British Journal of Pain最新文献

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A systematic review of screening diagnostic tools for trigeminal neuralgia. 三叉神经痛筛查诊断工具的系统综述。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 DOI: 10.1177/20494637221146854
Thn Teshima, J M Zakrzewska, R Potter
{"title":"A systematic review of screening diagnostic tools for trigeminal neuralgia.","authors":"Thn Teshima,&nbsp;J M Zakrzewska,&nbsp;R Potter","doi":"10.1177/20494637221146854","DOIUrl":"https://doi.org/10.1177/20494637221146854","url":null,"abstract":"<p><strong>Background and objective: </strong>Trigeminal neuralgia (TN) is a rare chronic neuropathic pain condition of sudden and severe pain, often described as an electric shock. Diagnosis is challenging for non-expert clinicians, particularly in primary care settings. We wanted to identify and assess the diagnostic accuracy of existing screening tools for TN and orofacial pain that could be used to support the diagnosis of TN in primary care.</p><p><strong>Databases and data treatment: </strong>We searched key databases (MEDLINE, ASSIA, Embase, and Web of Knowledge and PsycINFO) supplemented by citation tracking from January 1988 to 2021. We used an adapted version of the Quality of Diagnostic Accuracy Studies (QUADAS-2) to assess the methodological quality of each study.</p><p><strong>Results: </strong>Searches identified five studies, from the UK, USA and Canada; three validated self-report questionnaires; and two artificial neural networks. All screened for multiple orofacial pain diagnoses, including dentoalveolar pain, musculoskeletal pain (temporomandibular disorders) and neurological pain (trigeminal neuralgia, headache, atypical facial pain and postherpetic neuralgia). The overall quality assessment was low for one study.</p><p><strong>Conclusions: </strong>Diagnosis of TN can be challenging for non-expert clinicians. Our review found few existing screening tools to diagnose TN, and none is currently suitable to be used in primary care settings. This evidence supports the need to adapt an existing tools or to create a new tool for this purpose. The development of an appropriate screening questionnaire could assist non-expert dental and medical clinicians to identify TN more effectively and empower them to manage or refer patients for treatment more effectively.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"255-266"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2b/d3/10.1177_20494637221146854.PMC10278451.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Comparison of Social Exclusion Towards People with Depression or Chronic Back Pain. 抑郁症和慢性背痛患者的社会排斥比较。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 DOI: 10.1177/20494637221148337
Lucy Roberts-West, Amy Gravatt, Natasha Guest, Ashley Hunt, Laraib Siddique, Danijela Serbic
{"title":"A Comparison of Social Exclusion Towards People with Depression or Chronic Back Pain.","authors":"Lucy Roberts-West,&nbsp;Amy Gravatt,&nbsp;Natasha Guest,&nbsp;Ashley Hunt,&nbsp;Laraib Siddique,&nbsp;Danijela Serbic","doi":"10.1177/20494637221148337","DOIUrl":"https://doi.org/10.1177/20494637221148337","url":null,"abstract":"<p><strong>Objectives: </strong>Research comparing mental and physical health stigma is scarce. The aim of this study was to compare social exclusion towards hypothetical males and females with depression or chronic back pain. Furthermore, the study investigated whether social exclusion is associated with participant's empathy and personality traits, while controlling for their sex, age and personal exposure to mental/physical chronic health conditions.</p><p><strong>Design: </strong>This study employed a cross-sectional questionnaire design.</p><p><strong>Methods: </strong>Participants (<i>N</i> = 253) completed an online vignette-based questionnaire and were randomly allocated to either a depression or chronic back pain study condition. Measures of social exclusion through respondents' willingness to interact with hypothetical individuals, empathy and the Big Five personality traits were completed.</p><p><strong>Results: </strong>Willingness to interact scores did not significantly differ depending on the diagnosis or sex of the hypothetical person in the vignette. For depression, higher levels of conscientiousness significantly predicted less willingness to interact. Whilst being a female participant and having higher empathy significantly predicted greater willingness to interact. For chronic back pain, higher empathy significantly predicted greater willingness to interact, with no significant predictors found from the Big Five personality traits.