Cerebrovascular Diseases Extra最新文献_第6页

Comparison of Stroke Risk Factors between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort 北美烟雾病队列中有症状和无症状患者卒中危险因素的比较

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-05-19 DOI: 10.1159/000525098

Mukaish Kumar, A. Larson, M. S. Jabal, L. Rinaldo, L. Savastano, G. Lanzino, F. Meyer, V. Lehman, J. Klaas

{"title":"Comparison of Stroke Risk Factors between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort","authors":"Mukaish Kumar, A. Larson, M. S. Jabal, L. Rinaldo, L. Savastano, G. Lanzino, F. Meyer, V. Lehman, J. Klaas","doi":"10.1159/000525098","DOIUrl":"https://doi.org/10.1159/000525098","url":null,"abstract":"Background: Risk factors for stroke in symptomatic and asymptomatic moyamoya disease (MMD) patients have recently been reported in a Japanese cohort. Such information in a North American population is lacking. Objective: We sought to elucidate the prevalence of stroke risk factors among North American patients with ischemic, hemorrhagic, and asymptomatic MMD. Methods: We retrospectively reviewed our institution’s database between 1990 and 2021. We excluded cases of moyamoya syndrome. We divided 119 patients into 3 groups based on the onset pattern; ischemic, hemorrhagic, and asymptomatic. We compared the prevalence of well-known stroke risk factors (diabetes, hypertension, etc.) between these three groups of patients. In the asymptomatic group, we analyzed the prevalence of cerebrovascular events on follow-up from the time of diagnosis. Results: Overall, 119 patients with MMD were available with predominately White ethnicity (80.7%). The mean age was 39 years, and 73.9% were female. Patients presented with ischemic stroke (82%) and hemorrhagic stroke (11%); 7% of patients were asymptomatic. The prevalence of stroke risk factors did not differ among ischemic, hemorrhagic, or asymptomatic MMD patients. In 8 asymptomatic patients, there was 81.8 months (SD ±51.0) of follow-up, and none of them developed any cerebrovascular events. Conclusions: No significant differences in the prevalence of stroke risk factors between MMD cohorts were found, corroborating evidence provided in a recent Japanese-based study. There were no apparent associations between stroke risk factors and interval cerebrovascular events in an asymptomatic group of MMD patients.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 1","pages":"72 - 75"},"PeriodicalIF":1.9,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42271879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Low-Cost Feedback Program for Reducing the Door-to-Computed Tomography Time 降低计算机断层扫描时间的低成本反馈程序

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-04-28 DOI: 10.1159/000524725

T. Mitsuhashi, J. Tokugawa, H. Mitsuhashi

{"title":"Low-Cost Feedback Program for Reducing the Door-to-Computed Tomography Time","authors":"T. Mitsuhashi, J. Tokugawa, H. Mitsuhashi","doi":"10.1159/000524725","DOIUrl":"https://doi.org/10.1159/000524725","url":null,"abstract":"Introduction: Early restoration of blood flow in stroke patients can be achieved by reducing the door-to-computed tomography (DTC) time. Previous research has proposed several methods to reduce the DTC time, but the implementation costs limit its transferability. This study aimed to propose a novel, simple, and low-cost method for reducing the DTC time by providing feedback on each patient’s DTC time to a small group of medical workers and physicians. Methods: A field experiment was conducted for 233 days, and the DTC time of 249 patients with stroke symptoms who were transported via ambulance to a medium-sized university hospital in Japan within 24 h after stroke onset was obtained. The first and second feedback reports on the 59th day and 154th day, respectively, were provided at the beginning of the field experiment. Using the data collected during the first 58 days as baseline data, the baseline data were compared with the post-intervention data. As part of the intervention, feedback on the DTC time for each patient was provided to six medical workers and physicians during regular meetings. The primary outcome was a continuous measure of DTC time (in min). The feedback effect hypothesis was formulated prior to data collection. Results: In a sample of 68 patients at baseline, the mean DTC time was 18.16 min with a standard deviation of 7.38 min. As a result of the two feedback reports, in the sample with outliers, the mean and standard deviation decreased to 15.64 min and 5.97 min, respectively. The difference in means was 2.51 min (p = 0.021 in t tests). Results of the test of the equality of the standard deviations suggested that the two standard deviations were not equal (p = 0.065). Conclusions: The low-cost interventions successfully reduced both the mean DTC time and variation, suggesting an improvement in the quality and consistency of medical services. The result of our fine-grained analysis with a field-experiment design supports the role of feedback in achieving early treatment as suggested in the Target: Stroke initiative.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 1","pages":"63 - 71"},"PeriodicalIF":1.9,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43434554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of the MRA-Based Road Mapping of the Para-Aortic Access Route before Mechanical Thrombectomy in Patients with Acute Ischemic Stroke 基于mri的急性缺血性脑卒中机械取栓前主动脉旁通路路径测绘的疗效

