Bulletin of Tokyo Dental College最新文献_第4页

Surgical Periodontal Therapy Using Recombinant Human Fibroblast Growth Factor-2 in Combination with Carbonate Apatite Granules for Stage III Grade B Periodontitis: A Case Report with 1-year Follow-up. 重组人成纤维细胞生长因子-2联合碳酸钙磷灰石颗粒治疗III期B级牙周炎:1例1年随访报告。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-09-05 Epub Date: 2022-08-15 DOI: 10.2209/tdcpublication.2022-0008

Tasuku Murakami, Kentaro Imamura, Naoko Watanabe-Egawa, Sachiyo Tomita, Atsushi Saito

{"title":"Surgical Periodontal Therapy Using Recombinant Human Fibroblast Growth Factor-2 in Combination with Carbonate Apatite Granules for Stage III Grade B Periodontitis: A Case Report with 1-year Follow-up.","authors":"Tasuku Murakami, Kentaro Imamura, Naoko Watanabe-Egawa, Sachiyo Tomita, Atsushi Saito","doi":"10.2209/tdcpublication.2022-0008","DOIUrl":"https://doi.org/10.2209/tdcpublication.2022-0008","url":null,"abstract":"This report describes a case of generalized chronic periodontitis requiring periodontal treatment including regenerative therapy. The patient was a 60-year-old woman who visited the Tokyo Dental College Suidobashi Hospital with the chief complaint of tooth mobility and pain in tooth #26. Periodontal examination at the first visit revealed that 32.0% of sites had a probing depth of ≥4 mm and 43.8% bleeding on probing. Radiographic examination revealed vertical bone resorption in #17. Horizontal resorption was noted in other areas. Initial periodontal therapy consisting of plaque control, scaling and root planing, and caries treatment was performed based on a clinical diagnosis of Stage III Grade B periodontitis. Tooth #26 was extracted due to bone resorption extending as far as the root apex. After reevaluation, periodontal regenerative therapy using recombinant human fibroblast growth factor-2 (rhFGF-2) in combination with carbonate apatite (CO3Ap) granules was performed for #17. Following reevaluation, a zirconia crown (#16) and zirconia bridge (#24-27) were placed. Following further reevaluation, the patient was placed on supportive periodontal therapy (SPT). The periodontal regenerative therapy using rhFGF-2 with CO3Ap granules yielded an improvement in the vertical bone resorption observed in #17. This improvement has been adequately maintained over a 1-year period postoperatively. Continued SPT is needed to maintain stable periodontal conditions.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"63 3","pages":"145-153"},"PeriodicalIF":0.5,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40412087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Novel Regulator Involved in Differentiation of Mouse iPS Cells into Odontoblast-like Cells. 小鼠iPS细胞向成牙细胞样细胞分化的新调控因子的鉴定。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-09-05 Epub Date: 2022-08-15 DOI: 10.2209/tdcpublication.2021-0045

Kenji Inoue, Kenichi Matsuzaka, Takashi Inoue

{"title":"Identification of Novel Regulator Involved in Differentiation of Mouse iPS Cells into Odontoblast-like Cells.","authors":"Kenji Inoue, Kenichi Matsuzaka, Takashi Inoue","doi":"10.2209/tdcpublication.2021-0045","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0045","url":null,"abstract":"Odontoblasts differentiate from dental papilla stem cells, but the genetic changes that occur during this process remain unclear. The aim of this study was to investigate gene expression patterns during differentiation of mouse iPS cells into odontoblast-like cells. Mouse iPS cells were cultured on a collagen type-1 scaffold with bone morphogenetic protein 4 (BMP4) and retinoic acid (RA). The results of immunofluorescence studies for dentin sialoprotein, dentin matrix protein 1 (DMP1), and nestin were positive. A qRT-PCR analysis revealed that mRNA expression levels of neural crest marker sex determining region Y box (Sox)-10, dentin sialophosphoprotein (Dspp), and Dmp1 were up-regulated, but that mRNA expression levels of the mineralization markers bone sialoprotein and osteocalcin were down-regulated. Microarray analysis showed that 2,597 entities were up-regulated and 1,327 down-regulated among a total of 15,330 investigated. Sox11 was among the up-regulated genes identified. The Sox11 mRNA expression level with odontoblast induction after day 11 was higher than that after day 2 (p<0.05). Gene knockdown using small interference RNA (siRNA) silencing was used to characterize the function of Sox11. The Dspp mRNA expression level in Sox11 siRNA-treated cells was significantly lower than that in the control (p<0.05). These results suggest that BMP4 and RA induce mouse iPS cells to differentiate into odontoblast-like cells. The differentiation efficiency is not high, however, and many stem cells remain. The results also suggest that Sox11 is an important factor in odontoblastic differentiation.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"63 3","pages":"119-128"},"PeriodicalIF":0.5,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40412085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

