Current Clinical Microbiology Reports最新文献_第7页

Fungal Infections Associated With the Use of Novel Immunotherapeutic Agents. 真菌感染与新型免疫治疗剂的使用有关。

IF 2.7

Current Clinical Microbiology Reports Pub Date : 2020-12-01 Epub Date: 2020-09-26 DOI: 10.1007/s40588-020-00154-4

Marilia Bernardes, Tobias M Hohl

{"title":"Fungal Infections Associated With the Use of Novel Immunotherapeutic Agents.","authors":"Marilia Bernardes, Tobias M Hohl","doi":"10.1007/s40588-020-00154-4","DOIUrl":"10.1007/s40588-020-00154-4","url":null,"abstract":"Purpose of the review: Recent concerns have emerged regarding the potential of immunotherapy to cause infection. In this review, we summarize the current literature on invasive fungal infections that occur during treatment with immune checkpoint inhibitors and chimeric antigen receptor T cell therapy.Recent findings: Fungal infections are uncommon with the use of checkpoint inhibitors. Most cases are caused by invasive aspergillosis and pneumocystis pneumonia and occur in patients requiring high dose corticosteroids for the management of immune-related adverse events. Conversely, fungal infections are commonly reported during therapy with CAR T cells. Most cases are caused by invasive aspergillosis and candidiasis and are likely the result of prolonged neutropenia following the conditioning regimen or immunosuppressant use for the management of cytokine release syndrome and neurotoxicity.Summary: Treatment-related toxicities that require prolonged immunosuppressive agents appear to play a key role in the development of fungal infections during immunotherapy. Ongoing surveillance is needed to fully address the risks of fungal infections with these novel agents.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"7 4","pages":"142-149"},"PeriodicalIF":2.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320460/pdf/nihms-1670800.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39266303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Non-coding RNAs in Fungal Pathogenesis and Antifungal Drug Responses 非编码RNA在真菌发病机制和抗真菌药物反应中的作用

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-10-02 DOI: 10.1007/s40588-020-00151-7

S. Dhingra

引用次数: 5

Candida auris infection and biofilm formation: going beyond the surface. 耳念珠菌感染与生物膜形成：超越表面。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2020-09-01 Epub Date: 2020-07-17 DOI: 10.1007/s40588-020-00143-7

Mark V Horton, Jeniel E Nett

引用次数: 0

Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies. 鸟分枝杆菌:一种遗传性免疫缺陷犬种的新兴病原体。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-09-01 Epub Date: 2020-08-18 DOI: 10.1007/s40588-020-00145-5

Giovanni Ghielmetti, Urs Giger

{"title":"Mycobacterium avium: an Emerging Pathogen for Dog Breeds with Hereditary Immunodeficiencies.","authors":"Giovanni Ghielmetti, Urs Giger","doi":"10.1007/s40588-020-00145-5","DOIUrl":"https://doi.org/10.1007/s40588-020-00145-5","url":null,"abstract":"Purpose of review: Among the nontuberculous mycobacteria (NTM), Mycobacterium avium complex (MAC) is the leading cause of pulmonary disease in humans. Innate and acquired immunodeficiencies have been associated with an increased host susceptibility to NTM infections. The underlying mechanisms predisposing humans and dogs to MAC infections is being elucidated.Recent findings: Although MAC infection is infrequently diagnosed in dogs, a strong breed predisposition particularly for Miniature Schnauzer and Basset Hound dogs is evident. A recessively inherited defect of the adaptor protein CARD9 has recently been documented to be responsible for the increased susceptibility to MAC in the Miniature Schnauzer breed.Summary: Given the zoonotic potential of a MAC infected dog particularly to immunocompromised human patients, diseased dogs pose a public health risk. While not a reportable disease, treatment of systemic mycobacteriosis is generally not effective and discouraged in dogs. The collaborative efforts by microbiologists, veterinary clinicians, dog breeders, primary care physicians, and infectious disease specialists applying the One Health approach is therefore crucial for the best management and prevention of MAC infection.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"7 3","pages":"67-80"},"PeriodicalIF":5.2,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-020-00145-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25591205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Persistence in Livestock Mycoplasmas—a Key Role in Infection and Pathogenesis 家畜支原体的持久性:感染和发病的关键作用

