British Journal of Pain最新文献

{"title":"Supporting recruitment into complex trials: An embedded qualitative process evaluation in the RADICAL trial of radiofrequency denervation for chronic low back pain.","authors":"Cecily K Palmer, Vikki Wylde, Cathy Price, Kate E Ashton, Andrew J Moore","doi":"10.1177/20494637261450519","DOIUrl":"10.1177/20494637261450519","url":null,"abstract":"<p><strong>Aims: </strong>A qualitative process evaluation was embedded into the pilot phase of the RADICAL randomised controlled trial of radiofrequency denervation for chronic and moderate-severe low back pain. The aim was to rapidly understand recruitment processes and inform development of strategies to overcome recruitment challenges.</p><p><strong>Methods: </strong>Audio recording of recruitment consultations between recruiting staff and potential patient participants, and interviews with patients who had consented to participate in the RADICAL trial. We used rapid thematic analysis to identify what information was provided, understanding of trial processes and potential challenges to recruitment.</p><p><strong>Results: </strong>Recruitment staff needed more support to clearly and effectively explain trial participation. Specific challenges included communicating trial procedures, explaining treatment equipoise and randomisation, and navigating the complex recruitment pathway. These findings led to the development of support materials for recruiters, including a process diagram and targeted training sessions to optimise information provision and informed consent.</p><p><strong>Conclusion: </strong>Embedding qualitative process evaluations within an RCT pilot can generate rapid insights into communication challenges and recruitment barriers. These insights can inform the development of practical support materials and process refinements to enhance recruitment, potentially strengthening trial viability.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261450519"},"PeriodicalIF":2.8,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients-reported desirable features and outcomes in migraine therapeutics and guidance for medical product life cycle: a scoping review of 6435 patients.","authors":"Alireza Maghdoori, Maryam Talebi, Shina Shahhosseini, Ghader Mohammadnezhad","doi":"10.1177/20494637261451494","DOIUrl":"https://doi.org/10.1177/20494637261451494","url":null,"abstract":"<p><strong>Background: </strong>Understanding patient preferences for migraine treatments is essential for patient-centered care and for informing the development and optimization of therapeutic options. Although individual preference-elicitation studies exist, evidence has not been systematically synthesized across methods and treatment contexts.</p><p><strong>Methods: </strong>We conducted a scoping review in accordance with PRISMA 2020 guidelines. PubMed, Scopus, Web of Science, and Google Scholar were searched for peer-reviewed studies that elicited patient preferences regarding acute or preventive migraine pharmacotherapies. Eligible studies employed qualitative or quantitative preference-elicitation methods.</p><p><strong>Results: </strong>20 studies comprising 6435 participants were included. Across preventive and acute treatment contexts, efficacy-related outcomes were consistently prioritized by patients. For preventive treatments, key valued attributes included reduction in migraine frequency, durability of effect, tolerability, and convenience, with preferences varying by prior treatment experience and disease severity. For acute treatments, rapid onset of action, complete pain relief, functional recovery, and minimal adverse events were most important. Preferences regarding route of administration were heterogeneous and context-dependent, reflecting trade-offs between convenience, invasiveness, and perceived effectiveness.</p><p><strong>Conclusions: </strong>Patient preferences for migraine treatments are multifactorial and vary across treatment goals, modalities, and patient subgroups. While methodological limitations across studies constrain definitive conclusions, this review highlights consistent priority attributes that may inform shared decision-making, outcome selection in clinical trials, and patient-centered aspects of migraine therapy development.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261451494"},"PeriodicalIF":1.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ongoing challenge of chronic pain identification and management in cancer survivorship.","authors":"Christina Liossi","doi":"10.1177/20494637261450370","DOIUrl":"10.1177/20494637261450370","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261450370"},"PeriodicalIF":1.5,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fibromyalgia syndrome diagnosis and treatment experiences on health information-seeking behaviour: A cross-sectional online survey.","authors":"Juliette Allen, Andreas Goebel, Nicholas Fallon","doi":"10.1177/20494637261447443","DOIUrl":"10.1177/20494637261447443","url":null,"abstract":"<p><strong>Background: </strong>Patients with fibromyalgia syndrome (FMS) often report prolonged diagnostic pathways and inadequate care, prompting reliance on self-management and online health information. This study aimed to quantify the association between specific clinical experiences and the sources and extent of health information-seeking behaviours in people with FMS.</p><p><strong>Methods: </strong>A cross-sectional online survey was completed by adults who self-reported a diagnosis of FMS. Measures assessed symptom severity, diagnostic and treatment experiences, frequency and duration of symptom flares, perceived stigma and caring from healthcare professionals, and engagement with health information sources, including traditional and digital platforms. Associations between clinical experiences and health information-seeking behaviours were examined using non-parametric tests and hierarchical regression analyses.