{"title":"Effect of tranexamic acid in the treatment of angiotensin-converting enzyme inhibitor-induced angioedema: A systematic review and meta-analysis.","authors":"Kanmani Indra Couppoussamy, Sasikumar Mahalingam, Gunaseelan Rajendran, Suruthi Purushothaman, Anitha Ramkumar, Yuvaraj Krishnamoorthy, Ezhilkugan Ganessane, Aswin Kumaran","doi":"10.4103/tjem.tjem_170_25","DOIUrl":"10.4103/tjem.tjem_170_25","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of tranexamic acid (TXA) in the treatment of angiotensin-converting enzyme inhibitor-induced angioedema.</p><p><strong>Methods: </strong>A systematic review was conducted using PubMed, Scopus, Embase, and ProQuest databases from inception to January 2025, following PROSPERO registration (CRD42025524300). We included observational studies that evaluated the use of TXA in angiotensin-converting enzyme inhibitor-induced angioedema. Proportion meta-analyses were performed on the data obtained from the selected studies.</p><p><strong>Results: </strong>Only four retrospective studies met the inclusion criteria, including two cohort studies, one retrospective study, and one case series, encompassing a limited sample size of 133 patients. Meta-analysis showed that approximately 98% of patients treated with TXA did not require intubation, and 76% avoided intensive care unit admission. However, the absence of randomized controlled trials and the retrospective nature of the studies substantially limit the strength and generalizability of these results.</p><p><strong>Conclusion: </strong>TXA may be a potential treatment option for angiotensin-converting enzyme inhibitor-induced angioedema by lowering intensive care unit admission and intubation; however, current evidence is limited and primarily retrospective. Robust prospective, randomized controlled trials are needed to draw definitive conclusions.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"45-54"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonography-guided serratus anterior plane block for intercostal drain tube insertion pain.","authors":"Joshua Daniel Birru, Varsha Shinde","doi":"10.4103/tjem.tjem_151_25","DOIUrl":"10.4103/tjem.tjem_151_25","url":null,"abstract":"<p><p>Intercostal drainage (ICD) tube insertion is a life-saving procedure through which blood, fluid, or air is drained out of the pleural space surrounding the lungs. This treatment is essential to manage conditions such as hemothorax, pleural effusion, and pneumothorax. In addressing the severe pain accompanying these conditions and pain caused by ICD tube insertion, emergency physicians are increasingly turning to newer techniques for pain management. We are presenting one such technique, which is the serratus anterior plane block (SAPB) guided by ultrasonography. This emerging approach holds promise in improving pain management and patient comfort, making it a crucial consideration in individuals requiring an ICD. In this case series, we present cases that required an ICD tube insertion for which SAPB was administered to manage the pain caused by the ICD tube. The pain reduced significantly in all patients following SAPB administration, and they did not require any additional analgesics for an average of 6-8 h after the block. This case series shows a more efficient way of managing pain in patients requiring ICD tube insertion.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"78-81"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhamed Hanizar Hajanajumudin, Muhaimin Noor Azhar, Aida Bustam, Aliyah Zambri, Khadijah Poh
{"title":"Correlation between venous excess ultrasound and acute kidney injury in patients with sepsis: A pilot study.","authors":"Muhamed Hanizar Hajanajumudin, Muhaimin Noor Azhar, Aida Bustam, Aliyah Zambri, Khadijah Poh","doi":"10.4103/tjem.tjem_173_25","DOIUrl":"10.4103/tjem.tjem_173_25","url":null,"abstract":"<p><strong>Objectives: </strong>Venous congestion is increasingly recognized as a contributor to acute kidney injury (AKI) in critically ill patients. The venous excess ultrasound (VExUS) score has been proposed to assess systemic venous congestion, but its role in emergency department (ED) sepsis remains underexplored. This pilot study investigated the association between VExUS scores, development of AKI, and other outcomes in septic ED patients.