Journal of Dual Diagnosis最新文献

{"title":"Treatment Outcomes for Co-Occurring Borderline Personality Disorder and Substance Use Disorders: A Systematic Review.","authors":"Ayla Sadeghi, Anthony Ngoy, Tony George, Joshua L Gowin, Anthony C Ruocco, Victor M Tang, Matthew E Sloan","doi":"10.1080/15504263.2026.2726792","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726792","url":null,"abstract":"<p><p><b>Objective:</b> Almost half of patients diagnosed with borderline personality disorder (BPD) have a co-occurring substance use disorder (SUD). Patients with co-occurring BPD and SUD have poorer treatment outcomes, including lower rates of BPD remission and higher rates of substance-related harms. This systematic review aimed to evaluate existing treatments for co-occurring BPD and SUD. <b>Methods:</b> A systematic search was conducted using PsycINFO, Medline, PubMed, and Embase from inception to December 5, 2023. Selected studies assessed psychological or pharmacological interventions for patients with co-occurring BPD and SUDs. The impact of treatment on SUD and BPD symptoms was assessed. As an exploratory outcome, we examined the effects of interventions on emotion regulation. <b>Results<i>:</i></b> Seventeen studies met our eligibility criteria. The most commonly studied intervention was dialectical behavior therapy (DBT; k = 9); most other interventions were evaluated by single studies. Treatment with DBT reduced SUD symptoms in some but not all studies. Overall, three psychotherapy studies assessed emotion regulation and found improvements following treatment. There were few pharmacotherapy trials in patients with BPD and SUD. There is evidence from these studies to suggest that specific pharmacotherapies for SUDs reduce substance use in patients with concurrent BPD. <b>Conclusions:</b> There is evidence that DBT improves emotion regulation for patients with co-occurring BPD and SUDs and some evidence that it reduces substance use. Future studies should systematically assess both BPD and SUD outcomes using larger samples and evaluate integrated treatments for BPD and SUDs.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-16"},"PeriodicalIF":1.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and Correlates of Suicidality Among People With Opioid Dependence-A Cross-Sectional, Community-Based Study.","authors":"Pooja Shakya, Ravindra Rao, Ashwini Mishra, Alok Agarwal, Roshan Bhad, Atul Ambekar, Nisha Prajapati, Deepak Yadav","doi":"10.1080/15504263.2026.2726799","DOIUrl":"10.1080/15504263.2026.2726799","url":null,"abstract":"<p><strong>Objective: </strong>Limited data exist on suicidality among non-treatment-seeking individuals with opioid dependence in low- and middle-income countries. The objectives of the study were to assess the prevalence and correlates of suicidality and perceived burdensomeness among community-dwelling individuals with opioid dependence and to assess association of socio-clinical factors with suicidality and perceived burdensomeness.</p><p><strong>Methods: </strong>This cross-sectional study utilized baseline data from a prospective community-based cohort study conducted in an urban socioeconomically disadvantaged area of Delhi, India. Adult males meeting ICD-10 criteria for opioid dependence and not engaged in treatment for at least 6 months were recruited using snowball sampling. Suicidality was assessed using the Ask Suicide-Screening Questions (ASQ). Depressive symptoms (using Patient Health Questionnaire-9), anxiety symptoms (Generalized Anxiety Disorder-7), severity of opioid dependence (Leeds Dependence Questionnaire), and high-risk behaviors were evaluated. Logistic regression analyses were conducted to identify factors independently associated with suicidality and perceived burdensomeness.</p><p><strong>Results: </strong>Among 396 male participants, 24.5% screened positive for suicidality (presence of either suicidal ideations in past week or self-harm attempt in the past), and 32.8% endorsed perceived burdensomeness (either wish to die or feeling of burden on family). Suicidal ideation was reported by 20.2% (<i>n</i><b> </b>= 80), among whom 56% (<i>n</i> = 45) had engaged in at least one past self-harm attempt. Significant factors associated with suicidality included younger age at onset of opioid use, injection drug use, concurrent alcohol use, history of family discord, and depressive symptoms (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>Suicidality is highly prevalent among non-treatment-seeking individuals with opioid dependence in community settings. Co-occurring depressive and anxiety symptoms significantly contribute to suicide risk, underscoring the critical importance of integrated mental health screening within opioid use disorder services. Early identification and intervention targeting psychiatric comorbidity may reduce suicide risk in this vulnerable dual diagnosis population.