Biomedical Engineering Letters最新文献_第10页

Margetuximab conjugated-PEG-PAMAM G4 nano-complex: a smart nano-device for suppression of breast cancer. 玛格妥昔单抗偶联peg - pamam G4纳米复合物:用于抑制乳腺癌的智能纳米装置。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-08-01 DOI: 10.1007/s13534-022-00225-z

Yasaman Khakinahad, Saeedeh Sohrabi, Shokufeh Razi, Asghar Narmani, Sepideh Khaleghi, Mahboubeh Asadiyun, Hanieh Jafari, Javad Mohammadnejad

{"title":"Margetuximab conjugated-PEG-PAMAM G4 nano-complex: a smart nano-device for suppression of breast cancer.","authors":"Yasaman Khakinahad, Saeedeh Sohrabi, Shokufeh Razi, Asghar Narmani, Sepideh Khaleghi, Mahboubeh Asadiyun, Hanieh Jafari, Javad Mohammadnejad","doi":"10.1007/s13534-022-00225-z","DOIUrl":"https://doi.org/10.1007/s13534-022-00225-z","url":null,"abstract":"Abstract: Breast cancer due to its high incidence and mortality is the second leading cause of death among females. On the other hand, nanoparticle-based drug delivery is one of the most promising approaches in cancer therapy, nowadays. Hence, margetuximab- and polyethylene glycol-conjugated PAMAM G4 dendrimers were efficiently synthesized for targeted delivery of quercetin (therapeutic agent) to MDA-MB-231 breast cancer cells. Synthesized nano-complexes were characterized using analytical devices such as FT-IR, TGA, DLS, Zeta potential analyzer, and TEM. The size less than 40 nm, - 18.8 mV surface charge, efficient drug loading capacity (21.48%), and controlled drug release (about 45% of drug release normal pH after 8 h) were determined for the nano-complex. In the biomedical test, the cell viability was obtained 14.67% at 24 h of post-treatment for 800 nM concentration, and IC50 was ascertained at 100 nM for the nano-complex. The expression of apoptotic Bax and Caspase9 genes was increased by more than eightfolds and more than fivefolds after treatment with an optimal concentration of nanocarrier. Also, more than threefolds of cell cycle arrest was observed at the optimal concentration synthetics, and 27.5% breast cancer cell apoptosis was detected after treatment with 100 nM nano-complex. These outputs have been indicating the potential capacity of synthesized nano-complex in inhibiting the growth of breast cancer cells.Graphic abstract: ","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 3","pages":"317-329"},"PeriodicalIF":4.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308845/pdf/13534_2022_Article_225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9303642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

High-density neural recording system design. 高密度神经记录系统设计。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-08-01 DOI: 10.1007/s13534-022-00233-z

Han-Sol Lee, Kyeongho Eom, Minju Park, Seung-Beom Ku, Kwonhong Lee, Hyung-Min Lee

{"title":"High-density neural recording system design.","authors":"Han-Sol Lee, Kyeongho Eom, Minju Park, Seung-Beom Ku, Kwonhong Lee, Hyung-Min Lee","doi":"10.1007/s13534-022-00233-z","DOIUrl":"https://doi.org/10.1007/s13534-022-00233-z","url":null,"abstract":"Implantable medical devices capable of monitoring hundreds to thousands of electrodes have received great attention in biomedical applications for understanding of the brain function and to treat brain diseases such as epilepsy, dystonia, and Parkinson's disease. Non-invasive neural recording modalities such as fMRI and EEGs were widely used since the 1960s, but to acquire better information, invasive modalities gained popularity. Since such invasive neural recording system requires high efficiency and low power operation, they have been implemented as integrated circuits. Many techniques have been developed and applied when designing integrated high-density neural recording architecture for better performance, higher efficiency, and lower power consumption. This paper covers general knowledge of neural signals and frequently used neural recording architectures for monitoring neural activity. For neural recording architecture, various neural recording amplifier structures are covered. In addition, several neural processing techniques, which can optimize the neural recording system, are also discussed.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 3","pages":"251-261"},"PeriodicalIF":4.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308855/pdf/13534_2022_Article_233.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9543098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Circuits on miniaturized ultrasound imaging system-on-a-chip: a review. 芯片上微型超声成像系统电路综述。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-08-01 DOI: 10.1007/s13534-022-00228-w