External Root Resorption of Second Molars Due to Impacted Mandibular Third Molars during Orthodontic Retention. 正畸固位时下颌第三磨牙阻生对第二磨牙外牙根吸收的影响。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-09-05 Epub Date: 2022-08-15 DOI: 10.2209/tdcpublication.2021-0044

Dai Ariizumi, Teruo Sakamoto, Masae Yamamoto, Yasushi Nishii

引用次数: 1

Effects of Cuspal Inclination and Luting Agent on Fracture Load Values in Composite Resin CAD/CAM Crowns. 复合树脂CAD/CAM牙冠中牙尖倾斜度和胶合剂对断裂载荷值的影响。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-05-25 DOI: 10.2209/tdcpublication.2020-0017

Gen Kuroishi, Mamoru Yotsuya, Syuntaro Nomoto, R. Hisanaga, Toru Sato

{"title":"Effects of Cuspal Inclination and Luting Agent on Fracture Load Values in Composite Resin CAD/CAM Crowns.","authors":"Gen Kuroishi, Mamoru Yotsuya, Syuntaro Nomoto, R. Hisanaga, Toru Sato","doi":"10.2209/tdcpublication.2020-0017","DOIUrl":"https://doi.org/10.2209/tdcpublication.2020-0017","url":null,"abstract":"The purpose of this study was to evaluate whether change in cuspal inclination influences the fracture load values of composite resin computer-aided design/computer-aided manufacturing (CAD/CAM) crowns. Abutment teeth and CAD/CAM crowns were prepared as they would be for treating a mandibular first premolar with two cusps. The CAD/CAM crowns were designed so that 1) the principal stress lines would be radially distributed from the two points of contact with the indenter to the occlusal area of the abutment (Type I), or 2) the principal stress lines would pass outside the occlusal area of the abutment (Types II and III). The CAD/CAM crowns were mounted on the abutments using one of two types of resin or polycarboxylate cement. Fracture load values were measured using a universal tester. The Type I CAD/CAM crowns exhibited the highest mean fracture load value, followed by the Type II crowns and then the Type III crowns, with significant differences seen between all types (p<0.05). The luting agent used (resin or polycarboxylate cement) showed no effect on the fracture load value. With the Type II and Type III crowns, significant differences in the fracture load value were observed between the Super-Bond and Hy-Bond polycarboxylate cement groups (p<0.05).","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47240401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

New Method of Dental Personal Identification of Disaster Victims Using Oral Scanner. 用口腔扫描仪对灾难受害者进行牙科个人识别的新方法。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-05-25 DOI: 10.2209/tdcpublication.2021-0035

Yasutaka Nakamura, N. Kasahara, M. Hashimoto

{"title":"New Method of Dental Personal Identification of Disaster Victims Using Oral Scanner.","authors":"Yasutaka Nakamura, N. Kasahara, M. Hashimoto","doi":"10.2209/tdcpublication.2021-0035","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0035","url":null,"abstract":"Dentistry plays an important role in the identification of victims in large-scale disasters. The current poor status of and problems with victim identification work were highlighted in the aftermath of the Great East Japan Earthquake of March 11, 2011, in which some 10,000 people lost their lives. The techniques of dental identification therefore need to be improved if they are to cope with the problems associated with identification that will accompany the predicted Tokai earthquake and other unexpected large-scale disasters in the future. The purpose of this study was to determine the effectiveness of applying a digital impression-taking device employed in regular dental care to dental personal identification. The Trophy 3DI pro (Yoshida Dental) was applied to a total of 150 dental models. The diagnosis was accurate in 2,096 teeth from a sample of 2,100 comprising 1,240 non-treated teeth, 670 treated teeth, and 190 missing teeth, yielding a 99.8% level of statistical precision. These results suggest that the level of accuracy offered by this impression-taking device indicates that it would be a useful tool in establishing personal identification in disaster victims.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42400325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Chronic Periodontitis with Periodontal Surgery Including Regenerative Therapy Using Recombinant Human Fibroblast Growth Factor-2 and Papilla Preservation Technique: A Case Report with a Two-year Follow-up. 牙周手术治疗慢性牙周炎，包括使用重组人成纤维细胞生长因子-2和乳头保存技术的再生治疗：一例病例报告和两年随访。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-05-25 DOI: 10.2209/tdcpublication.2021-0048