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Mental Disorder Comorbidities and MOUD Receipt for Opioid Misuse: Lower Receipt for Persons with Psychotic Disorders.","authors":"John Moore, Tanya Renn, Michael Killian","doi":"10.1080/15504263.2026.2729324","DOIUrl":"https://doi.org/10.1080/15504263.2026.2729324","url":null,"abstract":"<p><p><b>Objective</b>: Medications for opioid use disorder (MOUD) have shown promise in facilitating positive treatment outcomes for those with comorbid mental disorders. However, whether MOUD receipt differs by specific mental disorder comorbidities has not been thoroughly investigated. To address this gap, the present study examined associations of specific mental disorder comorbidities with MOUD among discharges from outpatient substance use treatment. <b>Methods:</b> Data came from the 2016-2022 Treatment Episode Dataset-Discharges (TEDS-D). The analytic sample included 12,219 adult outpatient treatment discharges with comorbid OUD and mental disorders (mood disorder, anxiety disorder, or psychotic disorder comorbidity). Multilevel logistic regression models with random intercepts for state were used to examine associations between type of mental disorder and planned MOUD, adjusting for opioid-related, treatment-related, sociodemographic and state-level MOUD availability covariates. <b>Results</b>: When adjusting for covariates, discharges with depressive disorders (AOR = 1.48, 95% CI = 1.19-1.85) and anxiety disorders (AOR = 1.43, 95% CI = 1.14-1.80) had higher odds of MOUD than discharges with psychotic disorders. <b>Conclusions</b>: These findings signify the influence of specific mental disorder diagnoses with MOUD access. Disparities in access for those with comorbid psychotic disorders warrant further investigation.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Implementation of Current UK Guidance for the Treatment of Co-Occurring Mental Health and Substance Use Conditions: A Mixed Methods Systematic Review and Thematic Synthesis.","authors":"Zoe Swithenbank, Patricia Irizar, Lauren Halsall, Jo-Anne Puddephatt, Phil Parkes, Amy O'Donnell, Colin Angus, Colin Drummond, Kat Jackson, Laura Goodwin","doi":"10.1080/15504263.2026.2726794","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726794","url":null,"abstract":"<p><p><b>Background:</b> Clinical guidance exists on the provision of care for co-occurring mental health and substance use conditions in the UK. This systematic review aimed to identify the extent to which the guidance has been applied, including barriers and facilitators to delivery, and to examine use of strategies to support implementation of the guidance. <b>Methods:</b> We searched PsychINFO, MEDLINE, CINAHL, Embase, and Web of Science for articles published between 1^st January 2017 (when the guidance was published) to 28th January 2025. Studies were eligible if they focused on service use and/or treatment provision for adults in the UK with co-occurring substance use and mental health conditions. The findings were analyzed using a thematic synthesis, through line-by-line coding of study findings to develop analytical themes. <b>Results:</b> Three themes were identified from 17 eligible studies. Theme one reflects \"challenges to care for co-occurring conditions\", which describes how service users face 'wrong doors'; issues surrounding the recognition of co-occurring conditions; and access to care when and where it is needed, despite guidance recommending the 'no wrong doors' approach. Theme two reflects approaches for the \"integration of care\" as recommended in the guidance, such as communication across services and ensuring that support for people with co-occurring conditions is 'everyone's job'. The third theme highlights barriers (e.g., stigma) and facilitators (e.g., therapeutic optimism) to applying the guidance. <b>Conclusion:</b> This review identified an implementation gap between best practice guidance and the provision of care for co-occurring conditions in the UK setting, which needs to be explored across a global context. There were positive examples of strategies to implement the guidance, particularly from small-scale intervention evaluations, yet studies of larger scale real-world intervention implementation are needed.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-19"},"PeriodicalIF":1.