Jaemyung Lim

引用次数: 1

Deep brain stimulation for Parkinson's Disease: A Review and Future Outlook. 脑深部电刺激治疗帕金森病:回顾与展望

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-08-01 DOI: 10.1007/s13534-022-00226-y

Anahita Malvea, Farbod Babaei, Chadwick Boulay, Adam Sachs, Jeongwon Park

引用次数: 4

MCU-less biphasic electrical stimulation circuit for miniaturized neuromodulator. 微型神经调节剂的无mcu双相电刺激电路。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-08-01 DOI: 10.1007/s13534-022-00239-7

Himshekhar Das, Hangue Park

{"title":"MCU-less biphasic electrical stimulation circuit for miniaturized neuromodulator.","authors":"Himshekhar Das, Hangue Park","doi":"10.1007/s13534-022-00239-7","DOIUrl":"https://doi.org/10.1007/s13534-022-00239-7","url":null,"abstract":"A standalone neuro-stimulator circuit without a need of microcontroller (MCU) is presented. The neuro-stimulator circuit has a capability to produce a biphasic electrical stimulus with programmable pulse width and train duration. The proposed hardware system consists of commercial-off-the-shelf (COTS) components: a comparator to recognize triggering events and generate on/off signal for a variable train duration, a programmable timer to generate oscillatory signal with a fixed frequency and a variable pulse width, and a differentiator to convert monophasic pulses to biphasic pulses. The differentiator also works as a current driver having current drive capability of up to 40 mA. The proposed MCU-less biphasic electrical neuro-stimulator successfully generated biphasic stimuli with variable pulse widths from 400 µs to 5 ms and train durations from 35 to 55% of cycle duration. It works with fixed parameters programmed at the beginning, and does not need continuous MCU input. Therefore, the proposed standalone neuro-stimulator circuit has a potential to decrease power and area consumption and minimize the size of the neuro-stimulator system.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 3","pages":"285-293"},"PeriodicalIF":4.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308854/pdf/13534_2022_Article_239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Miniaturization for wearable EEG systems: recording hardware and data processing. 可穿戴脑电图系统的微型化：记录硬件和数据处理。

IF 3.2 4区医学

Biomedical Engineering Letters Pub Date : 2022-06-06 eCollection Date: 2022-08-01 DOI: 10.1007/s13534-022-00232-0

Minjae Kim, Seungjae Yoo, Chul Kim

{"title":"Miniaturization for wearable EEG systems: recording hardware and data processing.","authors":"Minjae Kim, Seungjae Yoo, Chul Kim","doi":"10.1007/s13534-022-00232-0","DOIUrl":"10.1007/s13534-022-00232-0","url":null,"abstract":"As more people desire at-home diagnosis and treatment for their health improvement, healthcare devices have become more wearable, comfortable, and easy to use. In that sense, the miniaturization of electroencephalography (EEG) systems is a major challenge for developing daily-life healthcare devices. Recently, because of the intertwined relationship between EEG recording and processing, co-research of EEG recording hardware and data processing has been emphasized for whole-in-one miniaturized EEG systems. This paper introduces miniaturization techniques in analog-front-end hardware and processing algorithms for such EEG systems. To miniaturize EEG recording hardware, various types of compact electrodes and mm-sized integrated circuits (IC) techniques including artifact rejection are studied to record accurate EEG signals in a much smaller manner. Active electrode and in-ear EEG technologies are also researched to make small-form-factor EEG measurement structures. Furthermore, miniaturization techniques for EEG processing are discussed including channel selection techniques that reduce the number of required electrode channel and hardware implementation of processing algorithms that simplify the EEG processing stage.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 3","pages":"239-250"},"PeriodicalIF":3.2,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A resonant current-mode wireless power transfer for implantable medical devices: an overview. 用于植入式医疗设备的谐振电流模式无线电力传输：概述。