</p><p><strong>Conclusion: </strong>Findings indicate that females and males with depression or chronic back pain face similar levels of social exclusion, with empathy being a core variable driving social exclusion behaviours. These findings enhance our understanding of potential variables driving social exclusion, in-turn informing campaign development to reduce public stigma towards depression and chronic back pain.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"267-280"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do lifestyle factors influence pain prognosis? A 1-year follow-up study. 生活方式会影响疼痛的预后吗?为期 1 年的跟踪研究。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 Epub Date: 2023-01-19 DOI: 10.1177/20494637231152975
Marc-Henri Louis, Anne Berquin, Arnaud Steyaert
{"title":"Do lifestyle factors influence pain prognosis? A 1-year follow-up study.","authors":"Marc-Henri Louis, Anne Berquin, Arnaud Steyaert","doi":"10.1177/20494637231152975","DOIUrl":"10.1177/20494637231152975","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this observational longitudinal study was to investigate the impact of lifestyle factors on the prognosis of patients with pain.</p><p><strong>Methods: </strong>This study was part of a large prospective longitudinal study conducted in general practice (GP). Participants completed questionnaires at baseline (T0) and one year later (T1). Outcomes analysed were the EQ-5D index, presence of pain and the ability to perform a light work for 1 hour without difficulty.</p><p><strong>Results: </strong>Among 377 individuals with pain at T0, 294 still reported pain at T1. This subgroup had a significantly higher BMI, more painful sites, higher pain intensity, more sleep problems, poorer general self-rated health (GSRH) and higher Örebro Musculoskeletal Pain Screening Questionnaire (ÖMPSQ) score at T0 than pain-free individuals at T1. There were no differences in age, sex, physical activity and smoking. In multivariable analyses, the number of painful sites, GSRH, sleep problems, pain duration, pain intensity and 2 short-form 10-item Örebro musculoskeletal pain questionnaire (SF-ÖMPSQ) items were independently associated with at least one outcome 1 year later. Only GSRH was strongly associated with all outcomes. The accuracy of GSRH at T0 to classify participants according to dichotomous outcomes was overall moderate (0.7 < AUC <0.8).</p><p><strong>Conclusions: </strong>Lifestyle factors appear to have little influence on the outcome of patients with pain in GP. Conversely, poorer GSRH - which probably integrates the subjects' perception of several factors - could be considered a negative prognostic factor in patients with pain.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"293-305"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Power to the People, to the people': Training for social prescribers improves support of persistent pain. “权力给人民,给人民”:对社会开处方者的培训改善了对持续性疼痛的支持。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 DOI: 10.1177/20494637231152979
Alex Corline, Frances Cole, Louise Trewern, Chris Penlington
{"title":"'Power to the People, to the people': Training for social prescribers improves support of persistent pain.","authors":"Alex Corline,&nbsp;Frances Cole,&nbsp;Louise Trewern,&nbsp;Chris Penlington","doi":"10.1177/20494637231152979","DOIUrl":"https://doi.org/10.1177/20494637231152979","url":null,"abstract":"<p><strong>Introduction: </strong>Supported self-management is an important aspect of managing pain, however widely held beliefs about the biomedical nature of pain and limited time availability can make it a tricky concept to introduce to patients. Social prescribers are in an ideal position to support self-management of pain if appropriate training is available to support them. This study aimed to evaluate training for social prescribers and to explore their opinions and experiences about providing self-management support.</p><p><strong>Methods: </strong>This was a mixed methods study. Repeated measures t-tests were used to compare the reported confidence of attendees in supporting different facets of self-management before and after the training. Thematic analysis of interviews was used to develop a deeper understanding of how participants related the training to their work with patients.