Biomedical Engineering Letters最新文献

{"title":"Specialized ECG data augmentation method: leveraging precordial lead positional variability.","authors":"Jeonghwa Lim, Yeha Lee, Wonseuk Jang, Sunghoon Joo","doi":"10.1007/s13534-024-00455-3","DOIUrl":"https://doi.org/10.1007/s13534-024-00455-3","url":null,"abstract":"<p><p>Deep learning has demonstrated remarkable performance across various domains. One of the techniques contributing to this success is data augmentation. The essence of data augmentation lies in synthesizing data while preserving accurate labels. In this research, we introduce a data augmentation technique optimized for electrocardiogram (ECG) data by focusing on the unique angles between precordial leads in 12-lead ECG, considering situations that may occur in a clinical environment. Subsequently, we utilize the proposed data augmentation technique to train a deep learning model for diagnosing atrial fibrillation or atrial flutter, generalized supraventricular tachycardia, first-degree atrioventricular block, left bundle branch block and myocardial infarction from ECG signals, and evaluate its performance to validate the effectiveness of the proposed method. Compared to other data augmentation methods, our approach demonstrated improved performance across various datasets and most tasks, thereby showcasing its potential to enhance diagnostic accuracy. Additionally, our method is simple to implement, offering a gain in total training time compared to other augmentation methods. This study holds the potential to positively advance further development in the fields of bio-signal processing and deep learning technology, addressing the issue of the lack of optimized data augmentation techniques applicable to ECG data in the future.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13534-024-00455-3.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"377-388"},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of age on ankle versus hip proprioceptive contribution in balance recovery: application of vibratory stimulation for altering proprioceptive performance.","authors":"Mehran Asghari, Karam Elali, Nima Toosizadeh","doi":"10.1007/s13534-024-00451-7","DOIUrl":"https://doi.org/10.1007/s13534-024-00451-7","url":null,"abstract":"<p><p>While tripping is the leading cause of injurious falls in older adults, the influence of ankle and hip proprioceptive information in balance recovery among older adults is still not clearly understood. The objective of this study was to assess the influence of ankle vs. hip proprioceptive information by altering muscle spindle performance using vibratory stimulation among older adults and healthy young control participants. Two groups of young (<i>n</i> =  20, age =  22.2 ± 3.1 years) and older adult (<i>n</i>  =  33, age = 74.0 ± 3.8 years) participants were recruited and went through treadmill perturbation (sudden backward treadmill movement mimicking a trip), while they were equipped with vibratory devices (no vibration, and 40 and 80 Hz) on either ankle or hip muscles. Kinematics of the recovery were measures using motion sensors on lower extremities and the trunk. Results showed that vibratory stimulation on ankle significantly influenced balance recovery response (i.e., increased reaction time by 18% and increased recovery step length by 21%) among healthy young control, while it showed no effect when placed on hip muscles. On the other hand, while vibratory stimulation on ankle showed no effect on balance recovery among older adults, it significantly influenced balance recovery when applied to the hip muscles (i.e., increased reaction time by 12% and increased recovery step length by 10%). Current findings suggest that the role of ankle vs. hip proprioceptive information in balance recovery may change by aging. Findings may potentially be used for targeting the appropriate location for balance interventions and reducing the fall risk in older adults.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"337-347"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-assisted diagnostic approach for the influenza-like illness in children: decision support system for patients and clinicians.","authors":"Youngro Lee, Jongmo Seo, Yun-Kyung Kim","doi":"10.1007/s13534-024-00450-8","DOIUrl":"https://doi.org/10.1007/s13534-024-00450-8","url":null,"abstract":"<p><p>Influenza-like illnesses (ILI), such as influenza and RSV, pose significant global health burdens, especially in febrile children under 6 years old. Differentiating these from bacterial infections based solely on clinical symptoms is challenging. While PCR tests are reliable, they are costly and time-consuming. An effective predictive tool would help doctors prioritize tests and guide parents on seeking emergency care for their febrile children. We collected data from 2,559 children who visited the hospital for ILI inspections. We developed XGBoost models, comparing nine different machine learning