Cerebrovascular Diseases Extra最新文献

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Ten Years of Cerebrovascular Diseases EXTRA 脑血管病十年特刊
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-03-26 DOI: 10.1159/000515830
{"title":"Ten Years of Cerebrovascular Diseases EXTRA","authors":"","doi":"10.1159/000515830","DOIUrl":"https://doi.org/10.1159/000515830","url":null,"abstract":"","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 1","pages":"44 - 44"},"PeriodicalIF":1.9,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44610641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-Vessel Occlusion Might Indicate Higher Possibility of Success in Reperfusion following Mechanical Thrombectomy in Acute Middle Cerebral Artery Occlusion. 急性大脑中动脉闭塞患者机械取栓后,短血管闭塞可能提示再灌注成功的可能性更高。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-11-12 DOI: 10.1159/000519556
Tomoyuki Yoshihara, Ryuzaburo Kanazawa, Takanori Uchida, Tetsuhiro Higashida, Hidenori Ohbuchi, Naoyuki Arai, Yuichi Takahashi
{"title":"Short-Vessel Occlusion Might Indicate Higher Possibility of Success in Reperfusion following Mechanical Thrombectomy in Acute Middle Cerebral Artery Occlusion.","authors":"Tomoyuki Yoshihara,&nbsp;Ryuzaburo Kanazawa,&nbsp;Takanori Uchida,&nbsp;Tetsuhiro Higashida,&nbsp;Hidenori Ohbuchi,&nbsp;Naoyuki Arai,&nbsp;Yuichi Takahashi","doi":"10.1159/000519556","DOIUrl":"https://doi.org/10.1159/000519556","url":null,"abstract":"<p><strong>Background: </strong>The impact of the length of the occluded vessel in acute large-vessel occlusion on successful reperfusion by mechanical thrombectomy remains unclear. This study evaluated whether diameter and length of the occluded vessel in acute middle cerebral artery (MCA) occlusion might relate to successful reperfusion following mechanical thrombectomy.</p><p><strong>Methods: </strong>This retrospective study included patients with acute MCA occlusion who underwent intra-aortic injection of contrast medium to obtain maximum intensity projection (MIP) images acquired by flat-panel detector computed tomography (FD-CT) equipped with an angiographic system. All patients received mechanical thrombectomy and were divided into two groups: those with successful reperfusion (Thrombolysis in Cerebral Infarction [TICI] 2b/3) and those without. We compared the diameter and length of the occluded vessel between the groups. In the sub-analysis of patients with stent retriever use, ratio of length of occluded vessel to length of the active zone was compared.</p><p><strong>Results: </strong>We enrolled 29 patients (median age: 73, M1 occlusion: 51%, stent retriever use: 72%). Eighteen patients achieved TICI 2b/3 with significantly larger distal end diameter (1.7 [interquartile range: 1.5-1.9] vs. 1.2 [1.2-1.5] mm, p = 0.007) and shorter length (7.1 [4.9-9.7] vs. 12.3 [7.2-15.8] mm, p = 0.043) of the occluded vessel. Sub-analysis of 21 patients showed that the cut-off value for TICI 2b/3 reperfusion was 0.32 as the ratio between the occluded vessel and stent retriever active zone (receiver operating characteristic area under the curve: 0.90).</p><p><strong>Conclusion: </strong>In acute MCA occlusion, larger diameter of the distal end and shorter length of the occluded vessel on FD-CT MIP images might indicate a higher possibility of achieving TICI 2b/3 following mechanical thrombectomy.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 3","pages":"131-136"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/b2/cee-0011-0131.PMC8647116.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39710195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Burden of Stroke in Myanmar. 缅甸的中风负担。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-05-10 DOI: 10.1159/000515123
Narayanaswamy Venketasubramanian, Yee Mon Khine, Ohnmar Ohnmar, Myat Po Po Kyaw Khin, Min Thit Win