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Agitation in Psychiatric Inpatients Associated with Increased Exposure to Nicotine Replacement.","authors":"Blake Sala Tenna, Michael Christmass","doi":"10.1080/15504263.2026.2726788","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726788","url":null,"abstract":"<p><p><b>Objective:</b> Nicotine addiction remains one of the most prevalent substance use disorders worldwide, particularly within psychiatric inpatient populations. The inability of many psychiatric patients to leave the ward has caused patients to experience acute nicotine withdrawal that can exacerbate underlying mental health conditions. The aim of this project was to reduce the time to nicotine replacement therapy (NRT) initiation and ensure adequate dosing to decrease nicotine withdrawal-related agitation and aggression. <b>Methods:</b> The project was implemented in three stages: a baseline data collection period of three months; on-the-job NRT education for all staff; and a post-education data collection period of three months. <b>Results:</b> Between the pre- and post-education groups, there was: an increase (63.6% pre-, 86.7% post-) in patients prescribed NRT within 24 hours (<i>p</i> = .024) and; an increase (14.6% pre-, 70% post-) in the supply of adequate NRT for nicotine dependence (<i>p</i> < .001). For post-education patients, there was a trend toward decreased surrogate markers of agitation and arousal. <b>Conclusion:</b> NRT education for staff was successful in reducing time to prescription and increasing number of patients receiving adequate NRT. Patients that received adequate NRT in a timely manner were less likely to demonstrate severe agitation.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-5"},"PeriodicalIF":1.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Nicotine Use in Schizophrenia Through a Psychosocial Lens: A Narrative Review.","authors":"Fathima Shibin C, Sojan Antony, Shreedevi A U, Jayant Mahadevan, Venkata Senthil Kumar Reddi","doi":"10.1080/15504263.2026.2726798","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726798","url":null,"abstract":"<p><p><b>Objective:</b> Nicotine use in schizophrenia remains markedly higher than in the general population, contributing to increased morbidity, relapse, and functional impairment. While biological factors have been widely studied, limited attention has been given to the psychosocial factors that sustain nicotine use in this group. This review synthesizes available evidence on these psychosocial influences to inform intervention planning and policy development. <b>Methods:</b> A narrative review was conducted using PubMed, Scopus, ProQuest, and Google Scholar to identify studies from 2000 to 2025 that examined psychosocial, socio-cultural, or systemic factors associated with nicotine use in schizophrenia. Thirty articles meeting the inclusion criteria were analyzed thematically across three domains: psychological, socio-cultural, and systemic influences. <b>Results:</b> Psychological factors such as stress regulation, cognitive enhancement, loneliness, maladaptive coping, and low self-efficacy reinforced nicotine use. Socio-cultural determinants included male gender, unmarried status, peer influence, social exclusion, stigma, and familial smoking patterns, while systemic enablers encompassed institutional permissiveness, limited cessation support, and pro-tobacco policies. Collectively, these dimensions interact to maintain nicotine dependence and impede recovery and contribute to an increased risk of relapse in schizophrenia, poorer prognosis, higher Disability- Adjusted Life Years, impaired functional recovery, and disability. <b>Conclusions:</b> Nicotine use in schizophrenia is reinforced by interconnected psychosocial and structural forces extending beyond biological vulnerability. A biopsychosocial approach-combining psychoeducation, family support, social rehabilitation, and institutional policy reform-offers a pathway to sustainable cessation and functional recovery in this population.