JOURNAL OF MEDICAL INVESTIGATION最新文献_第4页

Lipolysis-stimulated lipoprotein receptor is involved in fatty acid binding protein 4-mediated prostate cancer cell growth in bone. 脂溶刺激脂蛋白受体参与脂肪酸结合蛋白4介导的骨内前列腺癌细胞生长。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2025-01-01 DOI: 10.2152/jmi.72.34

Tetsuyuki Takahashi, Takaaki Tsunematsu, Hisanori Uehara

引用次数: 0

Current State of Healthcare Robots for Older Adults in Care Facilities in Japan and the Related Ethical Issues for Nurses. 日本护理机构中老年人医疗保健机器人的现状以及护士的相关道德问题。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2025-01-01 DOI: 10.2152/jmi.72.8

Yuko Yasuhara

引用次数: 0

Application of a paraffin-embedded pleural effusion cell block to detect mycobacteria : A case of Mycobacterium goodii pleuritis. 应用石蜡包埋胸腔积液细胞块检测分枝杆菌：一例良地分枝杆菌胸膜炎。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2025-01-01 DOI: 10.2152/jmi.72.202

Yasumichi Matsuzawa, Yuriko Igarashi, Michihiro Kunishige, Hiroki Takahashi, Kenya Sumitomo, Yoshiro Murase, Satoshi Mitarai, Tsutomu Shinohara

{"title":"Application of a paraffin-embedded pleural effusion cell block to detect mycobacteria : A case of Mycobacterium goodii pleuritis.","authors":"Yasumichi Matsuzawa, Yuriko Igarashi, Michihiro Kunishige, Hiroki Takahashi, Kenya Sumitomo, Yoshiro Murase, Satoshi Mitarai, Tsutomu Shinohara","doi":"10.2152/jmi.72.202","DOIUrl":"https://doi.org/10.2152/jmi.72.202","url":null,"abstract":"The diagnosis of pleuritis caused by mycobacteria is not always easy. Ziehl-Nielsen staining utilizing cell blocks (CBs) of lower respiratory samples was reported to be useful in the diagnosis of pulmonary tuberculosis. However, CBs of pleural effusion (PE) are not commonly used in the differential diagnosis of benign pleuritis. A 100-year-old woman was transferred to our emergency department due to respiratory failure. The patient had massive right PE and an elevated serum carbohydrate antigen 125 level, but no tumor lesions were identified. Mycobacterial examinations using the usual procedures for PE did not lead to a definitive diagnosis. However, Ziehl-Nielsen staining detected several accumulations of acid-fast bacilli in paraffin-embedded PE-CB sections. Finally, sequence analysis of the 16S rRNA gene using the remaining PE-CB showed high homology (99.79%) to that of Mycobacterium goodii. This case suggests that analysis of PE-CBs may be useful for diagnosing suspected cases of mycobacteria-induced pleuritis with negative acid-fast bacilli smears for PE. J. Med. Invest. 72 : 202-206, February, 2025.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"72 1.2","pages":"202-206"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Location of ethmoidal arteries in relation to ethmoid cells and the anterior skull base. 乙状动脉与乙状细胞和前颅底的位置关系。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.273

Seiichiro Kamimura, Keisuke Ishitani, Hitoshi Shono, Ryo Kanamura, Tatsuya Fujii, Eiji Kondo, Takahiro Azuma, Go Sato, Yoshiaki Kitamura

