Current Clinical Microbiology Reports最新文献_第7页

The Interplay Between Neutral and Adaptive Processes Shapes Genetic Variation During Candida Species Evolution 中性和适应性过程之间的相互作用形成了念珠菌物种进化过程中的遗传变异

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-06-23 DOI: 10.1007/s40588-021-00171-x

Iuliana V. Ene, Meleah A. Hickman, A. Gerstein

引用次数: 2

Hemozoin: a Complex Molecule with Complex Activities. 血色素:具有复杂活性的复杂分子。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-06-01 Epub Date: 2021-04-11 DOI: 10.1007/s40588-021-00166-8

Trisha Dalapati, Julie M Moore

{"title":"Hemozoin: a Complex Molecule with Complex Activities.","authors":"Trisha Dalapati, Julie M Moore","doi":"10.1007/s40588-021-00166-8","DOIUrl":"https://doi.org/10.1007/s40588-021-00166-8","url":null,"abstract":"Purpose of review: Malaria is a disease caused by parasites that reside in host red blood cells and use hemoglobin as a nutrient source. Heme released by hemoglobin catabolism is modified by the parasite to produce hemozoin (HZ), which has toxic effects on the host. Experimentation aiming to elucidate how HZ contributes to malaria pathogenesis has utilized different preparations of this molecule, complicating interpretation and comparison of findings. We examine natural synthesis and isolation of HZ and highlight studies that have used multiple preparations, including synthetic forms, in a comparative fashion.Recent findings: Recent work utilizing sophisticated imaging and detection techniques reveals important molecular characteristics of HZ synthesis and biochemistry. Other recent studies further refine understanding of contributions of HZ to malaria pathogenesis yet highlight the continuing need to characterize HZ preparations and contextualize experimental conditions in the in vivo infection milieu.Summary: This review highlights the necessity of collectively determining what is physiologically relevant HZ. Characterization of isolated natural HZ and use of multiple preparations in each study are recommended with application of in vivo studies whenever possible. Adoption of such practices is expected to improve reproducibility of results and elucidate the myriad of ways that HZ participates in malaria pathogenesis.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-021-00166-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A One Health Perspective on a Multi-hurdle Approach to Combat Campylobacter spp. in Broiler Meat 肉鸡肉中弯曲杆菌多障碍防治的一个健康视角

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-04-08 DOI: 10.1007/s40588-021-00167-7

S. Kittler, G. Shakeri, E. Peh, M. Plötz

引用次数: 5

Alternative Curing Methods 替代养护方法

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-03-13 DOI: 10.1007/s40588-021-00164-w

Lisa Siekmann, M. Plötz, C. Krischek

引用次数: 10

Physical Methods for the Decontamination of Meat Surfaces 肉类表面去污的物理方法

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-23 DOI: 10.1007/s40588-021-00156-w

T. Albert, P. Braun, Jasem Saffaf, C. Wiacek

引用次数: 12

Assessment of the Effectiveness of Pre-harvest Meat Safety Interventions to Control Foodborne Pathogens in Broilers: a Systematic Review 采前肉类安全干预措施控制肉鸡食源性病原体的有效性评估：系统综述

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-14 DOI: 10.1007/s40588-021-00161-z

Joana Pessoa, Maria Rodrigues da Costa, T. Nesbakken, D. Meemken

引用次数: 7

Wild Game Meat—a Microbiological Safety and Hygiene Challenge? 野生野味——微生物安全和卫生挑战?

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-07 DOI: 10.1007/s40588-021-00158-8

E. Gomes-Neves, A. Abrantes, M. Vieira-Pinto, Alexandra Müller

引用次数: 21

Developmental Status of the Potential Vaccines for the Mitigation of the COVID-19 Pandemic and a Focus on the Effectiveness of the Pfizer-BioNTech and Moderna mRNA Vaccines. 缓解COVID-19大流行的潜在疫苗的发展现状及对辉瑞- biontech和Moderna mRNA疫苗有效性的关注

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-01-01 Epub Date: 2021-03-03 DOI: 10.1007/s40588-021-00162-y

Rashed Noor

{"title":"Developmental Status of the Potential Vaccines for the Mitigation of the COVID-19 Pandemic and a Focus on the Effectiveness of the Pfizer-BioNTech and Moderna mRNA Vaccines.","authors":"Rashed Noor","doi":"10.1007/s40588-021-00162-y","DOIUrl":"https://doi.org/10.1007/s40588-021-00162-y","url":null,"abstract":"Purpose of review: Along with the continued in silico-based studies for drug designing and repurposing followed by the corresponding cell culture studies, the ongoing clinical trials with some completed regarding finding the drug efficacy and the vaccine development against the severe acute respiratory coronavirus 2 (SARS-CoV-2) have been the most functional and indispensable issue during the current COVID-19 pandemic within 2020 and onward. The present review attempted to figure out the update on this effective vaccine and discussed the other promising vaccines.Recent findings: A range of investigations on the SARS-CoV-2 genomics, on its similarities with SARS-CoV-1, and with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been accomplished and the host immune dodging mechanisms by the SARS-CoV-2 have been unraveled which in turn led the scientists around the world to work rigorously on the vaccine development. Working with various vaccine platforms so far revealed the efficacy of the mRNA-1273 vaccine as the most effective one as resulted through the clinical trials which resulted in 95% positive output.Summary: Although currently commercialized mRNA-1273 vaccine appears to be effective, still several points are to be pondered regarding the sustainability of vaccine efficacy against the rising variants of SARS-CoV-2.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-021-00162-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25450104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

