Advanced Fiber Materials最新文献

{"title":"Hierarchically Designed Electrothermal Liquid Gating E-Dressing for Intelligent Wound Exudate Management and Healing Therapy","authors":"Zhiye Qiu,&nbsp;Mengzheng Wang,&nbsp;Binghui Wang,&nbsp;Bingjie Xu,&nbsp;Minghua Wu,&nbsp;Yujie Gao,&nbsp;Jindan Wu","doi":"10.1007/s42765-025-00642-6","DOIUrl":"10.1007/s42765-025-00642-6","url":null,"abstract":"<div><p>Effective management of wound exudate is critical for mitigating inflammation and promoting moist wound healing. However, achieving efficient, dynamic, and controllable exudate regulation remains a significant challenge. To address this, we developed a smart trilayer electronic dressing (E-dressing) composed of a silver nanowire (Ag NW) heater, a thermoresponsive cotton fabric (CTP) interlayer, and hydrophobic polyurethane (PU) nanofibers. Upon electrical stimulation, Ag NW-induced heating triggers rapid hydrophilicity switching in the CTP layer. This process dynamically generates a Janus interface that enables spontaneous unidirectional fluid transport from the PU layer to the Ag NW layer, with the volume of removed exudate being precisely modulated by the stimulation duration. Simultaneously, the Ag NWs component allows for real-time thermal monitoring of wound status. The E-dressing exhibited potent antibacterial activity, inhibiting <i>Staphylococcus aureus</i> (<i>S. aureus</i>) by (98.7 ± 0.5)% and <i>Escherichia coli</i> (<i>E. coli</i>) by (99.9 ± 0.1)%, thereby significantly reducing infection risk. In diabetic mouse models, wound treated with the E-dressing combined with electrical stimulation achieved nearly complete closure. Compared to controls, the treatment also induced a 31-fold increase in neovascularization density during the early stage and enhanced collagen deposition by 157.7% by day 12. This intelligent system offers a novel strategy for maintaining moisture balance and promoting chronic wound repair. With its dual functionality of remote thermal regulation and real-time monitoring, the E-dressing represents a promising platform for advanced smart wound therapeutics.</p><h3>Graphical Abstract</h3><p>This E-dressing enables dynamic exudate management through reversible wettability modulation. Upon electrical activation,Joule heating induces a hydrophilic transition in the thermoresponsive cotton layer,generating an on-demand Janus interface with the hydrophobic PU substrate to drive autonomous fluid transport away from the wound bed. De-energizing the system restores cotton hydrophobicity, establishing a fluid-retentive barrier. The platform concurrently delivers inherent antibacterial functionality and enables real-time thermal monitoring capabilities.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"714 - 732"},"PeriodicalIF":21.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible Electrospun PDMS/PVDF-HFP Composite Nanofibers-Based Hybrid Nanogenerators for Efficient Mechanical Energy Harvesting and Multi-Sensing Applications","authors":"Venkata Siva Kavarthapu,&nbsp;Punnarao Manchi,&nbsp;Anand Kurakula,&nbsp;Hong Mu Park,&nbsp;Yeong Hwan Ko,&nbsp;Jae Su Yu","doi":"10.1007/s42765-025-00638-2","DOIUrl":"10.1007/s42765-025-00638-2","url":null,"abstract":"<div><p>The swift adoption of self-powered energy-harvesting technologies presents an exciting opportunity. However, the challenge lies in the development of flexible, energy-efficient, sensitive, and easy-to-assemble devices. Electrospun nanofibrous films can be used in hybrid nanogenerators (HyNGs) for advanced triboelectric nanogenerators (TENGs), converting mechanical energy into electrical energy and serving self-powered sensor applications due to their exceptional electrical output, lightweight nature, and flexibility. In this study, polydimethylsiloxane (PDMS) is integrated into a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) polymer by electrospinning to fabricate PDMS/PVDF-HFP composite fibrous films (CFFs)-based HyNGs. The CFF exhibits exceptional β-phase fraction and dielectric properties that help to improve the HyNG’s electrical performance in a contact-separation mode. The optimized HyNG exhibits exceptional stability and durability during long-term operation, making it effective for harvesting biomechanical energy from