</p><p><strong>Results: </strong>Average confidence improved in all aspects of supporting self-management, and particularly with regard to supporting understanding pain, acceptance, pacing, setting goals, sleep and managing setbacks. Challenges were identified around explaining pain in an accurate and accessible way in order to provide a meaningful rationale for self-management.</p><p><strong>Conclusion: </strong>Training for social prescribers in self-management support is feasible and leads to improvements in self-reported confidence. Further research is needed to determine the impact on patients and over a longer period of time.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"281-292"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/3e/10.1177_20494637231152979.PMC10278448.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An updated audit of the patient selection process for pain management programmes in a speciality care service before and during the COVID-19 pandemic. 在COVID-19大流行之前和期间对专科护理服务中疼痛管理规划的患者选择过程进行的最新审计。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 DOI: 10.1177/20494637221147200
Valentina Buscemi, Joe Chicken, Tim Mahy, Lucie Knight, Whitney Scott
{"title":"An updated audit of the patient selection process for pain management programmes in a speciality care service before and during the COVID-19 pandemic.","authors":"Valentina Buscemi,&nbsp;Joe Chicken,&nbsp;Tim Mahy,&nbsp;Lucie Knight,&nbsp;Whitney Scott","doi":"10.1177/20494637221147200","DOIUrl":"https://doi.org/10.1177/20494637221147200","url":null,"abstract":"<p><strong>Background: </strong>The provision of pain management programmes (PMPs) changed substantially in response to the COVID-19 pandemic with virtual delivery implemented in many services. Little is known about patient selection processes for virtual PMPs and how this might differ from in-person programmes. The aim of this audit was to document the patient selection process for PMPs at a speciality pain service prior to and during the pandemic.</p><p><strong>Methods: </strong>This retrospective audit used data from consecutive patients attending a multidisciplinary assessment to determine the suitability of a PMP. Anonymized data were extracted from assessment letters and hospital records in the months prior to the pandemic (n =168) and during the start of the pandemic once the service began delivering virtual PMPs (n =171).</p><p><strong>Results: </strong>For the standard pain management pathway, most patients were offered a PMP option within the service before and during the pandemic, although a greater proportion of patients were offered treatment during the pandemic. For the neuromodulation pathway, most patients were offered a pre-neuromodulation PMP option, and this was similar before and during the pandemic. Psychosocial complexities and unwillingness to engage in a pain management approach that does not principally focus on pain reduction were the most common reasons that patients were not offered a programme.</p><p><strong>Discussion: </strong>This audit points to a pattern of more inclusive assessment outcomes within our service over time and particularly during the pandemic. Offering a range of in-person and virtual PMPs can meet a wider range of patient need. Research is needed to understand how to best assess and match patients with the breadth of treatment delivery formats now available.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"226-238"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10024844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
BPS ASM 2023 abstract supplement BPS ASM 2023摘要补编
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 DOI: 10.1177/20494637231177771
{"title":"BPS ASM 2023 abstract supplement","authors":"","doi":"10.1177/20494637231177771","DOIUrl":"https://doi.org/10.1177/20494637231177771","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 1","pages":"1 - 63"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46499612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Yarning about pain: Evaluating communication training for health professionals at persistent pain services in Queensland, Australia. 了解疼痛:评估澳大利亚昆士兰持续性疼痛服务机构对医护人员进行的沟通培训。
IF 1.8
British Journal of Pain Pub Date : 2023-06-01 Epub Date: 2023-01-30 DOI: 10.1177/20494637221149831