algorithms. Our AI-assisted diagnostic pipeline consists of two stages: Decision Support System for patients (DSS-P): An in-house model using sex, age, symptoms, and medical history to decide on hospital visits. Decision Support System for clinicians (DSS-C): An in-hospital model incorporating breath sound types and Chest X-ray results to determine the necessity of clinical tests. We tested various experimental settings, including the addition of RAT-tested samples and the combined consideration of influenza and RSV. The performance for influenza achieved an Area Under the Curve of 0.749 and 0.776, while RSV achieved 0.907 and 0.924 in DSS-P and DSS-C, respectively. We identified biomarkers, noting that most biomarkers had opposite effects for influenza and RSV. This study developed predictive models for influenza and RSV and explored their underlying mechanisms. An expectation tool to guide doctors in prioritizing tests or assisting parents in deciding on emergency care for their febrile child would be invaluable. Biomarker analysis performed can provide insight on clinical fields.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13534-024-00450-8.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"327-336"},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure-volume analysis of thermodynamic workload of voiding - an application in pelvic organ prolapse patients subjected to robotic-assisted sacrocolpopexy.","authors":"Hui-Hsuan Lau, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsien-Yu Peng, Dylan Chou, Tsung-Hsien Su, Jie-Jen Lee, Tzer-Bin Lin","doi":"10.1007/s13534-024-00453-5","DOIUrl":"https://doi.org/10.1007/s13534-024-00453-5","url":null,"abstract":"<p><strong>Purpose: </strong><i>Given objective benefits of robotic-assisted sacrocolpopexy (RSCP)</i> to the voiding function/deficit of patients with pelvic organ prolapse (POP) waits to be clarified, this study investigated if RSCP modifies voiding functions of POP patients by focusing on its impact on the outlet resistance-dependent voiding workload using pressure-volume analysis (PVA), a protocol thermodynamically assaying work expenditure by the bladder in voiding cycles.</p><p><strong>Methods: </strong>Pre- and post-operative cystometry and PVA of 22 female patients, who underwent RSCP for POP (stage ≥ II), were reviewed. <i>Mean voiding resistance (Rvod)</i>, <i>mean voiding pressure (Pvod)</i>, <i>mean voiding flow (Fvod)</i>, voided volume (Vvod), voiding time (Tvod), and the trajectory-enclosed area (Apv) were analyzed.</p><p><strong>Results: </strong>The PVA, in which trajectory shaped an enclosed loop representing a voiding cycle, was established by adapting from the time-domain cystometry. Compared to the pre-operative control, RSCP decreased Rvod, Pvod, and Tvod (<i>p</i> = 0.003, 0.042, and 0.040, respectively. All <i>N</i> = 22) but increased Fvod (<i>p</i> = 0.036, <i>N</i> = 22) without markedly affecting Vvod (<i>p</i> = 0.580, <i>N</i> = 22). Apv was decreased after RSCP (<i>p</i> = 0.017, <i>N</i> = 22). The RSCP-decreased Rvod (ΔRvod) displayed a moderate correlation with both the decreased Pvod (ΔPvod, <i>r</i> = 0.551, <i>p</i> = 0.007, <i>N</i> = 22) and the increased Fvod (ΔFvod, <i>r</i>=-0.625, <i>p</i> = 0.001, <i>N</i> = 22). The ΔFvod moderately correlated with the decreased Tvod (ΔTvod, <i>r</i>=-0.620, <i>p</i> = 0.002, <i>N</i> = 22). Moreover, the RSCP-decreased Apv (ΔApv) displayed correlation with the ΔPvod (<i>r</i> = 0.385, <i>p</i> = 0.047, <i>N</i> = 22).</p><p><strong>Conclusions: </strong>Through diminishing outlet resistance of POP patients, RSCP not only prompted urine emission thereby increased voiding efficacy but also decreased the pressure developed for driving urine flow that lessened voiding workload.<i>Clinical Trial Registration</i> ClinicalTrials.gov (NCT05682989).</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"357-365"},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of femoral neck system removal after femoral neck fracture healing on biomechanical stability and screw stripping risk.","authors":"Se-Won Lee, Jeongah Pak, Dohyung Lim","doi":"10.1007/s13534-024-00452-6","DOIUrl":"https://doi.org/10.1007/s13534-024-00452-6","url":null,"abstract":"<p><p>This study aims to determine whether the removal of the femoral neck system (FNS) after bony union affects the biomechanical stability of the femur. Considering the technical challenges and potential complications, including screw stripping reported in recent studies, the study explores whether its removal impacts stress distribution within the femur and increases the risk of complications, such as screw stripping. The femurs were grouped into Intact, Group U (healed fractures with FNS in place), and Group R (healed fractures with FNS removed). Subgroup analysis was performed using Pauwels' classification for fractures at 30, 50, and 70 degrees. Finite element analysis (FEA) was used to model and evaluate the biomechanical behavior. Material properties for the models were derived from the literature. No significant difference in biomechanical stability was observed between Group U and Group R across the fracture angles tested, indicating that removal of FNS does not compromise the structural integrity of the femur. However, the risk of screw stripping during removal requires consideration. Removing the femoral neck system (FNS) after fracture healing preserves the femur's biomechanical stability, regardless of fracture angle. However, increased stress at the distal locking screw suggests caution to avoid complications such as screw stripping.