low-power portable devices. Furthermore, it can operate as a sensor that engages an Arduino for motion-sensing applications. When combined with Arduino and Bluetooth modules, the HyNG sensor can offer an innovative solution for fitness tracking by transmitting step-count data directly to a smartphone. This capability empowers users to monitor their health through their activity levels effectively. Additionally, the HyNGs operate to build real-time speed sensing and overspeed alerts and find vehicle direction applications. From these results, the proposed HyNG can be leveraged by artificial intelligence models to simulate real-world scenarios and support decision-making processes that improve road safety applications.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"655 - 670"},"PeriodicalIF":21.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programming Ordered Tissue Reconstruction via Artificial Bionic Tendon Sheath for Tendinopathy Treatment","authors":"Chao Li,&nbsp;Wentao Li,&nbsp;Ronghui Deng,&nbsp;Lingan Huang,&nbsp;Yifan Song,&nbsp;Xianjie Wei,&nbsp;Bingbing Xu,&nbsp;Guoqing Cui,&nbsp;Zehao Chen,&nbsp;Jiakuo Yu","doi":"10.1007/s42765-025-00637-3","DOIUrl":"10.1007/s42765-025-00637-3","url":null,"abstract":"<div><p>Excessive interface friction and advanced glycation end products (AGEs) disrupt collagen ordered deposition, promoting scar formation in tendinopathies. Inspired by tendon sheath anatomy, we developed a bionic bilayer nano-membrane via electrospinning and photocrosslinking to initiate the directional and orderly regeneration process of tendon tissue. The lubricating layer (PP), containing phosphatidylserine (PS), reduces frictional stress, while the regenerative layer (GM/GV), composed of gelatin methacrylate (GM) and vanillin-modified gelatin (GV), scavenges ROS and mitigates AGEs-induced collagen disorder deposition. This parallel bilayer structure guides tendon cell alignment and promotes ordered collagen deposition. Additionally, vanillin suppresses the AGEs/TGF-β/Smad pathway, reducing scar formation and tissue adhesion. In vitro/in vivo tests showed a fivefold decrease in coefficient of friction (COF) and a tenfold increase in Achilles tendon function index (AFI) compared to the PCL and normal groups, respectively. The PP@GM/GV membrane, regulated by mechano-biochemical coupling factors, offers a promising strategy for tendinopathy repair, and holds significant potential for clinical translation in guiding functional tendon regeneration and improving patient outcomes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"629 - 654"},"PeriodicalIF":21.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional Conformable IL-PANSion with Multisensory Capabilities for Soft Device Applications","authors":"Shiju Yang,&nbsp;Haoxiang Jin,&nbsp;Yiyao Zhang,&nbsp;Shangkui Yang,&nbsp;Junlong Tan,&nbsp;Lixue Yang,&nbsp;Xiaofei Song,&nbsp;Rongjie Kang,&nbsp;Shaoli Fang,&nbsp;Ray H. Baughman,&nbsp;Jiuke Mu","doi":"10.1007/s42765-025-00645-3","DOIUrl":"10.1007/s42765-025-00645-3","url":null,"abstract":"<div><p>Equipping advanced intelligent machines with human-like nervous systems requires new sensing materials capable of conformal integration into complex multidimensional structures. Here, we introduce an ionic liquid-enhanced polyacrylonitrile/AgNO₃ formulation (IL-PANSion)—designed to be fabricated in diverse forms, including air-spun fibers, multi-material 2D printed layers, and 3D injection-molded networks. By leveraging room-temperature air spinning, IL-PANSion fibers achieve high tensile strain (up to 300 times that of conventional polyacrylonitrile fibers) and maintain over 650% stretchability for extended periods in open air. The material’s robust supramolecular network exhibits self-healing behavior, rapidly restoring mechanical integrity and conductivity after damage. In addition to mechanical strain sensing (gauge factor of 4.41), IL-PANSion detects temperature changes (<i>S</i>_T of 1.75 °C⁻¹), near-infrared radiation, and organic solvents, all within a single platform. By integrating IL-PANSion-based sensors into soft robotic systems, we demonstrate autonomous path-planning capabilities and the accurate identification of organic gases. Furthermore, the material can conformally fill or coat 3D structures to form hollow tubular sensors, enabling real-time monitoring of internal fluid flow and pressure—an important step toward biomimetic “organ-level” sensing. These findings showcase IL-PANSion’s versatile processing, combined with multimodal, self-healing sensing properties, making it a promising candidate for next-generation wearable health monitors, soft robotic skins, and smart infrastructures requiring integrated volumetric sensing.