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-03-17 DOI: 10.1159/000524112

S. Kobayashi, T. Osanai, N. Fujima, A. Hamaguchi, T. Sugiyama, Toshitaka Nakamura, K. Hida, M. Fujimura

{"title":"Efficacy of the MRA-Based Road Mapping of the Para-Aortic Access Route before Mechanical Thrombectomy in Patients with Acute Ischemic Stroke","authors":"S. Kobayashi, T. Osanai, N. Fujima, A. Hamaguchi, T. Sugiyama, Toshitaka Nakamura, K. Hida, M. Fujimura","doi":"10.1159/000524112","DOIUrl":"https://doi.org/10.1159/000524112","url":null,"abstract":"Introduction: The aim of this study was to clarify whether magnetic resonance angiography (MRA)-based road mapping of the para-aortic transfemoral access route can reduce the procedural time of mechanical thrombectomy in patients with acute ischemic stroke. We further investigated the role of pre-procedural MRA-based road mapping in optimal initial catheter selection for rapid mechanical thrombectomy. Materials and Methods: We retrospectively reviewed 57 consecutive patients with acute ischemic stroke who underwent mechanical thrombectomy at our hospital between April 2018 and May 2021. Twenty-nine patients underwent MRA-based road mapping to visualize the para-aortic access route, whereas 28 patients only underwent routine head magnetic resonance imaging/angiography without MRA-based road mapping before neuro-interventional procedures. We then compared the basic procedural times required for mechanical thrombectomy, such as the time from femoral artery puncture to recanalization (“puncture to recanalization time”) and the time from the admission to recanalization (“door to recanalization time”), between the groups. Results: MRA-based road mapping significantly reduced the “puncture to recanalization time” (52.0 min vs. 70.0 min; p = 0.019) and the “door to recanalization time” (146 min vs. 183 min; p = 0.013). Conclusion: MRA-based road mapping of the para-aortic access route is useful to reduce the procedural time of mechanical thrombectomy in acute stroke patients, possibly by enabling optimal initial catheter selection during the procedure.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 1","pages":"47 - 52"},"PeriodicalIF":1.9,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43073440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improving Stroke Care in Bhutan 改善不丹的中风护理

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-03-04 DOI: 10.1159/000523903

Yangchen Yangchen, T. Tenzin, Narsingh Rai, S. Yangzom, N. Venketasubramanian

引用次数: 2

Prognostic Factors of the Lethality of Stroke at the Sourô Sanou University Teaching Hospital of Burkina Faso 布基纳法索SourôSanou大学教学医院卒中致死率的预后因素

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-03-02 DOI: 10.1159/000523888

H. Kpoda, L. Savadogo, D. R. S. Samadoulougou, I. Traoré, S. Somda, D. Lemogoum, I. Sombié, A. Millogo, M. Dramaix, P. Donnen

{"title":"Prognostic Factors of the Lethality of Stroke at the Sourô Sanou University Teaching Hospital of Burkina Faso","authors":"H. Kpoda, L. Savadogo, D. R. S. Samadoulougou, I. Traoré, S. Somda, D. Lemogoum, I. Sombié, A. Millogo, M. Dramaix, P. Donnen","doi":"10.1159/000523888","DOIUrl":"https://doi.org/10.1159/000523888","url":null,"abstract":"Introduction: Stroke is a major public health concern. It is a frequent pathology, 80% of which is of ischemic origin. Approximately 86% of all stroke deaths worldwide occur in low- and middle-income countries. The objective of this study was to investigate prognostic factors for in hospital lethality of stroke cases admitted in a public university hospital in Burkina Faso. Methods: This was a retrospective cohort study with a descriptive and analytical aim on adults admitted for a stroke confirmed by a brain scan at the Sourô Sanou University Teaching Hospital (CHUSS) of Bobo-Dioulasso over the period from January 1, 2009, to December 31, 2013. Results: The proportion of cases confirmed by the brain CT scan was 32% of all patients admitted for stroke in the CHUSS. The overall case fatality was 27.6%. This lethality was more pronounced in patients with hemorrhagic stroke (35.8%) compared to patients with ischemic stroke (22.4%). Median survival was higher in patients with ischemic stroke than those with hemorrhagic one (36 and 25 days, respectively) with a statistically significant difference (p value = 0.001). In multivariate analysis and hemorrhagic stroke (hazard ratio [HR]: 2.25; CI 95%: 1.41–3.61), an altered state of consciousness (HR: 1.90; CI 95%: 1.20–2.99) and the presence of central facial paralysis (HR: 1.67; CI 95%: 1.04–2.67) are factors that increased significantly the lethality. Conclusion: The study has identified three prognostic factors of lethality that are the hemorrhagic stroke type, the altered state of consciousness, and the central facial paralysis. Given the high case fatality, it is important to develop and implement effective prevention and management strategies adapted to the resources for the optimal control of stroke in Africa.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 1","pages":"36 - 46"},"PeriodicalIF":1.9,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44815574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subarachnoid and Intraventricular Hemorrhage in a Patient with a Pure Arterial Malformation and Two Associated Aneurysms in the Posterior Inferior Cerebellar Artery: A Case Report and Literature Review. 小脑后下动脉两处伴发动脉瘤的纯动脉畸形患者蛛网膜下腔和脑室内出血：病例报告和文献综述。