</p><p><strong>Methods: </strong>This was a prospective observational pilot study conducted from July 2023 to December 2023 in a university-affiliated tertiary ED. Adult patients with sepsis and an inferior vena cava diameter ≥2 cm after initial resuscitation were enrolled. VExUS was assessed at enrolment. The primary outcome was AKI within 72 h based on the Kidney Disease Improving Global Outcomes criteria. Secondary outcomes included mortality, organ dysfunction scores, and other outcomes. Associations were analyzed using Kendall's tau-b correlation and group comparisons with Mann-Whitney <i>U</i>-test.</p><p><strong>Results: </strong>Thirty-one patients were included, mean age 64.2 years. VExUS scores were Grade 1 in 64.5%, Grade 2 in 25.8%, and Grade 3 in 9.7%. Median VExUS scores did not differ between patients with and without AKI (2.0 [2.0-3.0] vs. 2.0 [2.0-3.0], <i>P</i> = 0.729), died and survived at 28 days (2.0 [2.0-2.25] vs. 2.0 [2.0-3.0], <i>P</i> = 0.419) or 60 days (2.0 [2.0-3.0] vs. 2.0 [2.0-3.0], <i>P</i> = 0.693). VExUS showed moderate correlations with creatinine (τ = 0.392, <i>P</i> = 0.004), sequential organ failure assessment (τ =0.267, <i>P</i> = 0.041), and inotrope requirements (τ = 0.299, <i>P</i> = 0.041).</p><p><strong>Conclusion: </strong>In septic ED patients, VExUS was not associated with AKI or mortality but correlated with markers of organ dysfunction.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"37-44"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mert Pehlivan, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Ihsan Dengiz, Melike Kucukceylan, Mehmet Gorur
{"title":"Midazolam or propofol added to ketamine: Which combination is better for the reduction of shoulder dislocation in the emergency department?","authors":"Mert Pehlivan, Selen Acehan, Salim Satar, Muge Gulen, Sarper Sevdimbas, Ihsan Dengiz, Melike Kucukceylan, Mehmet Gorur","doi":"10.4103/tjem.tjem_211_25","DOIUrl":"10.4103/tjem.tjem_211_25","url":null,"abstract":"<p><strong>Objective: </strong>Glenohumeral dislocation is the most common type of shoulder dislocation and a leading cause of shoulder instability. Adequate muscle relaxation and pain control are essential for successful reduction. This study compared the effectiveness and safety of ketamine-midazolam (KM) versus ketamine-propofol (KP) for procedural sedation in anterior shoulder dislocations in the emergency department (ED). Effectiveness was evaluated using Ramsay sedation scale (RSS) scores, sedation onset, total procedure and recovery times, and reduction success. Safety was assessed by recording adverse events.</p><p><strong>Methods: </strong>This prospective, single-blind, randomized trial included patients ≥18 years presenting to a tertiary ED with anterior shoulder dislocation. Patients were randomized into two groups: KM (ketamine plus midazolam) and KP (ketamine plus propofol). Demographic and clinical characteristics, RSS scores, procedure and recovery times, adverse events, and additional sedation requirements were recorded.</p><p><strong>Results: </strong>Sixty-four patients were analyzed, 32 in each group. The overall mean RSS score was 4.5 ± 1.0, significantly higher in the KP group (<i>P</i> < 0.001). Adverse events were more common in the KM group, including higher rates of respiratory depression (<i>P</i> = 0.023) and tachycardia (<i>P</i> < 0.001). The mean procedure time was 5.7 ± 4.7 min, and recovery time was 36.3 ± 14.4 min, both significantly shorter in the KP group (<i>P</i> = 0.025 and <i>P</i> < 0.001, respectively).</p><p><strong>Conclusion: </strong>In the ED, the ketamine-propofol combination appears to be a safe and effective option for procedural sedation and analgesia, particularly in interventions such as shoulder reduction.