{"title":"Burden of Stroke in Myanmar.","authors":"Narayanaswamy Venketasubramanian,&nbsp;Yee Mon Khine,&nbsp;Ohnmar Ohnmar,&nbsp;Myat Po Po Kyaw Khin,&nbsp;Min Thit Win","doi":"10.1159/000515123","DOIUrl":"https://doi.org/10.1159/000515123","url":null,"abstract":"<p><p>Myanmar is home to over 51 million people. The age- and sex-standardized mortality rate due to stroke is 165.4/100,000, while the rate of age- and sex-standardized disability-adjusted life years lost due to stroke is 2971.3/100,000. The prevalence of stroke among adults aged 40-99 years is 1.5%. Stroke is the leading cause of morbidity and mortality and comprises 20% of the neurological workload. There are only 10 stroke units in the whole country. Doctors are aware of the importance of hypertension in stroke prevention and the need for physiotherapy after stroke, but, until recently and in rural areas, they also tend to use steroids and neuroprotectants, and lower blood pressure aggressively acutely after stroke; antiplatelets are not widely used. Thrombolysis service is available at some tertiary centers but mechanical thrombectomy is not yet available.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 2","pages":"49-51"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38968448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Benefit of Endovascular Thrombectomy for Stroke on Functional Outcome Is Sustained at 12 Months. 血管内血栓切除术对脑卒中患者功能预后的益处持续了12个月。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-08-06 DOI: 10.1159/000517929
Balaki Parameshwaran, Dennis Cordato, Mark Parsons, Andrew Cheung, Nathan Manning, Jason Wenderoth, Cecilia Cappelen-Smith
{"title":"The Benefit of Endovascular Thrombectomy for Stroke on Functional Outcome Is Sustained at 12 Months.","authors":"Balaki Parameshwaran,&nbsp;Dennis Cordato,&nbsp;Mark Parsons,&nbsp;Andrew Cheung,&nbsp;Nathan Manning,&nbsp;Jason Wenderoth,&nbsp;Cecilia Cappelen-Smith","doi":"10.1159/000517929","DOIUrl":"https://doi.org/10.1159/000517929","url":null,"abstract":"<p><strong>Background and purpose: </strong>The short-term benefits of endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) have been widely documented, yet there is limited evidence to show that this is sustained in the long term. We aimed to determine whether the benefit of EVT on functional outcome at 3 months is maintained at 12 months and the factors correlating with functional independence and quality of life.</p><p><strong>Methods: </strong>Data for analysis came from a prospective registry of consecutive patients undergoing EVT at a single Comprehensive Stroke Center (Oct 2018-Sep 2019). A phone interview was conducted for 12-month patient outcomes. Functional outcome was assessed by the modified Rankin Scale (mRS). Quality of life was determined by return to usual place of residence, work, or driving and calculation of a health utility index using the European Quality of Life-5 Dimensions questionnaire (EQ-5D-3L).</p><p><strong>Results: </strong>Of the 151 patients who underwent EVT during the study period, 12-month follow-up was available for 145 (96%). At 12 months, 44% (n = 64) of patients were functionally independent (mRS 0-2) compared to 48% at 3 months. Mortality at 12 months was 26% compared to 17% at 3 months. Significant predictors of functional independence at 12 months were younger age and lower baseline National Institutes of Health Stroke Scale. Better quality of life significantly correlated with return to usual place of residence and driving.</p><p><strong>Conclusion: </strong>Three-month functional independence was sustained at 12 months, indicating that EVT remains beneficial for patients with AIS in the longer term.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 2","pages":"81-86"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/26/cee-0011-0081.PMC8460944.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39377298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stroke Burden and Services in the Philippines. 菲律宾的中风负担与服务。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-05-11 DOI: 10.1159/000516238
Jose C Navarro, Narayanaswamy Venketasubramanian
{"title":"Stroke Burden and Services in the Philippines.","authors":"Jose C Navarro, Narayanaswamy Venketasubramanian","doi":"10.1159/000516238","DOIUrl":"10.1159/000516238","url":null,"abstract":"","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 2","pages":"52-54"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/3e/cee-0011-0052.PMC8216023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38901346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis. 利用超声和炎症改善缺血性脑卒中的预测:动脉粥样硬化多民族研究的二次分析。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 DOI: 10.1159/000514373
Hediyeh Baradaran, Alen Delic, Ka-Ho Wong, Nazanin Sheibani, Matthew Alexander, J Scott McNally, Jennifer J Majersik, Adam De Havenon