IF 2

Cerebrovascular Diseases Extra Pub Date : 2022-01-01 Epub Date: 2022-08-10 DOI: 10.1159/000525598

Katarzyna Wójtowicz, Łukasz Przepiórka, Przemysław Kunert, Andrzej Marchel

{"title":"Subarachnoid and Intraventricular Hemorrhage in a Patient with a Pure Arterial Malformation and Two Associated Aneurysms in the Posterior Inferior Cerebellar Artery: A Case Report and Literature Review.","authors":"Katarzyna Wójtowicz, Łukasz Przepiórka, Przemysław Kunert, Andrzej Marchel","doi":"10.1159/000525598","DOIUrl":"10.1159/000525598","url":null,"abstract":"Introduction: Pure arterial malformations (PAMs) are rare vascular abnormalities defined as dilated, tortuous arterial loops without any associated venous compartment. PAMs are thought to be benign developmental anomalies that can be safely managed conservatively.Methods: We present a case of life-threatening hemorrhage in a patient with a PAM associated with two aneurysms and review the literature describing hemorrhages associated with PAMs.Results: A 65-year-old female presented with subarachnoid and intraventricular hemorrhage. A digital subtraction angiography revealed a posterior inferior cerebellar artery PAM associated with two saccular aneurysms, which were subsequently microsurgically clipped. At the 1-year follow-up, the patient was neurologically intact. In our literature review, we identified 21 papers describing a total of 37 PAMs. Patients were predominantly female (64.9%) and their median age was 35 years. Almost half (48.6%) of PAMs were associated with aneurysms. In the group of PAMs that were not associated with an aneurysm, the intracranial hemorrhage rate was 15.8%, while in cases of coexisting PAM and aneurysm it was 44.4% (p = 0.0789).Conclusions: PAM natural history remains unknown, particularly in cases of coexistence with aneurysms. Patients so affected require careful observation. The description of PAMs as benign vascular malformations should be revised. Surgical management of hemorrhagic PAMs coexisting with aneurysms is possible and should be considered.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 3","pages":"117-122"},"PeriodicalIF":2.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/cb/cee-0012-0116.PMC9710451.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Stroke Care in a Primary Stroke Centre Using AI-Decision Support. 使用ai决策支持改善初级卒中中心的卒中护理。

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-01-01 DOI: 10.1159/000522423

Bence Gunda, Ain Neuhaus, Ildikó Sipos, Rita Stang, Péter Pál Böjti, Tímea Takács, Dániel Bereczki, Balázs Kis, István Szikora, George Harston

