Taylor R Fox, Anna C S Garrison, Kyle S Minor, Jesse C Stewart, Melissa A Cyders
{"title":"A Meta-Analysis on the Effect of Depression on Adherence to Medication for Opioid Use Disorder.","authors":"Taylor R Fox, Anna C S Garrison, Kyle S Minor, Jesse C Stewart, Melissa A Cyders","doi":"10.1080/15504263.2025.2515018","DOIUrl":"https://doi.org/10.1080/15504263.2025.2515018","url":null,"abstract":"<p><p><b>Objective:</b> U.S. Food and Drug Administration (FDA)-approved medications for Opioid Use Disorder (MOUD) effectively reduce opioid cravings, use, relapse, and overdose. However, adherence to MOUD is a significant challenge. Depression relates to poorer adherence across several medical conditions and may be a prime factor relating to poor MOUD adherence. The goal of this meta-analysis is to quantify the relationship between depression and MOUD adherence and to identify moderators of this association. <b>Methods:</b> A systematic literature search was conducted using PsycINFO, PubMed, Embase, and Cumulative Index of Nursing and Allied Health Literature [CINAHL] databases. Pearson's <i>r</i> was used for the effect size statistic. A random effects model was utilized for all effect size analyses. <b>Results:</b> Nine studies met eligibility criteria, with a total of 3493 participants. Higher baseline depressive symptoms were found to predict greater prospective adherence to MOUD (<i>r</i> = 0.130, 95% <i>CI</i>: 0.060-0.199, <i>p</i> < .001). This effect was not moderated by the MOUD type or depression measurement type. <b>Conclusions:</b> In contrast to prior medical adherence research, depression predicted better, not poorer, adherence to MOUD. The literature was limited by few studies examining naltrexone, limited diversity of samples, and a lack of clear consensus on adherence measurement. Future research should test whether this relationship extends to naltrexone; use samples with more racial minorities, women and gender minorities, and inpatient samples; clearly define and measure adherence, and identify mechanisms and moderators of this relationship, to best inform future clinical applications and improve outcomes for those with OUD.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonor Valente, Alberto Freitas, Manuel Gonçalves-Pinho
{"title":"Bipolar Disorder Hospitalizations and Substance Use Disorders: A Nationwide Retrospective Study From 2008 To 2015.","authors":"Leonor Valente, Alberto Freitas, Manuel Gonçalves-Pinho","doi":"10.1080/15504263.2025.2515027","DOIUrl":"https://doi.org/10.1080/15504263.2025.2515027","url":null,"abstract":"<p><strong>Objective: </strong>Bipolar Disorder (BD) is often complicated by co-occurring substance use disorders (SUD). We assessed the prevalence of SUD among BD hospitalization episodes and analyzed its association with hospitalization outcomes.</p><p><strong>Methods: </strong>We performed a retrospective observational study using a database containing all hospitalizations registered in Portuguese public hospitals from 2008 to 2015. Hospitalizations with a primary or secondary diagnosis of BD were selected. To compare episodes with and without a diagnosis of SUD, an independent sample <i>t</i>-test was used for age, whereas the non-parametric Mann-Whitney <i>U</i> test was used for LoS, CCI, and charges. Sex, in-hospital mortality, re-hospitalizations, and psychiatric comorbidities were analyzed using the Pearson's chi-squared test.</p><p><strong>Results: </strong>SUD was registered in 11.3% of episodes, with alcohol use disorder being the most prevalent (5.8%). A non-linear increase in the number of hospitalizations throughout the study period was found. Episodes with a concomitant register of SUD were associated with younger (44.1 ± 12.5 years old) and male hospitalizations (56.6%), shorter length of stay (LoS) (15.0 (8.0;24.0) days), higher Charlson Comorbidity Index (CCI) (0.24 ± 0.76), and with higher rates of attention-deficit, conduct, and disruptive behavior disorders, personality disorders, and suicide and intentional self-inflicted injury, compared to those without this comorbidity.</p><p><strong>Conclusions: </strong>Comorbid SUD increased and had a measurable impact on BD hospitalization outcomes. Timely detection and management of SUD among BD patients may likely prevent the high burden.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brian J Stevenson, Amanda Falcón, Erin Reilly, Steven D Shirk, Taylor Hunt, Lisa Mueller