{"title":"Using Ultrasound and Inflammation to Improve Prediction of Ischemic Stroke: A Secondary Analysis of the Multi-Ethnic Study of Atherosclerosis.","authors":"Hediyeh Baradaran,&nbsp;Alen Delic,&nbsp;Ka-Ho Wong,&nbsp;Nazanin Sheibani,&nbsp;Matthew Alexander,&nbsp;J Scott McNally,&nbsp;Jennifer J Majersik,&nbsp;Adam De Havenon","doi":"10.1159/000514373","DOIUrl":"https://doi.org/10.1159/000514373","url":null,"abstract":"<p><strong>Introduction: </strong>Current ischemic stroke risk prediction is primarily based on clinical factors, rather than imaging or laboratory markers. We examined the relationship between baseline ultrasound and inflammation measurements and subsequent primary ischemic stroke risk.</p><p><strong>Methods: </strong>In this secondary analysis of the Multi-Ethnic Study of Atherosclerosis (MESA), the primary outcome is the incident ischemic stroke during follow-up. The predictor variables are 9 carotid ultrasound-derived measurements and 6 serum inflammation measurements from the baseline study visit. We fit Cox regression models to the outcome of ischemic stroke. The baseline model included patient age, hypertension, diabetes, total cholesterol, smoking, and systolic blood pressure. Goodness-of-fit statistics were assessed to compare the baseline model to a model with ultrasound and inflammation predictor variables that remained significant when added to the baseline model.</p><p><strong>Results: </strong>We included 5,918 participants. The primary outcome of ischemic stroke was seen in 105 patients with a mean follow-up time of 7.7 years. In the Cox models, we found that carotid distensibility (CD), carotid stenosis (CS), and serum interleukin-6 (IL-6) were associated with incident stroke. Adding tertiles of CD, IL-6, and categories of CS to a baseline model that included traditional clinical vascular risk factors resulted in a better model fit than traditional risk factors alone as indicated by goodness-of-fit statistics.</p><p><strong>Conclusions: </strong>In a multiethnic cohort of patients without cerebrovascular disease at baseline, we found that CD, CS, and IL-6 helped predict the occurrence of primary ischemic stroke. Future research could evaluate if these basic ultrasound and serum measurements have implications for primary prevention efforts or clinical trial inclusion criteria.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 1","pages":"37-43"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000514373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10295451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Modeling the Impact of Prehospital Triage on a True-Life Drip and Ship Mechanical Thrombectomy Urban Patient Cohort. 模拟院前分诊对真实生活点滴和船舶机械取栓的城市患者队列的影响。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-11-25 DOI: 10.1159/000520078
Stavros Matsoukas, Brian Giovanni, Liorah Rubinstein, Shahram Majidi, Laura K Stein, Johanna T Fifi
{"title":"Modeling the Impact of Prehospital Triage on a True-Life Drip and Ship Mechanical Thrombectomy Urban Patient Cohort.","authors":"Stavros Matsoukas,&nbsp;Brian Giovanni,&nbsp;Liorah Rubinstein,&nbsp;Shahram Majidi,&nbsp;Laura K Stein,&nbsp;Johanna T Fifi","doi":"10.1159/000520078","DOIUrl":"https://doi.org/10.1159/000520078","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to model the effect of prehospital triage of emergent large vessel occlusion (ELVO) to endovascular capable center (ECC) on the timing of thrombectomy and intravenous (IV) thrombolysis using real-world data from a multihospital system.</p><p><strong>Methods: </strong>We selected a cohort of 77 consecutive stroke patients who were brought by emergency medical services (EMS) to a nonendovascular capable center and then transferred to an ECC for mechanical thrombectomy (MT) (\"actual\" drip and ship [DS] cohort). We created a hypothetical scenario (bypass model [BM]), modeling transfer of the patients directly to an ECC, based on patients' initial EMS pickup address and closest ECC. Using another cohort of 73 consecutive patients, who were brought directly to an ECC by EMS and underwent endovascular intervention, we calculated mean door-to-needle and door-to-arterial puncture (AP) times (\"actual\" mothership [MS] cohort). Timings in the actual MS cohort and the actual DS cohort were compared to timings from the BM cohort.</p><p><strong>Results: </strong>Median first medical contact (FMC) to IV thrombolysis time was 87.5 min (interquartile range [IQR] = 38) for the DS versus 78.5 min (IQR = 8.96) for the BM cohort, with p = 0.1672. Median FMC to AP was 244 min (IQR = 97) versus 147 min (IQR = 8.96) (p < 0.001), and median FMC to TICI 2B+ time was 299 min (IQR = 108.5) versus 197 min (IQR = 8.96) (p < 0.001) for the DS versus BM cohort, respectively.