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"746 - 761"},"PeriodicalIF":21.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic Fabrication of Janus Triboelectric Fibers with Bamboo-Like Architecture for Motion Sensing Applications","authors":"Wuchao Wang,&nbsp;Yinghong Wu,&nbsp;Lucyna Hämmerle,&nbsp;Carlo Menon,&nbsp;Kongchang Wei,&nbsp;René M. Rossi","doi":"10.1007/s42765-025-00641-7","DOIUrl":"10.1007/s42765-025-00641-7","url":null,"abstract":"<div><p>Fiber-based triboelectric nanogenerators (f-TENGs) hold great promise for healthcare applications, addressing increasing demand for wearables and self-powered devices in our aging society. To date, many co-axial multilayer fibers have been developed for the fabrication of stand-alone single-thread f-TENGs, whose developments are often constrained by low-throughput fabrication processes that require advanced techniques and additional assembly steps. Herein, we describe a novel Janus bamboo-like f-TENG for human motion sensing. With the microfluidic wet spinning (MWS) technique, polytetrafluoroethylene (PVDF) and thermoplastic polyurethane (TPU) were precisely distributed in two halves of Janus fibers, with PVDF as tribo-negative and TPU as tribo-positive materials separated by bamboo-like cavities. We demonstrated that such f-TENGs can be facilely integrated into wearable sensors for monitoring human body movements at different frequencies and motion amplitudes. The continuous and controlled fabrication of such f-TENGs enabled by MWS offers new opportunities for the future development of self-powered and miniaturized wearable devices.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"700 - 713"},"PeriodicalIF":21.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42765-025-00641-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Triple-Coaxial Soft Fiberbot with All-in-One Sensation–Actuation Capability and High Acid/Alkali-Resistant Stability","authors":"Hao Zhu,&nbsp;Lei Fu,&nbsp;Ju Bai,&nbsp;Shengzhao Li,&nbsp;Shen Yuan,&nbsp;Yin Cao,&nbsp;Guanggui Cheng,&nbsp;Jianning Ding,&nbsp;Ting Zhang,&nbsp;Tie Li","doi":"10.1007/s42765-025-00636-4","DOIUrl":"10.1007/s42765-025-00636-4","url":null,"abstract":"<div><p>Intelligent fiberbots integrate selective proprioception and autonomous motility, revealing great application prospects in medical examination and environmental monitoring. However, most fiberbots are limited by the hysteretic sensation–actuation capabilities and often fail in harsh environments (e.g., acid or alkali solutions). To address these issues, this study successfully developed a novel triple-coaxial fibrous composite-derived soft fiberbot. It was fabricated via an artful three-layer (core–middle–sheath) wet-spinning strategy, with each layer serving a specific function. The sheath layer has the properties of acid/alkali-resistant and self-illuminating, the middle layer enables programmable magnetic actuation, and the core layer provides high-selective sensing of mechanics and temperature. In addition, benefiting from its high ductility and seamless interface, the assembled fiberbot exhibits excellent mechanical properties and can maintain continuous visual motion for up to 10h under complex conditions. To further demonstrate the potential of this triple-coaxial fiberbot, several motion patterns are designed by the tactics of three-dimensional printing mold-assisted molding and magnetization. The magnetized fiberbot can not only perform helical propulsion and inchworm-inspired crawling, but also self-sense its own locomotion. Moreover, it can recognize the target states (such as the hardness and temperature) in the acidic stomach and alkaline overheated seawater, achieving a high-fine recognition accuracy of 98.3%. In summary, this work provides a feasible assembly strategy for constructing intelligent fiberbots. These fiberbots combine all-in-one functionalities of programmable actuation, selective sensation, and acid/alkali resistance. This breakthrough opens up broad prospects for future applications in medical examination and harsh environmental monitoring.