Biomedical Engineering Letters最新文献

{"title":"Correction: Recent strategies for designing adhesive hydrogels to enhance muscle tissue regeneration.","authors":"Yesung Lee, Youbin Park, Mikyung Shin","doi":"10.1007/s13534-026-00558-z","DOIUrl":"10.1007/s13534-026-00558-z","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13534-025-00540-1.].</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"573"},"PeriodicalIF":2.8,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional hydrogels as submucosal injectable materials in therapeutic endoscopy.","authors":"Chi-Pin James Wang, Chun Gwon Park, Se-Na Kim","doi":"10.1007/s13534-026-00561-4","DOIUrl":"10.1007/s13534-026-00561-4","url":null,"abstract":"<p><p>Therapeutic endoscopy, including endoscopic submucosal dissection (ESD), has transformed the management of early gastrointestinal (GI) cancers by enabling the resection of large and complex lesions. However, its widespread adoption remains limited by technical difficulty and the high risk of complications such as bleeding, perforation, and stricture. Submucosal injection materials (SIMs) are critical to ESD procedures as they provide mucosal elevation, but the elevation achieved by solution-based SIMs is typically short-lived due to rapid absorption or diffusion, often necessitating multiple injections during surgery. Recent advances in injectable hydrogels present a promising strategy to overcome these limitations. Owing to their tunable physicochemical and biological properties, hydrogels can prolong submucosal elevation, reduce injection force, and actively contribute to the management of complications. Preclinical investigations of two-component, thermoresponsive, and shear-thinning hydrogels have demonstrated favorable biocompatibility and compatibility with endoscopic delivery systems. Moreover, functional hydrogels engineered with hemostatic, adhesive, antifibrotic, or regenerative properties have shown potential to mitigate intraprocedural bleeding, accelerate wound healing, and prevent stricture formation. This review aims to provide a comprehensive overview of preclinical hydrogel-based SIMs, focusing on how these novel materials may reshape the tools and strategies available in advanced endoscopic practices, particularly ESD.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"329-352"},"PeriodicalIF":2.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molybdenum disulfide based nanohybrids: insights into their role in electrochemical cancer biomarker detection.","authors":"Naveen Thanjavur, Young-Joon Kim","doi":"10.1007/s13534-026-00562-3","DOIUrl":"https://doi.org/10.1007/s13534-026-00562-3","url":null,"abstract":"<p><p>Cancer remains a leading cause of global mortality, where early detection and continuous monitoring are critical for improving therapeutic outcomes. However, conventional diagnostic techniques suffer from high cost, long assay times, invasiveness, and limited sensitivity at early disease stages. In this context, electrochemical biosensors have emerged as promising alternatives due to their rapid response, cost effectiveness, low sample volume requirements, high sensitivity, and compatibility with point-of-care testing. Recent advances highlight the pivotal role of electrode materials in translating biomolecular recognition into reliable electrical signals, particularly for detecting cancer-associated biomarkers near clinically relevant threshold levels. Among emerging semiconducting materials, molybdenum disulfide (MoS₂) has attracted significant attention owing to its layered two-dimensional structure, tunable bandgap, abundant electroactive edge sites, and versatile surface chemistry. This review critically examines recent progress in MoS₂ nanohybrid based electrochemical biosensors for cancer detection, focusing on material design strategies, fabrication approaches, and biomarker-specific sensing architectures. Emphasis is placed on MoS₂ hybrid systems incorporating carbon nanostructures, metal nanomaterials, metal oxides, polymers, MOFs, and other nanostructures, as well as their roles in enhancing signal transduction and real-time applicability in clinical samples. Finally, current challenges are outlined towards developing clinically translatable electrochemical sensing systems for early cancer detection and disease diagnosis. Furthermore, this review highlights the potential of integrating semiconductor-based electrochemical sensors with threshold-based diagnostic strategies as a promising future direction for point-of-care cancer detection.