Advanced Fiber Materials最新文献

{"title":"Remodeling Electrophysiological Microenvironment for Promoting Bone Defect Repair via Electret Hybrid Electrospun Fibrous Mat","authors":"Jinjie Cui,&nbsp;Bin Yu,&nbsp;Dejian Li,&nbsp;Zeyu Fu,&nbsp;Xiuyi Yang,&nbsp;Lingyong Jiang,&nbsp;Xudong Wang,&nbsp;Kaili Lin","doi":"10.1007/s42765-024-00457-x","DOIUrl":"10.1007/s42765-024-00457-x","url":null,"abstract":"<div><p>Improving the osteogenic properties of bone grafts plays a critical role in the repair and functional restoration of critical-sized bone defects. The endogenous electric field, one of the most crucial physiological signals, has been confirmed to maintain physiological function and reconstruct the structure of bone, which is inadequate in bone defect sites. Strategies for the development of electroactive osteogenic biomaterials arise to remodel and promote the electrophysiological microenvironment. Among the electroactive materials, electret biomaterials can provide a stable and persistent endogenous electrical stimulation, which better conforms to the physiological microenvironment and has long-term effectiveness in the bone repair process. Herein, an electret hybrid electrospun fibrous mat (EHFM) was developed to mimic the structure of the natural extracellular matrix (ECM) with a suitable and persistent electrophysiological microenvironment. The EHFM was constructed with a core–shell structure, in which silicon dioxide electrets were loaded in the core-layer to remodel and maintain the electrical microenvironment over the long term. The EHFM significantly promoted the osteogenesis of bone mesenchymal stem cells (BMSCs) in vitro and showed remarkable ability in bone repair, which was three times better than that of the control group in a critical-sized rat calvarial defect model. Furthermore, it was verified that EHFM-derived osteogenesis was related to the activation of the calcium ion-sensing receptor (CaSR), while increasing intracellular calcium ion concentration of BMSCs. This study puts forward a novel engineering strategy to promote bone defect repair by remodeling a stable and persistent electrophysiological microenvironment, showing potential for clinical applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 6","pages":"1855 - 1873"},"PeriodicalIF":17.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effect of Core/Shell-Structured Composite Fibers: Efficient Recovery of Rare-Earth Elements from Spent NdFeB Permanent Magnets","authors":"Youngkyun Jung,&nbsp;Yun Lee,&nbsp;Su-Jin Yoon,&nbsp;Jae-Woo Choi","doi":"10.1007/s42765-024-00442-4","DOIUrl":"10.1007/s42765-024-00442-4","url":null,"abstract":"<div><p>NdFeB magnets are third-generation permanent magnets that are employed as indispensable components in various industries. Notably, rare-earth elements (REEs) such as Dy and Nd must be efficiently recovered from end-of-life magnets to enable resource circulation and reinforce unstable supply chains. To that end, this paper reports synergistically performing core/shell-structured composite fibers (CSCFs) containing sodium polyacrylate and nanoporous zeolitic imidazolate framework-8 (NPZIF-8) nanocrystals as a readily recoverable adsorbent with an exceptional REE-adsorbing ability. The CSCF core forms an NPZIF-8 nanocrystal shell on the fiber surface as well as draws REEs using its dense sodium carboxylate groups into the NPZIF-8 nanocrystal lattice with high specific surface area. The CSCFs exhibit significantly higher maximum adsorption capacities (468.60 and 435.13 mg·g⁻¹) and kinetic rate constants (2.02 and 1.92 min⁻¹) for the Nd³⁺ and Dy³⁺ REEs than those of previously reported REE adsorbents. Additionally, the simple application of the CSCFs to an adsorption reactor considerably mitigates the adsorbent-shape-induced pressure drop, thereby directly influencing the energy efficiency of the recovery. Moreover, the high REE-recovery ability, tractability, and recyclability of the CSCFs offers a pragmatic pathway to achieving cost-effective REE recovery. Overall, this study provides new insights into designing synergistically performing core/shell architectures for feasible REE recovery.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 6","pages":"1729 - 1745"},"PeriodicalIF":17.