</p><p><strong>Results: </strong>A total of 384 adults completed the survey (75.3% female; median age 41 years). Most participants reported experiencing symptom flares (88.0%), occurring approximately every 2-3 weeks and lasting a median of 3 days. Participants reported significantly more negative than neutral experiences across multiple diagnostic and treatment variables, including diagnostic difficulty and challenges accessing specialist care. Most respondents (84.1%) actively sought health information, most commonly from healthcare professionals, websites, and online network platforms. Nearly half reported difficulties accessing satisfactory health information. Greater diagnostic difficulty, difficulty finding a specialist, and higher perceived caring from healthcare professionals independently predicted engagement with a wider range of health information sources.</p><p><strong>Conclusions: </strong>Patients with FMS frequently report dissatisfaction with their clinical experiences. Positive and negative diagnostic and treatment experiences are associated with the extent of health information-seeking among people with FMS. These findings highlight the importance of clinical experiences in shaping how patients seek health information and underscore the role of supportive clinical relationships in fostering informed and collaborative care.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261447443"},"PeriodicalIF":2.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise testing in a paediatric chronic pain cohort - A cross-sectional observation study.","authors":"Andrew Gorrie, Bethany McLennan, Emily Yeoh, Tiina Jaaniste","doi":"10.1177/20494637261445408","DOIUrl":"10.1177/20494637261445408","url":null,"abstract":"<p><strong>Background: </strong>The utility of exercise testing in an interdisciplinary paediatric chronic pain assessment is unknown. The aims of this study were to explore exercise testing results in a paediatric chronic pain cohort and associations with baseline patient-reported outcome measures (PROMs), including various measures of pain experience and functioning.</p><p><strong>Methods: </strong>There were 153 participants, aged 6-17 years, attending the Sydney Children's Hospital Interdisciplinary Chronic and Complex Pain Clinic with data analysed retrospectively. Exercise tests included the six-minute walk test (6MWT), plank, prone extension and pushups. Results were described and stratified by age, and Spearmen correlation coefficients (<i>r</i> _s) were determined between baseline exercise testing results and PROMs, and between different exercise tests.</p><p><strong>Results: </strong>The 6MWT distances were greater in the younger subgroup, however, there were no other differences in exercise tests between age groups. Associations between baseline exercise testing results and baseline PROMs ranged from very weak to moderate (<i>r</i> _s's = .18-.40). Associations between different exercise testing results ranged from very weak to moderate (<i>r</i> _s's = .17-.52). The 6MWT, plank and pushups each had at least five weak to moderate associations with PROMs and the prone extension test had one weak association.</p><p><strong>Conclusions: </strong>Exercise testing results in a paediatric chronic pain cohort are presented, including with age stratification. The results of the current study suggest that exercise testing provides unique information to supplement other forms of assessment. There is a need for standardised exercise protocols with normative datasets, so that clinical and research findings are more comparable across settings.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261445408"},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of opioid cessation after surgery in opioid-naïve patients in the United Kingdom: A qualitative study.","authors":"Fausto Morell-Ducos, Jennifer Samson, Jamie Smart, Xolani Dereck Gondongwe, Amanda C de C Williams","doi":"10.1177/20494637261443815","DOIUrl":"https://doi.org/10.1177/20494637261443815","url":null,"abstract":"<p><strong>Background: </strong>Opioid analgesia is frequently prescribed after surgery, with the expectation that patients will cease use within weeks, yet up to 25% of opioid-naïve patients may develop persistent postoperative opioid use. Opioid stewardship interventions are increasingly used to mitigate this risk, but little is known of the psychological factors influencing successful opioid cessation in the community after surgery in the UK.</p><p><strong>Aim: </strong>To identify psychological factors influencing opioid use and cessation after discharge following surgery in the UK.</p><p><strong>Design: </strong>Interviews with post-surgical patients 3 months after discharge; qualitative framework analysis summarised as themes.</p><p><strong>Methods: </strong>Opioid-naïve patients discharged on opioids after all-type surgery were invited three months later to a telephone interview that explored their experience of reducing opioids at home, and what influenced these decisions. Data were transcribed and qualitatively analysed.</p><p><strong>Results: </strong>48 participants were interviewed: all had ceased opioid use within one month of surgery. Four themes, comprising 15 subthemes, described diverse considerations: relationship with opioids - balance of benefits and risks; relationship with pain; relationship with clinicians; and views about addiction, including moral perspectives.</p><p><strong>Conclusion: </strong>Those interviewed made complex decisions on tapering opioids drawing on beliefs and previous experiences, relationships to healthcare, and prior experiences of pain. The themes identified lend further support, in the UK healthcare setting, to specific opioid stewardship interventions, especially patient education, pack-size limitation, and transitional pain services.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261443815"},"PeriodicalIF":1.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer pain knowledge and attitudes of healthcare professionals: A systematic review of surveys and their measurement properties.","authors":"Martin Galligan, Rebecca Verity, Theresa Wiseman, Emma Briggs","doi":"10.1177/20494637261442745","DOIUrl":"10.1177/20494637261442745","url":null,"abstract":"<p><strong>Background: </strong>Effective management of cancer-related pain (CRP) requires support from knowledgeable healthcare professionals. Existing literature states that healthcare professionals' knowledge of CRP is poor. However, there is no consistency in how knowledge and attitudes are assessed or the standards against which they are measured. This systematic review evaluates the cancer-related content and psychometric properties of surveys used to assess knowledge of CRP.