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 3","pages":"575-593"},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of PVA/PAA/GO nanofiber scaffolds for advanced wound dressing applications.","authors":"Yousof Moradian Haftcheshmeh, Majid Salehi, Tahereh Sadat Tabatabai, Tayebeh Sadat Tabatabai, Mozhgan Fazli, Vahid Shirshahi","doi":"10.1007/s13534-026-00552-5","DOIUrl":"https://doi.org/10.1007/s13534-026-00552-5","url":null,"abstract":"<p><p>This study aimed to develop and evaluate nanofiber scaffolds for advanced wound dressing applications. The nanofibers were fabricated using polyvinyl alcohol, sodium polyacrylic acid, and graphene oxide and were systematically assessed for their physical, chemical, and biological properties. Morphological analysis through scanning electron microscopy revealed a uniform and homogeneous nanofiber structure, while tensile testing confirmed their excellent mechanical strength. Crystallographic characteristics were examined using X-ray diffraction, and Fourier Transform Infrared Spectroscopy verified the chemical composition. The nanofibers demonstrated remarkable fluid absorption capabilities, accommodating both water and blood, which are crucial for effective wound management. Tests for water vapor porosity and permeability further highlighted their ability to create an optimal environment for wound healing. Biological evaluations, including hemolysis and blood adaptation tests, confirmed the nanofibers' biocompatibility. Antibacterial efficacy was thoroughly assessed using MIC, MBC, anti-biofilm, and bacterial penetration tests, showcasing significant inhibitory effects on bacterial activity. Cytotoxicity analysis (MTT) and nuclear staining (DAPI) revealed low toxicity and excellent biocompatibility. Additionally, scratch wound assays demonstrated the positive impact of the nanofibers on cellular migration and signaling, vital for tissue regeneration. In vivo experiments and histological analyses provided further evidence of the nanofibers' ability to support tissue repair and regeneration.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 3","pages":"799-815"},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wear and loosening in THA: results from a multidirectional simulator.","authors":"Atef Boulila, Lanouar Bouzid, Mahfoudh Ayadi","doi":"10.1007/s13534-025-00536-x","DOIUrl":"10.1007/s13534-025-00536-x","url":null,"abstract":"<p><p>Wear and loosening remain major concerns in total hip arthroplasty (THA), particularly in younger, more active patients who demand long-lasting implants. This study investigates wear behavior in three common prosthetic geometries and their material combinations using the TUNIS-3DOF hip simulator under physiological load conditions while adhering to ISO guidelines. A total of ultra-high molecular weight polyethylene (UHMWPE) acetabular cups were combined with stainless steel (SS316L), cobalt-chromium-molybdenum (CoCrMo), and zirconia (ZrO₂) femoral heads and subjected to six million gait cycles. All configurations exhibited a biphasic pattern of wear: a high wear \"running in\" phase, then a level linear regime. Zirconia heads had the lowest wear rates, while SS316L had the highest wear rates, especially exhibited in the early phases of testing. Both increased head diameter and decreased cup thickness both increased wear substantially, such changes commercially could be problematic regarding osteolysis and loosening. The change from abrasive to adhesive was related to radial stress, helped by analytical modelling. These results support the possibility of using reinforced or thicker cups, which may be made by incremental forming or additive methods, to strengthen implant longevity. This research assists in the process of maximizing THA designs to provide prolonged longevity and clinical results-especially in mechanically demanding patient populations.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"539-560"},"PeriodicalIF":2.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive conductors for organ-specific soft bioelectronic interfaces.","authors":"Il Ho Cho, Da Yeon Jang, Hye Jin Kim","doi":"10.1007/s13534-026-00549-0","DOIUrl":"10.1007/s13534-026-00549-0","url":null,"abstract":"<p><p>The realization of precision medicine relies on bioelectronics capable of reliably recording and modulating physiological signals across different organs. However, conventional interfaces based on rigid metals or silicon fail to conform to the soft and deformable nature of biological tissues, leading to signal degradation and long-term instability. These limitations highlight the need for organ-specific interfaces that reflect distinct electrical and mechanical requirements. In this review, we focus on adaptive conductor as key materials to address these challenges and synthesize