Christina M Bernardes, Stuart Ekberg, Stephen Birch, Andrew Claus, Matthew Bryant, Renata Meuter, Jermaine Isua, Paul Gray, Joseph P Kluver, Eva Malacova, Corey Jones, Kushla Houkamau, Marayah Taylor, Ivan Lin, Gregory Pratt
{"title":"Yarning about pain: Evaluating communication training for health professionals at persistent pain services in Queensland, Australia.","authors":"Christina M Bernardes, Stuart Ekberg, Stephen Birch, Andrew Claus, Matthew Bryant, Renata Meuter, Jermaine Isua, Paul Gray, Joseph P Kluver, Eva Malacova, Corey Jones, Kushla Houkamau, Marayah Taylor, Ivan Lin, Gregory Pratt","doi":"10.1177/20494637221149831","DOIUrl":"10.1177/20494637221149831","url":null,"abstract":"<p><strong>Background: </strong>Providing cultural education to health professionals is essential in improving the quality of care and outcomes for Aboriginal and Torres Strait Islander patients. This study reports the evaluation of a novel training workshop used as an intervention to improve communication with Aboriginal and Torres Strait Islander patients of persistent pain services.</p><p><strong>Methods: </strong>In this single-arm intervention study, health professionals undertook a one-day workshop, which included cultural capability and communication skills training based on a clinical yarning framework. The workshop was delivered across three adult persistent pain clinics in Queensland. At the end of the training, participants completed a retrospective pre/post evaluation questionnaire (5 points Likert scale<i>, 1 = very low to 5 = very high)</i>, to rate their perceived importance of communication training, their knowledge, ability and confidence to communicate effectively. Participants also rated their satisfaction with the training and suggested improvements for future trainings.</p><p><strong>Results: </strong>Fifty-seven health professionals were trained (<i>N</i> = 57/111; 51% participation rate), 51 completed an evaluation questionnaire (<i>n</i> = 51/57; 90% response rate). Significant improvements in the perceived importance of communication training, knowledge, ability and confidence to effectively communicate with Aboriginal and Torres Strait Islander patients were identified (<i>p < 0.001</i>). The greatest increase was in the perceived confidence pre-training mean of 2.96 (SE = 0.11) to the post-training mean of 4.02 (SE = 0.09).</p><p><strong>Conclusion: </strong>This patient-centred communication training, delivered through a novel model that combines cultural capability and the clinical yarning framework applied to the pain management setting, was highly acceptable and significantly improved participants' perceived competence. This method is transferrable to other health system sectors seeking to train their clinical workforce with culturally sensitive communication skills.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 3","pages":"306-319"},"PeriodicalIF":1.8,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All Change at the BJP. BJP 的所有变化
IF 1.8
British Journal of Pain Pub Date : 2023-04-01 Epub Date: 2023-04-05 DOI: 10.1177/20494637231167722
Felicia Cox, Roger Knaggs
{"title":"All Change at the BJP.","authors":"Felicia Cox, Roger Knaggs","doi":"10.1177/20494637231167722","DOIUrl":"10.1177/20494637231167722","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 2","pages":"116"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9294484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy of sensory neural entrainment on acute and chronic pain: A systematic review and meta-analysis. 感觉神经夹带治疗急性和慢性疼痛的疗效:系统回顾和荟萃分析。
IF 1.8
British Journal of Pain Pub Date : 2023-04-01 DOI: 10.1177/20494637221139472
Rhys Maddison, Hamde Nazar, Ilona Obara, Quoc C Vuong
{"title":"The efficacy of sensory neural entrainment on acute and chronic pain: A systematic review and meta-analysis.","authors":"Rhys Maddison,&nbsp;Hamde Nazar,&nbsp;Ilona Obara,&nbsp;Quoc C Vuong","doi":"10.1177/20494637221139472","DOIUrl":"https://doi.org/10.1177/20494637221139472","url":null,"abstract":"<p><strong>Background: </strong>Changes to the power of neural oscillations in cortical and sub-cortical structures can change pain perception. Rhythmic sensory stimulation is a non-invasive method that can increase power in specific frequencies of neural oscillations. If the stimulation frequency targets those frequencies related to pain perception, such as alpha or theta frequencies, there can be a reduction in perceived pain intensity. Thus, sensory neural entrainment may provide an alternative to pharmacological intervention for acute and chronic pain. This review aimed to identify and critically appraise the evidence on the effectiveness of sensory entrainment methods for pain perception.