{"title":"Location of ethmoidal arteries in relation to ethmoid cells and the anterior skull base.","authors":"Seiichiro Kamimura, Keisuke Ishitani, Hitoshi Shono, Ryo Kanamura, Tatsuya Fujii, Eiji Kondo, Takahiro Azuma, Go Sato, Yoshiaki Kitamura","doi":"10.2152/jmi.71.273","DOIUrl":"https://doi.org/10.2152/jmi.71.273","url":null,"abstract":"Background: Ethmoidal arteries are at risk of accidental injury during endoscopic sinus surgery (ESS).Aims/objectives: We aimed to examine the location of ethmoidal arteries in relation to ethmoid cells and the anterior skull base (ASB) in Japanese patients.Material and methods: CT images of 100 sides of 50 patients were retrospectively reviewed. The location of anterior ethmoidal arteries (AEAs), middle ethmoidal arteries (MEAs) and posterior ethmoidal arteries (PEAs) in relation to ethmoidal cells and their distance from the ASB were evaluated.Results: AEAs and PEAs were present in all sides. 60% of AEAs and 9% of PEAs ran below the level of ASB. MEAs were present in 21 sides and ran below the ASB in 23.8% (5/21) of these sides. The incidence of AEAs running below the level of ASB was significantly higher in the sides with supraorbital ethmoid cells (SOECs) than in those without SOECs.Conclusion and significance: This study revealed the position and the distance from ASB of AEAs, PEAs, and MEAs in relation to ethmoid cells in Japanese patients. In cases with SOECs, surgeons should be careful not to injure the AEAs running below the level of ASB. J. Med. Invest. 71 : 273-278, August, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 3.4","pages":"273-278"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full-Endoscopic Foraminal Decompression for Foraminal Stenosis Following Osteoporotic Vertebral Fracture in an Elderly Woman Under Local Anesthesia:A Case Report. 在局部麻醉下用全内窥镜椎间孔减压术治疗老年女性骨质疏松性椎体骨折后的椎间孔狭窄：病例报告。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.179

Yu Otake, Fumitake Tezuka, Kazuta Yamashita, Masatoshi Morimoto, Kosuke Sugiura, Makoto Takeuchi, Shunsuke Tamaki, Junzo Fujitani, Hiroshi Kageyama, Koichi Sairyo

{"title":"Full-Endoscopic Foraminal Decompression for Foraminal Stenosis Following Osteoporotic Vertebral Fracture in an Elderly Woman Under Local Anesthesia:A Case Report.","authors":"Yu Otake, Fumitake Tezuka, Kazuta Yamashita, Masatoshi Morimoto, Kosuke Sugiura, Makoto Takeuchi, Shunsuke Tamaki, Junzo Fujitani, Hiroshi Kageyama, Koichi Sairyo","doi":"10.2152/jmi.71.179","DOIUrl":"10.2152/jmi.71.179","url":null,"abstract":"Osteoporotic vertebral fracture (OVF) is common in the elderly population. In this report, we describe a case with radiculopathy due to foraminal stenosis caused by OVF in a very elderly patient that was treated successfully by full-endoscopic foraminotomy under local anesthesia. The patient was an 89-year-old woman who presented with a chief complaint of left leg pain for 5 years. She visited a couple of hospitals and finally consulted us to determine the exact cause of the pain. Computed tomography scans were obtained and selective nerve root block at L3 was performed. The diagnosis was radiculopathy at L3 due to foraminal stenosis following OVF. The patient had severe heart disease, so we decided to avoid surgery under general anesthesia and planned full-endoscopic spine surgery under local anesthesia. We performed transforaminal full-endoscopic lumbar foraminotomy at L3-L4 to decompress the L3 nerve root. The leg pain disappeared completely immediately after surgery. Postoperative computed tomography confirmed appropriate bone resection. The leg pain did not recur during a year of postoperative follow-up. OVF may cause lumbar radiculopathy as a result of foraminal stenosis, and transforaminal full-endoscopic lumbar foraminotomy under local anesthesia would be the best option in an elderly patient with poor general condition. J. Med. Invest. 71 : 179-183, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"179-183"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric Home-Visiting Nurses' Views on the Care Information Required of Psychiatric Hospital Nurses. 精神科家庭巡诊护士对精神科医院护士所需护理信息的看法。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.162

Yoshiyuki Takashima, Allan Paulo Blaquera, Feni Betriana, Hirokazu Ito, Yuko Yasuhara, Gil Soriano, Tetsuya Tanioka