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphite Wrapped FeNi3/Co with Carbon Nanotubes Anchored on MgO@Carbon Fiber Reinforcements via Continuous Fabrication for High-Efficiency Microwave Attenuation","authors":"Chengjuan Wang,&nbsp;Haotian Jiang,&nbsp;Xianzhao Cao,&nbsp;Xu He,&nbsp;Xuanbo Chen,&nbsp;Bowen Cui,&nbsp;Xiaodan Xu,&nbsp;Yanxiang Wang,&nbsp;Chengguo Wang","doi":"10.1007/s42765-024-00446-0","DOIUrl":"10.1007/s42765-024-00446-0","url":null,"abstract":"<div><p>Carbon fiber (CF) has emerged as a promising candidate for microwave absorbers to resolve the escalating electromagnetic wave (EMW) pollution issue, not just serving as a structural reinforcement. However, the drawbacks, such as high conductivity, limit its ability to strongly absorb EMWs over a wide bandwidth. To address these challenges, graphite wrapped FeNi₃/Co with carbon nanotubes (CNTs) anchored on MgO@CF heterostructures were synthesized by introducing MgO nanofilms on a CF surface and subsequent chemical vapor deposition catalyzed by two-phase catalysts. The synthesis of MgO suppresses the etching of CF during the experimental processes, effectively maintaining the inherent structure of CF, which is conducive to constructing rich conductive networks and developing excellent mechanical properties. By modulating the catalyst concentration, deposited CNTs with appropriate defects increase the conduction loss and stimulate defect polarization loss. The abundant interfaces formed by multiple components lead to fulfilling interface polarization, while the doping of O heteroatoms causes dipole polarization. In addition, the introduction of FeNi₃/Co generates effective magnetic loss and optimizes electromagnetic parameters to form more matching impedance conditions. At a low filler loading of 23 wt%, the stable sample obtains a remarkable minimum reflection loss of up to − 72.08 dB at merely 1.38 mm with an effective absorption bandwidth reaching 4.88 GHz at only 1.44 mm, which is superior to that of numerous distinguished carbon-based composites in regard to being “thin, light, wide and strong”. CST simulation reveals that the maximum radar cross section reduction acquires 26.88 dBm², ascertaining the radar stealth capability of the distinctive heterostructure. Moreover, great mechanical and electromagnetic interference shielding performance is demonstrated by epoxy composites. Henceforth, this study proposes profound insights into the intricate relationship between the structure and EMW absorbing mechanism, and elucidates an attractive strategy for mass-producing modified CF-based hybrids for versatile applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1640 - 1656"},"PeriodicalIF":17.2,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Wet-Spun PEDOT:PSS Fibers for Thermoelectric Applications Through Innovative Triple Post-treatments","authors":"Yu-Yu Deng,&nbsp;Xiao-Lei Shi,&nbsp;Ting Wu,&nbsp;Yicheng Yue,&nbsp;Wei-Di Liu,&nbsp;Meng Li,&nbsp;Fang Yue,&nbsp;Pei Huang,&nbsp;Qingfeng Liu,&nbsp;Zhi-Gang Chen","doi":"10.1007/s42765-024-00441-5","DOIUrl":"10.1007/s42765-024-00441-5","url":null,"abstract":"<div><p>Owing to the high flexibility, low thermal conductivity, and tunable electrical transport property, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) exhibits promising potential for designing flexible thermoelectric devices in the form of films or fibers. However, the low Seebeck coefficient and power factor of PEDOT:PSS have restricted its practical applications. Here, we sequentially employ triple post-treatments with concentrated sulfuric acid (H₂SO₄), sodium borohydride (NaBH₄), and 1-ethyl-3-methylimidazolium dichloroacetate (EMIM:DCA) to enhance the thermoelectric performance of flexible PEDOT:PSS fibers with a high power factor of (55.4 ± 1.8) μW m⁻¹ K⁻² at 25 °C. Comprehensive characterizations confirm that excess insulating PSS can be selectively removed after H₂SO₄ and EMIM:DCA treatments, which induces conformational changes to increase charge carrier mobility, leading to enhanced electrical conductivity. Simultaneously, NaBH₄ treatment is employed to adjust the oxidation level, further optimizing the Seebeck coefficient. Additionally, the assembled flexible fiber thermoelectric devices show an output power density of (60.18 ± 2.79) nW cm⁻² at a temperature difference of 10 K, proving the superior performance and usability of the optimized fibers. This work provides insights into developing high-performance organic thermoelectric materials by modulating polymer chains.