was initiated, and the patient was discharged on postoperative day 29. The tumor shrank after completing four courses of chemotherapy. The patient received home parenteral nutrition and had nine courses of chemotherapy.Conclusions: This case suggests that the introduction of chemotherapy may be feasible and effective even in patients with SBS secondary to SMA embolism. SBS should not preclude chemotherapy in patients with malignant tumors. J. Med. Invest. 73 : 260-264, February, 2026.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"260-264"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0