{"title":"Improved Stroke Care in a Primary Stroke Centre Using AI-Decision Support.","authors":"Bence Gunda, Ain Neuhaus, Ildikó Sipos, Rita Stang, Péter Pál Böjti, Tímea Takács, Dániel Bereczki, Balázs Kis, István Szikora, George Harston","doi":"10.1159/000522423","DOIUrl":"https://doi.org/10.1159/000522423","url":null,"abstract":"Background: Patient selection for reperfusion therapies requires significant expertise in neuroimaging. Increasingly, machine learning-based analysis is used for faster and standardized patient selection. However, there is little information on how such software influences real-world patient management.Aims: We evaluated changes in thrombolysis and thrombectomy delivery following implementation of automated analysis at a high volume primary stroke centre.Methods: We retrospectively collected data on consecutive stroke patients admitted to a large university stroke centre from two identical 7-month periods in 2017 and 2018 between which the e-Stroke Suite (Brainomix, Oxford, UK) was implemented to analyse non-contrast CT and CT angiography results. Delivery of stroke care was otherwise unchanged. Patients were transferred to a hub for thrombectomy. We collected the number of patients receiving intravenous thrombolysis and/or thrombectomy, the time to treatment; and outcome at 90 days for thrombectomy.Results: 399 patients from 2017 and 398 from 2018 were included in the study. From 2017 to 2018, thrombolysis rates increased from 11.5% to 18.1% with a similar trend for thrombectomy (2.8-4.8%). There was a trend towards shorter door-to-needle times (44-42 min) and CT-to-groin puncture times (174-145 min). There was a non-significant trend towards improved outcomes with thrombectomy. Qualitatively, physician feedback suggested that e-Stroke Suite increased decision-making confidence and improved patient flow.Conclusions: Use of artificial intelligence decision support in a hyperacute stroke pathway facilitates decision-making and can improve rate and time of reperfusion therapies in a hub-and-spoke system of care.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 1","pages":"28-32"},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/db/cee-0012-0028.PMC9082202.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Stroke Severity among Men and Women Acute Ischemic Stroke Patients in the Telestroke Network. 卒中网络中男性和女性急性缺血性卒中患者的卒中严重程度。

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-01-01 DOI: 10.1159/000525099

Nicolas Poupore, Camron Edrissi, Mareshah Sowah, Madison Stanley, Jonah Joffe, Donovan Lewis, Teanda Cunningham, Carolyn Breauna Sanders, Krista Knisely, Chase Rathfoot, Thomas I Nathaniel

{"title":"Stroke Severity among Men and Women Acute Ischemic Stroke Patients in the Telestroke Network.","authors":"Nicolas Poupore, Camron Edrissi, Mareshah Sowah, Madison Stanley, Jonah Joffe, Donovan Lewis, Teanda Cunningham, Carolyn Breauna Sanders, Krista Knisely, Chase Rathfoot, Thomas I Nathaniel","doi":"10.1159/000525099","DOIUrl":"https://doi.org/10.1159/000525099","url":null,"abstract":"Introduction: This study investigates gender differences among stroke patients treated in the telestroke network using specific risk factors that contribute to stroke severity.Methods: We examined gender differences in stroke severity among 454 patients hospitalized with acute ischemic stroke (AIS). The logistic regression model was used to predict clinical risk factors associated with stroke severity in men and women AIS patients.Results: In the adjusted analysis among women patients, increasing age (odds ratio [OR] = 1.05, 95% CI: 1.017-1.085, p = 0.003) and higher heart rate (OR = 1.031, 95% CI: 1.005-1.058, p = 0.021) were associated with worsening neurological functions, while direct admission (OR = 0.191, 95% CI: 0.079-0.465, p < 0.001) was associated with improving neurologic functions. Among men, hypertension (OR = 3.077, 95% CI: 1.060-8.931, p = 0.039) and higher international normalized ratio (INR) (OR = 21.959, 95% CI: 1.489-323.912, p = 0.024) were associated with worsening neurologic functions, while Caucasian (OR = 0.181, 95% CI: 0.062-0.526, p = 0.002) and obesity (OR = 0.449, 95% CI: 0.203-0.99, p = 0.047) were associated with neurologic improvement.Conclusion: Increasing age and heart rate in women, hypertension and greater INR in men contribute to worsening neurologic functions. There is a need to develop strategies to improve the care of both men and women in the telestroke network.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 2","pages":"93-101"},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/c0/cee-0012-0093.PMC9574206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Mild Stroke and High-Risk Transient Ischemic Attack in Current Clinical Practice. 当前临床实践中轻度脑卒中和高危短暂性脑缺血发作的结局。

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-01-01 DOI: 10.1159/000526969

