Candida auris infection and biofilm formation: going beyond the surface.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2020-09-01 Epub Date: 2020-07-17 DOI:10.1007/s40588-020-00143-7

Mark V Horton, Jeniel E Nett

引用次数: 50

Abstract

Purpose of review: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy.

Recent findings: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices.

Summary: Here we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.

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耳念珠菌感染与生物膜形成:超越表面。

回顾的目的:紧急真菌病原体C. auris正在世界各地的医院传播，侵袭性疾病患者的死亡率接近60%。该物种表现出较高的定殖能力，在医院表面持续存在，在医疗保健环境中迅速传播，并抵抗抗真菌治疗。最近的发现:目前的研究表明，金黄色葡萄球菌产生生物膜，表面附着的群落，抵抗抗真菌剂和抵抗干燥。当金黄色葡萄球菌在皮肤上生长或在医院环境和植入医疗设备的预期条件下生长时，形成这些生物膜。摘要:本文将重点介绍金黄色葡萄球菌生物膜的形成。我们说明了这一过程如何影响对抗菌素的耐药性并促进医院传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.