{"title":"Meaningful Employment Among Veterans with Co-Occurring Substance Use and Mental Health Disorders.","authors":"Brian J Stevenson, Amanda Falcón, Erin Reilly, Steven D Shirk, Taylor Hunt, Lisa Mueller","doi":"10.1080/15504263.2025.2517179","DOIUrl":"https://doi.org/10.1080/15504263.2025.2517179","url":null,"abstract":"<p><p><b>Objective</b>: To examine associations between employment-based self-regulatory processes and meaningful employment attainment among veterans with co-occurring conditions. <b>Methods</b>: A survey was administered to a national Qualtrics panel of 534 employed veterans self-reporting mental health and substance use conditions. We tested whether career exploration, goal clarity, job-searching skills, and self-regulation skills explained unique variance in meaningful employment beyond other relevant predictors: mental health symptoms, alcohol and drug use severity, economic constraints, marginalization, job prestige, and employment status. <b>Results</b>: Hierarchical regression analysis revealed career exploration, goal clarity, job-searching skills, and self-regulation skills were significantly associated with meaningful employment beyond other predictors. Job prestige, employment status, and mental health symptoms also had significant associations with meaningful employment, while economic constraints and alcohol use lost significance in the final model. <b>Conclusions</b>: Interventions promoting exploration, goal clarity, job-searching, and self-regulation may improve meaningful employment attainment while buffering the effects of alcohol use and economic constraints.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Qualitative Study of Cannabis Use and Family Dynamics Among Youth in Early Psychosis Programs.","authors":"Amar Ghelani","doi":"10.1080/15504263.2025.2517175","DOIUrl":"https://doi.org/10.1080/15504263.2025.2517175","url":null,"abstract":"<p><strong>Objective: </strong>Cannabis use contributes to negative psychosocial outcomes among youth in Early Psychosis Intervention (EPI) programs and families are crucial to recovery. This study sought to understand how youth in EPI programs perceive their families to influence their cannabis use and how cannabis affects family relationships.</p><p><strong>Methods: </strong>A qualitative approach and thematic analysis were used to investigate the perspectives of youth ages 20-30 in EPI programs (<i>n</i> = 15).</p><p><strong>Results: </strong>Participants described parental disapproval toward cannabis use, intra-family consumption, family influence, changing parental attitudes, and increased closeness.</p><p><strong>Conclusions: </strong>Most participants reported cannabis contributed to tension and conflicts with parents due to risk for exacerbating psychosis, though some family members enabled use through role modeling, approval, and intra-family consumption. Some noted positive effects of consumption on bonding and closeness. Research is needed to understand how parents can support their child's recovery after cannabis-related psychosis, and prevalence and contributing factors behind intra-family consumption.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corinne N Kacmarek, Julie Kreyenbuhl, Hildi J Hagedorn, Clayton H Brown, Elizabeth Jane Richardson, Max Spaderna, Madeline R Marks, Melanie E Bennett, Daniel J O Roche
{"title":"Provider Perspectives on Medication for AUD in Mental Health and Substance Use Disorder Clinics.","authors":"Corinne N Kacmarek, Julie Kreyenbuhl, Hildi J Hagedorn, Clayton H Brown, Elizabeth Jane Richardson, Max Spaderna, Madeline R Marks, Melanie E Bennett, Daniel J O Roche","doi":"10.1080/15504263.2025.2515026","DOIUrl":"https://doi.org/10.1080/15504263.2025.2515026","url":null,"abstract":"<p><p><b>Objectives:</b> Alcohol Use Disorder (AUD) is comorbid with major mental illnesses, but prescribing rates for medications for AUD (mAUD) are low. <b>Methods:</b> We surveyed 71 mental health and 42 substance use disorder (SUD) treatment providers in an academic medical center about AUD treatment practices. <b>Results:</b> Fifty-three mental health and 14 SUD providers responded. Among the n = 22 mental health