</p><p><strong>Methods: </strong>We undertook a systematic search across Medline, Embase, PsycInfo, Web of Science and Scopus in November 2020 to identify studies investigating the efficacy of sensory entrainment on adults. We assessed studies for their quality using the PRISMA checklist. A random-effects model was used in a meta-analysis to measure the effect of entrainment on pain perception.</p><p><strong>Results: </strong>Our systematic review yielded nine studies fitting the search criteria. Studies investigated the effect of visual and auditory entrainment on pain intensity rating, electrophysiological markers of pain and amount of analgesia needed during surgery. The meta-analysis suggests that alpha (8-13 Hz) sensory entrainment is effective for acute pain perception, whereas theta (4-7 Hz) entrainment is effective for chronic pain.</p><p><strong>Conclusions: </strong>Although there is heterogeneity in the current evidence, our review highlights the potential use of sensory entrainment to affect acute and chronic pain. Further research is required regarding the timing, duration and frequency of the stimulation to determine the best application for maximum efficacy.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 2","pages":"126-141"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficiency of pain inhibition and facilitation of fibromyalgia patients is not different from healthy controls: Relevance of sensitivity-adjusted test stimuli. 纤维肌痛患者的疼痛抑制和促进效率与健康对照组无异:敏感度调整测试刺激的相关性。
IF 1.8
British Journal of Pain Pub Date : 2023-04-01 Epub Date: 2022-12-06 DOI: 10.1177/20494637221138318
Roland Staud, Melyssa M Godfrey, Joseph L Riley, Roger B Fillingim
{"title":"Efficiency of pain inhibition and facilitation of fibromyalgia patients is not different from healthy controls: Relevance of sensitivity-adjusted test stimuli.","authors":"Roland Staud, Melyssa M Godfrey, Joseph L Riley, Roger B Fillingim","doi":"10.1177/20494637221138318","DOIUrl":"10.1177/20494637221138318","url":null,"abstract":"<p><strong>Background: </strong>Pain is a dynamic phenomenon dependent on the balance of endogenous excitatory and inhibitory systems, which can be characterized by quantitative sensory testing. Many previous studies of pain modulatory capacity of patients with fibromyalgia syndrome (FM) have reported decreased pain inhibition or increased pain facilitation. This is the first study to assess pain modulation, including conditioned pain modulation (CPM) and temporal pain summation, in the same healthy control (HC) and FM participants.</p><p><strong>Methods: </strong>Only sensitivity-adjusted stimuli were utilized for testing of conditioned pain modulation (CPM) and temporal pain summation in 23 FM patients and 28 HC. All subjects received sensitivity-adjusted ramp-hold (sRH) during testing of pain facilitation (temporal summation) and pain inhibition (CPM). CPM efficacy was evaluated with test stimuli applied either concurrently or after application of the conditioning stimulus. Finally, the effects of CPM on pressure pain thresholds were tested.</p><p><strong>Results: </strong>FM subjects required significantly less intense test and conditioning stimuli than HC participants to achieve standardized pain ratings of 50 ± 10 numerical rating scale (NRS) (<i>p</i> = 0.03). Using such stimuli, FM subjects' temporal pain summation and CPM efficacy was not significantly different from HC (all <i>p</i> > 0.05), suggesting similar pain facilitation and inhibition. Furthermore, the CPM efficacy of FM and HC participants was similar regardless of whether the test stimuli were applied during or after the conditioning stimulus (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Similar to previous studies, FM participants demonstrated hyperalgesia to heat, cold, and mechanical stimuli. However, using only sensitivity-adjusted stimuli during CPM and temporal summation testing, FM patients demonstrated similarly effective pain inhibition and facilitation than HC, suggesting that their pain modulation is not abnormal.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 2","pages":"182-194"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9306167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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