recent progress in the field. We first compare the electrical and mechanical characteristics of representative organs-including the brain, heart, bladder, colon, and peripheral nerves-and assess the limitations of existing devices. We then outline the essential requirements and fabrication strategies of adaptive conductors, categorized into geometrical designs, nanocomposite engineering, and polymer engineering. Finally, we survey applications of adaptive conductors across multiple organs and highlight how organ-specific design principles can be translated into practical bioelectronics. By integrating recent advances into an organ-specific framework, this review provides a roadmap for the development of next-generation organ-specific soft bioelectronic interfaces.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"283-306"},"PeriodicalIF":2.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomaly detection in brain MRI: a comprehensive review.","authors":"Jihun Kim, Youmin Shin","doi":"10.1007/s13534-026-00551-6","DOIUrl":"10.1007/s13534-026-00551-6","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) plays a central role in diagnosing neurological diseases, offering non-invasive, high-resolution views of brain anatomy. However, manual interpretation remains labor-intensive and subject to variability, particularly when detecting subtle or diffuse abnormalities. The growing volume of imaging data and limited availability of expert annotations have driven interest in artificial intelligence (AI)-based automation. Traditional supervised learning in neuroimaging demand large, annotated datasets and often struggle to generalize due to disease heterogeneity. Anomaly detection has gained attention as a scalable alternative: it models normal brain anatomy and flags deviations as potential abnormalities-without relying on labor-intensive, expert-labeled data. Because brain neuroscience is inherently complex, anomaly detection offers distinct promise in neuroimaging. In this review, we map the field of brain MRI anomaly detection across traditional statistics, classical machine learning (ML), and contemporary deep learning. We organize deep-learning work into three paradigms-reconstruction, generative, and self-supervised-highlighting their core assumptions, advantages, and caveats. Even with recent advances, critical challenges persist-including high false positive rates, unclear definitions of abnormality, limited interpretability, and vulnerability to domain shifts. To address these issues, emerging strategies such as hybrid learning, multimodal integration, and biologically grounded metrics (e.g., brain age gap) show promise in improving robustness and clinical relevance. We conclude with a research agenda for developing generalizable and interpretable AI systems that integrate into real-world neuroimaging workflows. We intend this review to serve as a practical and comprehensive guide for researchers and clinicians advancing reliable, scalable brain-MRI anomaly detection.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13534-026-00551-6.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"369-385"},"PeriodicalIF":2.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative and visual evaluation of dynamic isotropy in dual-axis random positioning machine (RPM) or clinostat for ground-based microgravity simulation.","authors":"Seungkwan Cho, Taehyun Lee, Migyo Shin, Doyong Kim, Tack-Joong Kim, Insu Park, Sangwoo Lee, Han Sung Kim","doi":"10.1007/s13534-026-00553-4","DOIUrl":"10.1007/s13534-026-00553-4","url":null,"abstract":"<p><p>Microgravity profoundly influences cellular morphology and function, yet ground-based simulation requires systems capable of randomizing the gravity vector. A dual-axis rotating machine (RM), such as a clinostat and random positioning machine (RPM), achieves quasi-isotropic gravitational averaging, but its quantitative optimization remains unclear. Here, a computational-experimental framework was established to evaluate dynamic isotropy of a dual-axis RM. Gravity vector trajectories were simulated across rotation ratios, and five metrics-Spherical Coverage (C), Cumulative Bias (H), Normalized Shannon Entropy (H/Hₘₐₓ), Mean Resultant Length (R), and Degree of Gravity Dispersion (DGD)-were integrated into an isotropy index (Sₒₚₜ). The isotropy peaked within an asynchronous range (4.0:3.8, 4.0:3.6, and 4.0:3.4 rpm), where gravity vectors exhibited uniform spherical coverage and minimal bias. To further assess the influence of rotational strength beyond the rotational ratio, an additional experiment was conducted using Huh7 hepatocellular carcinoma spheroids. Under high-speed random rotation (~ 4.0 rpm), cells formed compact, circular spheroids, whereas low-speed (~ 1.0 rpm) or static cultures produced irregular aggregates. These findings indicate that not only the ratio between dual-axis rotations but also the absolute rotational intensity critically affects isotropy and cellular morphogenesis under simulated microgravity. This integrative framework establishes a quantitative foundation for optimizing dual-axis rotating machines.