{"title":"Psychiatric Home-Visiting Nurses' Views on the Care Information Required of Psychiatric Hospital Nurses.","authors":"Yoshiyuki Takashima, Allan Paulo Blaquera, Feni Betriana, Hirokazu Ito, Yuko Yasuhara, Gil Soriano, Tetsuya Tanioka","doi":"10.2152/jmi.71.162","DOIUrl":"https://doi.org/10.2152/jmi.71.162","url":null,"abstract":"The \"construction of a community-based comprehensive care system for mental disorders\" has been promoted in Japan. However, nurses in psychiatric hospitals do not intervene with community resources and support networks in Japan. This study aimed to determine the care information required by home visit nurses from psychiatric hospital nurses. A qualitative descriptive research design was employed. Semi-structured interviews were conducted with nine psychiatric home-visiting nurses, and content analysis was performed to analyze the data. Findings revealed 319 narratives about the information that psychiatric home-visiting nurses seek from psychiatric hospital nurses, which were classified into six main categories. Information needed for home-visiting nurses to provide care includes the following : 1) to build trust with home-visiting service users, 2) to help home-visiting service users live according to their wishes, 3) to help home-visiting service users continue treatment in the community, 4) to perform symptom management, 5) to provide family care, and 6) to protect the safety of home visiting nurses during home visits. Nurses in psychiatric hospitals should communicate this information to nurses who provide psychiatric home care. This will improve the quality of continuing care for home care users and support their recovery in community living. J. Med. Invest. 71 : 162-168, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"162-168"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Prefrontal Cortex Blood Flow Dynamics during Silent and Oral Reading Using Near-Infrared Spectroscopy. 利用近红外光谱分析默读和口语阅读时的双侧前额叶皮层血流动态。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.92

Natsue Nozaki, Kenji Mori, Tetsuya Tanioka, Keiko Mori, Kumi Takahashi, Hiroko Hashimoto, Takahiro Tayama, Aya Goji, Tatsuo Mori

{"title":"Bilateral Prefrontal Cortex Blood Flow Dynamics during Silent and Oral Reading Using Near-Infrared Spectroscopy.","authors":"Natsue Nozaki, Kenji Mori, Tetsuya Tanioka, Keiko Mori, Kumi Takahashi, Hiroko Hashimoto, Takahiro Tayama, Aya Goji, Tatsuo Mori","doi":"10.2152/jmi.71.92","DOIUrl":"https://doi.org/10.2152/jmi.71.92","url":null,"abstract":"This study aimed to investigate blood flow dynamics in the bilateral prefrontal cortex during silent and oral reading using near-infrared spectroscopy (NIRS). The subjects were 40 right-handed university students (20.5±1.8 years old, 20 men and 20 women). After completing the NIRS measurements, the subjects were asked to rate their level of proficiency in silent and oral reading, using a 5-point Likert scale. During oral reading, the left lateral prefrontal cortex (Broca's area) was significantly more active than the right side. During silent reading, prefrontal cortex activity was lower than that during oral reading, and there was no significant difference between both sides of the brain. A significant negative correlation was found between the change in oxy-hemoglobin (oxy-Hb) concentration in the left and right lateral prefrontal cortex during silent reading and silent reading speed. In addition, students with lower self-reported reading proficiency had significantly greater changes in oxy-Hb concentrations in the left and right lateral prefrontal cortex during silent/oral reading than did students with higher self-reported reading proficiency. Reading task assessment using NIRS may be useful for identifying language lateralization and Broca's area. The results demonstrate that NIRS is useful for assessing effortful reading and may be used to diagnose developmental dyslexia in children. J. Med. Invest. 71 : 92-101, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"92-101"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes. 吡咯喹啉醌二钠盐对大脑功能和生理过程的影响。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.23

