{"title":"Correlations between Interleukin-33 and -1α Levels in Gingival Crevicular Fluid and Plasma in Patients with Chronic or Aggressive Periodontitis and Disease-free Subjects.","authors":"Sujatha Pai B, A. Pradeep","doi":"10.2209/tdcpublication.2019-0002","DOIUrl":"https://doi.org/10.2209/tdcpublication.2019-0002","url":null,"abstract":"Interleukin (IL)-33 is a dual-function protein that may play important roles as both a cytokine and intracellular nuclear factor. It may also function similarly to prototypical alarmin IL-1α, as an endogenous danger signal to alert innate immune system cells to tissue damage during trauma or infection, as it can be released in the extracellular space after endothelial cell damage or mechanical injury. The aim of this study was to determine possible correlations between concentrations of IL-33 and IL-1α in gingival crevicular fluid (GCF) and plasma obtained from healthy patients, those with chronic periodontitis (CP), and those with generalized aggressive periodontitis (GAP) patients. Forty-five patients with an age range of 20-60 years were enrolled and divided into 3 groups: Group H, 30 samples (15 GCF and 15 plasma) from 15 patients with healthy periodontium; Group CP, 30 samples from 15 patients with CP; and Group GAP, 30 samples from 15 patients with GAP. The clinical periodontal parameters investigated in all groups comprised the gingival index score, probing pocket depth, and clinical attachment level. The GCF and plasma levels of IL-33 and IL-1α were quantitated using enzyme linked immunosorbent assay. The mean IL-33 concentrations in GCF and plasma were highest in Group GAP, followed by Group CP, with the lowest in Group H; the difference among them was statistically significant (p<0.05). Concentration of IL-1α followed the same trend as that of IL-33 in GCF, but was lower than detection levels in plasma. The GCF and plasma concentrations of IL-33 correlated with IL-1α concentrations in GCF. Concentrations of IL-33 and IL-1α in GCF varied significantly between healthy patients and those with disease, allowing healthy patients to be distinguished from those with GAP or CP. The results of this study suggest that IL-33 offers a potential inflammatory marker of periodontal disease, similar to IL-1α.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2019-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45946217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ohkubo, T. Ueda, Keina Miura, H. Sugito, Keisuke Ono, Fumi Seshima, Toshiyuki Morioka, Saki Uchiyama, Mitsutaka Yoshida, Y. Yajima
{"title":"\"Easy-to-eat Meals\" for Outpatients Following Dental Treatment.","authors":"M. Ohkubo, T. Ueda, Keina Miura, H. Sugito, Keisuke Ono, Fumi Seshima, Toshiyuki Morioka, Saki Uchiyama, Mitsutaka Yoshida, Y. Yajima","doi":"10.2209/tdcpublication.2018-0055","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0055","url":null,"abstract":"Patients often experience temporary difficulty in masticating during the period immediately following dental treatment. The purpose of this study was to investigate subjectively assessed satisfaction with a specially designed diet for such patients by means of a questionnaire. These \"easy-to-eat meals\" were planned and provided by this hospital in Japan, and comprised a combination of commercially available and nutritionally rich soft foods, jellied foods, drinks, and other items. The patients were required to commence consuming them immediately following dental treatment. The questionnaire contained 6 categories -Satisfaction, Taste, Meal completion, Convenience, Reduction in discomfort, and Likelihood of reuse - to be evaluated on a 10-cm visual analog scale (VAS). The overall response was positive in all 41 completed questionnaires, with an overall score of 6 or higher for every category. Orthodontics achieved the highest VAS score in every category, followed by oral implantology, prosthodontics, and conservative Original Article doi:10.2209/tdcpublication.2018-0055 dentistry. A correlation was observed between Satisfaction and each of the 5 remaining questionnaire categories (Taste: |r|=0.70, p≤0.00; Meal completion: |r|=0.60, p≤0.00; Convenience: |r|=0.56, p≤0.00; Reduction in discomfort: |r|=0.48, p=0.00; and Likelihood of reuse: |r|=0.79, p≤0.00). An acceptable level of convenience was obtained with these meals, as they were reported to be useful during the period immediately following treatment, when eating out or preparing meals was physically and/or psychologically difficult.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41912406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Takahashi, Hitoshi Yamamoto, S. Hirata, N. Sugihara, Riuji Mochizuki, Toshiyuki Takahashi, S. Mataki, A. Katakura
