Saudi Journal of Ophthalmology最新文献_第6页

Update on imaging the peripheral retina. 周边视网膜成像的最新进展。

IF 0.6

Saudi Journal of Ophthalmology Pub Date : 2024-06-28 eCollection Date: 2024-04-01 DOI: 10.4103/sjopt.sjopt_126_24

Paulo E Stanga

引用次数: 0

Authors reply about the race of the study population. 作者回答了研究人群的种族问题。

IF 0.6

Saudi Journal of Ophthalmology Pub Date : 2024-06-21 eCollection Date: 2024-07-01 DOI: 10.4103/sjopt.sjopt_101_24

Alicia Muñoz-Gallego

引用次数: 0

Optic disc morphology and interocular symmetry in children. 儿童的视盘形态和眼间对称性。

IF 0.6

Saudi Journal of Ophthalmology Pub Date : 2024-06-10 eCollection Date: 2024-07-01 DOI: 10.4103/sjopt.sjopt_88_24

Mahmood D Al-Mendalawi

引用次数: 0

Disease processes and terminology cannot be determined by opinion polls but have to be based on objective facts: The "white dots" case. 疾病过程和术语不能由民意调查来决定，而必须以客观事实为基础：白点 "案例。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_67_24

Carl P Herbort, Abdulrahman F Albloushi, Ioannis Papasavvas, Yoshihiko Usui, Masaru Takeuchi, Vania Lages, Marina Papadia, Alessandro Mantovani

引用次数: 0

Insights into neuro-ophthalmology. 深入了解神经眼科。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_27_24

Saif A Alryalat, Osama Al Deyabat, Andrew G Lee

引用次数: 0

Congenital superior oblique palsy in a patient with VACTERL association. 一名与 VACTERL 有关的患者的先天性上斜肌麻痹。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_297_23

Zeynep Acar, Büşra Yılmaz Tuğan

引用次数: 0

Teprotumumab in thyroid eye disease. 治疗甲状腺眼病的特普罗单抗

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_179_23

Hila Goldberg, Amina I Malik

{"title":"Teprotumumab in thyroid eye disease.","authors":"Hila Goldberg, Amina I Malik","doi":"10.4103/sjopt.sjopt_179_23","DOIUrl":"https://doi.org/10.4103/sjopt.sjopt_179_23","url":null,"abstract":"Thyroid eye disease (TED) is an inflammatory condition involving the periocular and orbital soft tissues, affecting most commonly patients with hyperthyroid disorders. Traditional treatments used for the active phase of the disease range from conservative lubrication for mild symptoms to systemic immunomodulating drugs for moderate-to-severe symptoms. Teprotumumab (Tepezza) is a monoclonal antibody with an inhibitory effect on insulin-like growth factor 1 and is the first Food and Drug Administration (FDA) approved targeted medical therapy for reducing the inflammatory signs and symptoms associated with TED. Two large multicenter, randomized, double-masked, placebo-controlled trials have confirmed the efficacy and safety of teprotumumab in patients with active, moderate-to-severe TED. Recent reports and publications have also demonstrated the efficacy of teprotumumab in a wider range of patients. In this review, we summarize the clinical features and pathophysiology of TED, disease course, and traditional management methods. We further detail the development of teprotumumab, the founding studies that brought it to its FDA approval, adverse events profile, and ongoing as well as future investigations.","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"38 1","pages":"29-33"},"PeriodicalIF":0.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11017013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibodies in neuro-ophthalmology. 神经眼科中的单克隆抗体。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-29 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_256_23

Caroline C Keehn, Arman Yazdian, Patrick J Hunt, Pamela Davila-Siliezar, Noor A Laylani, Andrew G Lee

{"title":"Monoclonal antibodies in neuro-ophthalmology.","authors":"Caroline C Keehn, Arman Yazdian, Patrick J Hunt, Pamela Davila-Siliezar, Noor A Laylani, Andrew G Lee","doi":"10.4103/sjopt.sjopt_256_23","DOIUrl":"https://doi.org/10.4103/sjopt.sjopt_256_23","url":null,"abstract":"Neuro-ophthalmologic diseases include a broad range of disorders affecting the afferent and efferent visual pathways. Recently, monoclonal antibody (mAb) therapies have emerged as a promising targeted approach in the management of several of these complex conditions. Here, we describe the mechanism-specific applications and advancements in neuro-ophthalmologic mAb therapies. The application of mAbs in neuro-ophthalmologic diseases highlights our increasing understanding of disease-specific mechanisms in autoimmune conditions such as neuromyelitis optica, thyroid eye disease, and myasthenia gravis. Due to the specificity of mAb therapies, applications in neuro-ophthalmologic diseases have yielded exceptional clinical outcomes, including both reduced rate of relapse and progression to disability, visual function preservation, and quality of life improvement. These advancements have not only expanded the range of treatable neuro-ophthalmologic diseases but also reduced adverse events and increased the response rate to treatment. Further research into neuro-ophthalmologic disease mechanisms will provide accurate and specific targeting of important disease mediators through applications of future mAbs. As our understanding of these diseases and the relevant therapeutic targets evolve, we will continue to build on our understanding of how mAbs interfere with disease pathogenesis, and how these changes improve clinical outcomes and quality of life for patients.","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"38 1","pages":"13-24"},"PeriodicalIF":0.4,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11017005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical profile of amblyopia in a tertiary care facility without proper vision screening in Saudi Arabia. 沙特阿拉伯一家未进行适当视力筛查的三级医疗机构中弱视的临床概况。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-03-26 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_87_22