Kazuto Ikemoto, Nur Syafiqah Mohamad Ishak, Mitsugu Akagawa

{"title":"The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes.","authors":"Kazuto Ikemoto, Nur Syafiqah Mohamad Ishak, Mitsugu Akagawa","doi":"10.2152/jmi.71.23","DOIUrl":"10.2152/jmi.71.23","url":null,"abstract":"Pyrroloquinoline quinone disodium salt (PQQ) is a red trihydrate crystal that was approved as a new food ingredient by FDA in 2008. Now, it is approved as a food in Japan and the EU. PQQ has redox properties and exerts antioxidant, neuroprotective, and mitochondrial biogenesis effects. The baseline intake level of PQQ is considered to be 20 mg/day. PQQ ingestion lowers blood lipid peroxide levels in humans, suggesting antioxidant activity. In the field of cognitive function, double-blind, placebo-controlled trials have been conducted. Various improvements have been reported regarding general memory, verbal memory, working memory, and attention. Furthermore, a stratified analysis of a population with a wide range of ages revealed unique effects in young people (20-40 years old) that were not observed in older adults (41-65 years old). Specifically, cognitive flexibility and executive speed improved more rapidly in young people at 8 weeks. Co-administration of PQQ and coenzyme Q10 further enhanced these effects. In an open-label trial, PQQ was shown to improve sleep and mood. Additionally, PQQ was found to suppress skin moisture loss and increase PGC-1α expression. Overall, PQQ is a food with various functions, including brain health benefits. J. Med. Invest. 71 : 23-28, February, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 1.2","pages":"23-28"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of pulmonary Mycobacterium heckeshornense infection coexisted with lung cancer. 一例肺部赫氏分枝杆菌感染与肺癌并存的病例。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.327

Masaki Hanibuchi, Mari Miki, Kanna Hiraoka, Masafumi Nakamura, Yoshimi Tsujimoto, Tokujiro Yamamura, Kojin Murakami, Hirokazu Ogino, Seidai Sato, Yasuhiko Nishioka

{"title":"A case of pulmonary Mycobacterium heckeshornense infection coexisted with lung cancer.","authors":"Masaki Hanibuchi, Mari Miki, Kanna Hiraoka, Masafumi Nakamura, Yoshimi Tsujimoto, Tokujiro Yamamura, Kojin Murakami, Hirokazu Ogino, Seidai Sato, Yasuhiko Nishioka","doi":"10.2152/jmi.71.327","DOIUrl":"10.2152/jmi.71.327","url":null,"abstract":"A 71-year-old male was referred to our institution for further examination of chest abnormal shadow. A cavitation in the right apical region, a mass adjacent to the pleura in the right upper lobe, and a nodule in the right middle lobe were observed in a chest computed tomography. The sputum smear and culture of acid-fast bacilli were positive, and Mycobacterium heckeshornense (M. heckeshornense) was identified with the matrix-assisted laser desorption ionization time-of-flight mass spectroscopy. Moreover, computed tomography-guided biopsy of a mass adjacent to the pleura in the right upper lobe yielded the diagnosis of primary lung adenocarcinoma. Taken together, the patient was finally diagnosed as coexistence of pulmonary M. heckeshornense infection and primary lung cancer. An anti-mycobacterial treatment with rifampicin, ethambutol and clarithromycin and a combined chemotherapy were fairly successful for pulmonary M. heckeshornense infection and primary lung adenocarcinoma, respectively. These observations suggest that triple anti-mycobacterial therapy may contribute to good controls of M. heckeshornense infection and that careful selection of anti-cancer drugs against lung cancer might be lead to favorable outcomes even during the course of anti-mycobacterial treatment. To the best of our knowledge, this is the first report of pulmonary M. heckeshornense infection coexisted with lung cancer. J. Med. Invest. 71 : 327-331, August, 2024.","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"71 3.4","pages":"327-331"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent Akinetic Mutism after Bilateral Paramedian Thalamic Infarction Caused by Artery of Percheron Occlusion:A Case Report. 佩切隆动脉闭塞导致双侧副丘脑梗死后的间歇性动眼神经障碍：病例报告。

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JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI: 10.2152/jmi.71.306

Daisuke Imazato, Yuichi Kubota, Hiroki Ebise, Suguru Yokosako, Naoyuki Arai, Shinji Hagiwara, Hidenori Ohbuchi

引用次数: 0