A Review on the Effectivity of the Current COVID-19 Drugs and Vaccines: Are They Really Working Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants? 当前COVID-19药物和疫苗的有效性综述:它们真的对严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)变体有效吗?

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-01-01 Epub Date: 2021-07-03 DOI: 10.1007/s40588-021-00172-w

Rashed Noor

{"title":"A Review on the Effectivity of the Current COVID-19 Drugs and Vaccines: Are They Really Working Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants?","authors":"Rashed Noor","doi":"10.1007/s40588-021-00172-w","DOIUrl":"https://doi.org/10.1007/s40588-021-00172-w","url":null,"abstract":"Purpose of review: In order to eradicate the COVID-19 pandemic, scientists around the world have been working very hard for a year or more with the motto of designing effective drugs and vaccines against the severe acute respiratory coronavirus 2 (SARS-CoV-2). Along with the positive results with the antiviral drugs and a few commercialized vaccines, the unresponsiveness as well as some side effects of such therapies have also been noticed, possibly due to the emergence of the SARS-CoV-2 variants. Therefore, current review summarized the actual effectiveness of the antivirals and vaccines which are in current use for the treatment of the COVID-19 patients.Recent findings: So far, some drugs have been found with hopeful results among which remdesivir and arbidol are with momentous clinical progress. Besides drug designing, vaccine development has been a major effort whereby the mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) vaccines showed the required efficacy and have been approved by the US Food and Drug Administration (USFDA).Summary: While a number of existing/repurposed/repositioned or new drugs and the currently used commercial vaccines against SARS-CoV-2 apparently seem to be effective against COVID-19 mitigation, the new variants of the virus as well as the recently increased cases raised the doubt about the usefulness of these agents. Current review figured out the efficacy of different drugs and vaccines in terms of their action potential against SARS-CoV-2 and further recommended some useful measures which may be useful for future remedies.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-021-00172-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39174652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

COVID-19: Diagnostics, Therapeutic Advances, and Vaccine Development. COVID-19：诊断、治疗进展和疫苗开发。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2021-01-01 Epub Date: 2021-02-15 DOI: 10.1007/s40588-021-00157-9

Sabhiya Majid, Mosin S Khan, Samia Rashid, Ayesha Niyaz, Rabia Farooq, Showkat A Bhat, Hilal A Wani, Waseem Qureshi

{"title":"COVID-19: Diagnostics, Therapeutic Advances, and Vaccine Development.","authors":"Sabhiya Majid, Mosin S Khan, Samia Rashid, Ayesha Niyaz, Rabia Farooq, Showkat A Bhat, Hilal A Wani, Waseem Qureshi","doi":"10.1007/s40588-021-00157-9","DOIUrl":"10.1007/s40588-021-00157-9","url":null,"abstract":"Purpose of review: Human race is currently facing the wrath of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly transmittable and pathogenic RNA virus, causing coronavirus disease 2019 (COVID-19), the worst ever global pandemic. Coronaviruses (CoVs) have emerged as a major public health concern. Urgent global response to COVID-19 outbreak has been to limit spread of SARS-CoV-2 via extensive monitoring and containment. Various treatment regimens have been adopted to manage COVID-19, with known drugs and drug combinations used to decrease the morbidity and mortality associated with COVID-19. Intensive research on various fronts including studying molecular and structural aspects of these viruses and unraveling the pathophysiology and mechanistic basis of COVID-19 aimed at developing effective prophylactic, therapeutic agents and vaccines has been carried out globally.Recent findings: No approved antiviral treatment except remdesivir exists for SARS-CoV-2 till date though novel drug targets have been identified. However, worldwide frantic and competitive vaccine development pharmaceutical race has borne fruit in the form of a number of promising candidate vaccines, out of which few have already received emergency use authorization by regulatory bodies in record time.Summary: This review highlights the painstaking efforts of healthcare workers and scientific community to successfully address the COVID-19 pandemic-though damage in the form of severe illness, loss of lives, and livelihood has left a serious mark. Focusing on extensive research on various therapeutic options and antiviral strategies including neutralizing antibodies, potential drugs, and drug targets, light has been shed on various diagnostic options and the amazing vaccine development process as well.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25391412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0