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"561-572"},"PeriodicalIF":2.8,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-perception fusion using shared-control method for brain-mobile robot.","authors":"Chenyang Wang, Mengfan Li, Pengfei Zhang, Ziqi Zhang, Fuyong Wang, Fei Kang","doi":"10.1007/s13534-026-00550-7","DOIUrl":"https://doi.org/10.1007/s13534-026-00550-7","url":null,"abstract":"<p><p>For human-robot collaboration, brain-computer interface is promising to express human perception to improve the adaptability of human-robot collaboration in complex environments. In this study, a multi-perception fusion using shared control method (MPF-SC) is proposed to accurately integrate human perception and robot perception. This MPF-SC is applied in brain-controlled mobile robots to accomplish navigation and obstacle avoidance in complex terrain with multiple undetectable obstacles. The MPF-SC establishes a mapping relationship between visual stimulus interface and environment by computer vision, and utilizes a grid costmap to describe the human perception. It integrates EEG and EMG signals with user intent to dynamically adjust the grid costmap, mapping obstacle regions and integrating robot navigation to jointly accomplish driving tasks-with the aim of achieving human-machine shared perception. Sixteen subjects participated in an online obstacle avoidance experiment and compared the performance of the proposed method with two traditional methods. The research results show that the MPF-SC can generate smoother trajectories, achieve a significantly reduced collision rate during navigation, and significantly enhance user comfort. The MPF-SC based on brain-computer interface, fully leverages human anticipation of risks and the robot's perception of obstacle environments, demonstrating that bilateral intelligence is capable of adapting to increasingly complex environments, thereby offering a novel avenue and intuitive avenue for human-machine shared control.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 3","pages":"781-798"},"PeriodicalIF":2.8,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of the water content of hydrophobic intraocular lenses on visual quality.","authors":"Jungmin Kim, Young-Sik Yoo, Jinheung Park, Woong-Joo Whang, Dae Yu Kim","doi":"10.1007/s13534-025-00528-x","DOIUrl":"10.1007/s13534-025-00528-x","url":null,"abstract":"<p><p>The impact of the water content of hydrophobic intraocular lenses (IOLs) on visual quality remains unclear. This study investigated how the water content influenced photic phenomena. Optical bench studies were conducted to compare two hydrophobic trifocal IOLs: PanOptix® (low-water content IOL) and Clareon® PanOptix® (high-water content IOL). Modulation transfer function (MTF) measurements were used to evaluate optical quality, while point spread function (PSF) images were used to evaluate photic phenomena. To validate the optical bench results, a retrospective observational case series study was conducted using medical records for 85 eyes from 85 patients (PanOptix®, n = 38; Clareon® PanOptix®, n = 47). Postoperative visual outcomes were evaluated two months after the operation using a defocus curve for uncorrected visual acuity and contrast sensitivity (CS) with and without glare. Subjective satisfaction regarding spectacle independence and dysphotopsia was evaluated using a questionnaire. The optical bench study showed that the high-water content IOL exhibited a 6.16% smaller glare diameter in near-vision PSF analysis, and slightly higher MTF values at near distances. The clinical study supported these results, showing that the high-water content IOL provided better uncorrected visual acuity (<i>P</i> < 0.05) and spectacle independence (<i>P</i> = 0.016) at near distances. Additionally, the high-water content IOL showed higher contrast sensitivity with glare at 6.3° (<i>P</i> = 0.040) and 4° (<i>P</i> = 0.018). Hydrophobic IOLs with a higher water content improved contrast sensitivity and subjective satisfaction by reducing glistening and minimizing photic phenomena.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"16 2","pages":"451-462"},"PeriodicalIF":2.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}