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1616 - 1628"},"PeriodicalIF":17.2,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42765-024-00441-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141507209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose-Based Conductive Hydrogels for Emerging Intelligent Sensors","authors":"Xue Yao,&nbsp;Sufeng Zhang,&nbsp;Ning Wei,&nbsp;Liwei Qian,&nbsp;Sergiu Coseri","doi":"10.1007/s42765-024-00418-4","DOIUrl":"10.1007/s42765-024-00418-4","url":null,"abstract":"<div><p>Flexible intelligent sensing is a burgeoning field of study that covers various disciplines, including but not restricted to chemistry, physics, electronics and biology. However, the widespread use of flexible sensors remains challenging because of certain constraints, such as limited stretchability, poor biocompatibility, low responsivity, and the complexity of multifunctional integration. Conductive hydrogels with remarkable material properties are presently in the spotlight of flexible sensing. In the pursuit of high-performance and “green” conductive hydrogel-based sensors, cellulose is a promising candidate owing to its renewability, low cost, appealing mechanical properties, easy modification and other functional characteristics. Herein, cutting-edge progress in the fabrication of conductive cellulose hydrogels (CCHs) using cellulose and cellulose derivatives in terms of structural features, preparation approaches, functional properties, applications, and prospects for sensors is comprehensively summarized. The correlation between CCHs performances, reinforcement strategies and sensor properties is highlighted to gain insight into the process of developing smart sensors by utilizing CCHs. Besides, the state-of-the-art advances of CCHs toward emerging wearable sensors, including strain/pressure sensors, temperature sensors, humidity sensors, and biosensors, are systematically discussed. Finally, potential challenges and future outlooks of such attractive CCH-based flexible sensors are presented, providing valuable information for the development of next-generation cellulose-based electronic devices.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1256 - 1305"},"PeriodicalIF":17.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections","authors":"Yixin Wang,&nbsp;Pengpeng Guan,&nbsp;Ruiyi Tan,&nbsp;Zhenghui Shi,&nbsp;Qing Li,&nbsp;Bitao Lu,&nbsp;Enling Hu,&nbsp;Weiwei Ding,&nbsp;Wenyi Wang,&nbsp;Bowen Cheng,&nbsp;Guangqian Lan,&nbsp;Fei Lu","doi":"10.1007/s42765-024-00439-z","DOIUrl":"10.1007/s42765-024-00439-z","url":null,"abstract":"<div><p>Microneedles (MNs) with unique three-dimensional stereochemical structures are suitable candidates for tissue fixation and drug delivery. However, existing hydrogel MNs exhibit poor mechanical properties after swelling and require complex preparation procedures, impeding their practical application. Hence, we engineered chitosan fiber-reinforced silk fibroin MN patches containing epigallocatechin gallate (SCEMN). A formic acid–calcium chloride system was introduced to fabricate hydrogel MNs with excellent inherent adhesion, and the incorporation of chitosan fiber as a reinforcing material enhanced mechanical strength and viscosity, thereby increasing the physical interlocking with tissue and the ability to maintain shape. The SCEMN with a lower insertion force firmly adhered to porcine skin, with a maximum detachment force of 11.98 N/cm². Additionally, SCEMN has excellent antioxidant and antibacterial properties, facilitates macrophage polarization from M1 to M2, and demonstrates superior performance in vivo for diabetic wound repair compared with the commercial product Tegaderm™. This study represents the first trial of fiber-reinforced hydrogel MNs for robust tissue adhesion. Our findings underscore the significance of this innovative approach for advancing MN technology to enhance tissue adhesion and accelerate wound healing.