{"title":"Effectiveness of Communication Studies Program at Tokyo Dental College Based on Comments from Members of Public in Educational Organization.","authors":"N. Takahashi, Hitoshi Yamamoto, S. Hirata, N. Sugihara, Riuji Mochizuki, Toshiyuki Takahashi, S. Mataki, A. Katakura","doi":"10.2209/tdcpublication.2018-0073","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0073","url":null,"abstract":"The purpose of this study was to investigate the effectiveness of the Communication Studies Program at Tokyo Dental College as a tool in behavioral education. The number of Patient Community members who had participated in multiple sets of the program for third-year students in the same year within the 3-year period spanning 2016 to 2018 (152, 148, and 129 students in 2016, 2017, and 2018 respectively), and the period during which they had participated in multiple sets were investigated. Comments on student behavior, including on hairstyle, clothes, and attitude, were also analyzed. The total number of members who had participated in multiple sets (1 set comprised 1 lecture and 2 training sessions) was 5; and their comments were more favorable during the second (sets 3 and 4) than the first half of the 1-month program (sets 1 and 2). During the first half, the students were criticized for speaking softly, having bad posture, not concentrating, and having an attitude inappropriate for a medical worker; but in the second half, they were praised for beginning to adopt the proper attitude for a medical worker, speaking louder, having better posture, and a very serious attitude. These findings suggest that the Communication Studies Program is effective in improving student behavior.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48079796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akira Watanabe, Shuji Yoshida, Takenobu Ishii, C. Saito, T. Shibahara
{"title":"Surgical Management of Median Cleft Lip Extending as Far as Alveolus Using Bone Grafting.","authors":"Akira Watanabe, Shuji Yoshida, Takenobu Ishii, C. Saito, T. Shibahara","doi":"10.2209/tdcpublication.2018-0070","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0070","url":null,"abstract":"Median clefts, which run through the midline of the upper lip, and alveolus are considered a type of craniofacial cleft. A Tessier number 0 median cleft lip is the rarest, and there are few reports concerning its surgical management. Here, we describe the case of a 6-year-old boy who presented at our hospital with a median cleft and alveolus of the upper lip with a shortened bifid frenulum. Inverted-V and Z-plasty incisions were performed for the median cleft and iliac bone grafting for the midline alveolus. At 1 year 5 months later, the postoperative course was uneventful, and proper approximation of the orbicularis oris muscle and vermilion were achieved, with a symmetrical Cupid's bow and labial tubercle and philtrum.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48693865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autotransplantation of Impacted Third Molar Using 3D Printing Technology: A Case Report.","authors":"Takashi Kamio, H. Kato","doi":"10.2209/tdcpublication.2018-0058","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0058","url":null,"abstract":"Here, we describe a case of autotransplantation of a mandibular horizontally impacted third molar using a 3-dimensional (3D) model based on limited cone-beam computed tomography (CBCT) images for diagnosis, 3D morphological evaluation, preoperative treatment planning, and surgical simulation. A 27-year-old woman visited this hospital for conservative treatment of the mandibular left second molar. Intraoral radiography and CBCT images revealed a C-shaped root canal in the mesial root, and compressive resorption of the distal root due to impingement of the crown of the horizontally impacted lower left third molar. Extraction was therefore planned. Multiple tooth-jaw bone 3D models for preoperative diagnosis were fabricated using a low-cost desktop 3D printer and surgical simulation of autotransplantation performed. The autotransplantation was then performed accordingly. Cone-beam computed tomography images and 3D models were extremely useful in obtaining a stereoscopic understanding of the morphology of the transplanted tooth and its surrounding anatomical structures. At the one-year postoperative recall, the patient was able chew with the transplanted tooth without pain, and no significant abnormalities were detected on intraoral radiographs, indicating a successful postoperative clinical course. Our experience of using 3D models fabricated based on CBCT images using a desktop 3D printer for preoperative diagnosis and surgical simulation suggests that this technique is useful in tooth autotransplantation.