IF 3.2 4区医学

Biomedical Engineering Letters Pub Date : 2022-05-17 eCollection Date: 2022-08-01 DOI: 10.1007/s13534-022-00231-1

Jong-Hun Kim, Najam Ul Hassan, Seung-Ju Lee, Yeon-Woo Jung, Se-Un Shin

{"title":"A resonant current-mode wireless power transfer for implantable medical devices: an overview.","authors":"Jong-Hun Kim, Najam Ul Hassan, Seung-Ju Lee, Yeon-Woo Jung, Se-Un Shin","doi":"10.1007/s13534-022-00231-1","DOIUrl":"10.1007/s13534-022-00231-1","url":null,"abstract":"Implantable Medical Devices (IMDs) have been developing in ways to be lighter and lower-power systems. In the view of such developments, the battery recharging capacity to ensure the stable operation of the system is essential. Wireless power transfer (WPT) was proposed as a solution to recharge the battery without complex metallic contacts. However, due to limitations such as threshold voltage of power switches and minimal input power of the multi-stage structure (Rectifier + Regulator/DC-DC converter) of conventional voltage-mode (VM) WPT, there are drawbacks of an input power range above a certain threshold level and limitations due to strict regulations on the human body. These issues make the design of the IMD battery charger much harder and prevent IMDs from being a more viable option for people-in-need. This paper introduces distinguishing characteristics of resonant current-mode (RCM) WPT technology to overcome the aforementioned issues. It also describes the basic theory, conventional circuits of VM/RCM, comparisons, and major challenges of RCM. Finally, advanced and efficiency-enhancing techniques of the-state-of-art works among the RCM topologies will be discussed to follow up the trend of RCM WPT.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 3","pages":"229-238"},"PeriodicalIF":3.2,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308851/pdf/13534_2022_Article_231.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9474338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery. 血管内光传递光声成像表征深部血栓形成。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-05-01 DOI: 10.1007/s13534-022-00216-0

Yuqi Tang, Huaiyu Wu, Paul Klippel, Bohua Zhang, Hsiao-Ying Shadow Huang, Yun Jing, Xiaoning Jiang, Junjie Yao

{"title":"Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.","authors":"Yuqi Tang, Huaiyu Wu, Paul Klippel, Bohua Zhang, Hsiao-Ying Shadow Huang, Yun Jing, Xiaoning Jiang, Junjie Yao","doi":"10.1007/s13534-022-00216-0","DOIUrl":"https://doi.org/10.1007/s13534-022-00216-0","url":null,"abstract":"Venous thromboembolism (VTE) is a condition in which blood clots form within the deep veins of the leg or pelvis to cause deep vein thrombosis. The optimal treatment of VTE is determined by thrombus properties such as the age, size, and chemical composition of the blood clots. The thrombus properties can be readily evaluated by using photoacoustic computed tomography (PACT), a hybrid imaging modality that combines the rich contrast of optical imaging and deep penetration of ultrasound imaging. With inherent sensitivity to endogenous chromophores such as hemoglobin, multispectral PACT can provide composition information and oxygenation level in the clots. However, conventional PACT of clots relies on external light illumination, which provides limited penetration depth due to strong optical scattering of intervening tissue. In our study, this depth limitation is overcome by using intravascular light delivery with a thin optical fiber. To demonstrate in vitro blood clot characterization, clots with different acuteness and oxygenation levels were placed underneath ten-centimeter-thick chicken breast tissue and imaged using multiple wavelengths. Acoustic frequency analysis was performed on the received PA channel signals, and oxygenation level was estimated using multispectral linear spectral unmixing. The results show that, with intravascular light delivery, clot oxygenation level can be accurately measured, and the clot age can thus be estimated. In addition, we found that retracted and unretracted clots had different acoustic frequency spectrum. While unretracted clots had stronger high frequency components, retracted clots had much higher low frequency components due to densely packed red blood cells. The PACT characterization of the clots was consistent with the histology results and mechanical tests.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 2","pages":"135-145"},"PeriodicalIF":4.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046522/pdf/13534_2022_Article_216.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10734354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Nonlinear model-based cardiac arrhythmia diagnosis using the optimization-based inverse problem solution. 基于非线性模型的心律失常诊断的最优化逆问题求解。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-05-01 DOI: 10.1007/s13534-022-00223-1