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1596 - 1615"},"PeriodicalIF":17.2,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fusing Fibre Batteries Interface via Biomimetic Gel Electrolyte","authors":"Yinan Yang,&nbsp;Yanyan Shao,&nbsp;Guoqing Lu,&nbsp;Yuanlong Shao","doi":"10.1007/s42765-024-00448-y","DOIUrl":"10.1007/s42765-024-00448-y","url":null,"abstract":"<div><p>The energy supply of rising electronic textile can resort to gel-based fibre batteries attributed to their flexibility and safety. However, their electrochemical performance is plagued by the poor electrolyte–electrode interface. Recently, Peng et al. designed channel structures to accommodate gel electrolyte yielding intimate and stable interfaces for high-performance fibre batteries. Encompassing excellent electrochemical performance, stability, safety and large-scale productivity, the as-fabricated fibre lithium-ion batteries (FLBs) demonstrated the potential to supply energy for textile electronics.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 4","pages":"949 - 951"},"PeriodicalIF":17.2,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MnO2/Poly-L-lysine Co-decorated Carbon Fiber Cloth with Decreased Evaporation Enthalpy and Enhanced Photoabsorption/Antibacterial Performance for Solar-Enabled Anti-fouling Seawater Desalination","authors":"Xinxing Song,&nbsp;Xiaolong Li,&nbsp;Bo Zhu,&nbsp;Songmei Sun,&nbsp;Zhigang Chen,&nbsp;Lisha Zhang","doi":"10.1007/s42765-024-00437-1","DOIUrl":"10.1007/s42765-024-00437-1","url":null,"abstract":"<div><p>Solar-driven seawater evaporation is a potential strategy for mitigating global freshwater shortage, but its application is hindered by the photothermal membranes with high evaporation enthalpy, unsatisfactory photoabsorption, and easy contamination by microorganism. To solve these problems, herein we reported the design of manganese oxide/poly-L-lysine co-decorated carbon-fiber cloth (CFC) with decreased evaporation enthalpy and enhanced photoabsorption/antibacterial performance. Manganese oxide (MnO₂) nanosheets (thickness: 10–30 nm, diameter: 400–450 nm) were grown in situ on the CFC surface by a hydrothermal method, and then the nanosheet surface was further decorated with poly-L-lysine (PLL) by the electrostatic adsorption. Co-decoration of MnO₂/PLL confers the conversion of hydrophobic CFC to superhydrophilic CFC/MnO₂/PLL, accompanied by the reduction of the evaporation enthalpy of bulk water to 2132.34 kJ kg⁻¹ for CFC/MnO₂/PLL sample. Such CFC/MnO₂/PLL exhibits a strong photoabsorption in wide range (280–2500 nm) with an absorption efficiency of 97.8%, due to the light-trapping effects from hierarchical structures. Simultaneously, CFC/MnO₂/PLL has excellent antibacterial performance toward <i>E. coli</i> (99.1 ± 0.2%) and <i>S. aureus</i> (98.2 ± 0.5%) within 60 min in the dark, due to the electrostatic interaction between the bacterial cell membrane and PLL. Subsequently, CFC/MnO₂/PLL was hung between the seawater tank and empty tank to construct a hanging evaporator. Under 1.0 kW m⁻² light irradiation, CFC/MnO₂/PLL shows a preeminent evaporation rate of 2.20 kg m⁻² h⁻¹. Importantly, when germy NaCl solution is evaporated, there is no solid-salt accumulation and bacteria contamination on CFC/MnO₂/PLL surface during the long-time test (12 h), conferring long-term anti-fouling seawater evaporation. Hence, this work provides new possibilities in the rational design of photothermal fabrics for solar-enabled efficient anti-fouling seawater desalination.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1569 - 1582"},"PeriodicalIF":17.