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43066068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Change in Anterior Crowding over 20 Years from Third Decade of Life in Untreated Angle Class I Crowding.","authors":"Yuka Saito, Aiko Tanoi, E. Motegi, K. Sueishi","doi":"10.2209/tdcpublication.2018-0049","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0049","url":null,"abstract":"Many studies have investigated age-related change in normal occlusion and during the post-retention phase of orthodontic treatment. None, however, have investigated such change in malocclusion. The purpose of this study was to compare age-related change in Angle Class I crowding with that in normal occlusion. Dental casts obtained from 10 men and 2 women in their 20s and then again in their 40s were digitized with a 3-dimensional laser scanner to measure anterior crowding, angulation, inclination, andarch width and length. A paired t -test was used to evaluate change in these values betweenthe two sets of casts. A student's t -test was used to compare values between the crowdingand normal groups. The casts obtained from individuals with untreated Angle Class Icrowding revealed that anterior crowding increased with age due to a decrease in thelength of the maxillary arch. Clear lingual inclination of the maxillary incisors and mesiolingual inclination of the maxillary canines were also observed. A decrease was observedin the anterior arch width and an increase in crowding due to lingual inclination of themandibular canines in the mandible. The space between the mandibular central incisors and between the mandibular lateral incisors and canines was particularly associated withan increase in crowding, suggesting that this was age-related. A comparison betweenpatients in their 40s with Angle Class I crowding and those with normal occlusion revealedthat the increase in maxillary anterior crowding was greater in the former. Mandibularanterior crowding increased at around the same rate, however.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42865772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Ishizuka, K. Yoshino, Seitaro Suzuki, R. Sato, Yuki Onose, Takako Eguchi, A. Takayanagi, H. Kamijo, N. Sugihara
{"title":"Factors Associated with Untreated Decayed Teeth in Male Sales Workers: An Internet Survey.","authors":"Y. Ishizuka, K. Yoshino, Seitaro Suzuki, R. Sato, Yuki Onose, Takako Eguchi, A. Takayanagi, H. Kamijo, N. Sugihara","doi":"10.2209/tdcpublication.2018-0053","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0053","url":null,"abstract":"The purpose of this study was to identify factors associated with untreated decayed teeth (DT) in male sales workers. The participants were recruited by screening a pool of Japanese registrants in an online database for eligibility for inclusion in the study. Between 20 February 2015 and 11 March 2015, those deemed eligible were asked to complete a questionnaire on the status of their oral health. Responses from a total of 142 male sales workers aged between 30 and 49 years were analyzed. Of these, 40 reported DT and 102 no untreated decayed teeth (NDT). The percentage of participants with DT was higher than that with NDT among night shift workers (p<0.001). A higher percentage of participants with DT reported pain when eating or drinking something cold (p=0.041), pain in the teeth or gingiva (p<0.001), or frequent stomatitis (p=0.030). A higher percentage of participants with DT reported eating between meals (p=0.027) and a lower percentage visiting a dental clinic in the past 6 months (p=0.017) compared with among participants with NDT. Those with NDT were more likely to report an inability to visit a dental clinic when they wanted to (p=0.033), but those with DT were more likely to report that their reasons for not visiting a dental clinic were that multiple visits were required for treatment (p=0.012) or that they did not like the treatment (p=0.005). Working the night shift (Odds Ratio [OR], 3.492; 95% Confidence Interval [CI], 1.347-8.725) and visiting a dental clinic in the past 6 months (OR, 0.084; 95%CI, 0.010-0.733) were identified as independent variables correlated with leaving DT untreated. Requiring oral health education and dental checkups at least once every 6 months may have a positive effect on oral health among male sales workers, especially those doing night shifts.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiromi Homma, M. Okada, Ayano Nakauchi, Eri Osawa, Nobuko Nagai, Atsuo Sakurai, S. Shintani
{"title":"Treatment of Child with Four Lost Maxillary Incisors due to Traffic Injury.","authors":"Hiromi Homma, M. Okada, Ayano Nakauchi, Eri Osawa, Nobuko Nagai, Atsuo Sakurai, S. Shintani","doi":"10.2209/tdcpublication.2018-0062","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0062","url":null,"abstract":"Tooth injury is frequently encountered in pediatric clinical practice. A clinician may be requested to not only respond at the time of injury, but also properly diagnose how such injury will affect the teeth and dentition. Here, we present a case of a child who lost 4 bilateral maxillary incisors due to a traffic accident, and in whom marked mesial inclination of the bilateral maxillary canines and bilateral maxillary first premolars would subsequently occur. Dental management was provided over an extended period. The boy, aged 9 years 11 months, visited our department with the chief complaint of premature loss of 4 bilateral maxillary incisors and eating disturbance associated with the loss of these