Maryam Gholami, Mahsa Maleki, Saeed Amirkhani, Ali Chaibakhsh

{"title":"Nonlinear model-based cardiac arrhythmia diagnosis using the optimization-based inverse problem solution.","authors":"Maryam Gholami, Mahsa Maleki, Saeed Amirkhani, Ali Chaibakhsh","doi":"10.1007/s13534-022-00223-1","DOIUrl":"https://doi.org/10.1007/s13534-022-00223-1","url":null,"abstract":"This study investigates a nonlinear model-based feature extraction approach for the accurate classification of four types of heartbeats. The features are the morphological parameters of ECG signal derived from the nonlinear ECG model using an optimization-based inverse problem solution. In the model-based methods, high feature extraction time is a crucial issue. In order to reduce the feature extraction time, a new structure was employed in the optimization algorithms. Using the proposed structure has considerably increased the speed of feature extraction. In the following, the effectiveness of two types of optimization methods (genetic algorithm and particle swarm optimization) and the McSharry ECG model has been studied and compared in terms of speed and accuracy of diagnosis. In the classification section, the adaptive neuro-fuzzy inference system and fuzzy c-mean clustering methods, along with the principal component analysis data reduction method, have been utilized. The obtained results reveal that using an adaptive neuro-fuzzy inference system with data obtained from particle swarm optimization will have the shortest process time and the best diagnosis, with a mean accuracy of 99% and a mean sensitivity of 99.11%.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 2","pages":"205-215"},"PeriodicalIF":4.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046521/pdf/13534_2022_Article_223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10857756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Rapid and low-cost, and disposable electrical sensor using an extended gate field-effect transistor for cardiac troponin I detection. 快速和低成本，和一次性的电子传感器使用扩展门场效应晶体管心脏肌钙蛋白I检测。

IF 4.6 4区医学

Biomedical Engineering Letters Pub Date : 2022-05-01 DOI: 10.1007/s13534-022-00219-x

Kang Hyeon Kim, Kyung Wook Wee, CheonJung Kim, Don Hur, Jeong Hoon Lee, Yong Kyoung Yoo

{"title":"Rapid and low-cost, and disposable electrical sensor using an extended gate field-effect transistor for cardiac troponin I detection.","authors":"Kang Hyeon Kim, Kyung Wook Wee, CheonJung Kim, Don Hur, Jeong Hoon Lee, Yong Kyoung Yoo","doi":"10.1007/s13534-022-00219-x","DOIUrl":"https://doi.org/10.1007/s13534-022-00219-x","url":null,"abstract":"Field effect transistor (FET) biosensor is based on metal oxide field effect transistor that is gated by changes in the surface charges induced the reaction of biomolecules. In most cases of FET biosensor, FET biosensor is not being reused after the reaction; therefore, it is an important concept of investigate the biosensor with simplicity, cheap and reusability. However, the conventional cardiac troponin I (cTnI) sensing technique is inadequate owing to its low sensitivity and high operational time and cost. In this study, we developed a rapid and low-cost, and disposable electrical sensor using an extended gate field-effect transistor (EGFET) to detect cTnI, as a key biomarker for myocardiac infarction. We first investigated pH sensing characteristics according to the pH level, which provided a logarithmically linear sensitivity in the pH sensing buffer solution of approximately 57.9 mV/pH. Subsequently, we prepared a cTnI sample and monitored the reaction between cTnI and cTnI antibodies through the changes in the drain current and transfer curves. Our results showed that the EGFET biosensor could successfully detect the cTnI levels as well as the pH with low-cost and rapid detection.","PeriodicalId":46898,"journal":{"name":"Biomedical Engineering Letters","volume":"12 2","pages":"197-203"},"PeriodicalIF":4.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046487/pdf/13534_2022_Article_219.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10668107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3