</p><p><strong>Conclusions: </strong>Modeled EMS prehospital triage of ELVO patients' results in shorter MT times without a change in thrombolysis times. As triage tools increase in sensitivity and specificity, EMS triage protocols stand to improve patient outcomes.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 3","pages":"137-144"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/73/30/cee-0011-0137.PMC8740215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39771116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke Burden and Stroke Services in Bangladesh. 孟加拉国的中风负担和中风服务。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-07-09 DOI: 10.1159/000517234
Narayanaswamy Venketasubramanian, Muzharul Mannan
{"title":"Stroke Burden and Stroke Services in Bangladesh.","authors":"Narayanaswamy Venketasubramanian,&nbsp;Muzharul Mannan","doi":"10.1159/000517234","DOIUrl":"https://doi.org/10.1159/000517234","url":null,"abstract":"Bangladesh, with a population of 165.6 million people, is located in the northwest region of South Asia, bordered on the west, north, and east by India, southeast by Myanmar, and south by the Bay of Bengal [1]. The per-capita income is USD 1,909, poverty rate is 20.5%, literacy (7+ years) is 73.2%, and life expectancy is 72.3 years; 74% live in rural areas. Stroke is a major cause of death and disability in the region, with an ageand sex-standardized mortality rate of 54.8 per 100,000 and disability-adjusted life years lost of 888.1 per 100,000 in Bangladesh [2]. The prevalence of stroke at approximately 1–2% of those aged over 20 years [3] is similar in males and females, and urban and rural areas [4], but increases with age such that the ratio of infarction to hemorrhage is 2.91 in the community [5]. Stroke incidence has not been studied in adequate epidemiological studies. In a large multicenter hospital study, 72% had ischemic stroke, and the frequency of hypertension, smoking, diabetes mellitus, ischemic heart disease, and dyslipidemia was 58%, 45%, 23%, 17%, and 5%, respectively [6]; these are not from population-based studies. Small-vessel “lacunar” disease was the most common type of ischemic stroke, and there is a clear seasonal variation in the frequency of hemorrhagic stroke [7, 8]. The high stroke mortality among Bangladeshi populations may be due to the high frequency of the conventional atherosclerotic risk factors, especially of hypertension and diabetes mellitus [9]; there is a strong belief over the importance of betel nut chewing, squatting and straining during defecation, chronic infection, vitamin D deficiency, and the combined effect of smoking and tobacco chewing [10]. Stroke mortality might be related to stroke severity, delayed diagnosis, and stroke care gaps discussed further below. Medical services are free in the community [11]. Community clinics are available at villages at ward levels, while small hospital services are located at the union and upazila levels. Secondary level care is provided at district hospitals; tertiary level care is provided at medical college hospitals and super-specialty hospitals. There are 2,213 hospitals with 45,723 registered physicians, but only 160 trained neurologists through training programs only provided at Dhaka Medical College (DMC) and Bangabandhu Sheikh Mujib Medical University (BSMMU). There are 2,300 technologists operating 250 CT scans and 80 MRIs in Bangladesh. Acute care for stroke patients is available in 2 government and 5 private hospitals, all situated in Dhaka, the capital city, while subacute care provided by neurologists is available in 23 government hospitals located in most parts of the country and 7 private hospitals. Stroke is the most common condition among neurology in-patients (48%) [12] and out-patients (24%) [13]. The Bangladesh Rehabilitation Assistance Committee (BRAC), a nongovernmental organization (NGO), provides stroke rehabilitation services to patients ","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 2","pages":"69-71"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000517234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39173802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Long-Term Cognitive Changes after Revascularization Surgery in Adult Patients with Ischemic Moyamoya Disease. 成年缺血性烟雾病患者血运重建术后的长期认知变化。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-11-22 DOI: 10.1159/000521028
