Biomedical Engineering Letters最新文献

{"title":"A review of emergent intelligent systems for the detection of Parkinson's disease.","authors":"Samiappan Dhanalakshmi, Ramesh Sai Maanasaa, Ramesh Sai Maalikaa, Ramalingam Senthil","doi":"10.1007/s13534-023-00319-2","DOIUrl":"10.1007/s13534-023-00319-2","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder affecting people worldwide. The PD symptoms are divided into motor and non-motor symptoms. Detection of PD is very crucial and essential. Such challenges can be overcome by applying artificial intelligence to diagnose PD. Many studies have also proposed the implementation of computer-aided diagnosis for the detection of PD. This systematic review comprehensively analyzed all appropriate algorithms for detecting and assessing PD based on the literature from 2012 to 2023 which are conducted as per PRISMA model. This review focused on motor symptoms, namely handwriting dynamics, voice impairments and gait, multimodal features, and brain observation using single photon emission computed tomography, magnetic resonance and electroencephalogram signals. The significant challenges are critically analyzed, and appropriate recommendations are provided. The critical discussion of this review article can be helpful in today's PD community in such a way that it allows clinicians to provide proper treatment and timely medication.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement of a RGBW-LED pen for diaphanoscopic illumination with adjustable color and intensity with tests on ex-vivo porcine eyes in terms of retinal risk and correlated color temperature","authors":"Nicole Fehler, David Schneider, Martin Hessling","doi":"10.1007/s13534-023-00317-4","DOIUrl":"https://doi.org/10.1007/s13534-023-00317-4","url":null,"abstract":"Abstract Diaphanoscopic illumination has the disadvantage that the intraocular spectrum is red-shifted due to transmission properties of the eyewall. This red-shift should be counteracted as well as the retinal risk should be reduced with adjusting the spectral distribution of the illumination light. Likewise, the illumination spectrum has to be adapted to the eye color of the patient. With the further development of a red, green, blue and white light-emitting diode (RGBW-LED) diaphanoscopy pen, the intensities of each color can be varied. The functionality of the LED pen is tested on ex-vivo porcine eyes. By measuring the transmission of the sclera and choroidea, the photochemical and thermal retinal hazard and the maximum exposure time are determined according to the standard DIN EN ISO 15004-2:2007. With this RGBW-LED pen the intraocular space can be illuminated clearly of up to 1.5 h without potential retinal damage according to DIN EN ISO 15004:2-2007. By adjusting the illumination spectrum the red-shift can be compensated and retinal risk can be reduced. By varying the LED intensities, the correlated color temperature in the eye can also be varied from cold white to warm white appearance as comfortable to the ophthalmologist. Additionally, a simple adjustment of the illumination to the eye color of the patient is possible. Using this RGBW-LED pen, the ophthalmologist can set the desired intraocular color appearance, which he prefers for special applications. He could also adjust the illumination to the eye color as this would reduce retinal hazard.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135395821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sneaky emotions: impact of data partitions in affective computing experiments with brain-computer interfacing","authors":"Yoelvis Moreno-Alcayde, V. Javier Traver, Luis A. Leiva","doi":"10.1007/s13534-023-00316-5","DOIUrl":"https://doi.org/10.1007/s13534-023-00316-5","url":null,"abstract":"Abstract Brain-Computer Interfacing (BCI) has shown promise in Machine Learning (ML) for emotion recognition. Unfortunately, how data are partitioned in training/test splits is often overlooked, which makes it difficult to attribute research findings to actual modeling improvements or to partitioning issues. We introduce the “data transfer rate” construct (i.e., how much data of the test samples are seen during training) and use it to examine data partitioning effects under several conditions. As a use case, we consider emotion recognition in videos using electroencephalogram (EEG) signals. Three data splits are considered, each representing a relevant BCI task: subject-independent (affective decoding), video-independent (affective annotation), and time-based (feature extraction). Model performance may change significantly (ranging e.g. from 50% to 90%) depending on how data is partitioned, in classification accuracy. This was evidenced in all experimental conditions tested. Our results show that (1) for affective decoding, it is hard to achieve performance above the baseline case (random classification) unless some data of the test subjects are considered in the training partition; (2) for affective annotation, having data from the same subject in training and test partitions, even though they correspond to different videos, also increases performance; and (3) later signal segments are generally more discriminative, but it is the number of segments (data points) what matters the most. Our findings not only have implications in how brain data are managed, but also in how experimental conditions and results are reported.