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"349-355"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity Analysis of Microstrip Patch Antenna Genres: Slotted and Through-hole Microstrip Patch Antenna.","authors":"Swati Todi, Poonam Agarwal","doi":"10.1007/s13534-024-00443-7","DOIUrl":"https://doi.org/10.1007/s13534-024-00443-7","url":null,"abstract":"<p><p>This paper demonstrates real-time, label-free, contact-based glucose sensor design of inset-fed Microstrip Patch Antenna (MSPA) genres: Slotted Microstrip Patch Antenna (SMSPA) and Through-hole Microstrip Patch Antenna (THMSPA). In SMSPA, multiple slots are created along the width edge of the patch. In THMSPA, a through-hole is introduced across the antenna including all the layers: patch, substrate and ground conductor of the MSPA. The proposed designs are geared towards enhancing the electric field distribution along the patch, and to utilize that region as the sensing area. The electric field intensity at the resonant frequency is 45505V/m, 53145V/m and 71348V/m for MSPA, SMSPA and THMSPA, respectively. Experimental sensitivity of the proposed glucose sensor increased from 8.901dB/g/ml to 23.575dB/g/ml and 41.525dB/g/ml for SMSPA and THMSPA, respectively. There is significant enhancement in sensitivity in terms of MHz/g/ml for MSPA, SMSPA and THMSPA which is 112.286, 174.857 and 548.571, respectively.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 1","pages":"249-260"},"PeriodicalIF":3.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced optimized nonlinear control strategies for prosthetic knee joints.","authors":"Atif Rehman, Rimsha Ghias, Syed Hassan Ahmed, Iftikhar Ahmad","doi":"10.1007/s13534-024-00447-3","DOIUrl":"https://doi.org/10.1007/s13534-024-00447-3","url":null,"abstract":"<p><p>Prosthetic knee joints are at the forefront of medical innovation, serving as crucial tools in restoring mobility and enhancing the quality of life for individuals grappling with knee-related ailments like osteoarthritis and injuries. By faithfully replicating the intricate biomechanics of the natural knee, these devices empower recipients to regain lost physical capabilities and lead active, fulfilling lives. This paper presents a novel methodology employing advanced control techniques, including sliding mode control (SMC) and super-twisting sliding mode control (STSMC), to explore lower limb dynamics and effectively manage a two-part knee joint replacement. Through meticulous parameter optimization using a genetic algorithm (GA), guided by the integral time absolute error as the optimization objective, the controllers are finely tuned to maximize performance and responsiveness in real-world scenarios. The stability of the proposed controllers is thoroughly validated using mathematical analysis based on Lyapunov stability criteria. This ensures they perform robustly and can withstand disturbances. Comprehensive performance evaluations conducted via MATLAB/Simulink simulations offer valuable insights into the comparative efficacy of different control strategies under varying conditions, facilitating informed decision-making and refinement of prosthetic knee design. Real-time validation of the proposed methodology is achieved through a hardware-in-loop experimental setup featuring the advanced C2000 Delfino MCU F28379D Launchpad.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 2","pages":"291-300"},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the endocrine connections of NAFLD: evidence from a comprehensive mendelian randomization study.","authors":"Fan Li, Mingjun Wu, Fenfen Wang, Linfei Luo, Zhengqiang Wu, Zixiang Huang, Zhili Wen","doi":"10.1007/s13534-024-00442-8","DOIUrl":"https://doi.org/10.1007/s13534-024-00442-8","url":null,"abstract":"<p><strong>Background: </strong>NAFLD is gaining recognition as a complex, multifactorial condition with suspected associations with endocrine disorders. This investigation employed MR analysis to explore the potential causality linking NAFLD to a spectrum of endocrine diseases, encompassing T1D, T2D, obesity, graves' disease, and acromegaly.