Apiluk Wesanonthawech, Pornpatr A Dharmasaroja

{"title":"Outcomes of Mild Stroke and High-Risk Transient Ischemic Attack in Current Clinical Practice.","authors":"Apiluk Wesanonthawech, Pornpatr A Dharmasaroja","doi":"10.1159/000526969","DOIUrl":"https://doi.org/10.1159/000526969","url":null,"abstract":"Introduction: Early assessment and management of patients with mild stroke and transient ischemic attack (TIA) by specialists were recommended. This study aimed to evaluate the outcomes of these patients and identify the predictive factors of clinical progression, unfavorable outcomes, and recurrent stroke.Methods: Patients with mild ischemic stroke (NIHSS ≤5) and high-risk TIA were studied. All patients were managed by stroke specialists within 24 h of stroke onset. The outcomes of the patients at 3 months and final follow-up were studied. Predictive factors of clinical progression, unfavorable outcomes, and recurrent stroke were analyzed.Results: 254 patients were studied. Thirty-eight patients (15%) had clinical progression during admission. Large artery atherosclerosis (OR 2.49, 95% CI: 1.06-5.81), cardioembolism (OR 3.34, 95% CI: 1.26-8.87), and brainstem stroke (OR 2.78, 95% CI: 1.28-6.01) were associated with clinical progression. At the final follow-up, median 22 months, 81 patients (32%) had unfavorable outcomes. Previous disability (OR 1.81, 95% CI: 3.31-100), moderate to severe white matter lesions (OR 2.90, 95% CI: 1.44-5.84), clinical progression (OR 12.5, 95% CI: 5.08-31.25), and recurrent stroke (OR 8.47, 95% CI: 3.21-22.72) were related to unfavorable outcomes. Eleven patients (4%) had recurrent stroke within 3 months and 31 patients (12%) at the final follow-up. Older age (OR 6.68, 95% CI: 2.35-19.02), diabetes mellitus (OR 2.59, 95% CI: 1.07-6.27), and smoking (OR 4.26, 95% CI: 1.52-11.95) were related to recurrent stroke.Conclusion: Implementation of the up-to-date standard care in clinical practice would bring good clinical outcomes to the patients with mild stroke and high-risk TIA.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 3","pages":"109-116"},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/c0/cee-0012-0108.PMC9710422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10783251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Prealbumin Levels on Admission as a Prognostic Marker in Stroke Patients Treated with Mechanical Thrombectomy. 入院时血清白蛋白前水平作为机械取栓治疗的脑卒中患者的预后指标。

IF 1.9

Cerebrovascular Diseases Extra Pub Date : 2022-01-01 DOI: 10.1159/000526354

Begoña López, Maria Castañón-Apilánez, Javier Molina-Gil, Santiago Fernández-Gordón, Gemma González, Antía Reguera Acuña, Jose Maria Jimenez, Davinia Larrosa Campo, Montserrat González Delgado, Lorena Benavente-Fernández, Maria Rico-Santos, Carmen García-Cabo, Sergio Calleja Puerta, Elena López-Cancio

{"title":"Serum Prealbumin Levels on Admission as a Prognostic Marker in Stroke Patients Treated with Mechanical Thrombectomy.","authors":"Begoña López, Maria Castañón-Apilánez, Javier Molina-Gil, Santiago Fernández-Gordón, Gemma González, Antía Reguera Acuña, Jose Maria Jimenez, Davinia Larrosa Campo, Montserrat González Delgado, Lorena Benavente-Fernández, Maria Rico-Santos, Carmen García-Cabo, Sergio Calleja Puerta, Elena López-Cancio","doi":"10.1159/000526354","DOIUrl":"https://doi.org/10.1159/000526354","url":null,"abstract":"Introduction: Prealbumin is a marker of malnutrition and inflammation. It has been associated with poor prognosis in cardiovascular disease, but less is known in stroke patients. Our objective was to evaluate the association of prealbumin levels at admission with prognosis in patients with stroke treated with mechanical thrombectomy.Methods: Retrospective study of a prospective database of consecutive patients treated with mechanical thrombectomy. Clinical, radiological, and blood parameters including serum prealbumin, and prognostic variables such as respiratory infection, in-hospital mortality, and the modified Rankin scale at 3 months were collected.Results: We included 319 patients between 2018 and 2019. Prealbumin levels were significantly lower in patients older than 80 years, women, patients with a prestroke Rankin score >2, a glomerular filtrate rate <60 mL/min, and in those with atrial fibrillation. Regarding prognostic variables, prealbumin levels were not associated with respiratory infection. Low prealbumin levels were associated with poor functional prognosis (Rankin score >2), in-hospital mortality, and 3-month mortality. In multivariate analysis, prealbumin was an independent risk factor associated with mortality at 3 months, OR 0.92 [0.86-0.98], p = 0.019.Conclusion: Lower prealbumin levels at admission behaved as an independent predictor of long-term mortality in patients treated with mechanical thrombectomy. These results should be replicated in other cohorts.","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"12 3","pages":"103-108"},"PeriodicalIF":1.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/8a/cee-0012-0102.PMC9941761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10742879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1