teeth. Initially, a denture was fitted. The bilateral maxillary canines subsequently demonstrated marked mesial inclination, however, and erupted from an area equivalent to that of the bilateral central incisors. The bilateral maxillary first premolars also showed mesial inclination and rotation. Taking esthetics into consideration, a Nance holding arch with resin buttons that extended to the maxillary incisors and attached to artificial teeth was used. This appliance was also equipped with a retracting hook, and the bilateral maxillary canines were moved downward and distally. Presently, the removable partial denture is worn for the purposes of retention, esthetics, and mastication. Long-term oral management will be necessary. Therefore, final prosthetic treatment for the missing maxillary incisors is planned for when the patient reaches adulthood.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47644889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Periodontal Regenerative Therapy Using Enamel Matrix Derivative in Patient with Chronic Periodontitis: a 3-year 6-month Follow-up Report.","authors":"H. Aoki, Fumi Seshima, A. Saito","doi":"10.2209/tdcpublication.2018-0061","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0061","url":null,"abstract":"Here, we report a case of chronic periodontitis requiring periodontal regenerative therapy. The patient was a 73-year-old man who visited Tokyo Dental College Suidobashi Hospital with the chief complaint of gingival swelling and mobile tooth in the mandibular incisor region. An initial examination revealed that 33% of sites had a probing depth (PD) of≥4 mm and 27% bleeding on probing. Radiographic examination revealed bone resorption extending as far as the root apex in #32 and 47, vertical bone resorption in #37, and horizontal resorption in other regions. Based on a clinical diagnosis of moderate chronic periodontitis, initial periodontal therapy was carried out followed by periodontal surgery. The patient's oral health-related quality of life was also assessed at the time of each periodontal assessment. Surgical periodontal therapy was subsequently performed at selected sites. Periodontal regenerative therapy using enamel matrix derivative was performed on #37. Other sites with a PD of ≥4 mm were treated with open flap debridement, and scaling and root planing. Following reevaluation, the patient was placed on supportive periodontal therapy. The patient's periodontal condition has remained stable over a 3-year 6-month period. The patient's oral health-related quality of life showed a marked improvement after periodontal therapy.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45141460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ryu, Maine Nakamura, Takashi Izumisawa, Ken Ishizaki, T. Ueda, K. Sakurai
{"title":"Morphological Investigation of Residual Ridge in Japanese Edentulous Elderly for Fabrication of Edentulous Stock Tray.","authors":"M. Ryu, Maine Nakamura, Takashi Izumisawa, Ken Ishizaki, T. Ueda, K. Sakurai","doi":"10.2209/tdcpublication.2018-0066","DOIUrl":"https://doi.org/10.2209/tdcpublication.2018-0066","url":null,"abstract":"The objective of this study was to determine the size of the residual ridge in edentulous elderly Japanese persons for preparation of edentulous stock trays and clarify any correlations among the items measured. The participants comprised 74 patients requesting construction of a complete denture for the maxilla, mandible, or both. The length, width, and anterior and posterior height of the maxillary and mandibular residual ridge was measured on a prepared working model using a caliper. For each of the maxillary and mandibular edentulous residual ridges, correlations among measurement items were analyzed employing Pearson's correlation coefficient. In participants who were edentulous in both the maxilla and mandible, correlations between the maxillary and mandibular measurement items were analyzed employing Pearson's correlation coefficient. The results revealed that the mean maxillary length of the residual ridge was 55.21±4.07 mm, while mean mandibular length was 56.03±4.04 mm. The mean posterior width of the maxillary jaw was 48.79±4.14 mm, while that of the mandibular jaw was 57.33±3.24 mm. A strong correlation was found between the length and width of the residual ridge in both the maxilla and mandible, but no strong correlation was detected between the height in the anterior tooth region and any other item measured. These findings suggest that the size of any given item can be estimated by measuring either the length or width of the residual ridge when selecting a stock tray. We also propose that it is necessary to prepare stock trays with several different heights in the anterior tooth region, regardless of the length and width of the tray, or to adjust the length of the tray.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2018-0066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47472481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}