Shatha Alfreihi, Rana Alsoby, Latifah Abu Haimed, Omar Asiri, Mohammed A Meeli

{"title":"Clinical profile of amblyopia in a tertiary care facility without proper vision screening in Saudi Arabia.","authors":"Shatha Alfreihi, Rana Alsoby, Latifah Abu Haimed, Omar Asiri, Mohammed A Meeli","doi":"10.4103/sjopt.sjopt_87_22","DOIUrl":"https://doi.org/10.4103/sjopt.sjopt_87_22","url":null,"abstract":"Purpose: To evaluate the clinical profile of amblyopia among patients referred to a tertiary care facility in Saudi Arabia.Methods: All patients between 1 and 14 years presenting to the amblyopia clinic from 2016 to 2020 were retrospectively reviewed. Amblyopia was defined as visual acuity <0.2 LogMAR (20/30) in the worse eye or two-line difference between the two eyes. We classified patients into strabismic, refractive, mixed strabismic, and refractive and deprivation amblyopia. We subclassified our cohort according to age (< and ≥5 years).Results: Three hundred and eighty-three patients (199 male 54%) were seen in our clinic. Seventeen patients were excluded because they did not meet our inclusion criteria. The mean age at presentation was 5.05 ± 2.49 years. Strabismic amblyopia was found in 180 (49%), refractive in 101 (27.6%), mixed in 69 (19%), and deprivation in 16 (4.2%). Anisometropia in 85.25% and isometropia in 14.75%. Hyperopic astigmatism was the most common refractive error in 246 (67.2%). Esotropia was the most common deviation (90%). Strabismic amblyopia was significantly higher in the <5 years group (62.4% vs. 36.7%). While refractive amblyopia was significantly higher in ≥5 years group (38.8% vs. 15.7%) (P < 0.001).Conclusion: Strabismic amblyopia was the most commonly diagnosed in our cohort, especially among patients <5 years of age. Refractive amblyopia was more common in older patients and may be under-detected due to the lack of proper vision screening. The implementation of proper vision screening should help in early detection and successful treatment at an early age.","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"38 1","pages":"78-82"},"PeriodicalIF":0.4,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic disc morphology and interocular symmetry in children. 儿童的视盘形态和眼间对称性。

IF 0.4

Saudi Journal of Ophthalmology Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI: 10.4103/sjopt.sjopt_229_22

Alicia Muñoz-Gallego, Martín Rodríguez-Salgado, Cristina López-López, José L Torres-Peña, Ana Ortueta-Olartecoechea, Javier De La Cruz, Pilar Tejada-Palacios

{"title":"Optic disc morphology and interocular symmetry in children.","authors":"Alicia Muñoz-Gallego, Martín Rodríguez-Salgado, Cristina López-López, José L Torres-Peña, Ana Ortueta-Olartecoechea, Javier De La Cruz, Pilar Tejada-Palacios","doi":"10.4103/sjopt.sjopt_229_22","DOIUrl":"https://doi.org/10.4103/sjopt.sjopt_229_22","url":null,"abstract":"Purpose: The purpose of the study was to obtain a pediatric reference database for optic disc parameters and interocular symmetry. To ascertain factors that modify these parameters (age, spherical equivalent [SE], and sex).Methods: This was a cross-sectional study. 90 patients aged 5-17 years fulfilled all the inclusion criteria. After a full examination including cycloplegic refraction, all patients underwent optical coherence tomography (OCT) of the papilla using the three-dimensional (3D) scan protocol of the Topcon 3D 2000 OCT device. We provide reference values for optic disc parameters in the pediatric population. We also retrieved interocular symmetry reference values for these parameters.Results: The multivariate regression analysis did not reveal variations in any of the optic disc parameters associated with age, sex, or SE (all P ≥ 0.126). The 95th percentile limit for absolute interocular differences for the cup-to-disc area ratio was 0.24. The multivariate regression analysis revealed the absence of a correlation between asymmetry of the optic disc parameters and age, sex, and the interocular difference in SE (all P ≥ 0.105).Conclusion: Pediatric reference databases for optic disc parameters and ranges of normality for interocular symmetry provide key diagnostic support in diseases that affect the optic nerve.","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"38 1","pages":"47-52"},"PeriodicalIF":0.4,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0