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roads to Recovery Capital: Associations Between Posttraumatic Stress Disorder and Recovery Capital Among Individuals with Opioid Use Disorder.","authors":"Noam G Newberger, Jewelia J Ferguson, Alana Egan, Dominique N Sheldon, Natalie T Chasten, Ben A Seebold, Alyssa L Avila, Josiah D Rich, Nicole H Weiss","doi":"10.1080/15504263.2026.2720397","DOIUrl":"https://doi.org/10.1080/15504263.2026.2720397","url":null,"abstract":"<p><p><b>Introduction:</b> Posttraumatic stress disorder (PTSD) is highly comorbid with opioid use disorder (OUD) and associated with poorer substance use outcomes, including more severe patterns of substance use, poorer psychosocial functioning, and greater risk of overdose. Recovery capital, or internal and external resources that may be drawn from to initiate and sustain recovery from substance use, has been linked to OUD treatment engagement and long-term recovery outcomes, such as reduced substance use and improved quality of life; however, there is limited research on the association between PTSD and recovery capital. Individual differences in motivation for OUD treatment affect treatment engagement and outcomes and may influence the association between PTSD symptoms and recovery capital. <b>Results:</b> Addressing critical gaps in the literature, the current study used a path analysis model to explicate the pathway from PTSD to recovery capital and assess the potential intermediary role of treatment motivation. Participants were 115 individuals currently in residential substance use treatment (<i>M</i>_age = 38.18 years; 70.4% white). <b>Results:</b> The overall path model demonstrated good fit (χ²[20] = 25.55; <i>p</i> = 0.18; RMSEA = 0.06 [90% CI: 0.00-0.12]; CFI = 0.94, TLI = 0.89). PTSD was negatively associated with recovery capital (<i>B</i> = -0.43, <i>p</i> = 0.030), but this association was not explained by treatment motivation (<i>B</i> = 0.13, <i>p</i> = 0.342). <b>Discussion:</b> Future research is needed to further identify the mechanisms by which PTSD influences recovery capital. Such studies may inform treatment and recovery outcomes for individuals with comorbid PTSD and OUD.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Dual Combustible and Electronic Cigarette Use Versus Combustible Cigarette Use Among Black Adults in Terms of Mental Health and Substance Use Problems.","authors":"Duckhyun Jo, Luke F Heggeness, Ava A Jones, Jessica M Thai, Rodrigo Castillo-Avilés, Justin M Shepherd, Brooke Y Redmond, Lorra Garey, Michael J Zvolensky","doi":"10.1080/15504263.2026.2726790","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726790","url":null,"abstract":"<p><strong>Objective: </strong>The Black population experiences numerous disparities in terms of tobacco use, including lower rates of cessation success relative to other ethnic/racial groups. Moreover, there has been a rise in electronic cigarette (e-cigarette) use in the general population, including the Black community. However, little work has sought to evaluate the impact of dual combustible and e-cigarette use among the Black population in terms of behavioral health problems. The present study examined differences in anxiety, depression, severity of drug use problems, and hazardous drinking between Black individuals who engage in exclusive combustible cigarette use and Black individuals who engage in dual use.</p><p><strong>Methods: </strong>A total of 498 Black adults who report daily combustible cigarette use (<i>M</i>_age = 45.37, <i>SD</i> = 14.68; 51.4% female) were included.</p><p><strong>Results: </strong>Analyses of covariance, controlling for age, sex, education, and income, showed that Black individuals who engaged in dual use reported statistically significantly higher levels of anxiety, depression, drug use problems, and hazardous drinking compared to Black individuals who engaged in exclusive cigarette smoking.</p><p><strong>Conclusions: </strong>These findings contribute to a growing body of literature that suggests dual use represents a vulnerable clinical subgroup that may require specialized care.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-11"},"PeriodicalIF":1.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Severity and Resilience in Outpatients Seeking Treatment for Cocaine Use Disorder.","authors":"Jade Bochereau, Emily Karsinti, Vanessa Bloch, El-Hadi Zerdazi, Beatriz Belforte, Delphine Moisan, Alice Deschenau, Olivier Cottencin, Aurélia Gay, Philippe Lack, Georges Brousse, Frank Bellivier, Bruno Etain, Florence Vorspan, Romain Icick","doi":"10.1080/15504263.2026.2726791","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726791","url":null,"abstract":"<p><strong>Objective: </strong>Cocaine use disorder (CocUD) remains a significant public health concern, with elevated mortality rates. Severe psychiatric disorders frequently co-occur with CocUD, possibly associated with an increased frequency of childhood trauma and with lower resilience - the capacity to overcome traumatic life events, compared to the general population. This study aimed to investigate the relationship between psychiatric severity, resilience and childhood trauma in treatment-seeking CocUD outpatients.