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Fiber Strain Sensor by Designing Coaxial Coiling Structure with Mutual Inductance Effect","authors":"Yulu Ai,&nbsp;Zhen Wang,&nbsp;Yue Liu,&nbsp;Yuanyuan Zheng,&nbsp;Jiaqi Wu,&nbsp;Junyi Zou,&nbsp;Songlin Zhang,&nbsp;Peining Chen,&nbsp;Huisheng Peng","doi":"10.1007/s42765-024-00445-1","DOIUrl":"10.1007/s42765-024-00445-1","url":null,"abstract":"<div><p>Fiber strain sensors with robust sensing performance are indispensable for human–machine interactions in the electronic textiles. However, current fiber strain sensors are confronted with the challenges of unavoidable deterioration of functional sensing components during wearable and extreme environments, resulting in unsatisfactory stability and durability. Here, we present a robust fiber strain sensor based on the mutual inductance effect. The sensor is assembled by designing coaxial helical coils around an elastic polyurethane fiber. When stretching the fiber sensor, the strain is detected by recording the voltage changes in the helical coils due to the variation in magnetic flux. The resultant fiber strain sensor shows high linearity (with a linear regression coefficient of 0.99) at a large strain of 100%, and can withstand various extreme environmental conditions, such as high/low temperatures (from − 30 °C to 160 °C), and severe deformations, such as twisting and pressing (with a pressure of 500 N/cm). The long-term cyclic stability of our fiber strain sensor (100,000 cycles at a strain of 100%) is superior to that of most reported flexible resistive and capacitive strain sensors. Finally, the mass-produced fiber strain sensors are woven into a smart textile system to accurately capture gestures.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1629 - 1639"},"PeriodicalIF":17.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141258601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Printing-Electrospinning Hybrid Nanofibrous Scaffold as LEGO-Like Bricks for Modular Assembling Skeletal Muscle-on-a-Chip Functional Platform","authors":"Zihan Wang,&nbsp;Sitian Liu,&nbsp;Mingying Han,&nbsp;Jie Xu,&nbsp;Maoyu Qin,&nbsp;Qiao Yang,&nbsp;Guanjie Zeng,&nbsp;Meng Long,&nbsp;Ting Li,&nbsp;Junfeiyang Yin,&nbsp;Liu Yu,&nbsp;Wenhua Huang,&nbsp;Ling Wang,&nbsp;Yaobin Wu","doi":"10.1007/s42765-024-00433-5","DOIUrl":"10.1007/s42765-024-00433-5","url":null,"abstract":"<div><p>Organ-on-a-chip stands as a pivotal platform for skeletal muscle research while constructing 3D skeletal muscle tissues that possess both macroscopic and microscopic structures remains a considerable challenge. This study draws inspiration from LEGO-like assembly, employing a modular approach to construct muscle tissue that integrates biomimetic macroscopic and microscopic structures. Modular LEGO-like hybrid nanofibrous scaffold bricks were fabricated by the combination of 3D printing and electrospinning techniques. Skeletal muscle cells cultured on these modular scaffold bricks exhibited a highly orientated nanofibrous structure. A variety of construction of skeletal muscle tissues further enabled development by various assembling processes. Moreover, skeletal muscle-on-a-chip (SMoC) was further assembled as a functional platform for electrical or perfusion stimuli investigation. The electrical stimulus was conveniently applied and tuned in such a SMoC platform to significantly enhance the differentiation of skeletal muscle tissues. Additionally, the effect of perfusion stimulation on skeletal muscle vascularization within the SMoC platform was also demonstrated. These findings highlight the potential of these assembled SMoCs as functional ex vivo platforms for skeletal tissue engineering and drug research applications, and such a LEGO-like assembly strategy could also be applied to the other engineering organ-on-chips fabrication, which facilitates the development of bionic functional platforms for various biomedical research applications.</p><h3>Graphical Abstract</h3><p>We developed a list of modular nanofibrous scaffold bricks by a hybrid fabrication method combining 3D printing and electrospinning techniques, featuring precise microscale and nanoscale structures. Emulating the LEGO-like assembly method, these bricks were assembled along the <i>x</i>–<i>y</i>–<i>z</i> axis to mimic various skeletal muscle structures. These developed engineered skeletal muscle tissues were further integrated into the microfluidic chip to develop the skeletal muscle-on-a-chip (SMoC) as an in vitro testing platform for both electrical and perfusion stimuli investigation.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"6 5","pages":"1521 - 1540"},"PeriodicalIF":17.2,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141258604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}