Saki Nakane-Koyachi, K. Imamura, A. Saito

{"title":"Treatment of Chronic Periodontitis with Periodontal Surgery Including Regenerative Therapy Using Recombinant Human Fibroblast Growth Factor-2 and Papilla Preservation Technique: A Case Report with a Two-year Follow-up.","authors":"Saki Nakane-Koyachi, K. Imamura, A. Saito","doi":"10.2209/tdcpublication.2021-0048","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0048","url":null,"abstract":"This report describes a case of generalized chronic periodontitis requiring periodontal therapy including periodontal regeneration. The patient was a 59-year-old man who visited the Tokyo Dental College Suidobashi Hospital with the chief complaint of mobility in tooth #47. Periodontal examination at the first visit revealed that 32.1% of sites had a probing depth of ≥4 mm and 32.7% of sites bleeding on probing. Radiographic examination revealed vertical bone resorption in #26 and horizontal resorption in #12, 13, 42, and 43. Based on a clinical diagnosis of severe chronic periodontitis, initial periodontal therapy consisting of plaque control, scaling and root planing, occlusal adjustment, caries treatment, and placement of an occlusal splint was performed. Tooth #47 was extracted due to bone resorption extending as far as the root apex. After reevaluation, surgical periodontal treatment was performed at the selected site. Periodontal regenerative therapy using recombinant human fibroblast growth factor (rhFGF)-2 and papilla preservation technique was performed for #26. To reduce periodontal pockets, open flap debridement was implemented for #12, 13, 42, and 43. After reevaluation, the patient was placed on supportive periodontal therapy (SPT). Periodontal regenerative therapy with rhFGF-2 and modified papilla preservation technique yielded an improvement in angular bone resorption which has been properly maintained for two years. Periodontal therapy with open flap debridement resulted in an improvement in horizontal bone resorption. Continued SPT is needed to maintain a stable periodontal condition.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49254136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment for Chronic Periodontitis with Class II Furcation Involvement: A Case Report with Four-year Follow-up. 慢性牙周炎伴ⅱ类分叉累及的治疗:一个四年随访的病例报告。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-05-25 DOI: 10.2209/tdcpublication.2021-0047

Yurie Kitamura, H. Aoki, A. Saito

{"title":"Treatment for Chronic Periodontitis with Class II Furcation Involvement: A Case Report with Four-year Follow-up.","authors":"Yurie Kitamura, H. Aoki, A. Saito","doi":"10.2209/tdcpublication.2021-0047","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0047","url":null,"abstract":"This report describes a case of generalized chronic periodontitis requiring periodontal treatment including surgery. The patient was a 64-year-old man who visited the Tokyo Dental College Suidobashi Hospital with the chief complaint of pain in tooth #27. An initial examination revealed a probing depth (PD) of ≥4 mm at 38.2% of sites and bleeding on probing at 26.5% of sites. Radiographic examination revealed vertical bone resorption in # 27, 34, and 47, and horizontal resorption in other areas. Based on a clinical diagnosis of severe chronic periodontitis, initial periodontal therapy consisting of plaque control, scaling and root planing was performed. Both #27 and #47 were extracted due to bone resorption extending as far as the root apex. After initial periodontal therapy, sites with a PD of ≥4 mm were observed at 16.7% of sites. Furcation involvement was observed in #16, 17, 36, and 37. The need and options for periodontal surgery based on these findings were explained to the patient. Open flap debridement was implemented for #16, 17, 31, 34, 36, and 37 to reduce periodontal pockets. After reevaluation, the patient was placed on supportive periodontal therapy. The results of the periodontal examination at first visit revealed a periodontal pocket depth of 6 mm and 7 mm in #16 and 17, respectively, and class II furcation involvement in both. Periodontal therapy with open flap debridement resulted in an improvement in horizontal bone resorption where there was class II furcation involvement. This improvement has been adequately maintained over a 4-year period.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47964060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of KnockOut Serum Replacement on Differentiation of Mouse-Induced Pluripotent Stem Cells into Odontoblasts. 敲除血清置换对小鼠诱导的多能干细胞分化为成齿细胞的影响。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-05-25 DOI: 10.2209/tdcpublication.2021-0042

Yuki Furukawa, Ayano Odashima, Tatsuki Hoshino, Shoko Onodera, A. Saito, T. Ichinohe, Toshifumi Azuma

{"title":"Effects of KnockOut Serum Replacement on Differentiation of Mouse-Induced Pluripotent Stem Cells into Odontoblasts.","authors":"Yuki Furukawa, Ayano Odashima, Tatsuki Hoshino, Shoko Onodera, A. Saito, T. Ichinohe, Toshifumi Azuma","doi":"10.2209/tdcpublication.2021-0042","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0042","url":null,"abstract":"Serum serves as a source of rich nutrients during in vitro cell culture, facilitating cell adhesion, growth, and differentiation. When culturing stem cells for transplantation, however, it must be remembered that such culture medium may contain substances potentially harmful to the proposed recipient and may even induce cellular damage. The purpose of this study was to determine whether KnockOut Serum Replacement (KSR), a chemically defined medium supplement, enhanced in vitro differentiation of induced pluripotent stem cells into odontoblasts. Cranial neural crest cells, precursors of odontoblasts, were generated from mouse-induced pluripotent stem cells. They were then cultured in serum-free Dulbecco's modified Eagle's/F12 medium containing fibroblast growth factor 8 with or without KSR. The cells cultured with KSR showed strong proliferation, acquired a spindle-like morphology, and connected with the surrounding cells. KnockOut Serum Replacement also boosted expression of odontoblast markers as measured by qRT-PCR, and increased dentin sialoprotein as assessed by immunostaining. These results confirmed that mouse-induced pluripotent stem cells differentiated into odontoblasts under serum-free conditions, and that KSR enhanced the efficiency of this process.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46645256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey on Availability of Domiciliary Dental Care under 16-km Rule. 在16公里规则下的住所牙科护理的可得性调查。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-03-08 Epub Date: 2022-02-15 DOI: 10.2209/tdcpublication.2021-0016