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"611 - 628"},"PeriodicalIF":21.3,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Textiles with Living Interfaces: Microbiome–Electronics Integration for Advanced Skin Health Management","authors":"Hanbai Wu,&nbsp;Yang Ming,&nbsp;Shuo Shi,&nbsp;Chuanwei Zhi,&nbsp;Daming Chen,&nbsp;Xin Hu,&nbsp;Rujun Yu,&nbsp;Shuang Qiu,&nbsp;Hang Mei Leung,&nbsp;Jinlian Hu,&nbsp;Jooyoun Kim,&nbsp;Joanne Yip,&nbsp;Bin Fei","doi":"10.1007/s42765-025-00625-7","DOIUrl":"10.1007/s42765-025-00625-7","url":null,"abstract":"<div><p>Smart textiles have emerged as a transformative class of materials that extend the role of conventional fabrics into personalized health management. This evolution is driven by the seamless integration of textiles with flexible electronics, enabling new paradigms in skin-interfaced systems. In the exploration of novel smart textiles for skin health, microorganisms living in the skin microenvironment necessitate consideration. Skin microbiomes are essential to skin homeostasis and balance the barrier to infection. Moreover, microbes have been extensively explored as functional components in skin health monitoring and therapeutic devices. In this review, the distribution of skin microbes, interactions between host and resident microbiota, and mechanisms of microbial functions in the skin microenvironment are introduced systematically. In addition, recent progress in skin-based flexible devices for health management, and design and fabrication methods for smart textiles are discussed. However, some challenges still exist in association with the integration of microbes into smart textiles, such as the biosafety of microbes, long-term storage, and activation. This review provides a summary of innovative technologies including microencapsulation, synthetic biology, optogenetics, and artificial intelligence for microbe-integrated smart textiles. Next-generation smart textiles will hold significant promise for precision skin disease diagnostics, personalized therapeutics, skin status monitoring, and intelligence regulation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 1","pages":"34 - 72"},"PeriodicalIF":21.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42765-025-00625-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grain-Growth-Inhibited Mullite Fiber Sponges with Superior Thermal Insulation and Sound Absorption Properties","authors":"Jiaxin Li,&nbsp;Yaling Zhai,&nbsp;Xiaolong Su,&nbsp;Zhenyan Lu,&nbsp;Jian Zhao,&nbsp;Guichao Tian,&nbsp;Chao Jia,&nbsp;Meifang Zhu","doi":"10.1007/s42765-025-00640-8","DOIUrl":"10.1007/s42765-025-00640-8","url":null,"abstract":"<div><p>Mullite fiber is one of the most outstanding oxide ceramic fibers for maintaining high-temperature performance while retaining flexibility. However, the rapid grain growth within mullite fibers inevitably compromises their flexibility, making the suppression of grain growth a significant challenge. Here, we develop high-performance mullite fibers with excellent flexibility at 1500 °C by optimizing the precursor-to-polymer molar ratio via solution blow spinning. Proper ratio control reduces excessive polymer content, minimizes pore defects, and, more importantly, suppresses grain growth during high-temperature treatment, thereby enhancing thermal stability and preserving fiber flexibility. The mullite fiber sponges exhibit excellent compressive resilience, high-temperature thermal insulation, and sound absorption properties. The sponges withstand 1000 compression-recovery cycles, achieve an ultralow thermal conductivity of 0.028 W m⁻¹ K⁻¹, and demonstrate a sound reduction coefficient of up to 0.82. This study highlights the optimization of precursor-to-polymer ratios as a promising strategy to enhance mullite fiber properties, providing valuable insights for efficiently producing high-performance ceramic fibers and potentially extending to the fabrication of other ceramic fiber materials.