Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival.

IF 3.1 Q2 MICROBIOLOGY
Current Clinical Microbiology Reports Pub Date : 2020-01-01 Epub Date: 2020-04-20 DOI:10.1007/s40588-020-00140-w
Wei Liu, Shuping Zhang, Sergei Nekhai, Sijin Liu
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Abstract

Purpose of the review: The ongoing outbreak of novel coronavirus pneumonia (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread concerns. Thus, therapeutic options are urgently needed, and will be discussed in this review.

Recent findings: Iron-containing enzymes are required for viruses most likely including coronaviruses (CoVs) to complete their replication process. Moreover, poor prognosis occurred in the conditions of iron overload for patients upon infections of viruses. Thus, limiting iron represents a promising adjuvant strategy in treating viral infection through oral uptake or venous injection of iron chelators, or through the manipulation of the key iron regulators. For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome (AIDS) patients. Increasing intracellular iron efflux via increasing iron exporter ferroportin expression also exhibits antiviral effect on human immunodeficiency virus (HIV). The implications of other metals besides iron are also briefly discussed.

Summary: For even though we know little about iron regulation in COVID-19 patients thus far, it could be deduced from other viral infections that iron chelation might be an alternative beneficial adjuvant in treating COVID-19.

Abstract Image

剥夺病毒的铁元素供应是一种很有前景的病毒生存辅助疗法
综述的目的:由 2019 年新型冠状病毒(SARS-CoV-2)引起的新型冠状病毒肺炎(COVID-19)在中国的持续爆发引发了广泛关注。因此,迫切需要治疗方案,本综述将对此进行讨论:包括冠状病毒(CoVs)在内的大多数病毒完成复制过程都需要含铁酶。此外,感染病毒的患者在铁超载的情况下预后不良。因此,通过口服或静脉注射铁螯合剂,或通过操纵关键的铁调节因子,限制铁是治疗病毒感染的一种很有前景的辅助策略。例如,铁螯合剂去铁酮(deferiprone)可延长获得性免疫缺陷综合征(艾滋病)患者的生存期。通过增加铁输出因子铁蛋白的表达来增加细胞内铁的外流,对人类免疫缺陷病毒(HIV)也有抗病毒作用。此外,还简要讨论了除铁以外的其他金属的影响:尽管迄今为止我们对 COVID-19 患者体内的铁调节知之甚少,但从其他病毒感染中可以推断出,铁螯合可能是治疗 COVID-19 的另一种有益辅助手段。
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来源期刊
CiteScore
7.50
自引率
1.90%
发文量
9
期刊介绍: Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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