Munetsugu Tashiro, SoIchiro Hirata, Kousuke Oozawa, Tetsunori Ozaki

{"title":"Survey on Availability of Domiciliary Dental Care under 16-km Rule.","authors":"Munetsugu Tashiro, SoIchiro Hirata, Kousuke Oozawa, Tetsunori Ozaki","doi":"10.2209/tdcpublication.2021-0016","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0016","url":null,"abstract":"In Japan, domiciliary care fees are only covered by the public health insurance system if the clinic concerned is located within 16 km of the patient's residence. This nationwide rule does not take local conditions into account and therefore may not be appropriate. The goal of the present study was to assess the current state of domiciliary dental care nationwide in view of this restriction to clarify the current situation and any inherent problems. Six dental institutions providing domiciliary dental care were selected by location (urban or mountainous area) and size. Travel time from clinics to the 16 km points and the longest time required for the journey from clinics were investigated. Two of the dental clinics were located in depopulated areas with few dental institutions. These clinics had to provide domiciliary dental care not only in the 16-km area around the clinic, but also in areas over 16 km away. Travel time to the 16-km points was between 52 and 90 min. On the other hand, the longest time for actual visiting was between 30 and 60 min. In some areas, no domiciliary dental care was available within the 16 km limit. This indicates that the 16-km area is too wide to be covered by one dental institution alone and that it poses a problem in areas with few dental institutions. This suggests that it would be preferable to consider time required to visit rather than geographical distance in forming policy. The 16-km limit often spans multiple residential areas, indicating that greater coordination is needed between the Community-based Integrated Care System and dental offices.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"63 1","pages":"41-51"},"PeriodicalIF":0.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39626534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Treponema Denticola Infection on Epithelial Cells. 密螺旋体感染对上皮细胞的影响。

IF 0.5

Bulletin of Tokyo Dental College Pub Date : 2022-03-08 Epub Date: 2022-02-15 DOI: 10.2209/tdcpublication.2021-0037

Eitoyo Kokubu, Yuichiro Kikuchi, Kazuko Okamoto-Shibayama, Kazuyuki Ishihara

{"title":"Effect of Treponema Denticola Infection on Epithelial Cells.","authors":"Eitoyo Kokubu, Yuichiro Kikuchi, Kazuko Okamoto-Shibayama, Kazuyuki Ishihara","doi":"10.2209/tdcpublication.2021-0037","DOIUrl":"https://doi.org/10.2209/tdcpublication.2021-0037","url":null,"abstract":"Chronic periodontitis is an infectious disease caused by periodontopathic bacteria in subgingival plaque. One major pathogen of this disease, Treponema denticola, has several virulence factors, including a major surface protein (Msp) and the surface protease dentilisin. The cytopathic effects of periodontopathic bacteria on epithelial cells disrupt the integrity of the barrier junction, resulting in the inflammation of periodontal tissue. The aim of this study was to investigate the effect of T. denticola virulence factors dentilisin and Msp on epithelial cells. The effects of T. denticola wild-type, Msp-mutant, and dentilisin-mutant strains on the contact junction in Madin-Darby canine kidney epithelial cells was evaluated based on ohmic values. Cultured oral carcinoma epithelial cells were scratched and exposed to the selected T. denticola strains and cell migration determined. Subsequent degradation of adherence proteins and proteins in the contact junctions was evaluated. Dissociation of cell contact junctions was detected in cells infected with wild-type T. denticola approximately 30 min after infection, but not in those exposed to the mutants. Inhibition of migration was observed in the wild-type and Msp-deficient mutants. The adherent proteins focal adhesion kinase, ZO-1, and paxillin were hydrolyzed by infection with the wild-type and Msp mutants. These results indicate that T. denticola disrupts the function of epithelial cells by hydrolyzing proteins at the intercellular junction and inhibiting healing of epithelial cells via hydrolyzed proteins associated with focal adhesion; Msp was also associated with these effects.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"63 1","pages":"13-22"},"PeriodicalIF":0.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39626537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0