</p></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"689 - 699"},"PeriodicalIF":21.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconfigurable 3D Stretchable Fabric Evaporator with Spiral Cone Array for Dynamically Matched Solar Intensity and Efficient Desalination","authors":"Zhiwei Lei,&nbsp;Shang Liu,&nbsp;Bihua Hu,&nbsp;Xingzhu Wang,&nbsp;Meng Lin,&nbsp;Baomin Xu","doi":"10.1007/s42765-025-00639-1","DOIUrl":"10.1007/s42765-025-00639-1","url":null,"abstract":"<div><p>Maintaining the match between input solar energy and required energy through evaporator density management is crucial for efficient solar steam generation compared to conventional static rigid evaporators. Herein, we developed a 3D spiral cone evaporator with dynamic stretchability and investigated the matching relationship between light intensity and evaporator density by employing coupled numerical and experimental approach. This evaporator not only has high mechanical strength, but also has excellent stretching and rebound properties. This design takes full advantage of the dynamic adjustability of 3D spiral cone arrays controlled by the tensile module when encountering different solar illumination, which successfully improves the solar energy utilization. In addition, the fabric cone and spiral surface structure have excellent thermal management capabilities, achieving localized salt crystallization at the apex and excellent antibacterial performance, effectively extending the service life of the evaporator. Consequently, solar energy utilization and vapor diffusion synergies are greatly promoted synergistically, with evaporation rate of 2.55 kg m⁻² h⁻¹ and solar efficiency of 94.3%, which is 34.9% higher than static evaporation. This dynamically stretchable evaporator provides a new strategy for evaporation systems, which helps to establish energy matching.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 2","pages":"671 - 688"},"PeriodicalIF":21.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147559249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus Adhesive Dressing with Macro/Micro Dual Design Enabling Sequential Microenvironment Regulation for Scarless Wound Healing","authors":"Meimei Fu,&nbsp;Yue Li,&nbsp;Yitao Zhao,&nbsp;Yuting Zhu,&nbsp;Zhou Fang,&nbsp;Zhuoyi Huang,&nbsp;Wenjun Luo,&nbsp;Xinyu Huang,&nbsp;Jintao Li,&nbsp;Zhiqi Hu,&nbsp;Keke Wu,&nbsp;Jinshan Guo","doi":"10.1007/s42765-025-00620-y","DOIUrl":"10.1007/s42765-025-00620-y","url":null,"abstract":"<div><p>Continuous wound healing micro-environment regulation and timely angiogenesis modulation are crucial for preventing excessive collagen accumulation and promoting scarless wound healing. Herein, a bilayer silk fibroin (SF)-based Janus adhesive dressing (SCE) was developed, featuring a lower layer of Ca²⁺/Zn²⁺-modified silk fibroin (SCZ) and an upper layer of silk fibroin core–shell electrospun fibers with epigallocatechin gallate (EGCG) encapsulated in the core (SE). The Ca²⁺/Zn²⁺ modification induced decrystallization of the SF, thereby conferring strong tissue adhesion to the lower SCZ layer and providing rapid hemostasis and initial anti-inflammatory effects upon wound contact. The macro (double layers) and micro (core–shell) dual design enabled EGCG to be slowly released during the early healing stage, exerting both antioxidant and synergistic anti-inflammatory effects in conjunction with Zn²⁺. With complete absorption of the lower layer and degradation of the shell of the upper layer, substantial amounts of EGCG were continuously released to inhibit angiogenesis during the later healing stages. In vivo studies employing both rat full-thickness skin wound models and rabbit ear scar models further confirmed the potential of SCE to promote scarless wound healing by combining early-stage hemostatic, antimicrobial, antioxidant, and anti-inflammatory properties with late-stage angiogenesis braking to reduce vascular density and blood supply, thereby allowing extracellular matrix remodeling and preventing collagen overproduction and deposition.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":459,"journal":{"name":"Advanced Fiber Materials","volume":"8 1","pages":"262 - 288"},"PeriodicalIF":21.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}