</p><p><strong>Method: </strong>Using JBI methodology for Systematic Reviews of Measurement Properties, the search was conducted in MEDLINE, EMBASE, CINAHL and PsycINFO (limited to 2011-2024). Screening and extraction were completed by two researchers using the COVIDENCE system. The COSMIN Risk of Bias checklist was used to assess psychometric properties, and additional data were extracted on content feasibility.</p><p><strong>Results: </strong>A total of 1024 papers were identified, and 37 were included in the final analysis. Sixteen different surveys were found, with four being used in multiple studies. No survey was deemed superior, and all were rated poorly using the COSMIN Risk of Bias checklist. The CRP content within the surveys varied significantly, with none capturing the complexity of CRP. The feasibility of administering these surveys in practice was not reported in the studies examined.</p><p><strong>Conclusion: </strong>The wide variation in the design and content of surveys identified makes it difficult to assess the current state of healthcare professionals' knowledge of CRP. This raises questions about the validity and reliability of their conclusions, as they lack a robust evaluation of psychometric properties. Further research is needed to accurately assess healthcare professionals' knowledge of CRP.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261442745"},"PeriodicalIF":2.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Withered Arm: Thomas Hardy's chronicle of complex regional pain syndrome.","authors":"Roxaneh Zarnegar","doi":"10.1177/20494637261435123","DOIUrl":"10.1177/20494637261435123","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261435123"},"PeriodicalIF":2.8,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with disability in women with chronic pelvic pain: A cross-sectional study.","authors":"Natany Santos Martins, Gleiciane Aguiar Brito, Simony Lira Nascimento, Mayle Andrade Moreira","doi":"10.1177/20494637261432838","DOIUrl":"10.1177/20494637261432838","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to explore the factors associated with disability in women with chronic pelvic pain (CPP).</p><p><strong>Methods: </strong>This is a cross-sectional study conducted in Brazil with women with CPP, between 18 and 45 years old. Disability was measured using the World Health Organisation Disability Assessment Scale (WHODAS 2.0). Socioeconomic and clinical data were collected, and instruments to assess pain intensity and catastrophising, sexual function, kinesiophobia, depression, physical activity and the sit-to-stand test were applied. Correlations of Spearman, Student's t-test and multiple linear regression were used for data analysis (α = 0.05).</p><p><strong>Results: </strong>168 women with a median age of 36 (IQR 29 - 40) years were evaluated. Those with greater pain intensity and catastrophising, sexual dysfunction, kinesiophobia, depression, who do not practice regular physical activity and with worse performance in the sit-to-stand test had greater disability on correlation analysis. However, only pain catastrophising (β = 6.40; 95%CI 0.44 - 12.36) and depression (β = 12.03; 95%CI 6.61 - 17.45) were predictors of disability (p < 0.05) in the adjusted linear regression model.</p><p><strong>Conclusion: </strong>Our results indicate that psychosocial factors (pain catastrophising and depression) have a stronger relationship with disability than pain intensity or physical factors (sit to stand and physical activity). Therefore, all clinicians involved in the care of women with CPP could systematically assess and address pain catastrophising and depression as part of comprehensive management to prevent disability.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261432838"},"PeriodicalIF":1.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From childhood struggles to adult strains: A systematic review of the impact of adverse childhood experiences on psycho-emotional functioning, pain outcomes, and quality of life in populations experiencing chronic pain.","authors":"Angeliki Gkiouzeli, Marie-Jo Brennstuhl, Amélie Couraillon, Pierrick Poisbeau, Christine Rotonda, Cyril Tarquinio","doi":"10.1177/20494637261429225","DOIUrl":"10.1177/20494637261429225","url":null,"abstract":"<p><p>Adverse childhood experiences (ACEs) are well-documented risk factors for later health problems, such as chronic pain and mental illness. We aimed to synthesise the impact of childhood trauma on psycho-emotional disorders, pain perception and cognitions, and quality of life in individuals with chronic pain. A systematic review was conducted following PRISMA guidelines for systematic reviews and meta-analyses. Eligible studies were identified by searching PubMed, PsychINFO, Embase, and Web of Science, with publication dates from 1988 to April 2023. Inclusion criteria were formulated according to the PECOS framework, and relevant research articles were screened for inclusion. Evidence from 18 studies highlights the significant impact of ACEs (and their typologies) on patients' psycho-emotional well-being, pain outcomes, and overall quality of life, with a cumulative effect emerging. However, significant methodological limitations, such as the lack of standardised measures to classify childhood adversity, prevent us from drawing definitive conclusions about the reported associations. The findings underscore the importance of integrated approaches to pain management that centre on the patient's life history and psycho-emotional status. Future research should address current limitations to strengthen our understanding of the role of ACEs in chronic pain research.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":" ","pages":"20494637261429225"},"PeriodicalIF":1.5,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}