</p><p><strong>Methods: </strong>Our methodology leveraged a stringent IV selection process, adhering to the STROBE-MR guidelines. The MR analysis was conducted utilizing three distinct methods: IVW, WM, and MR-Egger. The IVW method was prioritized as the primary analytical approach. We conducted MR analyses to analyze the causal relationship between NAFLD and metabolic disorders. We also examined 1400 metabolites implicated in NAFLD. Metabolic pathway analysis was performed using the MetaboAnalyst database.</p><p><strong>Results: </strong>The findings indicated that T2D (OR = 1.211, 95%CI: 0.836-1.585) and obesity (OR = 1.245, 95%CI: 0.816-1.674) are associated with an increased risk of NAFLD development. Further exploration into the the 1400 metabolites revealed that cys-gly and diacetylornithine are predictive of NAFLD, T2D, and obesity, whereas isovalerylcarnitine exhibited an inverse association, potentially inhibiting disease development. Metabolic pathways involving alanine, aspartate, and glutamate metabolism were identified as pivotal regulators in the pathophysiology of NAFLD, T2D, and obesity.</p><p><strong>Conclusion: </strong>The present study generated innovative viewpoints on the etiology of NAFLD. Our findings underscore the significant role of T2D and obesity in NAFLD pathogenesis through metabolic pathways, presenting opportunities for targeted therapeutic strategies and warranting further investigation.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13534-024-00442-8.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 1","pages":"239-248"},"PeriodicalIF":3.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-inspired learning rules for spiking neural network-based control: a tutorial.","authors":"Choongseop Lee, Yuntae Park, Sungmin Yoon, Jiwoon Lee, Youngho Cho, Cheolsoo Park","doi":"10.1007/s13534-024-00436-6","DOIUrl":"https://doi.org/10.1007/s13534-024-00436-6","url":null,"abstract":"<p><p>Robotic systems rely on spatio-temporal information to solve control tasks. With advancements in deep neural networks, reinforcement learning has significantly enhanced the performance of control tasks by leveraging deep learning techniques. However, as deep neural networks grow in complexity, they consume more energy and introduce greater latency. This complexity hampers their application in robotic systems that require real-time data processing. To address this issue, spiking neural networks, which emulate the biological brain by transmitting spatio-temporal information through spikes, have been developed alongside neuromorphic hardware that supports their operation. This paper reviews brain-inspired learning rules and examines the application of spiking neural networks in control tasks. We begin by exploring the features and implementations of biologically plausible spike-timing-dependent plasticity. Subsequently, we investigate the integration of a global third factor with spike-timing-dependent plasticity and its utilization and enhancements in both theoretical and applied research. We also discuss a method for locally applying a third factor that sophisticatedly modifies each synaptic weight through weight-based backpropagation. Finally, we review studies utilizing these learning rules to solve control tasks using spiking neural networks.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 1","pages":"37-55"},"PeriodicalIF":3.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease recognition based on waveform and spectral speech signal processing.","authors":"Ying Gu, Jie Ying, Quan Chen, Hui Yang, Jingnan Wu, Nan Chen, Yiming Li","doi":"10.1007/s13534-024-00444-6","DOIUrl":"https://doi.org/10.1007/s13534-024-00444-6","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder with an irreversible progression. Currently, it is diagnosed using invasive and costly methods, such as cerebrospinal fluid analysis, neuroimaging, and neuropsychological assessments. Recent studies indicate that certain changes in language ability can predict early cognitive decline, highlighting the potential of speech analysis in AD recognition. Based on this premise, this study proposes an AD recognition multi-channel network framework, which is referred to as the ADNet. It integrates both time-domain and frequency-domain features of speech signals, using waveform images and log-Mel spectrograms derived from raw speech as data sources. The framework employs inverted residual blocks to enhance the learning of low-level time-domain features and uses gated multi-information units to effectively combine local and global frequency-domain features. The study tests it on a dataset from the Shanghai cognitive screening (SCS) digital neuropsychological assessment. The results show that the method we proposed outperforms existing speech-based methods, achieving an accuracy of 88.57%, a precision of 88.67%, and a recall of 88.64%. This study demonstrates that the proposed framework can effectively distinguish between the AD and normal controls, and it may be useful for developing early recognition tools for AD.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"15 1","pages":"261-272"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}