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-07-24 DOI: 10.1007/s40588-020-00149-1

K. Hoelzle, Julia Ade, L. Hoelzle

引用次数: 11

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation. 皮卡病毒细胞重塑：加倍努力应对病毒引发的炎症

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2020-06-01 Epub Date: 2020-04-17 DOI: 10.1007/s40588-020-00138-4

Alexis Bouin, Bert L Semler

引用次数: 0

Biology and function of exo-polysaccharides from human fungal pathogens. 人真菌病原菌外多糖的生物学和功能。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-03-01 Epub Date: 2020-01-17 DOI: 10.1007/s40588-020-00137-5

Krystal Y Chung, Jessica C S Brown

引用次数: 3

Correction to: Herpesvirus DNA Polymerase Mutants—How Important Is Faithful Genome Replication? 更正：疱疹病毒DNA聚合酶突变体——忠实的基因组复制有多重要？

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-01-27 DOI: 10.1007/s40588-019-00136-1

J. Trimpert, N. Osterrieder

引用次数: 0

Reactive Arthritis: Update. 反应性关节炎:更新。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2020-01-01 Epub Date: 2020-09-26 DOI: 10.1007/s40588-020-00152-6

Ibtissam Bentaleb, Kawther Ben Abdelghani, Samira Rostom, Bouchra Amine, Ahmed Laatar, Rachid Bahiri

{"title":"Reactive Arthritis: Update.","authors":"Ibtissam Bentaleb, Kawther Ben Abdelghani, Samira Rostom, Bouchra Amine, Ahmed Laatar, Rachid Bahiri","doi":"10.1007/s40588-020-00152-6","DOIUrl":"https://doi.org/10.1007/s40588-020-00152-6","url":null,"abstract":"Purpose of review: The aim of this paper is to provide an overview about reactive arthritis, with an update regarding pathophysiology and therapeutic approach of the disease, outlining the clinical features and diagnostic approach, based on recent literature review.Recent findings: Reactive arthritis is considered to be part of the spectrum of the spondyloarthritis. Its epidemiology is changing worldwide due to several reasons, among them are as follows: different diagnosis approach and clinical presentations, different grades of infection, microbiome changes, etc. The understanding of pathophysiological models is challenging, but recent studies contribute to elucidate the major factors involved in the development of the disease. The management of ReA depends on the triggering agent and the phase of disease, whether it is acute or chronic.Summary: The association between the microbiome changes and spondyloarthropathies (ReA) is becoming increasingly evident. The results regarding the biologic treatment on refectory ReA are promising.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"7 4","pages":"124-132"},"PeriodicalIF":5.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-020-00152-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38453057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival. 剥夺病毒的铁元素供应是一种很有前景的病毒生存辅助疗法

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2020-01-01 Epub Date: 2020-04-20 DOI: 10.1007/s40588-020-00140-w

Wei Liu, Shuping Zhang, Sergei Nekhai, Sijin Liu

{"title":"Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival.","authors":"Wei Liu, Shuping Zhang, Sergei Nekhai, Sijin Liu","doi":"10.1007/s40588-020-00140-w","DOIUrl":"10.1007/s40588-020-00140-w","url":null,"abstract":"Purpose of the review: The ongoing outbreak of novel coronavirus pneumonia (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread concerns. Thus, therapeutic options are urgently needed, and will be discussed in this review.Recent findings: Iron-containing enzymes are required for viruses most likely including coronaviruses (CoVs) to complete their replication process. Moreover, poor prognosis occurred in the conditions of iron overload for patients upon infections of viruses. Thus, limiting iron represents a promising adjuvant strategy in treating viral infection through oral uptake or venous injection of iron chelators, or through the manipulation of the key iron regulators. For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome (AIDS) patients. Increasing intracellular iron efflux via increasing iron exporter ferroportin expression also exhibits antiviral effect on human immunodeficiency virus (HIV). The implications of other metals besides iron are also briefly discussed.Summary: For even though we know little about iron regulation in COVID-19 patients thus far, it could be deduced from other viral infections that iron chelation might be an alternative beneficial adjuvant in treating COVID-19.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"7 2","pages":"13-19"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37857556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0