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"62-70"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare case of purulent pericarditis arising from a hepato-pericardial fistula.","authors":"Khaled Alaboud Alkheder, Omar Farooq Al-Nahhas, Yousif Basim Al-Khafaji, Ammar Alshirazi Alssabagh, Sudarshana Reddy Thiyyagura","doi":"10.4103/tjem.tjem_256_24","DOIUrl":"10.4103/tjem.tjem_256_24","url":null,"abstract":"<p><p>Purulent pericarditis is a rare but severe complication of bacterial pericarditis, often secondary to intrathoracic infections, and can cause a hepatic abscess that ruptures into the pericardium, which is an uncommon symptom with a high mortality rate if untreated. We report on a 52-year-old man with a poorly differentiated hepatocellular carcinoma who presented with chest pain and pericardial effusion caused by a hepato-pericardial fistula. Imaging revealed hepatic microabscesses extending into the pericardium. The patient underwent a pericardial window procedure with purulent fluid drainage and was treated with meropenem for <i>Enterobacter cloacae</i>. Postoperatively, the bilateral pleural effusions required chest drains. After 3 weeks of multidisciplinary care, the patient was discharged in a stable condition. This case highlights the importance of early diagnosis and a multidisciplinary approach in managing rare complications of purulent pericarditis caused by hepatic abscesses. Timely surgical intervention and appropriate antibiotic therapy are crucial for favorable outcomes.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"75-77"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milan Manu, Naman Agrawal, Roshan Mathew, Saroj Kumar Pati, Amit Kumar Mishra, Debendra Kumar Tripathy
{"title":"Evaluation of STONE, modified STONE, and CHOKAI scores for predicting ureteric stone disease in Indian emergency patients: A prospective observational study.","authors":"Milan Manu, Naman Agrawal, Roshan Mathew, Saroj Kumar Pati, Amit Kumar Mishra, Debendra Kumar Tripathy","doi":"10.4103/tjem.tjem_277_25","DOIUrl":"10.4103/tjem.tjem_277_25","url":null,"abstract":"<p><strong>Objective: </strong>Acute flank pain is a common complaint in the emergency department (ED), with urolithiasis being a major cause. This prospective observational study evaluated the performance of the STONE, modified STONE, and CHOKAI scores in predicting ureteric stones in Indian ED patients with acute flank pain.</p><p><strong>Methods: </strong>The study included adult patients who underwent noncontrast computed tomography for suspected urolithiasis. Clinical scores were calculated independently, and their diagnostic accuracy was assessed using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Ureteric stones were diagnosed in 58.3% of the patients. The CHOKAI score demonstrated the highest accuracy (area under the curve [AUC] 0.89), followed by the modified STONE (AUC 0.84) and STONE (AUC 0.65) scores. Optimal cutoffs were identified using Youden's index. DeLong's test revealed that CHOKAI and modified STONE scores outperformed the STONE score, while the difference between CHOKAI and modified STONE was not significant. The Hosmer-Lemeshow test showed good calibration for the CHOKAI and modified STONE scores.</p><p><strong>Conclusions: </strong>The CHOKAI score demonstrated the highest diagnostic accuracy in our cohort and may be the preferred tool for predicting ureteric stones in this clinical setting. Further validation in larger multicenter studies is warranted.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"26 1","pages":"55-61"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of mass casualty incident triage tools for hospital-based triage.","authors":"Sarah S Abdul-Nabi, Eveline Hitti","doi":"10.4103/tjem.tjem_77_25","DOIUrl":"10.4103/tjem.tjem_77_25","url":null,"abstract":"<p><p>Mass casualty incidents (MCIs) pose significant challenges to the healthcare systems, particularly in low-and lower-middle-income countries where prehospital triage is often limited, and hospitals face sudden surges of casualties. While triage tools have been widely studied for field use, their effectiveness in hospital-based MCI response remains unclear. This review examines peer-reviewed studies on hospital-based triage tools used during mass casualties, focusing on their accuracy and applicability. A comprehensive search of MEDLINE identified six relevant studies, conducted across various income settings and utilizing different methodologies, including simulation-based research, retrospective analyses, and real-world debriefings. Several tools were assessed, including Simple Triage and Rapid Treatment, the Modified CareFlight system, and homegrown triage models developed in Berlin and Iran. While some tools showed potential in prioritizing critically ill patients and managing resource allocation, their application in the real-world hospital settings remains insufficiently studied. Existing research is limited by small sample sizes, reliance on simulations, and a lack of validation in live MCI scenarios. Given these gaps, further research is essential to evaluate triage models in real-time, high-volume, and resource-limited environments to ensure effective hospital-based mass-casualty response.