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135980914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound neuromodulation of cultured hippocampal neurons.","authors":"Seoyoung Hwang, Sang Beom Jun","doi":"10.1007/s13534-023-00314-7","DOIUrl":"10.1007/s13534-023-00314-7","url":null,"abstract":"<p><p>Ultrasound is becoming an emerging and promising method for neuromodulation due to its advantage of noninvasiveness and its high spatial resolution. However, the underlying principles of ultrasound neuromodulation have not yet been elucidated. We have herein developed a new in vitro setup to study the ultrasonic neuromodulation, and examined various parameters of ultrasound to verify the effective conditions to evoke the neural activity. Neurons were stimulated with 0.5 MHz center frequency ultrasound, and the action potentials were recorded from rat hippocampal neural cells cultured on microelectrode arrays. As the intensity of ultrasound increased, the neuronal activity also increased. There was a notable and significant increase in both the spike rate and the number of bursts at 50% duty cycle, 1 kHz pulse repetition frequency, and the acoustic intensities of 7.6 W/cm² and 3.8 W/cm² in terms of spatial-peak pulse-average intensity and spatial-peak temporal-average intensity, respectively. In addition, the impact of ultrasonic neuromodulation was assessed in the presence of a gamma-aminobutyric acid A (GABA_A) receptor antagonist to exclude the effect of activated inhibitory neurons. Interestingly, it is noteworthy that the predominant neuromodulatory effects of ultrasound disappeared when the GABA_A blocker was introduced, suggesting the potential of ultrasonic stimulation specifically targeting inhibitory neurons. The experimental setup proposed herein could serve as a useful tool for the clarification of the mechanisms underlying the electrophysiological effects of ultrasound.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49375934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of robotic-assisted total hip arthroplasty.","authors":"Kwangkyoun Kim, Seungcheol Kwon, Junhyuk Kwon, Jihyo Hwang","doi":"10.1007/s13534-023-00312-9","DOIUrl":"10.1007/s13534-023-00312-9","url":null,"abstract":"<p><p>Total hip arthroplasty (THA) is a successful surgical method for hip replacement but still poses challenges and risks. Robotic-assisted THA (rTHA) using new generation robotic systems has emerged to improve surgical precision and outcomes. The purpose of this paper is to review the literature on rTHA, with a focus on its advantages, such as individualized preoperative planning, intraoperative assistance, and improved accuracy in implantation, especially in complex cases. Additionally, it aims to explore the disadvantages associated with the use of rTHA, including high costs, the learning curve, and prolonged operation time compared to manual THA (mTHA), which are critical drawbacks that require careful consideration and efforts for minimization. Some financial analyses suggest that rTHA may offer cost-effectiveness and reduced postoperative costs compared to mTHA. While technological advancements are expected to reduce technical complications, there are still debates surrounding long-term outcomes. Practical limitations, such as limited availability and accessibility, also warrant attention. Although the development of rTHA shows promise, it is still in its early stages, necessitating critical evaluation and further research to ensure optimal patient benefits.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42209477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pupillometry as a window to detect cognitive aging in the brain.","authors":"Jiae Kim, Jiyeon Lee, Sang Beom Jun, Jee Eun Sung","doi":"10.1007/s13534-023-00315-6","DOIUrl":"10.1007/s13534-023-00315-6","url":null,"abstract":"<p><p>This study investigated whether there are aging-related differences in pupil dilation (pupillometry) while the cognitive load is manipulated using digit- and word-span tasks. A group of 17 younger and 15 cognitively healthy older adults performed digit- and word-span tasks. Each task comprised three levels of cognitive loads with 10 trials for each level. For each task, the recall accuracy and the slope of pupil dilation were calculated and analyzed. The raw signal of measured pupil size was low-pass filtered and interpolated to eliminate blinking artifacts and spike noises. Two-way ANOVA was used for statistical analyses. For the recall accuracy, the significant group differences emerged as the span increases in digit-span (5- vs. 7-digit) and word-span (4- vs. 5-word) tasks, while the group differences were not significant on 3-digit- and 3-word-span tasks with lower cognitive load. In digit-span tasks, there was no aging-related difference in the slope of pupil dilation. However, in word-span tasks, the slope of pupil dilation differed significantly between two groups as cognitive load increased, indicating that older adults presented a higher pupil dilation slope than younger adults especially under the conditions with higher cognitive load. The current study found significant aging effects in the pupil dilations under the more cognitive demanding span tasks when the types of span tasks varied (e.g., digit vs. word). The manipulations successfully elicited differential aging effects, given that the aging effects became most salient under word-span tasks with greater cognitive load especially under the maximum length.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13534-023-00315-6.