</p><p><strong>Methods: </strong>We analyzed the data from a multicenter, cross-sectional study, totalizing 305 CocUD outpatients recruited at specialized addiction care centers. Psychiatric severity was quantified using a custom composite score calculated as the sum of lifetime suicide attempts, psychiatric hospitalizations, and current psychotropic medications. Resilience and childhood trauma were assessed using validated instruments: the Connor-Davidson Resilience Scale (CD-RISC) and the Childhood Trauma Questionnaire (CTQ). The characterization of sociodemographic and clinical characteristics related to CoCUD allowed us to conduct unadjusted and adjusted analyses of associations between trauma, resilience and psychiatric severity.</p><p><strong>Results: </strong>The sample was predominantly male (77%), aged 38 ± 8.7 years. Mean age at onset of CocUD was 28 ± 8 years, and most patients were diagnosed with a comorbid substance use disorder (62% alcohol, 61% cannabis, 43% benzodiazepines and 49% opioid use disorder). Mean psychiatric severity score was 4.2 ± 10.3. Most patients reported at least one childhood abuse type (56.5 +/- 14 for the US version). The mean CD-RISC score was 47.3 ± 13. The mean CTQ score was 47 ± 17. Poisson regression showed a significant inverse relationship between psychiatric severity and total CD-RISC score (<i>p</i> =. 005), with a small effect size (β = -0.01). Psychiatric severity was independently but positively associated with greater CTQ total scores (<i>p</i> = 1.2 x 10-8, β = 0.01), female gender (<i>p</i> = 9.8x10^-8, β = 0.41) and comorbid benzodiazepine use disorder (<i>p</i> = 8.7x10^-10, β = 0.45).</p><p><strong>Conclusions: </strong>Although the psychiatric severity score was built arbitrarily, it showed complex interactions with resilience and trauma among CocUD outpatients. These findings underscore the importance of systematically assessing childhood trauma and developing resilience-focused psychotherapies for managing severe CocUD. Psychiatric severity may be measured using simple clinical variables to further tailor these interventions.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Risky Substance Use and Irritable Bowel Syndrome (IBS) Severity, Mental Health, and Smoking-Related Processes in Adults with IBS Who Smoke.","authors":"Duckhyun Jo, Yalda Farahmand, Kyra Friedman, Justin M Shepherd, Lorra Garey, Brooke Y Redmond, Andrew H Rogers, Andrea Bradford, Jeffrey M Lackner, Michael J Zvolensky, Jafar Bakhshaie","doi":"10.1080/15504263.2026.2726789","DOIUrl":"https://doi.org/10.1080/15504263.2026.2726789","url":null,"abstract":"<p><p><b>Objective:</b> Irritable Bowel Syndrome (IBS) is a debilitating chronic pain condition that presents a major and growing public health burden. Combustible cigarette smoking plays a role in the maintenance of IBS, and the co-occurrence of these conditions warrants greater focus. Moreover, given that smoking co-occurs with other substance use behaviors, the impact of these comorbid behaviors on physical and mental health-related outcomes among individuals with IBS who smoke is warranted. The goal of the present cross-sectional study was to assess relationships of risky alcohol, cannabis, and opioid use with IBS severity, anxiety and depression, and smoking-related processes among adults with IBS who smoke. <b>Methods:</b> In total, 263 adults who met Rome IV criteria for IBS and who smoked combustible cigarettes were included in the study. Hierarchical regression analyses were conducted to examine the influence of risky substance uses on IBS symptom severity, IBS-related quality of life, anxiety, depression, perceived barriers for smoking cessation, and cigarette dependence. <b>Results:</b> Results indicated that opioid use was statistically related to all criterion variables, whereas alcohol use was specifically associated with depression and anxiety. Cannabis use showed a statistically significant association only with anxiety symptoms. <b>Conclusions:</b> The present investigation is among the first to explore the role of risky substance use in terms of a wide array of IBS, mental health, and smoking processes among adults with IBS who smoke. The findings suggest that substance use should be a focal point of screening and intervention for the IBS population to optimize outcomes beyond the reach of medical therapies.</p>","PeriodicalId":46571,"journal":{"name":"Journal of Dual Diagnosis","volume":" ","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}