prescribers, a minority (29%) prescribed mAUD often. Sixty percent of mental health providers viewed mAUD as effective. Barriers to mAUD prescribing in mental health included believing SUD providers were better equipped to prescribe mAUD, whereas SUD providers assumed that patients were not interested in mAUD. All providers were willing to participate in mAUD education initiatives, but few were willing to engage in more time-intensive implementation activities. <b>Conclusions:</b> Improving knowledge and attitudes may improve mental health provider delivery of mAUD, but evidence-based strategies for improving prescribing may be less acceptable and feasible for providers.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erica Eaton, Christy Capone, Shannon Reese, M Tracie Shea, J Greg Serpa, Christopher Germer
{"title":"Mindful Self-Compassion for Veterans with Morally Injurious Experiences and Co-Occurring Posttraumatic Stress Disorder and Substance Use Disorder: A Feasibility Study.","authors":"Erica Eaton, Christy Capone, Shannon Reese, M Tracie Shea, J Greg Serpa, Christopher Germer","doi":"10.1080/15504263.2025.2474953","DOIUrl":"10.1080/15504263.2025.2474953","url":null,"abstract":"<p><p><b>Objective</b>: This study evaluates the feasibility and acceptability of delivering Mindful Self-Compassion (MSC) to veterans with moral injury and co-occurring PTSD and substance use disorder (PTSD-SUD). <b>Methods</b>: Veterans (N = 26; M age = 50.92; 100% male) were recruited for an 8-week MSC group. Participants completed measures of self-compassion, guilt, shame, PTSD, and substance use outcomes at baseline, post-treatment, and one-month post-treatment. <b>Results</b>: The recruitment target was easily met, and dropout rates were low (30.8%) for a comorbid veteran sample. Participants reported satisfaction with the intervention. Clinically meaningful change was examined for self-compassion, trauma-related symptoms, and substance use. A clinically meaningful increase for self-compassion and clinically meaningful decreases in PTSD symptoms, guilt, shame, and number of drinking days were observed. <b>Conclusions</b>: The open-label design and small sample size preclude conclusions regarding efficacy. However, these preliminary findings are encouraging and suggest further investigation of MSC as a compliment to existing trauma-related therapies (NCT03681288).</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"87-98"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of Dual DiagnosisPub Date : 2025-04-01Epub Date: 2025-03-14DOI: 10.1080/15504263.2025.2478897
Cynthia Ramasubbu, Sukhpreet Poonia, Erin Brady-Randle, Christian G Schutz, Reza Rafizadeh
{"title":"Psychostimulant Substitution Therapy for the Treatment of Stimulant Use Disorders in Patients with Schizophrenia or Schizoaffective Disorder: A Systematic Review.","authors":"Cynthia Ramasubbu, Sukhpreet Poonia, Erin Brady-Randle, Christian G Schutz, Reza Rafizadeh","doi":"10.1080/15504263.2025.2478897","DOIUrl":"10.1080/15504263.2025.2478897","url":null,"abstract":"<p><p><b>Objective:</b> Co-occurrence of schizophrenia/schizoaffective disorder (SSD) and stimulant use disorder (StUD) is an ongoing clinical problem and can lead to poor outcomes. Although emerging evidence has suggested psychostimulant substitution therapy may result in improved outcomes in those with StUD, the efficacy and safety of psychostimulant substitution therapy for StUD in those with concurrent SSD is uncertain. This review aims to systematically find and assess all available efficacy and safety evidence on the use of prescription psychostimulants in those with co-occurring SSD and StUD. <b>Methods:</b> Electronic searches of MEDLINE, PsycINFO, Embase, Scopus, ClinicalTrials, EU Clinical Trials, and CADTH were conducted from inception to February 27, 2024. Any study design was accepted if they involved the following concepts 1) SSD and StUD and 2) prescription psychostimulants. Given the paucity of trials meeting criteria, outcomes of interest were described qualitatively. Risk of bias was assessed using Q-Coh and ROB2. <b>Results:</b> Only seven articles met criteria, and most of these were case reports and series. The single RCT included was at high risk of bias. Outcomes included abstinence, reductions in non-prescribed stimulant use, psychiatric hospitalizations, levels of craving, improvements in mental health, improvements in psychosocial functioning, adherence to antipsychotic medications, and retention in treatment. Most of the results indicated that psychostimulant substitution therapy in individuals with SSD-StUD was not associated with improved outcomes. <b>Conclusion:</b> Available evidence for treatment of StUD via psychostimulant substitution therapy in individuals with SSD is lacking. More exploration is required for this clinical question to allow for current practice to be backed by evidence.