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47349287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undersampling and cumulative class re-decision methods to improve detection of agitation in people with dementia","authors":"Zhidong Meng, Andrea Iaboni, Bing Ye, Kristine Newman, Alex Mihailidis, Zhihong Deng, Shehroz S. Khan","doi":"10.1007/s13534-023-00313-8","DOIUrl":"https://doi.org/10.1007/s13534-023-00313-8","url":null,"abstract":"","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136349161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning curve for robot-assisted knee arthroplasty; optimizing the learning curve to improve efficiency.","authors":"Sang Jun Song, Cheol Hee Park","doi":"10.1007/s13534-023-00311-w","DOIUrl":"10.1007/s13534-023-00311-w","url":null,"abstract":"<p><p>The introduction of robot-assisted (RA) systems in knee arthroplasty has challenged surgeons to adopt the new technology in their customized surgical techniques, learn system controls, and adjust to automated processes. Despite the potential advantages of RA knee arthroplasty, some surgeons remain hesitant to adopt this novel technology owing to concerns regarding the cumbersome adaptation process. This narrative review addresses the learning-curve issues in RA knee arthroplasty based on the existing literature. Learning curves exist in terms of the operative time and stress level of the surgical team but not in the final implant positions. The factors that reduce the learning curve are previous experience with computer-assisted surgery (including robot or navigation systems), specialization in knee surgery, high volume of knee arthroplasty, optimization of the RA workflow, sequential implementation of RA surgery, and consistency of the surgical team. Worse clinical outcomes may occur in the early postoperative period, but not in the later period, in RA knee arthroplasty performed during the learning phase. No significant differences were observed in implant survival or complication rates between the RA knee arthroplasties performed during the learning and proficiency phases.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43782548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of perception by transcutaneous electrical Stimulation in terms of tingling intensity and temporal dynamics.","authors":"Stefan Manoharan, Hangue Park","doi":"10.1007/s13534-023-00308-5","DOIUrl":"10.1007/s13534-023-00308-5","url":null,"abstract":"<p><p>Electrotactile feedback is a cost-effective and versatile method to provide new information or to augment intrinsic tactile feedback. As tactile feedback provides critical information for human-environment interaction, electrotactile feedback, accordingly, has many purposes to improve the quality of human-environment interaction in both direct and remote settings. However, electrotactile feedback overlays tingling sensation on top of the natural tactile feedback. To better characterize electrotactile feedback and understand the origin of the tingling sensation, a need arises to characterize the human perception of electrotactile feedback qualitatively and quantitatively, while varying the key stimulation parameters, namely amplitude and frequency. This study consists of two experiments. In the first experiment, the voltage for each subject was characterized by setting perception and discomfort thresholds. In the second experiment, subjects received electrical stimulation in 9 different combinations of voltages and frequencies. On delivering stimulation with each parameter combination, subjects reported their perception in two comparative scales-pressure vs. tingling and constant vs. pulsing. Subjects also reported the location of perception for stimulation with every parameter combination. More tingling and less pressure was reported as frequency increased, while the tingling-pressure percept was not affected by the amplitude change. Additionally, less pulsing and more constant was reported as frequency increased, while the pulsing-constant percept was not affected by the amplitude change. Concurrently, the normalized level of voltage thresholds was decreased as frequency increased. Dependency of tingling-pressure percept on stimulation frequency suggests that incongruency between the stimulation frequency and the natural firing rate of the sensory neuron would be an important factor of the tingling sensation. This study is a steppingstone to further demystify the origin of the tingling percept caused by electrical stimulation, thus broadening the use of transcutaneous electrical stimulation as a way of providing tactile cue or augmentation.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44435482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial and channel attention-based conditional Wasserstein GAN for direct and rapid image reconstruction in ultrasound computed tomography.","authors":"Xiaoyun Long, Chao Tian","doi":"10.1007/s13534-023-00310-x","DOIUrl":"10.1007/s13534-023-00310-x","url":null,"abstract":"<p><p>Ultrasound computed tomography (USCT) is an emerging technology that offers a noninvasive and radiation-free imaging approach with high sensitivity, making it promising for the early detection and diagnosis of breast cancer. The speed-of-sound (SOS) parameter plays a crucial role in distinguishing between benign masses and breast cancer. However, traditional SOS reconstruction methods face challenges in achieving a balance between resolution and computational efficiency, which hinders their clinical applications due to high computational complexity and long reconstruction times. In this paper, we propose a novel and efficient approach for direct SOS image reconstruction based on an improved conditional generative adversarial network. The generator directly reconstructs SOS images from time-of-flight information, eliminating the need for intermediate steps. Residual spatial-channel attention blocks are integrated into the generator to adaptively determine the relevance of arrival time from the transducer pair corresponding to each pixel in the SOS image. An ablation study verified the effectiveness of this module. Qualitative and quantitative evaluation results on breast phantom datasets demonstrate that this method is capable of rapidly reconstructing high-quality SOS images, achieving better generation results and image quality. Therefore, we believe that the proposed algorithm represents a new direction in the research area of USCT SOS reconstruction.</p>","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47898632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}