Shun Uchida, Yoshitaka Kubo, Daisuke Oomori, Masahiro Yabuki, Kei Kitakami, Shunrou Fujiwara, Kenji Yoshida, Masakazu Kobayashi, Kazunori Terasaki, Kuniaki Ogasawara
{"title":"Long-Term Cognitive Changes after Revascularization Surgery in Adult Patients with Ischemic Moyamoya Disease.","authors":"Shun Uchida,&nbsp;Yoshitaka Kubo,&nbsp;Daisuke Oomori,&nbsp;Masahiro Yabuki,&nbsp;Kei Kitakami,&nbsp;Shunrou Fujiwara,&nbsp;Kenji Yoshida,&nbsp;Masakazu Kobayashi,&nbsp;Kazunori Terasaki,&nbsp;Kuniaki Ogasawara","doi":"10.1159/000521028","DOIUrl":"https://doi.org/10.1159/000521028","url":null,"abstract":"<p><strong>Introduction: </strong>Revascularization surgery for adult moyamoya disease (MMD) with ischemic presentation changes cognitive function and prevents further cerebral ischemic events. Most studies however repeated neuropsychological evaluation within 1 year after surgery. Our previous prospective cohort study of adult patients with MMD with misery perfusion who underwent direct revascularization surgery showed cognitive improvement and decline in 31% and 44%, respectively, of the patients 2 months after surgery. The present prospective study aimed to elucidate the 5-year cognitive changes after direct revascularization surgery in adult patients with cerebral misery perfusion due to ischemic MMD by following the same patients.</p><p><strong>Methods: </strong>In total, 31 patients were prospectively followed up for 5 years after direct revascularization surgery. Five types of neuropsychological tests were performed preoperatively, 2 months after surgery, and at the end of the 5-year follow-up. Cerebral blood flow (CBF) in the symptomatic cerebral hemisphere relative to that in the ipsilateral cerebellar hemisphere (hemispheric relative CBF [RCBF]) was measured using brain perfusion single-photon emission computed tomography preoperatively and at the end of the 5-year follow-up.</p><p><strong>Results: </strong>Based on results of pre- and postoperative neuropsychological tests, 11, 10, and 10 patients showed cognitive improvement, no change in cognitive function, and cognitive decline, respectively, at the end of the 5-year follow-up. These ratios were not significantly different compared with those 2 months after surgery (cognitive improvement, no change in cognitive function, and cognitive decline in 10, 8, and 13 patients, respectively). Although hemispheric RCBF was significantly greater at the end of the 5-year follow-up than before surgery in patients with cognitive improvement (80.7 ± 6.1% vs. 92.9 ± 5.5%; p = 0.0033) and in those showing no change in cognitive function (85.6 ± 3.5 vs. 91.5 ± 5.2%; p = 0.0093), this value was significantly lower at the end of the 5-year follow-up than before surgery in patients with cognitive decline (83.8 ± 3.7 vs. 81.0 ± 5.8%; p = 0.0367).</p><p><strong>Conclusion: </strong>One-third of adult patients with cerebral misery perfusion due to ischemic MMD who underwent direct revascularization surgery exhibited cognitive improvement, and one-third exhibited decline at the end of the 5-year follow-up. The former and latter patients had increased and decreased CBF, respectively, in the affected cerebral hemisphere at the end of the 5-year follow-up compared with preoperative brain perfusion.</p>","PeriodicalId":45709,"journal":{"name":"Cerebrovascular Diseases Extra","volume":"11 3","pages":"145-154"},"PeriodicalIF":1.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/21/cee-0011-0145.PMC8787508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39758898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Accession Site Does Not Influence the Risk of Stroke after Diagnostic Coronary Angiography or Intervention: Results from a Large Prospective Registry. 加入地点不影响诊断性冠状动脉造影或干预后卒中的风险:来自大型前瞻性登记的结果。
IF 1.9
Cerebrovascular Diseases Extra Pub Date : 2021-01-01 Epub Date: 2021-10-28 DOI: 10.1159/000519539
Jan Matějka, Ivo Varvařovský, Jan Tužil, Tomáš Doležal, Martin Bobak, Jan Pospíchal, Petr Geier, Jiří Vondrák, Karel Bláha, Jan Málek, Alena Staňková, Juraj Bujdák, Vladimír Rozsíval, Vojtěch Novotný, Tomáš Lazarák, Milan Plíva, Jan Večeřa, Petr Vojtíšek
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引用次数: 4
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