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"25 4","pages":"251-255"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Floral phantosmia and bradycardia: A unique case of digoxin toxicity in an elderly patient.","authors":"Marsida Kasa, Brunilda Elezi, Eglantina Sinamati, Nereida Spahia, Merita Rroji","doi":"10.4103/tjem.tjem_275_24","DOIUrl":"10.4103/tjem.tjem_275_24","url":null,"abstract":"<p><p>This case report presents a rare clinical manifestation of digoxin toxicity in a 73-year-old female with acute kidney injury, bradycardia, and unique sensory disturbances, including phantosmia (floral scent hallucinations) and photopsia (seeing sparkles of light). The patient, with a history of hypertension and atrial fibrillation, had been on digoxin for 2 weeks, raising concerns about possible digoxin intoxication. Upon admission, bradycardia, hypokalemia, and elevated serum digoxin levels confirmed toxicity. The patient's olfactory and visual hallucinations, rare symptoms in such cases, gradually resolved after stopping digoxin. This case emphasizes the importance of recognizing subtle and unusual symptoms, like changes in smell and vision, which can enhance early detection, especially in older patients, leading to quicker interventions and better patient outcomes.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"25 4","pages":"317-320"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emine Sarcan, Ahmet Burak Erdem, Şeyda Gedikaslan, Ali Kablan, Yusuf Coşkun
{"title":"Evaluation of the relationship between the hemoglobin, albumin, lymphocyte, platelet score, and clinical prognosis in patients with acute pancreatitis in the emergency department.","authors":"Emine Sarcan, Ahmet Burak Erdem, Şeyda Gedikaslan, Ali Kablan, Yusuf Coşkun","doi":"10.4103/tjem.tjem_167_25","DOIUrl":"10.4103/tjem.tjem_167_25","url":null,"abstract":"<p><strong>Objectives: </strong>In acute pancreatitis (AP), the variable clinical course and high mortality have led to the use of complex and time-consuming scoring systems. This study aimed to evaluate the diagnostic performance of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in predicting mortality and intensive care unit (ICU) admission in patients with AP, and to compare it with the Atlanta classification and the Bedside Index for Severity in AP (BISAP).</p><p><strong>Methods: </strong>This single-center retrospective study included 455 patients diagnosed with AP. Demographic data, laboratory findings, and clinical course of the patients were recorded, and HALP, BISAP, and Atlanta classification scores were calculated.</p><p><strong>Results: </strong>The Atlanta classification showed the highest predictive accuracy for both mortality and ICU admission (mortality: sensitivity 91%, specificity 96%; ICU admission: sensitivity 77%, specificity 99%). The HALP score demonstrated a moderate predictive ability for both mortality (sensitivity = 0.64; specificity = 0.79) and ICU admission (sensitivity = 0.74; specificity = 0.67). The sensitivity of the HALP score was significantly higher than that of the BISAP score for both outcomes (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Although the HALP score has a lower overall predictive power compared to the Atlanta and BISAP scores, its higher sensitivity and easily calculable structure compared to the BISAP score suggest that it may serve as a supportive tool for early prognostic assessment of AP patients in emergency department settings.</p>","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"25 4","pages":"280-287"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Noninvasive mechanical ventilation in acute cardiogenic pulmonary edema in the emergency department: A limited sum of factors determining response.","authors":"Hatice Aslan Sırakaya, Antonio M Esquinas","doi":"10.4103/tjem.tjem_86_25","DOIUrl":"10.4103/tjem.tjem_86_25","url":null,"abstract":"","PeriodicalId":46536,"journal":{"name":"Turkish Journal of Emergency Medicine","volume":"25 4","pages":"324-325"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}