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"167-181"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of Dual DiagnosisPub Date : 2025-04-01Epub Date: 2025-03-27DOI: 10.1080/15504263.2025.2478893
Glenn Sterner, Michael B Lavetsky, Matthew J Ercolani, Kayla Lopez
{"title":"Mental Health and Substance Use Treatment Provider Assessment of Telehealth Effectiveness for Adult and Adolescent Service Provision During the COVID-19 Pandemic.","authors":"Glenn Sterner, Michael B Lavetsky, Matthew J Ercolani, Kayla Lopez","doi":"10.1080/15504263.2025.2478893","DOIUrl":"10.1080/15504263.2025.2478893","url":null,"abstract":"<p><p><b>Objective:</b> This study examined behavioral health clinician perceptions at the beginning stages of the COVID-19 pandemic regarding their preparedness, training, and effectiveness in delivering telehealth to adults and adolescents in substance use and mental health settings. <b>Methods:</b> Data were collected through an anonymous online survey of 241 behavioral health practitioners in Pennsylvania from November 17, 2020, to January 3, 2021. Quantitative descriptive and qualitative analyses on survey results are presented. <b>Results:</b> Clinicians believed they were effective in their delivery of therapeutic services through telehealth modalities. However, they noted key training needs for delivering telehealth. Results indicate greater difficulty in delivering telehealth to adolescent clients and those with substance use. Practitioners indicate that telehealth allows greater access to treatment. <b>Conclusions:</b> Researchers recommend increasing training for practitioners and conducting training for patients. Policies should be reconsidered and address the changing landscape of behavioral health service provision.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"152-166"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of Dual DiagnosisPub Date : 2025-04-01Epub Date: 2025-03-17DOI: 10.1080/15504263.2025.2478802
Emmanuel D Thomas, Silvi C Goldstein, Jewelia J Ferguson, Diana Ho, Nicole H Weiss
{"title":"Exploring the Role of Racial Microaggressions in the Association Between Depression Symptoms and Drug Use and Related Harm Among Women of Color Experiencing Intimate Partner Violence.","authors":"Emmanuel D Thomas, Silvi C Goldstein, Jewelia J Ferguson, Diana Ho, Nicole H Weiss","doi":"10.1080/15504263.2025.2478802","DOIUrl":"10.1080/15504263.2025.2478802","url":null,"abstract":"<p><p><b>Objective:</b> Drug use and related harm among women of color who experience intimate partner violence (IPV) is a serious clinical concern. Depression symptoms have been identified as an important risk factor for the development of drug use and related harm among women of color with a history of IPV. The current study advances this research by examining the roles of distinct domains of racial microaggressions in the relation between depression symptoms and drug use and related harm in this population. <b>Method:</b> Participants were 103 women of color experiencing IPV (<i>M</i><sub>age</sub> = 40.39, 51% Black/African American). <b>Results:</b> Results indicated an indirect effect of depression symptoms on drug use and related harm via racial microaggression domains of Assumptions of Inferiority, Second-Class Citizen and Assumptions of Criminality, Microinvalidations, Exoticization and Assumptions of Similarity, and Environmental Microaggressions. <b>Conclusions:</b> Findings provide preliminary support for the role of racial microaggressions in the association between depression and drug use and related harm among women of color experiencing IPV.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"109-119"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}